Article
Chemistry, Organic
Satsuki Shigenaga, Haruko Shibata, Koto Tagami, Tadashi Kanbara, Tomoko Yajima
Summary: The eosin Y-catalyzed hydroperfluoroalkylation of electron-deficient alkenes is a selective and efficient reaction that proceeds smoothly under visible light irradiation. This reaction allows for the use of various perfluoroalkyl bromides and electron-deficient olefins, and all required chemicals are readily available and safe.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Bin Sun, Panyi Huang, Zhiyang Yan, Xiayue Shi, Xiaoli Tang, Jin Yang, Can Jin
Summary: A novel visible-light-induced radical tandem tri-fluoromethylation/cyclization reaction of unactivated alkenes with sodium perfluoroalkanesulfinates has been developed, leading to perfluoroalkyl-substituted quinazoline alkaloids. Remarkably, this transformation can be carried out without the use of any metal catalyst, strong oxidant, or external photosensitizer.
Article
Chemistry, Multidisciplinary
Youcan Zhang, Hui-Qing Geng, Xiao-Feng Wu
Summary: Transition-metal-catalyzed multi-component carbonylation using palladium catalyst was employed for the synthesis of functionalized esters from a range of phenols and alcohols, utilizing inexpensive carbon monoxide and perfluoroalkyl halides. The process showed good functional group tolerance, chemoselectivity, and applicability to pharmaceutical and bio-active substrates, resulting in high yields of the target products.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Jinbo Huang, Dandan Wu, Xiaokang Bai, Panyuan Cai, Wei-Guo Zhu
Summary: This method utilizes mild and eco-friendly visible light to induce direct radical cross-coupling perfluoroalkylation of imidazo[1,2-a]pyridines with perfluoroalkyl iodides, leading to the synthesis of valuable substituted products. Control experiments were conducted to confirm the involvement of a radical pathway in the reaction mechanism.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Yaxin Wang, Peng Wang, Helfried Neumann, Matthias Beller
Summary: A general and broadly applicable cobalt-catalyzed multicomponent 1,2-perfluoroalkylation carbonylation of alkenes has been developed, allowing the synthesis of beta-perfluoroalkyl-substituted amides, esters, and related derivatives in a one-pot manner. The method was also demonstrated to have application potential in the synthesis of pharmaceuticals and biologically active molecules, enabling the regioselective increase of molecular complexity of olefins toward functionalized perfluoroalkylated building blocks.
Article
Engineering, Chemical
Harin Yoo, Jung Hyeun Kim
Summary: This study investigates the use of TiO2/CuxO composite films as photoactive materials for the photodegradation of methylene blue (MB) pollutants, achieving high efficiency through effective charge separation and reduced recombination in the unique copper oxide phases.
ADVANCED POWDER TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Camila M. Kisukuri, Vitor A. Fernandes, Jose A. C. Delgado, Andreas P. Haering, Marcio W. Paixao, Siegfried R. Waldvogel
Summary: Electrosynthesis is a powerful and sustainable method for synthesizing small organic molecules, capable of generating highly reactive species under mild conditions. The installation of fluorinated alkyl groups, which has gained significant attention in medicinal chemistry and material science, presents a challenging transformation that has been addressed by several established electrochemical methods.
