Article
Cell & Tissue Engineering
Zhengqi Wang, Grace Emmel, Hong Seo Lim, Wandi Zhu, Astrid Kosters, Eliver E. B. Ghosn, Peng Qiu, Kevin D. Bunting
Summary: This study reveals the important role of STAT5ab gene in both hematopoietic and stromal cells, and the deletion of STAT5ab using specific Cre promoters leads to a reduction in multipotent hematopoietic progenitors. Furthermore, STAT5ab is involved in the secretion of niche factors in mesenchymal stem cells and the differentiation priming of hematopoietic stem cells.
Article
Biochemistry & Molecular Biology
Sabine Jurado, Anna S. Fedl, Markus Jaritz, Daniela Kostanova-Poliakova, Stephen G. Malin, Charles G. Mullighan, Sabine Strehl, Maria Fischer, Meinrad Busslinger
Summary: PAX5 is an important tumor suppressor gene in B-cell acute lymphoblastic leukemia, but it is also involved in coding for various PAX5 fusion proteins. A study found that the PAX5-JAK2 fusion protein can promote leukemia development in a mouse model.
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Article
Multidisciplinary Sciences
Benedict Shi Xiang Lian, Takumi Kawasaki, Norisuke Kano, Daisuke Ori, Moe Ikegawa, Ayako Isotani, Taro Kawai
Summary: This study demonstrates that DNA methylation at specific CpG dinucleotides plays an important regulatory role in Il6 gene expression. Hypomethylation of CpG+286 promotes Il6 expression, while deletion of CpG+348 leads to a reduction in Il6 expression associated with enhanced CTCF binding to the Il6 locus. Moreover, hypomethylation of CpG+286 in alveolar macrophages from aged mice results in higher Il6 expression in response to LPS compared to young mice.
Article
Immunology
Yingying Wei, Zachary Braunstein, Jun Chen, Xinwen Min, Handong Yang, Lihua Duan, Lingli Dong, Jixin Zhong
Summary: Multiple sclerosis (MS) is an autoimmune disease mediated by T cells, but the exact signaling pathways involved in effector T cells in MS are not well understood. This study investigated the role of Janus kinase 2 (JAK2) and its potential as a therapeutic target in MS. The results showed that knockout of JAK2 in T cells prevented the development of MS in mice. In vitro experiments also demonstrated that JAK2 disruption suppressed the differentiation of TH1 cells and the production of IFN gamma. These findings suggest that overactive JAK2 signaling in T lymphocytes plays a critical role in MS and could be targeted for therapeutic intervention.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tao Jiang, Tianshuang Xia, Fangliang Qiao, Nani Wang, Yiping Jiang, Hailiang Xin
Summary: Bones serve mechanical and defensive functions, as well as regulating calcium ions and housing bone marrow. The qualities of bones fluctuate throughout life, with functions increasing in some situations while deteriorating in others. Excessive osteoclast differentiation can lead to various bone pathologies, and the transcription factors and developmental/environmental signals play crucial roles in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Shang Guo, Nannan Qin, Xiuying Wang, Zanwen Zuo, Qizhang Li, Yuliang Wang
Summary: This study aimed to investigate the prolactin effects and mechanisms of freeze-dried powder of daylily buds in rats. It was found that daylily buds can improve lactation deficiency in rats induced by bromocriptine through the PRLR/JAK2/STAT5 pathway, and the freeze-dried processing method better retains the flavonoids and phenols that promote milk production.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Plant Sciences
Norbert Andrasi, Aladar Pettko-Szandtner, Laszlo Szabados
Summary: Plant heat shock factors (HSFs) are encoded by large gene families and are involved in responses to high temperatures and various abiotic stresses. They are regulated primarily at the transcript level, with alternative splicing and post-translational modifications providing additional variability. Plant HSFs participate in a complex network of protein-protein interactions and play crucial roles in transcriptional control.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Endocrinology & Metabolism
Anna Juliane Vesting, Alexander Jais, Paul Klemm, Lukas Steuernagel, Peter Wienand, Morten Fog-Tonnesen, Henning Hvid, Anna-Lena Schumacher, Christian Kukat, Hendrik Nolte, Theodoros Georgomanolis, Janine Altmueller, Manolis Pasparakis', Andreas Schmidt', Marcus Krueger', Marc Schmidt Supprian, Ari Waisman, Beate Katharina Straub, Nathanael Raschzok, Michel Bernier, Andreas L. Birkenfeld, Nadine Hoevelmeyer, Jens C. Bruening, F. Thomas Wunderlich
Summary: The non-canonical NFKB-inducing kinase (NIK/MAP3K14) plays a crucial role in metabolic nonalcoholic fatty liver disease (NAFLD) and the progression from NAFLD to hepatocellular carcinoma (HCC) by modulating JAK2/STAT5 signaling.
