Article
Medicine, Research & Experimental
Neelum Iqbal, Hafiz Muhammad Zubair, Mikhlid H. Almutairi, Muhammad Abbas, Muhammad Furqan Akhtar, Lotfi Aleya, Mohamed Kamel, Ammara Saleem, Qaiser Jabeen, Sobia Noreen, Mirza Muhammad Faran Ashraf Baig, Mohamed M. Abdel-Daim
Summary: Cordia rothii Roem. & Schult. possesses strong antioxidant and hepatoprotective activities, which may involve the Nrf2-NF kappa B pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, Research & Experimental
Muhammed Amanat, Md Sharif Reza, Md Sadikur Rahman Shuvo, Khondoker Shahin Ahmed, Hemayet Hossain, Muhammad Tawhid, Md Saifuzzaman, Mohammad Shariful Islam, Tanoy Mazumder, Md Amirul Islam, A. F. M. Shahid Ud Daula
Summary: The study evaluated the hepatoprotective effects of Zingiber roseum rhizome extract in CCl4 induced hepatotoxicity in mice. Seven phenolic compounds in the extract showed potential for inhibiting ROS production and displayed various biological activities, including antioxidant and hepato-protective activities.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ewa Florek, Marta Szukalska, Katarzyna Markiewicz, Izabela Miechowicz, Justyna Gornowicz-Porowska, Anna Jelinska, Joanna Kasprzyk-Pochopien, Joanna Nawrot, Agnieszka Sobczak, Malgorzata Horoszkiewicz, Wojciech Piekoszewski, Gerard Nowak
Summary: The extract from the leaves of Cynara scolymus L. has been found to have a high antioxidative potential and exhibits protective and regenerative effects on the liver, making it beneficial for reducing hepatocellular damage caused by xenobiotics.
Article
Pharmacology & Pharmacy
Syeda Hira, Muhammad Gulfraz, S. M. Saqlan Naqvi, Rehmat Ullah Qureshi, Hina Gul
Summary: The study demonstrated that the methanol leaf extract of Ficus carica and its fractions have significant hepatoprotective effects against CCl4-induced liver damage, as evidenced by improvements in biochemical parameters, antioxidant enzyme activities, and liver histopathology.
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Claudia Giannetto, Francesca Arfuso, Elisabetta Giudice, Maria Rizzo, Giuseppe Piccione, Kamel Mhalhel, Maria Levanti
Summary: Phytotherapy shows potential for the treatment of liver diseases in dogs. A study found that supplementation with Epacare pet + pasta (R) for 30 days led to changes in serum antioxidant substances and liver enzyme concentrations in dogs. Additionally, this treatment also influenced liver size.
Article
Biotechnology & Applied Microbiology
Wessam M. Aziz, Manal A. Hamed, Howaida Abd-Alla, Samia A. Ahmed
Summary: The study demonstrated that the ethanol extract of Pulicaria crispa has a significant therapeutic effect against CCl4-induced nephropathy by improving kidney function, oxidative stress, inflammation, nephrotoxicity, and renal histopathological features. Additional research is needed to establish the therapeutic and pharmacological applications of the plant.
Article
Biochemistry & Molecular Biology
Nemany A. N. Hanafy
Summary: The encapsulation of anthocyanins in hydrogel nanoparticles can enhance their retention in the heart, improve glycogen content in liver and heart tissues, reduce oxidative stress and fibrosis, and enhance histological cardiac functions after injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Environmental Sciences
Velid Unsal, Mustafa Cicek, Ilhan Sabancilar
Summary: This study discusses the damage-causing mechanism of free radicals produced by CCl4 on tissues/cells and the role of antioxidants in preventing tissue/cell damage. By maintaining a balance between free radicals and antioxidants, the negative effects induced by CCl4 can be reduced.
