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Chemistry, Medicinal
Ji-Hye Choi, Si-Hyun Kim, Eun-Byeol Lee, Ji-Su Kim, Ji-Eeun Jung, Un-Yul Jeong, Ju-Hui Kim, Hwan-Hee Jang, Shin-Young Park, Gi-Chang Kim, Jung-Hyun Lim, Sung-Hyen Lee
Summary: This study evaluated the effectiveness of Allium hookeri in controlling diabetic symptoms. The results showed that extracts of A. hookeri could reduce blood glucose and lipid profile abnormalities, as well as regulate kidney function and immune system.
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Nutrition & Dietetics
Shujuan Zheng, Yanan Wang, Jingjing Fang, Ruixuan Geng, Mengjie Li, Yuhan Zhao, Seong-Gook Kang, Kunlun Huang, Tao Tong
Summary: The study found that oleuropein may ameliorate the advanced stage of type 2 diabetes through modulating the composition and function of gut microbiota, providing a promising therapeutic approach for the treatment of advanced stage type 2 diabetes.
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Nutrition & Dietetics
Wenhui Xu, Jiayu Gong, Yifei Chen, Yiru Chen, Shutong Chen, Yanyan Wu, Yuan He, Chenxu Li, Haitao Yu, Lin Xie
Summary: This study aimed to explore the effects and mechanisms of maternal gestational diabetes mellitus (GDM) and selenium (Se) deficiency on the growth and glucose metabolism of offspring. The study found that GDM increased susceptibility to obesity in offspring, with gender differences observed in adulthood. Se deficiency only affected female offspring in adulthood. GDM and Se deficiency increased the risk of abnormal glucose metabolism in female offspring, but this effect gradually decreased in male offspring.
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Multidisciplinary Sciences
Shino Nemoto, Tetsuya Kubota, Hiroshi Ohno
Summary: This study investigates the genetic cause of phenotypic differences between B6J and B6N mice, identifying candidate genes with differential expression in metabolic tissues and providing comparative data on body weight, tissue weight, blood components, and energy balance. These findings have important implications for future research in related fields.
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Agriculture, Dairy & Animal Science
Nerea Marin, Amparo Moragon, Domingo Gil, Francisco Garcia-Garcia, Viviana Bisbal
Summary: This study compared the stress levels of three blood sampling methods in mice: saphenous vein phlebotomy, caudal vein phlebotomy, and tail cut blood collection. The results showed that saphenous vein phlebotomy was the least stressful method.
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Nutrition & Dietetics
Bingyang Liu, Yang Gou, Takamasa Tsuzuki, Takako Yamada, Tetsuo Iida, Sixian Wang, Ryoichi Banno, Yukiyasu Toyoda, Teruhiko Koike
Summary: This study found that administration of d-Allulose improved aerobic performance and recovery from exhaustion in mice. It increased maximal aerobic speed, decreased blood lactate levels, and increased liver glycogen levels. It also improved insulin sensitivity. Overall, d-Allulose administration had similar effects to exercise training.
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Biochemistry & Molecular Biology
Sa Guo, Hui Ouyang, Wendi Du, Junmao Li, Mi Liu, Shilin Yang, Mingzhen He, Yulin Feng
Summary: The study demonstrates that Gynura procumbens (GP) can improve type 2 diabetes by activating the PI3K/Akt signaling pathway to improve insulin resistance and glucose metabolism.
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Chemistry, Medicinal
Ji-Su Kim, Hyun-Ju Kim, Eun-Byeol Lee, Ji-Hye Choi, Jieun Jung, Hwan-Hee Jang, Shin-Young Park, Ki-Chan Ha, Yu-Kyung Park, Jong-Cheon Joo, Sung-Hyen Lee
Summary: This study investigated the effects of Allium hookeri (AH) on glycemia in prediabetic subjects. The results showed that AH supplementation moderately reduced blood glucose and insulin levels, and improved insulin sensitivity.
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Food Science & Technology
Mirai Yamazaki, Misaki Okito, Akio Harada, Keisuke Miyake, Takashi Tamiya, Takehiro Nakamura
Summary: This study investigates the underlying mechanism of D-allulose in suppressing hepatic fat accumulation by examining the regulation of miRNA. The results indicate that changes in miRNA associated with PPAR gamma may be responsible for the inhibitory effect of D-allulose on hepatic lipid accumulation.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
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Cell Biology
Claes Fryklund, Mathis Neuhaus, Bjorn Moren, Andrea Borreguero-Munoz, Richard Lundmark, Karin G. Stenkula
Summary: This study investigates the adipocyte plasticity and systemic insulin sensitivity in response to high-fat diet (HFD) feeding. The results show that there is a metabolic tipping point between 8 and 12 weeks of HFD feeding where the adipocyte size plasticity deteriorates. Additionally, an increased pool of hypertrophic inguinal adipocytes may contribute to aggravated insulin resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
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Endocrinology & Metabolism
Lijuan Chen, Lin Guo, Susu Feng, Congcong Wang, Zhicheng Cui, Sijing Wang, Qingmiao Lu, Hang Chang, Bo Hang, Antoine M. Snijders, Jian-Hua Mao, Yibing Lu, Dafa Ding
Summary: This study confirms the effectiveness of FMT in treating patients with T2DM and demonstrates its positive impact on gut microbiome, serum metabolites, intestinal epithelial barrier, inflammation, and circulating immune cells.
