Article
Medicine, General & Internal
Geng Wang, Miaoru Zhen, Shasha Liu, Kunliang Qiu, Cui Liu, Ji Wang, Mingzhi Zhang
Summary: This study compared the diagnostic classification of Bruch's membrane opening-minimum rim width (BMO-MRW) and RNFL thickness in normal myopic subjects, finding that RNFL thickness classified a significantly higher proportion of eyes as outside normal limits/borderline in at least 1 quadrant. The low myopic group had a significantly lower proportion of eyes classified as outside normal limits/borderline compared to moderate and high myopic groups.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Do-Young Park, Soon-Cheol Cha
Summary: The purpose of this study was to investigate factors associated with an increase in neuroretinal rim (NRR) thickness measured based on Bruch's membrane opening-minimum rim width (BMO-MRW) after trabeculectomy in patients with primary open-angle glaucoma. The results showed that NRR thickness measured based on BMO-MRW increased with decreasing intraocular pressure post-trabeculectomy, with younger patients and greater IOP reduction associated with the increase in BMO-MRW. Biomechanically, the NRR seems to comprise cells and substances sensitive to changes in IOP and age.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Ki Yup Nam, Bum Jun Kim, Woo Hyuk Lee, Yong Seop Han
Summary: In patients with epiretinal membrane featuring peripapillary involvement, the measurements of BMO-MRW and RNFL thickness showed good repeatability, with BMO-MRW measurements demonstrating better repeatability than RNFL thickness measurements in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Gabriel Ayub, Vital Paulino Costa, Jose Paulo Cabral de Vasconcellos
Summary: This study found that BMO-MRW and RNFLT measurements are significantly reduced 3 months after an APAC, with a strong correlation with intraocular pressure.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Oncology
Ali Ceyhun Gedik, Kemal Turgay Ozbilen, Serife Bayraktar, Emre Altinkurt, Belgin Izgi
Summary: The study investigated the changes in retinal nerve fiber layer thickness in myopic children, finding that BMO-MRW and APS-RNFL are less affected by the degree of myopia compared to standard RNFL.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Ophthalmology
Kemal Turgay Ozbilen, Tuncay Gunduz, Selva Nur Cukurova Kartal, Ali Ceyhun Gedik, Mefkure Eraksoy, Murat Kurtuncu
Summary: The study investigated the potential of novel OCT parameters as alternative biomarkers in MS patients, with APS-RNFL technique showing slightly more reliability than S-RNFL technique, while BMO-MRW was not found to be a successful alternative.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Xiu Juan Zhang, Shu Min Tang, Yu Meng Wang, Yuzhou Zhang, Hei-Nga Chan, Yi Han Lau, Ka Wai Kam, Poemen P. Chan, Patrick Ip, Alvin L. Young, Clement C. Tham, Li Jia Chen, Chi Pui Pang, Jason C. Yam
Summary: The study aims to identify normative values and determinants for Bruch's membrane opening (BMO) and the minimum rim width of BMO (BMO-MRW) among healthy children. The results indicate that BMO-MRW increases with age among children and other factors such as the thickness of the optic nerve head and peripapillary retinal nerve fiber layer also have an impact on BMO parameters.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Camila S. Zangalli, Alessandro A. Jammal, Alexandre S. C. Reis, Gabriel Ayub, Alberto Diniz-Filho, Augusto Paranhos, Jayter S. Paula, Vital P. Costa
Summary: A study conducted in a Brazilian multiracial population found that both minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (RNFLT) measurements have comparable diagnostic performance in distinguishing early to moderate glaucoma from healthy eyes.
JOURNAL OF GLAUCOMA
(2023)
Article
Multidisciplinary Sciences
Donghee Park, Sung Pyo Park, Kyeong Ik Na
Summary: This study compared the rate of thinning between retinal nerve fiber layer thickness (RNFLT) and Bruch's membrane opening minimum rim width (BMO-MRW) in different severities of open-angle glaucoma (OAG). It was found that the fastest rate of thinning in RNFLT consistently occurred in the inferotemporal sector, while BMO-MRW showed a change in the fastest thinning sector from inferotemporal to superotemporal as the severity of OAG increased. The differences in these parameters may help in understanding the pathogenesis of glaucoma and predicting its progression.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Hyun Sup Choi, Chan Woong Joo, Sung Pyo Park, Kyeong Ik Na
Summary: The study found that in early glaucoma, the optic nerve head parameter BMO-MRA decreased faster than the peripapillary retinal nerve fiber layer thickness and visual field index, which may help with the detection of early glaucomatous damage.
