Article
Gastroenterology & Hepatology
Qiaoyan Liu, Bo Li, Yikang Li, Yiran Wei, Bingyuan Huang, Jubo Liang, Zhengrui You, You Li, Qiwei Qian, Rui Wang, Jun Zhang, Ruiling Chen, Zhuwan Lyu, Yong Chen, Mingxia Shi, Xiao Xiao, Qixia Wang, Qi Miao, Jing-Yuan Fang, Merrill Eric Gershwin, Min Lian, Xiong Ma, Ruqi Tang
Summary: Comparative analysis of gut microbiome and metabolome in IgG4-SC and PSC patients revealed distinct host-microbe interactions that may contribute to disease pathogenesis, highlighting the uniqueness of IgG4-SC.
Review
Biochemistry & Molecular Biology
Ji-Won Park, Jung-Hee Kim, Sung-Eun Kim, Jang Han Jung, Myoung-Kuk Jang, Sang-Hoon Park, Myung-Seok Lee, Hyoung-Su Kim, Ki Tae Suk, Dong Joon Kim
Summary: Cholangiopathies are various biliary diseases that affect the biliary epithelium and can lead to cholestasis and liver cirrhosis. Primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC) are the most important progressive cholangiopathies in adults, with research focusing on genetic risk, epigenetic changes, dysregulated mucosal immunity, and altered biliary epithelial cell function. Understanding the molecular pathogenesis of these diseases can help clinicians prevent and treat them more effectively.
Article
Gastroenterology & Hepatology
Daniel E. Radford-Smith, Emmanuel A. Selvaraj, Rory Peters, Michael Orrell, Jonathan Bolon, Daniel C. Anthony, Michael Pavlides, Kate Lynch, Alessandra Geremia, Adam Bailey, Emma L. Culver, Fay Probert
Summary: Serum metabolomic profiling has the potential to accurately distinguish between PSC and IgG4-SC, improve the diagnosis of IgG4-RD, and differentiate IgG4-SC from PSC.
LIVER INTERNATIONAL
(2022)
Review
Gastroenterology & Hepatology
Annarosa Floreani, Sara De Martin
Summary: PSC is a chronic cholestatic liver disease with no effective treatment currently available. There is controversy over the use of UDCA in PSC treatment. Novel pharmacological strategies targeting bile composition, immunomodulation, gut microbiome, and fibrosis are emerging, suggesting potential for personalized combination therapies for successful PSC treatment.
DIGESTIVE AND LIVER DISEASE
(2021)
Article
Gastroenterology & Hepatology
Damjana Bogatic, Robert Bryant, Kate D. Lynch, Samuel P. Costello
Summary: Primary sclerosing cholangitis (PSC) is a progressive liver disease with poor prognosis and no effective therapies to prevent progression. This study evaluated potential medical therapies that may exert their effects in PSC by modulation of the gut-liver axis.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Gastroenterology & Hepatology
Natassia Tan, John Lubel, William Kemp, Stuart Roberts, Ammar Majeed
Summary: Primary sclerosing cholangitis (PSC) is an orphan, cholestatic liver disease characterized by inflammatory biliary strictures. The pathophysiology of PSC is poorly understood, but it is likely driven by immune dysregulation, gut dysbiosis, and environmental exposures. Currently, there is no proven medical therapy to alter disease progression in PSC, and liver transplantation is the only option for end-stage liver disease. Manipulation of the gut microbiome and bile acid metabolism show promise in phase II trials. Statins and aspirin may reduce the risk of malignancy in PSC patients. Balloon dilatation is safer and equally effective compared to biliary stent insertion for clinically relevant strictures.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Fuat H. Saner, Alexandra Frey, Bjoern-Ole Stueben, Dieter P. Hoyer, Katharina Willuweit, Martina Daniel, Jassin Rashidi-Alavieh, Jurgen W. Treckmann, Hartmut H. Schmidt
Summary: In this retrospective study of 82 patients who underwent liver transplantation for primary sclerosing cholangitis (PSC), the authors assessed morbidity, survival rates, PSC recurrence, and the impact of donor characteristics in long-term follow-up. The study showed that PSC patients had excellent 10-year survival rates and a lower lab-MELD score was associated with longer survival. Donor characteristics did not affect patient survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Atsushi Tanaka, Junko Hirohara, Toshiaki Nakano, Kosuke Matsumoto, Olivier Chazouilleres, Hajime Takikawa, Bettina E. Hansen, Fabrice Carrat, Christophe Corpechot
Summary: The addition of bezafibrate to ursodeoxycholic acid in patients with primary biliary cholangitis was associated with improved prognosis, as evident from a large retrospective cohort study. The combination therapy showed a significant decrease in all-cause and liver-related mortality or need for liver transplantation, indicating the potential benefits of this treatment approach.