REVIEWS ON ENVIRONMENTAL HEALTH
(2021)
Article
Medicine, Research & Experimental
Tomislav Kostic, Dejan Popovic, Zoran Perisic, Dragana Stanojevic, Sonja Dakic, Sandra Saric, Danijela Djordjevic Radojkovic, Svetlana Apostolovic, Nenad Bozinovic, Snezana Ciric Zdravkovic, Stefan Milutinovic, Bojan Maricic, Nikola Zivkovic, Mladjan Golubovic, Miodrag Djordjevic, Radomir Damjanovic, Abraham Bell, Boris Dindic
Summary: The study demonstrates that aminoguanidine has a significant hepatoprotective effect in acute liver damage induced by CCl4, attributed to its antioxidant effects, inhibition of pro-oxidative and pro-inflammatory mediators, and induction of damaged hepatocytes into apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Rositsa Mihaylova, Reneta Gevrenova, Alexandra Stefanova, Dimitrina Zheleva-Dimitrova, Vessela Balabanova, Gokhan Zengin, Rumyana Simeonova, Georgi Momekov
Summary: Oxidative stress is a common phenomenon in liver disorders and it affects patient survival and drug effectiveness. In this study, the antioxidant and hepatoprotective activities of the Prenanthes purpurea extract were investigated. The extract contains various secondary metabolites, including quinic acid and flavonoids, which contribute to its hepatoprotective activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Environmental
Chenhui Wei, Shu Tao, Dongqiang Zhu
Summary: This study demonstrates that highly porous, graphitized activated carbon can enhance the reductive dechlorination of carbon tetrachloride by sulfides. The graphitic carbon and micropore structure of activated carbon play key roles in this reaction, facilitating electron transfer from sulfides and the formation of carbon disulfide.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pawittra Chaibuth, Nontakarn Chuaytanee, Jutawat Hojitsiriyanont, Kittipong Chainok, Sumrit Wacharasindhu, Oliver Reiser, Mongkol Sukwattanasinitt
Summary: The catalytic properties of copper(II) complexes and their application in atom transfer radical addition (ATRA) reactions of alkyl halides to alkenes were studied. The complexes were effectively reduced to active copper(I) species through Eight-induced homolysis, enabling efficient catalysis of the addition reaction at room temperature. The complexes can be conveniently generated in situ for the reaction and exhibit excellent regio- and stereoselectivity.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Toxicology
Arvind Kumar Shakya, Neetu Sharma, Monika Bhadauria, Satendra Kumar Nirala, Sadhana Shrivastava, Sangeeta Shukla
Summary: This study investigated the hepatoprotective potential of MD and SD against CCl4 induced liver toxicity, with MD showing significant hepatoprotective potential and regulatory effect on oxidative stress compared to SD.
TOXICOLOGY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Pin-Ho Pan, Ya-Yu Wang, Shih-Yi Lin, Su-Lan Liao, Yu-Fang Chen, Wei-Chi Huang, Chun-Jung Chen, Wen-Ying Chen
Summary: 18-β-Glycyrrhetinic acid has promising hepatoprotective effects against cholestatic liver injury, improving liver histology and reducing oxidative stress, inflammation, apoptosis, impaired autophagy, and fibrosis.
Article
Pharmacology & Pharmacy
Hui Yong, Shulin Shan, Shuai Wang, Zhidan Liu, Zhaoxiong Liu, Cuiqin Zhang, Yiyu Yang, Zhengcheng Huang, Fuyong Song
Summary: The study reveals that abnormal accumulation of TDP-43 on mitochondria may be involved in the progression of liver fibrosis. Enhancing mitophagy to eliminate mitochondrial TDP-43 aggregation can improve mitochondrial function and promote regression of liver fibrosis.
Article
Parasitology
Shih-Chan Lai, Cheng-You Lu, Ling-Yuh Shyu, Ke-Min Chen
PARASITOLOGY RESEARCH
(2020)
Article
Parasitology
Ling-Yuh Shyu, Ke-Min Chen, Cheng-You Lu, Shih-Chan Lai
JOURNAL OF PARASITOLOGY
(2020)
Review
Medicine, Research & Experimental
Yung Ming Chang, M. Manoj Kumar, Cheng You Lu, Chuan Te Tsai, Chin Chuan Tsai, Po Hsiang Liao, Shu Luan Lin, Chia Cheng Chang, B. Mahalakshmi, Wei Wen Kuo, Chih Yang Huang
Article
Environmental Sciences
Yen-Lun Kung, Cheng-You Lu, Khan Fareen Badrealam, Wei-Wen Kuo, Marthandam Asokan Shibu, Cecilia Hsuan Day, Ray-Jade Chen, Shang-Yeh Lu, Viswanadha Vijaya Padma, Chih-Yang Huang
Summary: The study demonstrates that AMG can alleviate Ang II-induced cardiomyocyte enlargement, reduce the expression of hypertrophic and inflammatory markers, and increase oxidative stress related proteins. These findings highlight the cardio-protective role of AMG against Ang II-induced cardiomyopathies.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biology
Fu-Tzu Pai, Cheng-You Lu, Chia-Hsin Lin, John Wang, Ming-Cheng Huang, Chuan-Teng Liu, Ying-Chyi Song, Cheng-Lung Ku, Hung-Rong Yen
Summary: The study demonstrated the potential antiarthritic effects of PCL by inhibiting inflammation and increasing MDSCs, suggesting that PCL may be a promising therapeutic herb for the treatment of rheumatoid arthritis.
