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Pharmacology & Pharmacy
Napaporn Khuanphram, Sirinya Taya, Prachya Kongtawelert, Rawiwan Wongpoomchai
Summary: The combination of sesame extract and hesperidin showed enhanced chemopreventive effects compared to using hesperidin alone, by inducing cell apoptosis, suppressing cell proliferation, and modulating hepatic lipogenesis. This may provide insights for alternative treatments against hepatocellular carcinoma.
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Biochemistry & Molecular Biology
Nagwa G. Tawfik, Wafaa R. Mohamed, Hanan S. Mahmoud, Mohammed A. Alqarni, Ibrahim A. Naguib, Alzhraa M. Fahmy, Osama M. Ahmed
Summary: Isatin has shown potential in preventing liver tumor formation in experimental rats by enhancing cellular antioxidant, anti-inflammatory, and detoxification mechanisms, partly through upregulation of the Nrf2 signaling pathway.
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Biochemistry & Molecular Biology
Jie Zheng, Do-Hee Kim, Xizhu Fang, Seong Hoon Kim, Soma Saeidi, Su-Jung Kim, Young-Joon Surh
Summary: The study suggests that sulforaphane may stimulate tumor progression in hepatocarcinogenesis rather than preventing it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
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Pharmacology & Pharmacy
Fikret Altindag, Seda Bogoksayan, Sinan Bayram
Summary: This study evaluated the protective effects of eumelanin on diethylnitrosamine-induced liver injury. The results showed that eumelanin treatment reduced histopathological changes, inflammation, and necrotic cells in the liver. Eumelanin also decreased cell apoptosis and the expression of inflammatory mediators.
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Pharmacology & Pharmacy
Masaaki Ishibashi, Masakazu Ishii, Shinichiro Yamamoto, Yasuo Mori, Shunichi Shimizu
Summary: The study demonstrates that 5-FU enhances the activation of TRPM2 channel, and inhibition of H2O2-induced Ca2+ concentration increase by 5-FU in Trpm2 KO mice, alleviating the reduction of blood cells induced by 5-FU.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
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Chemistry, Multidisciplinary
Ruikui Zhang, Tao Wu, Juan Yang, Ming Liu, Jiangyan Luo, Chi Ma, XiaoYing Ma, Guixiang Xu, Sheng Zheng
Summary: This study investigates the modulating mechanism of gambo-genic acid in diethylnitrosamine-induced liver cancer in rats. The results show that gambo-genic acid significantly improves oxidative stress markers, apoptosis mediators, and serum biomarkers in DEN-induced liver cancer model rats, and reverses the histopathological changes caused by DEN.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Health Care Sciences & Services
Betul Cicek, Sidika Genc, Yesim Yeni, Mehmet Kuzucu, Ahmet Cetin, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Ahmet Hacimuftuoglu, Georgios Lazopoulos, Aristidis Tsatsakis, Konstantinos Tsarouhas, Ali Taghizadehghalehjoughi
Summary: This study aimed to investigate the beneficial effects of artichoke leaf extract on DEN-induced brain toxicity. The results showed that high-dose artichoke treatment effectively improved impaired neuronal function and oxidative stress induced by DEN, and significantly increased the levels of neuroprotective factors Klotho and PPAR gamma.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
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Oncology
Andrea Reszegi, Katalin Karaszi, Gabor Toth, Kristof Rada, Lorand Vancza, Lilla Turiak, Zsuzsa Schaff, Andras Kiss, Laszlo Szilak, Gabor Szabo, Gabor Petovari, Anna Sebestyen, Katalin Dezso, Eszter Regos, Peter Tatrai, Kornelia Baghy, Ilona Kovalszky
Summary: Syndecan-1 plays a dual role in tumor development, either promoting or inhibiting tumors depending on the cancer type. In the context of liver cancer, transgenic expression of human syndecan-1 delayed tumor formation by downregulating lipid metabolism, inhibiting mTOR and beta-catenin pathways, and activating Foxo1 and p53 transcription factors. This oncoprotective effect was mediated by a beneficial modulation of lipid metabolism and molecular signaling pathways involved in cell cycle regulation and intermediary metabolism.
Review
Nutrition & Dietetics
K. Nanavati, K. Rutherfurd-Markwick, S. J. Lee, N. C. Bishop, A. Ali
Summary: Curcumin, extracted from turmeric, is a natural polyphenol with potent antioxidant and anti-inflammatory properties. Studies have shown that curcumin supplementation can reduce muscle pain, increase antioxidant capacity, and decrease creatine kinase activity, while also having an anti-inflammatory effect. Additionally, curcumin can improve muscle performance and enhance oxidative capacity.
EUROPEAN JOURNAL OF NUTRITION
(2022)
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Environmental Sciences
Nahed Abdel-Aziz, Sawsan M. El-Sonbaty, Marwa G. A. Hegazy
Summary: By utilizing manganese nanoparticles (Mn NPs) and low-dose gamma radiation in combination therapy, significant anticancer effects were observed in HCC-induced rats, including repair of damage, balanced oxidative status, decreased inflammatory biomarkers, and promotion of apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
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Chemistry, Multidisciplinary
Osama M. Ahmed, Adel A. Ahmed, Hanaa Fahim, Mohamed Y. Zaky
Summary: This study demonstrates that quercetin and naringenin may alleviate hepatocarcinogenesis through enhancement of anti-inflammatory, antioxidant, and apoptotic actions.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
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Biochemistry & Molecular Biology
Charatda Punvittayagul, Arpamas Chariyakornkul, Kanokwan Jarukamjorn, Rawiwan Wongpoomchai
Summary: The study found that vanillic acid exhibited significant protection against diethylnitrosamine- and 1,2-dimethylhydrazine-induced hepatocarcinogenesis by inducing detoxifying enzymes, reducing proliferation, and inducing apoptosis.