JOURNAL OF HEPATOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daniel R. Ludwig, Mark A. Anderson, Malak Itani, Kedar G. Sharbidre, Neeraj Lalwani, Raj M. Paspulati
Summary: This article reviews the clinical features, pathogenesis, diagnosis, and imaging findings of primary and secondary sclerosing cholangitis. It also discusses various etiologies of secondary sclerosing cholangitis, highlighting the unique imaging findings and clinical context of each diagnosis.
ABDOMINAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Martine Walmsley, David Tornai, Nora Cazzagon, Angela Leburgue, Anna Mrzljak, Henrike Lenzen, Marco Carbone, Joao Madaleno, Ana Lleo, Norman Junge, Christoph Schramm, Annika Bergquist
Summary: The aim of this study was to assess patient-reported quality of care in primary sclerosing cholangitis (PSC) and identify areas for improvement. The results indicated that PSC patients experience a high symptom burden and would benefit from more widespread use of elastography, bone density scan, and appropriate treatment for itch. Personalized prognostic information and guidance on improving health should be provided to individuals with PSC.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
David N. Assis, Christopher L. Bowlus
Summary: Primary sclerosing cholangitis (PSC) is a chronic liver disease characterized by fibroinflammatory damage to the biliary tree. It is often associated with inflammatory bowel disease and carries an increased risk of liver failure and cholangiocarcinoma. The complexity of the disease and lack of effective therapy have been challenges, but recent advancements in patient characterization, prognostication, and medical management offer hope for progress in the future. This review summarizes current understanding of PSC and highlights areas for further investigation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kevin P. Quinn, Siri A. Urquhart, Laurens P. Janssens, Ryan J. Lennon, Victor G. Chedid, Laura E. Raffals
Summary: Patients with primary sclerosing cholangitis (PSC) who undergo ileal pouch-anal anastomosis (IPAA) are more likely to develop pouchitis compared to non-PSC patients. PSC-associated pouchitis presents with unique clinical characteristics, including chronic pouchitis, moderate-to-severe pouch inflammation, prepouch ileitis, and less response to conventional antimicrobial therapy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sudhakar K. Venkatesh, Christopher L. Welle, Frank H. Miller, Kartik Jhaveri, Kristina Ringe, John E. Eaton, Helen Bungay, Lionel Arrive, Ahmed Ba-Ssalamah, Aristeidis Grigoriadis, Christoph Schramm, Ann S. Fulcher
Summary: Primary sclerosing cholangitis (PSC) is a chronic inflammatory disorder that affects the bile ducts and increases the risk of hepato-biliary malignancies. MRI/MRCP is considered the imaging standard, but there are no universally accepted reporting standards or definitions.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, Research & Experimental
Raanan Greenman, Michal Segal-Salto, Neta Barashi, Ophir Hay, Avi Katav, Omer Levi, Ilan Vaknin, Revital Aricha, Sarit Aharoni, Tom Snir, Inbal Mishalian, Devorah Olam, Johnny Amer, Ahmad Salhab, Rifaat Safadi, Yaakov Maor, Palak Trivedi, Christopher J. Weston, Francesca Saffioti, Andrew Hall, Massimo Pinzani, Douglas Thorburn, Amnon Peled, Adi Mor
Summary: CCL24 is involved in fibrosis and inflammation in liver and its inhibition can reduce liver injury. This study found that blocking CCL24 improves inflammation, fibrosis, and cholestasis in PSC, and reduces proliferation and senescence of cholangiocytes.