Article
Medicine, Research & Experimental
Marthandam Asokan Shibu, Yu-Jung Lin, Chien-Yi Chiang, Cheng-You Lu, Debakshee Goswami, Navaneethan Sundhar, Surbhi Agarwal, Md Nazmul Islam, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Wan-Ting Tsai, Wei-Wen Kuo, Chih-Yang Huang
Summary: This study evaluated the effects of a herbal drink on aging-related disorders and found that it maintains stem cell homeostasis, provides cytoprotection, regulates blood glucose metabolism, enhances autophagic clearances in neurons, and suppresses cancer growth and migration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Cheng-You Lu, Cecilia Hsuan Day, Chia-Hua Kuo, Tso-Fu Wang, Tsung-Jung Ho, Pei-Fang Lai, Ray-Jade Chen, Chun-Hsu Yao, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: Oxidative stress-induced brain cell damage is associated with neurodegenerative diseases. Calycosin, a compound in Huangqi, shows potential as a therapeutic candidate in protecting astrocytes from oxidative injury by regulating oxidative stress through the AKT/Nrf2/HO-1 signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Cell & Tissue Engineering
Hsi-Lung Hsieh, Ching-Chung Liang, Cheng-You Lu, Jen-Tsung Yang, Chiu-Yen Chung, Yu-Shien Ko, Tsong-Hai Lee
Summary: This study investigated the impact of induced pluripotent stem cells (iPSCs) on the thrombolytic effect of low-dose rt-PA. The results showed that the combination use of low-dose rt-PA and iPSCs improved recanalization, reduced inflammatory response, and induced the expression of angiogenic factors.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Environmental Sciences
Da-Tong Ju, Dao Van Thao, Cheng-You Lu, Ayaz Ali, Marthandam Asokan Shibu, Ray-Jade Chen, Cecilia Hsuan Day, Tzu-Ching Shih, Cheng-Yen Tsai, Chia-Hua Kuo, Chih-Yang Huang
Summary: This study found that CHIP-overexpressing WJMSCs could alleviate nerve damage in diabetic rats by activating the AMPK alpha/AKT and PGC1 alpha/SIRT1 signaling pathway and suppressing inflammation through NF-kappa B pathway. These findings suggest the potential therapeutic effects of CHIP-overexpressing WJMSCs in treating diabetic neuropathy complications.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Chih-Yang Huang, Yi-Chen Su, Cheng-You Lu, Ping-Ling Chiu, Yung-Ming Chang, Da-Tong Ju, Ray-Jade Chen, Liang-Yo Yang, Tsung-Jung Ho, Hui-Chuan Kao
Summary: Studies have shown that folic acid and folinic acid can protect the heart and prevent cardiac hypertrophy and fibrosis in aged triple-transgenic AD model mice.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Jhong-Kuei Chen, Chia-Hua Kuo, Wei-Wen Kuo, Cecilia Hsuan Day, Tso-Fu Wang, Tsung-Jung Ho, Pi-Yu Lin, Shinn-Zong Lin, Tzu-Ching Shih, Cheng-Yen Shih, Chih-Yang Huang, Cheng-You Lu
Summary: Rheumatoid arthritis is an autoimmune and chronic inflammatory disease. A study found that Artemisia argyi extract could reduce the expression of pro-inflammatory cytokines and transcription factor NF-kappa B, suggesting its potential therapeutic strategy for reducing inflammation associated with rheumatoid arthritis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Parasitology
Cheng-You Lu, Ke-Min Chen, Wei-Wen Kuo, Shih-Chan Lai, Tsung-Jung Ho, Po-Tang Lai, Chih-Yang Huang, Tso-Fu Wang
Summary: Angiostrongylus cantonensis causes parasitic meningitis in humans. The drugs albendazole (ABZ) and calycosin have been shown to have anti-inflammatory effects in this disease. This study investigated the combined effects of ABZ and calycosin in treating angiostrongyliasis, and found that the combination therapy effectively reduced inflammation and improved blood-brain barrier function. These findings provide new insights into the treatment of human parasitic diseases.
Article
Environmental Sciences
Cheng-You Lu, Chia-Hua Kuo, Wei-Wen Kuo, Dennis Jine-Yuan Hsieh, Tso-Fu Wang, Cheng-Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang
Summary: The study found that Ohwia caudata extract (OCE) inhibits inflammatory response and reduces proliferation and activation of fibroblast-like synoviocytes in rheumatoid arthritis (RA) through regulation of suppressors of cytokine signaling 3 (SOCS3) and the JAK2/STAT3 pathway. This suggests that OCE may be further investigated as a candidate anti-inflammatory and anti-arthritic agent.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, Research & Experimental
Chien-Yi Chiang, Yu-Jung Lin, Wen-Tsan Weng, Heng-Dao Lin, Cheng-You Lu, Wan-Jing Chen, Cheng Yen Shih, Pi-Yu Lin, Shinn-Zong Lin, Tsung-Jung Ho, Marthandam Asokan Shibu, Chih-Yang Huang
Summary: This study evaluated the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects. The results showed that JSHT has anti-inflammatory effects, regulates cellular stress, and relieves depression symptoms associated with long COVID. JSHT attenuates the cytokine storm by repressing NF-κB cascades and provides protective functions against symptoms associated with long COVID-19 infection.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Tian-Kuo Lee, Cheng-You Lu, Sheng-Tzung Tsai, Pao-Hui Tseng, Yu-Chen Lin, Shinn-Zong Lin, Jonas C. Wang, Chih-Yang Huang, Tsung-Lang Chiu
Summary: This study reported the complete recovery of a 46-year-old male patient with hemiplegia due to ischemic stroke after receiving allogeneic umbilical cord blood cell therapy. The patient did not experience serious adverse events or GVHD during the 12-month study period and showed improvement in NIHSS, Berg Balance Scale, and Barthel index scores.
CELL TRANSPLANTATION
(2021)