期刊
JOURNAL OF FLUORINE CHEMISTRY
卷 131, 期 11, 页码 1113-1121出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jfluchem.2010.04.004
关键词
Diaryliodonium salts; Fluorination; Ligand exchange; PET; F-18; Aryl fluorides; Reductive elimination
资金
- National Science Foundation [CHE 0717562]
Diaryliodonium salts are shown to undergo rapid fluoride-promoted aryl exchange reactions at room temperature in acetonitrile Aryl exchange is shown to be exquisitely sensitive to the concentration of fluoride ion in solution fast exchange is observed as the fluoride concentration approaches a stoichiometric amount at 50 mM substrate concentration Tie reaction is slowed but not halted if benzene is the solvent indicating that free fluoride ion or a four-coordinate anionic I(III) species may be responsible for the exchange The fluoride-promoted aryl exchange reaction is general and allows direct measurement of the relative stabilities of diaryliodonium salts featuring different aryl substituents The aryl exchange reaction may be of practical use for the preparation of hitherto inaccessible diaryliodonium salts thus it also has implications for labeling radiotracers for molecular imaging with F-18-fluoride (t(1/2) = 109 7 min) (C) 2010 Elsevier B V All rights reserved
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据