Article
Gastroenterology & Hepatology
Kris V. Kowdley, Lisa Forman, Bertus Eksteen, Nadege Gunn, Vinay Sundaram, Charles Landis, Stephen A. Harrison, Cynthia Levy, Alexander Liberman, Adrian M. Di Bisceglie, Gideon M. Hirschfield
Summary: The study aimed to evaluate the safety and efficacy of HTD1801 in treating primary sclerosing cholangitis (PSC). The results showed that HTD1801 had a significant and sustained effect in reducing alkaline phosphatase (ALP). Furthermore, HTD1801 was generally well tolerated. Therefore, HTD1801 may be a novel approach for the treatment of PSC.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Hiroyuki Kato, Keisuke Tateishi, Dosuke Iwadate, Keisuke Yamamoto, Hiroaki Fujiwara, Takuma Nakatsuka, Yotaro Kudo, Yoku Hayakawa, Hideaki Ijichi, Motoyuki Otsuka, Takahiro Kishikawa, Ryota Takahashi, Koji Miyabayashi, Yousuke Nakai, Yoshihiro Hirata, Atsushi Toyoda, Shinichi Morishita, Mitsuhiro Fujishiro
Summary: This study discovered the correlation between 3D genome structures and molecular subtypes of pancreatic cancer (PC) through Hi-C analysis. They found that HNF1B regulates the expression of related genes by influencing the 3D structures. These findings are significant for a better understanding of the molecular features of PC.
Editorial Material
Gastroenterology & Hepatology
Tatsuya Sato, Tomotaka Saito, Tsuyoshi Hamada, Yousuke Nakai, Mitsuhiro Fujishiro
Letter
Gastroenterology & Hepatology
Tomotaka Saito, Tsuyoshi Hamada, Yousuke Nakai
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Kazunaga Ishigaki, Rintaro Fukuda, Yousuke Nakai, Go Endo, Kohei Kurihara, Kota Ishida, Shuichi Tange, Shinya Takaoka, Yurie Tokito, Yukari Suzuki, Hiroki Oyama, Sachiko Kanai, Tatsunori Suzuki, Yukiko Ito, Tatsuya Sato, Ryunosuke Hakuta, Kei Saito, Tomotaka Saito, Tsuyoshi Hamada, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Mitsuhiro Fujishiro
Summary: This study compared the clinical outcomes of slim-delivery and conventional large-cell stents for the endoscopic management of unresectable hilar malignant biliary obstruction. The results showed that slim-delivery stents shortened the stent placement time, had a lower early adverse event rate, and had comparable rates and time to recurrent biliary obstruction compared to conventional stents.
DIGESTIVE ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Yousuke Nakai, Tsuyoshi Hamada, Tomotaka Saito, Hideyuki Shiomi, Akinori Maruta, Takuji Iwashita, Keisuke Iwata, Mamoru Takenaka, Atsuhiro Masuda, Saburo Matsubara, Tatsuya Sato, Tsuyoshi Mukai, Ichiro Yasuda, Hiroyuki Isayama
Summary: This review summarizes the indications and timing of interventional and supportive treatment modalities for patients with pancreatic fluid collections (PFCs) and discusses clinical unmet needs for future research.
