Article
Medicine, General & Internal
Yoshiaki Usui, Yukari Taniyama, Mikiko Endo, Yuriko N. Koyanagi, Yumiko Kasugai, Isao Oze, Hidemi Ito, Issei Imoto, Tsutomu Tanaka, Masahiro Tajika, Yasumasa Niwa, Yusuke Iwasaki, Tomomi Aoi, Nozomi Hakozaki, Sadaaki Takata, Kunihiko Suzuki, Chikashi Terao, Masanori Hatakeyama, Makoto Hirata, Kokichi Sugano, Teruhiko Yoshida, Yoichiro Kamatani, Hidewaki Nakagawa, Koichi Matsuda, Yoshinori Murakami, Amanda B. Spurdle, Keitaro Matsuo, Yukihide Momozawa
Summary: This study reveals that certain genetic variants associated with Helicobacter pylori infection can increase the risk of gastric cancer. Individuals carrying these genetic variants and infected with H. pylori have an even higher risk of developing gastric cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Silvia Salvatori, Irene Marafini, Federica Laudisi, Giovanni Monteleone, Carmine Stolfi
Summary: H. pylori infection contributes to the onset and development of gastric cancer through the mechanisms of chronic inflammation and DNA damage to gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Rui M. Ferreira, Joana Figueiredo, Ines Pinto-Ribeiro, Irene Gullo, Dionyssios N. Sgouras, Laura Carreto, Patricia Castro, Manuel A. Santos, Fatima Carneiro, Raquel Seruca, Ceu Figueiredo
Summary: Helicobacter pylori infection induces overexpression of laminin gamma 2 in gastric cancer cells, promoting cell invasion and resistance to apoptosis through modulation of Src, JNK, and AKT activity. Laminin gamma 2 and its downstream effectors could be potential therapeutic targets, and H. pylori eradication may delay the onset and progression of gastric cancer.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
So Dam Lee, Haengdueng Jeong, Bo Ram Hwang, Byeong Min Yu, Yejin Cho, Ki Teak Nam, Hyunki Kim, Yong Chan Lee
Summary: Strains of Helicobacter pylori positive for CagA may contribute to the development of gastric cancer through the induction of CK2 activation and CK28 degradation. The downregulation of CK28 and subsequent activation of AKT and Snail signaling pathways may play a crucial role in the epithelial-to-mesenchymal transition (EMT) in gastric cancer. CK2 could be a potential molecular target for the treatment of H. pylori-infected gastric cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Medicine, General & Internal
Jaskamal Padda, Khizer Khalid, Ayden Charlene Cooper, Gutteridge Jean-Charles
Summary: Gastric carcinoma is the third leading cause of cancer mortality worldwide, with a noticeable increase in new cases in Eastern Asia. Helicobacter pylori is responsible for the increased incidence of gastric cancer, utilizing multiple strains to survive chronically in the host cell epithelium.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Oncology
Michelle C. C. Lim, Phatcharida Jantaree, Michael Naumann
Summary: Helicobacter pylori is a pathogenic bacterium that resides in the stomach lining and causes inflammation called type B gastritis. The chronic inflammation induced by H. pylori and other factors may lead to the development of stomach neoplasms and adenocarcinoma. Dysregulation of cellular processes in the stomach lining and microenvironment is a characteristic of H. pylori infection. In this review, we discuss the contradictory role of H. pylori in promoting or suppressing apoptosis in gastric epithelial cells and highlight the key processes in the microenvironment that contribute to apoptosis and gastric carcinogenesis.
Article
Biochemistry & Molecular Biology
Rejina Shrestha, Naoko Murata-Kamiya, Satoshi Imai, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Masanori Hatakeyama
Summary: The initial step in bacterial infection is the adherence of the bacterium to the target cell surface. This study found that the mouse stomach has a much lower expression level of Ceacam1 compared to the human stomach, which leads to the inability of the bacteria to deliver the CagA protein due to the lack of interaction between HopQ and Ceacam1 in mouse gastric epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Aina Ichihara, Hinako Ojima, Kazuyoshi Gotoh, Osamu Matsushita, Susumu Take, Hiroyuki Okada, Akari Watanabe, Kenji Yokota
Summary: This study aimed to explore the association between different antibody reactivities and bacterial genome organization. High-reactive strains showed high gene homology, while inversion around the vacA gene was found in the genome of poorly responsive antigen strains.
