Organocatalysis approach to trifluoromethylation with fluoroform

The organic base methodology exploits an access to generate the trifluoromethyl anion for carbonyl, ester, acid halide, epoxide, deuterium donor, and carbon dioxide substrates to afford the trifluoromethylation products with good overall efficiency even in organocatalysis conditions. The NMR analysis of the mixture of fluoroform and P-4-base shows no change thereof. However, on addition of electrophiles, the trifluoromethylation products were obtained efficiently. (C) 2013 Published by Elsevier B.V.