期刊
JOURNAL OF FOOD AND DRUG ANALYSIS
卷 22, 期 1, 页码 49-63出版社
FOOD & DRUG ADMINSTRATION
DOI: 10.1016/j.jfda.2014.01.004
关键词
Electron spin resonance; Lipid peroxidation; Nanomaterials; Reactive oxygen species
资金
- US Food and Drug Administration (FDA) Nanotechnology CORES Program
- Office of Cosmetics and Colors (CFSAN/FDA)
- National Natural Science Foundation of China [21303153]
Many of the biological applications and effects of nanomaterials are attributed to their ability to facilitate the generation of reactive oxygen species (ROS). Electron spin resonance (ESR) spectroscopy is a direct and reliable method to identify and quantify free radicals in both chemical and biological environments. In this review, we discuss the use of ESR spectroscopy to study ROS generation mediated by nanomaterials, which have various applications in biological, chemical, and materials science. In addition to introducing the theory of ESR, we present some modifications of the method such as spin trapping and spin labeling, which ultimately aid in the detection of short-lived free radicals. The capability of metal nanoparticles in mediating ROS generation and the related mechanisms are also presented. Copyright (C) 2014, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
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