Article
Multidisciplinary Sciences
Xue-Jing Huang, Shao-Fen Jian, Dong-Liang Chen, Chu Zhong, Jian-Hua Miao
Summary: Exogenous sucrose concentration has significant effects on the growth and metabolism of Andrographis paniculata plants. Moderate concentration of sucrose promotes plant growth, increases carbon supply and nitrogen uptake. However, high concentration of sucrose uncouples carbon and nitrogen metabolism, reduces nitrogen metabolism and induces plant senescence.
SCIENTIFIC REPORTS
(2022)
Review
Plant Sciences
Maoyuan Jiang, Feiya Sheng, Zhen Zhang, Xiao Ma, Tianhui Gao, Chaomei Fu, Peng Li
Summary: Andrographis paniculata is widely used in subtropical regions for treating various ailments and has potential antiviral properties.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Sya'ban Putra Adiguna, Jonathan Ardhianto Panggabean, Respati Tri Swasono, Siti Irma Rahmawati, Fauzia Izzati, Asep Bayu, Masteria Yunovilsa Putra, Carmen Formisano, Chianese Giuseppina
Summary: This study established the extraction and fractionation of Andrographis paniculata and quantified the andrographolide and its derivatives in each fraction. The 50% methanolic fraction exhibited the best cytotoxic, anti-inflammatory, and antihypertensive activities compared to other extracts. It also had the highest quantification of andrographolide and its derivatives.
Article
Plant Sciences
Mona El Samarji, Maria Younes, Marianne El Khoury, Tony Haykal, Nazira Elias, Natalia Gasilova, Laure Menin, Ahmad Houri, Nisrine Machaka-Houri, Sandra Rizk
Summary: This study evaluated the anticancer effects of the ethanolic bulb extract of Sternbergia clusiana on breast cancer cells and revealed its potential cellular mechanism. The extract showed selective antiproliferative effects and activated the apoptotic pathway. It also exhibited antioxidant effects. LC-MS/MS analysis identified several bioactive compounds. Therefore, Sternbergia clusiana could be considered as an antioxidant and anticancer agent for breast cancer treatment.
Article
Environmental Sciences
Tran Nhat Phuong, Nguyen Duy Tai, Abeer S. Aloufi, Baskaran Subramani, Sridevi Dhanarani Theivaraj
Summary: This study evaluated the antifungal, anti-lung cancer, and anti-hyperglycemic activities of Andrographis paniculata flower aqueous extract. It found that the extract contains valuable phytochemicals and showed activity against fungal pathogens, lung cancer cells, and diabetes-related enzymes.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Tran Nhat Phuong, Nguyen Duy Tai, Abeer S. Aloufi, Baskaran Subramani, Sridevi Dhanarani Theivaraj
Summary: The aqueous extract of Andrographis paniculata flower exhibits antifungal, anti-lung cancer, and anti-diabetic activities. It contains pharmaceutically valuable compounds and shows significant inhibition against fungal pathogens and lung cancer cell line (A549). It also demonstrates considerable inhibition of alpha-amylase and alpha-glucosidase, indicating its potential anti-diabetic effects. The extract is rich in bioactive compounds, making it a promising candidate for biomedical applications.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Khaled Meghawry El-Zahar, Mubarak Eid Al-Jamaan, Faisal Rasmi Al-Mutairi, Abdallah Mohamed Al-Hudiab, Mohamed Saleh Al-Einzi, Ahmed Abdel-Zaher Mohamed
Summary: This study evaluated the phenolic and flavonoid components in the ethanolic extract of barberry leaf and roots, as well as their antioxidant, antifungal, and antibacterial effects. The results showed that both the root and leaf extracts inhibited the growth of pathogenic bacteria and fungi. The root extract also exhibited excellent antioxidant activity. This research suggests that both the roots and leaves of barberry have significant antibacterial activity and can be used as a source of bioactive compounds for human health benefits.