MOLECULAR METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Mengyuan Wang, Qian Li, Lingbo Liu
Summary: Gene expression regulation involves multiple processes and various regulatory factors. This review provides an overview of key factors involved in gene expression regulation, such as transcription factors, chromatin accessibility, histone modifications, DNA methylation, and RNA modifications. Additionally, methods for detecting these regulatory factors are also described.
Article
Plant Sciences
Maite Colinas, Jacob Pollier, Dries Vaneechoutte, Deniz G. Malat, Fabian Schweizer, Liesbeth De Milde, Rebecca De Clercq, Joana G. Guedes, Teresa Martinez-Cortes, Francisco J. Molina-Hidalgo, Mariana Sottomayor, Klaas Vandepoele, Alain Goossens
Summary: Catharanthus roseus produces a variety of MIA metabolites in a heavily branched pathway, with gene expression being highly specific to cell type, organ, and stress. Further study of ORCA TFs reveals subfunctionalization in terms of regulating target genes and working synergistically with MYC2. Specific amino acid residues within ORCA DNA-binding domains play a role in regulating MIA pathway branches differently.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Plant Sciences
Lingling Zhang, Weimin Fang, Fadi Chen, Aiping Song
Summary: Transcription factors play a crucial role in balancing plant development and stress responses. Branching is an important process in plant morphogenesis and is closely related to plant biomass and crop yield. Transcription factors are involved in regulating branching and development, as well as various plant hormone pathways and photoresponses.
Article
Multidisciplinary Sciences
Shin'ya Ohmori, Jun Takai, Satoshi Uemura, Akihito Otsuki, Tetsuya Mori, Kinuko Ohneda, Takashi Moriguchi
Summary: Inflammation-dependent cytokine production in mast cells is regulated by the collaborative activity of GATA2 and PU.1 through their overlapping binding sites in distal cis-regulatory regions.
Article
Biochemistry & Molecular Biology
Semun Seong, Jung Ha Kim, Kabsun Kim, Inyoung Kim, Jeong-Tae Koh, Nacksung Kim
Summary: The study reveals that STAT5 negatively regulates the differentiation of bone marrow mesenchymal stem cells into adipocytes and plays a crucial role in bone homeostasis by directly and indirectly regulating osteoclast differentiation.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Wilson Cheuk Wing Chan, Zhijia Tan, Michael Kai Tsun To, Danny Chan
Summary: Bone is a dynamic tissue that responds to environmental changes such as nutrition and mechanical stress. Bone homeostasis is maintained through bone remodeling in adulthood, which involves a controlled balance between bone-resorbing osteoclasts and bone-forming osteoblasts. During embryonic development, bones can form through intramembraneous or endochondral ossification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Amy J. Elliott, Emily R. White Hat, Jyoti Angal, Victoria Grey Owl, Susan E. Puumala, DenYelle Baete Kenyon
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2016)
Article
Emergency Medicine
Heather G. Zook, Anupam B. Kharbanda, Andrew Flood, Brian Harmon, Susan E. Puumala, Nathaniel R. Payne
JOURNAL OF EMERGENCY MEDICINE
(2016)
Article
Genetics & Heredity
Shelby Brown, Susan Puumala, Jennifer Leonhard, Megan Bell, Jason Flanagan, Lori Williamson Dean, Quinn Stein
JOURNAL OF GENETIC COUNSELING
(2018)
Article
Emergency Medicine
Heather G. Zook, Nathaniel R. Payne, Susan E. Puumala, Katherine M. Ziegler, Anupam B. Kharbanda