BMJ OPEN DIABETES RESEARCH & CARE
(2023)
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Multidisciplinary Sciences
Linda F. Boeswald, Jasmin Wenderlein, Wolfgang Siegert, Reinhard K. Straubinger, Ellen Kienzle
Summary: Data on mineral digestibility is essential for understanding mineral homeostasis and improving dietary recommendations. While there is ample information on mineral digestibility in farm animals and pets, there is a lack of data in laboratory mice under maintenance conditions, which is crucial for studying mineral homeostasis. This study analyzed data on intake, faecal excretion, and apparent digestibility of various minerals in C57BL/6J mice fed different maintenance diets.
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Nutrition & Dietetics
Sophie B. Chehade, George B. H. Green, Christopher D. Graham, Ayanabha Chakraborti, Bijal Vashai, Amber Moon, Michael B. Williams, Benjamin Vickers, Taylor Berryhill, William van der Pol, Landon Wilson, Mickie L. Powell, Daniel L. Smith, Stephen Barnes, Casey Morrow, M. Shahid Mukhtar, Gregory D. Kennedy, James A. Bibb, Stephen A. Watts
Summary: Investigations have shown that western dietary patterns play a causative role in obesity and disease pathogenesis, and the quality and quantity of dietary fats and carbohydrates can predict the development of these disorders. Traditional rodent diets do not reflect modern human dietary habits, and high-fat diets used in previous studies did not accurately represent human fat intake levels. Recent research focuses on developing pre-clinical diets that resemble human diets. This study emphasizes the importance of diet quality in maintaining metabolic homeostasis and highlights the need for relevant pre-clinical diets to study chronic diseases affected by western dietary consumption patterns.
FRONTIERS IN NUTRITION
(2022)
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Biochemistry & Molecular Biology
Pamela R. Westmark, Aaron K. Gholston, Timothy J. Swietlik, Rama K. Maganti, Cara J. Westmark
Summary: This study assessed sleep-wake cycles in mice with different genotypes and dietary interventions. The results showed that a high-fat, low-carbohydrate ketogenic diet increased non-rapid eye movement (NREM) sleep and decreased activity levels in both wild type and Fmr1(KO) mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
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Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
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Food Science & Technology
Jeong Bin Min, Eun Suh Kim, Ji-Soo Lee, Hyeon Gyu Lee
FOOD SCIENCE AND BIOTECHNOLOGY
(2018)
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Biochemistry & Molecular Biology
Im Kyung Oh, In Young Bae, Hyeon Gyu Lee
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
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Biochemistry & Molecular Biology
Soo Yoon Lee, Kwang Yeon Lee, Hyeon Gyu Lee
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2018)
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Food Science & Technology
Im Kyung Oh, In Young Bae, Hyeon Gyu Lee
JOURNAL OF CEREAL SCIENCE
(2018)
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Food Science & Technology
Yun-Ju Cho, Dong-Hyeon Kim, Dana Jeong, Kun-Ho Seo, Heon Sang Jeong, Hyeon Gyu Lee, Hyunsook Kim
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
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Food Science & Technology
Im Kyung Oh, In Young Bae, Hyeon Gyu Lee
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Food Science & Technology
Su San Na Kang, Hyeon Gyu Lee, Hyunsook Kim
LWT-FOOD SCIENCE AND TECHNOLOGY
(2018)
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Food Science & Technology
Imkyung Oh, JaeHwan Lee, Hyeon Gyu Lee, Suyong Lee
FOOD RESEARCH INTERNATIONAL
(2019)
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Food Science & Technology
Ji-Hye Kwon, Hyeon Gyu Lee, Kun-Ho Seo, Hyunsook Kim
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
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Biochemistry & Molecular Biology
In Young Bae, Im Kyung Oh, Da Sol Jung, Hyeon Gyu Lee
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
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Food Science & Technology
Kyung Hyun Lee, Ji-Soo Lee, Eun Suh Kim, Hyeon Gyu Lee
LWT-FOOD SCIENCE AND TECHNOLOGY
(2019)
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Agriculture, Multidisciplinary
Eun Suh Kim, Da Young Kim, Ji-Soo Lee, Hyeon Gyu Lee
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2019)
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Agriculture, Multidisciplinary
Su J. Jeong, Ji-Soo Lee, Hyeon G. Lee
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2020)
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Biophysics
Joo Hee Chung, Ji-Soo Lee, Hyeon Gyu Lee
COLLOIDS AND SURFACES B-BIOINTERFACES
(2020)
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Biochemistry & Molecular Biology
Adriana Rivera-Piza, Lynkyung Choi, Jaeeun Seo, Hyeon Gyu Lee, Jiyoung Park, Sang-Ik Han, Sung-Joon Lee
JOURNAL OF FOOD BIOCHEMISTRY
(2020)