Review
Cell Biology
Jacek Baj, Alicja Forma, Monika Sitarz, Piero Portincasa, Gabriella Garruti, Danuta Krasowska, Ryszard Maciejewski
Summary: Gastric cancer is a prevalent malignancy worldwide and ranks as the fourth leading cause of cancer-related deaths. The pathogenesis of gastric cancer involves the interaction between genetic and environmental factors, with Helicobacter pylori infection playing a major role. Understanding the mechanisms of H. pylori pathogenicity is crucial for developing eradication strategies to prevent carcinogenesis.
Article
Infectious Diseases
Mengheng Mi, Fangcao Wu, Jian Zhu, Fang Liu, Guzhen Cui, Xueqing Wen, Yue Hu, Zhaohui Deng, Xiaojuan Wu, Zhengrong Zhang, Tingna Qi, Zhenghong Chen
Summary: The research revealed the presence of heterogeneous Helicobacter pylori strains with resistance to different drugs and virulence within the gastric mucosa of individual patients. Genetic diversity among monoclonal strains influenced antibiotic susceptibility and some strains exhibited genotype variations impacting treatment efficacy.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Oncology
Yuka Koizumi, Sheny Ahmad, Miyuki Ikeda, Akiko Yashima-Abo, Ginny Espina, Ryo Sugimoto, Tamotsu Sugai, Takeshi Iwaya, Gen Tamura, Keisuke Koeda, Lance A. Liotta, Fumiaki Takahashi, Satoshi S. Nishizuka
Summary: Helicobacter pylori infection has a positive impact on the prognosis of advanced gastric cancer patients, potentially through the modulation of the host immune system.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Microbiology
Xinbo Xu, Chunxi Shu, Xidong Wu, Yaobin Ouyang, Hong Cheng, Yanan Zhou, Huan Wang, Cong He, Chuan Xie, Xingxing He, Junbo Hong, Nonghua Lu, Zhongming Ge, Yin Zhu, Nianshuang Li
Summary: This study reveals the existence of a positive feedback loop between TAZ and beta-catenin in the pathogenesis of H. pylori infection-induced gastric cancer. TAZ inhibition may serve as a potential target for the prevention of H. pylori infection-associated gastric cancer.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Mahjerin Nasrin Reza, Shahin Mahmud, Nadim Ferdous, Ishtiaque Ahammad, Mohammad Uzzal Hossain, Md. Al Amin, A. K. M. Mohiuddin
Summary: In this study, two siRNA molecules were designed to silence the CagA and VacA genes of H. pylori, which are significantly involved in gastric cancer development. These designed siRNAs should effectively silence the CagA and VacA genes during siRNA mediated treatment in gastric cancer.
Review
Microbiology
Seyedeh Zahra Bakhti, Saeid Latifi-Navid
Summary: The oral microbiota may play a role in the development and progression of gastric cancer, but the causal relationship between oral microbiota and gastric cancer remains controversial. Exploring the interaction and relationship between the oral microbiota and Helicobacter pylori in gastric cancer, as well as the impact of oral microbiota on the mechanisms of carcinogenesis, could offer new insights for the diagnosis and prevention of gastric cancer.
Article
Cardiac & Cardiovascular Systems
Xiujuan Xia, Linfang Zhang, Hao Wu, Feng Chen, Xuanyou Liu, Huifang Xu, Yuqi Cui, Qiang Zhu, Meifang Wang, Hong Hao, De-Pei Li, William P. Fay, Luis A. Martinez-Lemus, Michael A. Hill, Canxia Xu, Zhenguo Liu
Summary: This study found that CagA(+) H. pylori effectively colonizes gastric mucosa and impairs endothelial function, leading to increased atherosclerosis through exosomes-mediated ROS formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)