JOURNAL OF GLAUCOMA
(2021)
Article
Ophthalmology
Dan Samaha, Langis Michaud
Summary: This study found that scleral lens wear significantly decreases BMO-MRW, which may be attributed to changes in intraocular pressure, and is not affected by corneal rigidity, central corneal thickness, or refractive error. Further research is needed to better understand the significance of these changes at the optic nerve head during scleral lens wear.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Mustafa Hepokur, Cansu Yuksel Elgin, Medine Gunes, Fatma Sali, Halit Oguz
Summary: This study compared the correlations between lamina cribrosa (LC) and related structures with Bruch's membrane opening-minimum rim width (BMO-MRW) and retinal nerve fiber layer (RNFL) thickness in pseudoexfoliation syndrome (PXS) and different stages of pseudoexfoliation glaucoma (PXG). The results showed that BMO-MRW may be more sensitive than RNFL in diagnosing and monitoring PXS and PXG.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Do Hee Park, Kyung Yoon Kook, Yeon Soo Kang, Helong Piao, Mi Sun Sung, Sang Woo Park
Summary: BMO-MRW is a useful parameter for diagnosing early glaucoma in myopic eyes, but its diagnostic performance may decrease in myopic eyes with large Bruch membrane opening (BMO) area.
JOURNAL OF GLAUCOMA
(2021)
Article
Medicine, General & Internal
Sat Byul Seo, Hyun-kyung Cho
Summary: This study aimed to use a deep learning model based on BMO optic disc photography to discriminate early NTG from GS. The CNN model showed high accuracy and AUC, indicating its potential for diagnosing early glaucoma.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Najia Uzair, Mariam Shamim, Syed Asaad Mamoon, Saliha Naz, Lubna Feroz, Komalta Kumari
Summary: This study compared the reliability of BMO-MRW OCT and RNFL in myopic patients with glaucoma, demonstrating that BMO-MRW OCT performs better in detecting glaucomatous damage in moderately myopic eyes.
JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN
(2021)
Article
Ophthalmology
Kazunori Hirasawa, Corey A. Smith, Michael E. West, Glen P. Sharpe, Lesya M. Shuba, Paul E. Rafuse, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: This study aimed to identify characteristics of patients with early open-angle glaucoma showing greater macular perfusion density (PD) loss compared to macular ganglion cell layer (GCL) thickness loss. Results indicated that patients with more PD loss were associated with lower signal strength in OCT and OCT angiography, thicker retinal nerve fiber layer thickness, and female sex. Less than one-third of patients with early glaucoma experienced more perfusion loss compared to conventional structural loss in the macula.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Takeshi Yabana, Michele L. Hooper, Spring R. Farrell, Balwantray C. Chauhan
Summary: The study evaluated the specificity of genetically encoded calcium sensor GCaMP3 expression in retinal ganglion cells (RGCs) of transgenic mice. It was found that the numbers of GCaMP3+ and RBPMS+ cells decreased significantly after optic nerve transection (ONT), while the number of ChAT+ cells remained unchanged.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Ophthalmology
Michael E. West, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: In the study comparing the 24-2 and 10-2 tests in glaucoma patients with early damage, it was found that the AUC values were not significantly different between the two tests, but the sensitivity of the 24-2 test was higher at matched specificity. The repeatability of test results during follow-up ranged from 55% to 70%.
Article
Computer Science, Interdisciplinary Applications
Alireza Karimi, Rafael Grytz, Seyed Mohammadali Rahmati, Christopher A. Girkin, J. Crawford Downs
Summary: This study investigated the effects of different element types on the resulting ONH stresses and strains. Results showed that 10-noded tetrahedral elements yielded similar results to 20-noded hexahedral elements with significantly lower computational time, while linear element types did not yield acceptable results.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Ophthalmology
Lindsay A. Rhodes, Shilpa Register, Irfan Asif, Gerald McGwin, Jinan Saaddine, Van Thi Ha Nghiem, Cynthia Owsley, Christopher A. Girkin
Summary: The study aims to develop a model eye health system using telemedicine to prevent vision loss and address eye health among underserved and at-risk populations. It will compare the effectiveness of remote and in-person eye disease detection, as well as the impact of financial incentives and patient education on follow-up adherence. Cost and cost-effectiveness analyses will also be conducted to evaluate the telemedicine program against standard care.