DIGESTIVE ENDOSCOPY
(2023)
Article
Medicine, Research & Experimental
Tatsuya Sato, Tomotaka Saito, Mamoru Takenaka, Takuji Iwashita, Hideyuki Shiomi, Toshio Fujisawa, Nobuhiko Hayashi, Keisuke Iwata, Akinori Maruta, Tsuyoshi Mukai, Atsuhiro Masuda, Saburo Matsubara, Tsuyoshi Hamada, Tadahisa Inoue, Hiroshi Ohyama, Masaki Kuwatani, Hideki Kamada, Shinichi Hashimoto, Toshiyasu Shiratori, Reiko Yamada, Hirofumi Kogure, Takeshi Ogura, Kazunari Nakahara, Shinpei Doi, Kenji Chinen, Hiroyuki Isayama, Ichiro Yasuda, Yousuke Nakai
Summary: With the increasing popularity of endoscopic ultrasound (EUS)-guided transmural interventions, the management of walled-off necrosis (WON) of the pancreas is still debatable. This study aims to compare the efficacy and safety of immediate direct endoscopic necrosectomy (DEN) with the drainage-oriented step-up approach for WON patients. Evaluation: 8 out of 10.
Article
Gastroenterology & Hepatology
Tsuyoshi Hamada, Hiroki Oyama, Yousuke Nakai, Shuichi Tange, Junichi Arita, Ryunosuke Hakuta, Hideaki Ijichi, Kazunaga Ishigaki, Sachiko Kanai, Yoshikuni Kawaguchi, Hirofumi Kogure, Suguru Mizuno, Kei Saito, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Naminatsu Takahara, Mariko Tanaka, Keisuke Tateishi, Tetsuo Ushiku, Kiyoshi Hasegawa, Mitsuhiro Fujishiro
Summary: This study investigated the long-term effects of dilation of the main pancreatic duct (MPD) on intraductal papillary mucinous neoplasms (IPMNs) and found that MPD dilation was associated with higher incidence and prevalence of pancreatic carcinoma.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hirotoshi Ishiwatari, Takanori Kawabata, Hiroki Kawashima, Yousuke Nakai, Shin Miura, Hironari Kato, Hideyuki Shiomi, Nao Fujimori, Takeshi Ogura, Osamu Inatomi, Kensuke Kubota, Toshio Fujisawa, Mamoru Takenaka, Hiroshi Mori, Kensaku Noguchi, Yuki Fujii, Teiichi Sugiura, Noboru Ideno, Tomoki Nakafusa, Atsushi Masamune, Hiroyuki Isayama, Naoki Sasahira
Summary: For preoperative biliary drainage (PBD) of malignant hilar biliary obstruction (MHBO), the proportion of adverse events (AEs), including cholangitis, after endoscopic biliary drainage (EBD) until surgery was similar when either endoscopic nasobiliary drainage (ENBD) or endoscopic biliary stenting (EBS) was used.
DIGESTIVE ENDOSCOPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Kohei Kurihara, Yousuke Nakai, Mitsuhiro Fujishiro
DIGESTIVE ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Hiroki Oyama, Tsuyoshi Hamada, Yousuke Nakai, Mariko Tanaka, Go Endo, Ryunosuke Hakuta, Kota Ishida, Kazunaga Ishigaki, Sachiko Kanai, Kohei Kurihara, Tomotaka Saito, Tatsuya Sato, Tatsunori Suzuki, Yukari Suzuki, Shinya Takaoka, Shuichi Tange, Yurie Tokito, Naminatsu Takahara, Tetsuo Ushiku, Mitsuhiro Fujishiro
Summary: This study investigated the changes of blood markers and morphological features in the prediagnostic period of pancreatic carcinomas related to IPMNs. It was found that concomitant carcinomas were more likely to cause CA19-9 elevation compared to IPMN-derived carcinomas. Elevated HbA1c levels were only observed in a small number of patients. All patients with elevated blood markers had positive findings on cross-sectional imaging, and high-risk stigmata or worrisome features were observed in all concomitant carcinomas except one. Morphological alterations were well correlated with the long-term risk of IPMN-derived carcinomas but not with that of concomitant carcinomas.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Rintaro Fukuda, Ryunosuke Hakuta, Yousuke Nakai, Tsuyoshi Hamada, Shinya Takaoka, Yurie Tokito, Yukari Suzuki, Hiroki Oyama, Sachiko Kanai, Kensaku Noguchi, Tatsunori Suzuki, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Naminatsu Takahara, Suguru Mizuno, Yukiko Ito, Hirofumi Kogure, Mitsuhiro Fujishiro
Summary: This study successfully developed a predictive model for post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) and categorized patients into low, moderate, and high-risk groups. The model showed good predictive ability in both the training and validation cohorts. Further research is needed to investigate the prevention of PEP in high-risk patients.