Article
Medicine, Research & Experimental
Mohammad Iqbal, Muhammad Dawood Shah, Senty Vun-Sang, Yasumasa Okazaki, Shigeru Okada
Summary: This study demonstrated that dietary supplementation of curcumin reduced renal cell tumor incidence and protected against oxidative stress induced by Fe-NTA in mice. The results suggest that curcumin may be beneficial for preventing renal cell tumors and oxidative stress damage mediated by Fe-NTA.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Lei Song, Ming Li, Chi Feng, Rigaiqiqige Sa, Xiaodong Hu, Jie Wang, Xiaoyu Yin, Chelimuge Qi, Wu Dong, Jingfeng Yang
Summary: This study found that curcumin can promote glutathione synthesis, aiding in the recovery from ethanol-induced liver damage in zebrafish larvae. The results also showed that ethanol and curcumin affect the regulation of multiple signaling pathways.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
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Pharmacology & Pharmacy
Mahmoud Abdelghaffar Emam, Sameh Mohamed Farouk, Ahmed Aljazzar, Abeer A. A. Abdelhameed, Abeer A. A. Eldeeb, Fatma Abdel-monem Gad
Summary: Curcumin and cinnamon have shown protective effects against lead acetate-induced splenotoxicity in rats, by restoring hemato-biochemical, immunological, oxidative stress, histological, and immunohistological parameters.
FRONTIERS IN PHARMACOLOGY
(2023)
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Food Science & Technology
Helmi Moqbel, Seham Salah El Dine El Hawary, Nadia Mohammed Sokkar, El Motaz Bellah El-Naggar, Noha El Boghdady, Ali Mahmoud El Halawany
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2018)
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Cell Biology
Olfat Gamil Shaker, Noha Ahmed El Boghdady, Abeer El-Dessouki El Sayed
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Noha A. El-Boghdady, Manal F. Ismail, Mahmoud F. Abd-Alhameed, Amira S. Ahmed, Hanaa H. Ahmed
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2018)
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Medicine, Research & Experimental
Tarek K. Motawi, Hebatallah A. Darwish, Iman Diab, Maged W. Helmy, Mohamed H. Noureldin
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Oncology
Tarek M. K. Motawi, Nadia Zakhary, Hebatallah A. Darwish, Hassan M. Abdalla, Samer A. Tadros
CLINICAL BREAST CANCER
(2019)
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Biochemistry & Molecular Biology
Asmaa A. ElMonier, Noha A. El-Boghdady, Mohamed A. Abdelaziz, Amira A. Shaheen
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2019)
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Biochemistry & Molecular Biology
Noha Ahmed El Boghdady, Olfat Gamil Shaker
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2019)
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Biotechnology & Applied Microbiology
Tarek K. Motawi, Samia A. Ahmed, Noha A. El-Boghdady, Nadia S. Metwally, Noha N. Nasr
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Biochemistry & Molecular Biology
Suzan Magdy Ismail, Noha Ahmed El Boghdady, Hesham Salah Hamoud, Marwa Ismail Shabayek
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
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Biotechnology & Applied Microbiology
Tarek K. Motawi, Samia A. Ahmed, Noha A. El-Boghdady, Nadia S. Metwally, Noha N. Nasr
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Biochemistry & Molecular Biology
Nermin Abdel Hamid Sadik, Noha Ahmed El-Boghdady, Nesreen Nabil Omar, Hager Abd Al-Hamid
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
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Medicine, Research & Experimental
Noha A. El-Boghdady, Maher A. Kamel, Rouaina M. El-Shamy
METABOLIC SYNDROME AND RELATED DISORDERS
(2020)
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Neurosciences
Heba A. Ewida, Rana K. Zayed, Hebatallah A. Darwish, Amira A. Shaheen
Summary: Long noncoding RNAs play a critical role in cerebral gene expression, with the study identifying changes in lncRNAs and target gene expression related to stroke, as well as significant alterations in serum markers.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Endocrinology & Metabolism
Aya A. Zayed, Mae M. Seleem, Hebatallah A. Darwish, Amira A. Shaheen
Summary: This study investigated the expression levels of lncRNAs BDNF-AS and 17A in Egyptian patients with epilepsy and their correlation with BDNF, p-CREB, GABA, and glutamate. The results showed increased expression of these lncRNAs in epileptic patients, especially in those with symptomatic focal epilepsy. Additionally, epileptic patients had lower levels of BDNF, p-CREB, and GABA, and higher levels of glutamate. These findings suggest that these lncRNAs may be involved in the pathogenesis of epilepsy through inhibition of the GABA/p-CREB/BDNF pathway.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Omaima Ali, Hebatallah A. Darwish, Kamal M. Eldeib, Samy A. Abdel Azim
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2018)