期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 135, 期 -, 页码 240-245出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2011.11.011
关键词
Isocoumarins; Dihydroisocoumarins; Antimetastatic activity; Anti-cancer activity; MCF-7; Human breast cancer
资金
- Higher Education Commission Islamabad, Pakistan [20-946/RD/07/607]
Synthesis of some fluorinated isocoumarins and 3,4-dihydroisocoumarins is reported. Structures of the synthesized compounds were confirmed by spectral and elemental analysis. All the synthesized compounds were evaluated for their antimetastatic activity and anti-cancer activity against breast cell line (MCF-7). Among all the tested compounds 3h [3-(3',4'-difluorophenyl)isocoumarin] has shown excellent antimetastatic activity, however the growth inhibitory response of the tested compounds [3a-h, 4a-h, 5e-h, 6a-h and 7a, c, d] for MCF-7 human breast carcinoma cell line was moderate at higher concentrations (100-400 mu M) and negligible at lower concentrations. (C) 2011 Elsevier B.V. All rights reserved.
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