Article
Oncology
Kazuma Kishi, Masaki Kuwatani, Yuki Ohnishi, Yasuhiro Kumaki, Hiroyuki Kumeta, Hajime Hirata, Yunosuke Takishin, Ryutaro Furukawa, Kosuke Nagai, Hiroki Yonemura, Shunichiro Nozawa, Ryo Sugiura, Kazumichi Kawakubo, Tomoyasu Aizawa, Naoya Sakamoto
Summary: A metabolomic analysis of duodenal juice was performed to identify differences between malignant and benign biliary diseases, demonstrating the potential of duodenal juice metabolomics as a diagnostic biomarker for biliary diseases.
Article
Gastroenterology & Hepatology
Shigeto Ishii, Hiroyuki Isayama, Naoki Sasahira, Saburo Matsubara, Yousuke Nakai, Toshio Fujisawa, Ko Tomishima, Takashi Sasaki, Kazunaga Ishigaki, Hirofumi Kogure, Takeshi Okamoto, Takeshi Otsuka, Yusuke Takasaki, Akinori Suzuki
Summary: This study evaluated the feasibility and safety of a newly developed partially covered self-expandable metallic stent (PC-SEMS) for EUS-guided hepaticogastrostomy (EUS-HGS), which effectively prevents stent migration.
ENDOSCOPIC ULTRASOUND
(2023)
Article
Gastroenterology & Hepatology
Ryunosuke Hakuta, Yousuke Nakai, Hiroki Oyama, Kensaku Noguchi, Sachiko Kanai, Yusuke Nomura, Tatsunori Suzuki, Kazunaga Ishigaki, Kei Saito, Tomotaka Saito, Tsuyoshi Hamada, Naminatsu Takahara, Suguru Mizuno, Hirofumi Kogure, Kyoji Moriya, Mitsuhiro Fujishiro
Summary: This study suggests that regular use of proton pump inhibitors (PPIs) is associated with a higher risk of biliary infection after endoscopic biliary drainage. This highlights the importance of avoiding unnecessary use of PPIs to reduce the occurrence of biliary infection.
Article
Gastroenterology & Hepatology
Shiro Hayashi, Mamoru Takenaka, Hirofumi Kogure, Takayuki Yakushijin, Yousuke Nakai, Kenji Ikezawa, Shinjiro Yamaguchi, Toshio Fujisawa, Yuzuru Tamaru, Iruru Maetani, Hirotsugu Maruyama, Satoshi Asai, Tadayuki Takagi, Koji Nagaike, Yasuki Hori, Tetsuya Sumiyoshi, Hidetaka Tsumura, Hisashi Doyama, Toshiyuki Yoshio, Kazuo Hara, Seiichiro Abe, Ichiro Oda, Motohiko Kato, Hiroko Nebiki, Tatsuya Mikami, Masanori Miyazaki, Kazuhiro Matsunaga, Makoto Hosono, Tsutomu Nishida
Summary: A follow-up survey conducted in Japan revealed some improvement in radiation protection equipment and education among endoscopy-fluoroscopy departments, although the progress was relatively limited compared to the previous survey in 2020.