PEDIATRIC EMERGENCY CARE
(2019)
Article
Health Care Sciences & Services
Tess L. Weber, Katherine M. Ziegler, Anupam B. Kharbanda, Nathaniel R. Payne, Chad Birger, Susan E. Puumala
BMC HEALTH SERVICES RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Gregory C. Shearer, Kamil Borkowski, Susan L. Puumala, William S. Harris, Theresa L. Pedersen, John W. Newman
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
(2018)
Article
Immunology
Amanda J. Nickel, Susan E. Puumala, Anupam B. Kharbanda
Article
Obstetrics & Gynecology
Susan E. Puumala, Renae K. Rich, Lonnie Roy, Regina Reynolds, Francesqca E. Jimenez, Jackline G. Opollo, Jeri Brittin
JOURNAL OF PERINATOLOGY
(2020)
Article
Genetics & Heredity
Malia Triebold, Karina Skov, Lindsay Erickson, Sarah Olimb, Susan Puumala, Ian Wallace, Quinn Stein
Summary: The number of certified genetic counselors (CGCs) in the United States has increased over the past few decades, with most CGCs living or working in metropolitan statistical areas (MSAs) with populations over 50,000 people, consistent with the overall population distribution in the country. Some MSAs have more than one CGC per 100,000 people, likely due to associations with specific institutions.
JOURNAL OF GENETIC COUNSELING
(2021)
Article
Oncology
Steven F. Powell, Miroslaw Mazurczak, Elie G. Dib, Jonathon S. Bleeker, Louis H. Geeraerts, Matthew Tinguely, Michele M. Lohr, Steven C. McGraw, Ashley W. Jensen, Christie A. Ellison, Lora J. Black, Susan E. Puumala, Valerie J. Reed, W. Keith Miskimins, John H. Lee, William C. Spanos
Summary: Adding dichloroacetate to cisplatin-based chemoradiotherapy appears to be safe with no detrimental effect on survival and expected metabolite changes compared to placebo. This supports further investigation into combining metabolic agents to chemoradiotherapy.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Public, Environmental & Occupational Health
Francesqca E. Jimenez, Renae K. Rich, Susan E. Puumala, Melinda Kentfield, Lori Schoenholtz, Jeri Brittin
Summary: The study evaluated the effects of transitioning from centralized to decentralized nursing models at two rural community hospitals. While one hospital experienced a decrease in length of stay and improved patient satisfaction, the other showed no significant change in outcomes and even a decrease in certain aspects of patient satisfaction.
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Renae K. Rich, Francesqca E. Jimenez, Susan E. Puumala, Sheila DePaola, Kathy Harper, Lonnie Roy, Jeri Brittin
Summary: The study aimed to evaluate the quantitative effects of new hospital design on adult inpatient outcomes, finding that there was no clear net change in healing and safety outcomes but improvement in patient satisfaction related to the environment.
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2021)
Review
Public, Environmental & Occupational Health
Francesqca E. Jimenez, Susan E. Puumala, Michael Apple, Lou Ann Bunker-Hellmich, Renae K. Rich, Jeri Brittin
HERD-HEALTH ENVIRONMENTS RESEARCH & DESIGN JOURNAL
(2019)
Article
Public, Environmental & Occupational Health
Wyatt J. Pickner, Katherine M. Ziegler, Jessica D. Hanson, Nathaniel R. Payne, Heather G. Zook, Anupam B. Kharbanda, Tess L. Weber, Jaymi N. Russo, Susan E. Puumala
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2018)
Article
Health Care Sciences & Services
Susan E. Puumala, Katherine M. Burgess, Anupam B. Kharbanda, Heather G. Zook, Dorothy M. Castille, Wyatt J. Pickner, Nathaniel R. Payne