Article
Food Science & Technology
Oladipupo Odunayo Olatunde, Steffi Louisa Della Tan, Soottawat Benjakul
Summary: The study found that ethanolic guava leaf extract treated with sedimentation process had the lowest chlorophyll content but highest total phenolic content and antioxidant properties. It effectively reduced lipid oxidation in Pacific white shrimp during refrigerated storage.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
S. M. Kamruzzaman, Latifa Bulbul, Md Zahir Alam, Md Mostafizur Rahman
Summary: This study investigated the effects of M. paniculata extracts on convulsions and antioxidant activities in mice. It identified six polyphenolic compounds in the extracts, with epicatechin and quercetin found in the highest amounts. The oral administration of MP significantly reduced convulsions and mortality rates, while also increasing GABA levels and antioxidant activities.
Article
Pharmacology & Pharmacy
Ahmad Alshehri, Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Tahani M. Almeleebia, Mohd Saeed, Dharmendra Kumar Yadav, Irfan Ahmad Ansari
Summary: The study revealed the antioxidant, anticancer, and anti-inflammatory activities of Adenium obesum, commonly known as desert rose, suggesting its potential as a herbal-based medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paulina Strugala, Anna Urbaniak, Patryk Kurys, Aleksandra Wloch, Teresa Kral, Maciej Ugorski, Martin Hof, Janina Gabrielska
Summary: The study examined the antioxidant and cytotoxic activities of purple potato ethanolic extract of the Blue Congo variety (BCE), demonstrating its ability to protect lipid membranes against peroxidation and inhibit the growth of colon cancer cells.
Article
Biochemistry & Molecular Biology
Aymen Souid, Clara Maria Della Croce, Stefania Frassinetti, Morena Gabriele, Luisa Pozzo, Marco Ciardi, Chedly Abdelly, Karim Ben Hamed, Christian Magne, Vincenzo Longo
Summary: Sea fennel, a halophyte plant, produces essential oils and polyphenols with antioxidant and biological effects. Its leaf hydro-alcoholic extract showed strong antioxidant, antimicrobial, and antimutagenic properties, making it a potential functional food source.
Article
Biochemistry & Molecular Biology
Jameel M. Al-Khayri, Sakshi Dubey, Gopishankar Thirumoorthy, Praveen Nagella, Adel Abdel-Sabour Rezk, Wael Fathi Shehata
Summary: Using in silico approach, several phytochemicals from Andrographis paniculata were identified as potential drug molecules against diphtheria. Docking and molecular dynamics simulation studies narrowed down the search to bisandrographolide and andrographiside as hit compounds. Further modification and in vitro/in vivo studies can be conducted to evaluate their effectiveness.
Article
Biology
Manisha Parthasarathy, Sabina Evan Prince
Summary: This study aimed to investigate the potential effect of aqueous leaf extract of Andrographis paniculata against methotrexate-induced hepatotoxicity. The results confirmed the beneficial effect of Andrographis paniculata extract on restoring hepatic enzyme markers, lipid profile, antioxidant level, anti-inflammatory marker (IL-10), anti-apoptosis (bcl-2), and suppressing inflammatory cytokines (TNF-α and IL-6), apoptosis marker (caspase 3), and cellular tissue damage caused by methotrexate. Overall, Andrographis paniculata reduces oxidative stress, inflammatory processes, and apoptosis, providing protection against methotrexate-induced hepatotoxicity.
Article
Nutrition & Dietetics
Wang Yuan, Bisheng Zheng, Tong Li, Rui Hai Liu
Summary: Pistachios contain phytochemicals that are beneficial to health, including phenolics, vitamin E, and carotenoids. Both raw and roasted pistachios have high levels of phenolics and flavonoids, and exhibit strong total antioxidant and cellular antioxidant activity. Roasted pistachios have higher levels of vitamin E, while raw pistachios have more carotenoids. Roasted pistachio extracts show superior antiproliferative activity against certain cancer cells.