期刊
JOURNAL OF FOOD BIOCHEMISTRY
卷 36, 期 1, 页码 1-11出版社
WILEY
DOI: 10.1111/j.1745-4514.2010.00498.x
关键词
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资金
- Industrial Technology Research Institute, Taiwan, Republic of China [5331G14300]
- Taiwan Yes Deep-Sea water corporation [0994267S]
- China Medical University [CMU97-213]
- National Science Council, Taiwan, Republic of China [NSC96-2320-B-040-025-MY3]
- Taiwan Department of Health Clinical Trial and Research Center of Excellence [DOH100-TD-B-111-004]
- Taiwan Department of Health Cancer Research Center of Excellence [DOH100-TD-C-111-005]
- National Science Council
- Ministry of Education
- Chung Shan Medical University
Our recent studies indicated that electrodialysed deep-sea water (ED-DSW) revealed the cardiovascular health effects, such as hindrances of the dietary-induced evaluation of total cholesterol (TC), triglyceride (TG) and nonhigh-density-lipoprotein cholesterol (HDL-C), as well as improvement of HDL-C/non-HDL-C ratio and blood pressure. In the current study, we further revealed the beneficial effects of ED-DSW on high-cholesterol dietary mice by reducing abnormal cardiac architecture, apoptosis and enhancing insulin-like growth factor-1 receptor (IGF-1R) cardiac survival signaling compared with those mice that were treated with distilled water, reverse osmosis (RO)-DSW or 10% (v/v) dilution with ddH2O (10% DSW). These findings further clarified the possible mechanisms of cardiac protective effects of ED-DSW and might suggest ED-DSW as an ingredient of cardiovascular health food in some niche markets.
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