JOURNAL OF GLAUCOMA
(2021)
Article
Ophthalmology
Eugene A. Lowry, Steven L. Mansberger, Stuart K. Gardiner, Hongli Yang, Facundo Sanchez, Juan Reynaud, Shaban Demirel, Claude F. Burgoyne, Brad Fortune
Summary: The frequency and severity of optic nerve head prelaminar schisis were found to be greater in glaucoma and glaucoma suspect eyes compared to healthy control eyes, and were associated with markers of glaucoma severity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Yong Woo Kim, Glen P. Sharpe, Donna M. Hutchison, Paul E. Rafuse, Lesya M. Shuba, Marcelo T. Nicolela, Jayme R. Vianna, Balwantray C. Chauhan
Summary: The impact of glaucoma severity on the rates of change in minimum rim width (MRW), peripapillary retinal nerve fiber layer (RNFL), and macular ganglion cell layer (GCL) thickness was studied. The study found that glaucoma patients had a faster rate of change in GCL thickness compared to healthy subjects, while there were no significant differences in the rates of change in MRW and RNFL. Age and visual field mean deviation (MD) also had some impact on the rates of change.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Ophthalmology
Johnny Di Pierdomenico, Delaney C. M. Henderson, Sara Giammaria, Victoria L. Smith, Alienor J. Jamet, Corey A. Smith, Michele L. Hooper, Balwantray C. Chauhan
Summary: Age and intraocular pressure (IOP) are the two most important risk factors for the development and progression of open-angle glaucoma. This paper provides a review on the evaluation of retinal ganglion cell loss in experimental glaucoma (EG) using serial in vivo imaging. The study compares the effects of elevated IOP on ganglion cell complex thickness and individual RGC dendritic morphology changes in adult and old mice, highlighting the potential of single RGC imaging for understanding RGC loss.
PROGRESS IN RETINAL AND EYE RESEARCH
(2022)
Article
Health Policy & Services
Kelley R. Davis, Sharon L. Norman, Bradley G. Olson, Shaban Demirel, Asma A. Taha
Summary: This quality improvement project aimed to evaluate the impact of an educational intervention to improve the quality of providers' recommendations and subsequent vaccination rates. The results showed that the quality of vaccine recommendations was improved after the intervention, but the vaccination rates did not increase. The study found that providers' delivery style is important for increasing vaccination rates.
JOURNAL OF PEDIATRIC HEALTH CARE
(2022)
Article
Multidisciplinary Sciences
Facundo G. Sanchez, Stuart K. Gardiner, Shaban Demirel, Jack P. Rees, Steven L. Mansberger
Summary: This study used a registry of blind persons and geospatial analytics to determine the associations of blindness within rural and urban counties. The results showed that the prevalence of blindness varied among counties and was associated with factors such as age, race, income, and density of eye care providers.
Article
Ophthalmology
Nick Grissom, Stuart K. Gardiner, Jack P. Rees, Facundo G. Sanchez, Steven L. Mansberger, Emmett T. Cunningham Jr, Claude F. Burgoyne, Karen Rice, Christina Belter, Robert M. Kinast
Summary: This study evaluated eye drop self-administration in low-vision patients and found that a nose-pivoted drop delivery device (NPDD) can improve eye drop delivery. The use of NPDD increased the success rate of eye drop delivery and reduced bottle tip contact. Patients reported higher satisfaction and increased confidence in independently using eye drops with NPDD.
OPHTHALMOLOGY GLAUCOMA
(2023)
Article
Ophthalmology
Claude f. Burgoyne, Ya xing Wang, Jin wook Jeoung, S. E. U. N. G. W. O. O. Hong, S. T. U. A. R. T. Gardiner, J. U. A. N. Reynaud, B. R. A. D. Fortune, Michael j. a. Girard, G. L. E. N. Sharpe, M. A. R. C. E. L. O. Nicolela, Balwantray c. Chauhan, H. O. N. G. L. Yang
Summary: This study used OCT to compare highly myopic and normal eyes and found that pNC-SB increased and pNC-CT decreased in highly myopic eyes, with the greatest changes in the inferior sectors. The results support the hypothesis that sectors of maximum pNC-SB may predict areas of greatest susceptibility to aging and glaucoma in future longitudinal studies of highly myopic eyes.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Rami Darwich, Faisal Jarrar, Mustafa Syed, Glen P. Sharpe, Balwantray C. Chauhan
Summary: Both spectral-domain (SD) and swept-source (SS) optical coherence tomography (OCT) showed similar visualization of optic nerve head (ONH) structures, with a tendency for higher visualization rates with SS-OCT.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Akshay Govind, Shaban Demirel, Kristin Lee, Melissa Amundson, Richard Bryan Bell, Eric Dierks
Summary: This study aimed to identify predictors of intraoperative difficulty, operating time, and postoperative examination abnormalities in subjects undergoing post-traumatic orbital reconstructions. The results showed that medial wall involvement is associated with intraoperative difficulty, and anteriorly positioned fractures are better treated transorbitally.
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2023)
Letter
Ophthalmology
Brooklyn Rawlyk, Balwantray C. Chauhan
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2021)