Article
Chemistry, Applied
Zhuangzhuang Guo, Xiaoyu Chen, Yingying Xue, Jingya Li, Dapeng Zou, Yangjie Wu, Yusheng Wu
Summary: A copper-catalyzed cascade difunctionalization reaction has been reported, which allows for the construction of Csp(3)-CF2/C-C bonds by reacting unactivated olefins with readily available R-f-I reagents. This strategy provides a convenient access to a variety of useful perfluoroalkylated tricyclimidazole derivatives in reasonable yields. Preliminary mechanistic studies suggest that the reaction proceeds through a radical/SET pathway. The transformation offers mild conditions, simple operation, atomic economy, and a broad substrate scope.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Physical
Sara Amouzad, Mehdi Khosravi, Niaz Monadi, Behzad Haghighi, Suleyman I. Allakhverdiev, Mohammad Mahdi Najafpour
Summary: The study shows that anodization time and potassium hydroxide concentration have significant effects on the photo-electrochemical properties of photocatalysts, while calcination temperature affects the anatase to rutile ratio.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Review
Chemistry, Multidisciplinary
Maria Laura Uhrig, Erwin W. Mora Flores, Al Postigo
Summary: Fluoroalkyl-substituted carbohydrates play important roles in wetting, antifreeze, and coating agents, and are significant to the synthetic carbohydrate community. This study summarizes the methods for installing R-F groups onto carbohydrates and derivatives, as well as presents new advances in the synthesis of fluoroalkyl-substituted iminosugars.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Youcan Zhang, Hui-Qing Geng, Xiao-Feng Wu
Summary: The study presents a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation reaction, successfully synthesizing various β-perfluoroalkyl amides. The reaction system shows good compatibility with a wide range of substrates, including anilines, alkylamines, and demonstrates good functional-group tolerance and excellent chemoselectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Physical
Yelan Xiao, Yuen-Kiu Chun, Shun-Cheung Cheng, Chi-On Ng, Man-Kit Tse, Ngai-Yu Lei, Ruoyang Liu, Chi-Chiu Ko
Summary: This study successfully prepared perfluoroalkyl amides and esters through photoredox catalysis, investigating the effects and mechanisms of different photocatalysts, and conducting detailed experimental and computational analyses.
CATALYSIS SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Xuling Pan, Wei Wang, Xiuhui Gao, Gefei Hao, Tingting Li
Summary: A photo-induced indole 2-alkylation reaction was developed using unactivated stereo-congested alkenes as the alkylation reagent. The reaction was initiated by the inexpensive perfluoroalkyl iodide C4F9I under blue LED light. The reaction could produce a variety of 2-branched alkylated indole molecules with high efficiency and good tolerance towards functional groups. Mechanistic studies showed that the reaction was accelerated by protons generated from the crack of the indole-derived radical cation species.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Masoud Emami Mehr, Hossein Maleki-Ghaleh, Mohadeseh Yarahmadi, Majid Kavanlouei, M. Hossein Siadati
Summary: In this study, core/shell ZnO/TiO2 nanocomposite samples were prepared using the sol-gel method at different time spans. The sample prepared in the 15-minute time span (ZnTi15) exhibited the highest photocatalytic activity and charge carrier density, making it the optimal sample. The formation of a heterojunction at the ZnO/TiO2 interface could be attributed to the increased photocurrent density observed for the ZnTi15 sample.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Chemistry, Organic
Li Dong, Xiaoqing Wang, Yudi Nie, Shuo Yu, Haotong Li, Qian Zhao, Zixuan Fan, Yuqian Wang, Xiaoting Tan, Zhengsen Yu
Summary: A simple and metal-free method for perfluoroalkylation of 4-quinolones has been developed using sodium perfluoroalkyl sulfinates and ammonium peroxodisulfate in DMSO under mild conditions. The results show high yields and broad functionality. Experimental results suggest a radical mechanism pathway involved in this method.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Xianda Wu, Minghong Chen, Shuiyun Zheng, Fu-Sheng He, Jie Wu
Summary: Here, we report a new method for synthesizing sulfilimines through an iron-catalyzed reaction between sulfenamides and 2,2,2-trifluor-diazoethane. This protocol features operational simplicity, mild conditions, and can be conducted in open air, providing a facile approach to trifloromethylated sulfilimines in moderate to good yields.
JOURNAL OF FLUORINE CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Ita Hajdin, Romana Pajkert, Haibo Mei, Jianlin Han, Gerd-Volker Roeschenthaler
Summary: A catalyst- and solvent-free 1,3-dipolar cycloaddition reaction using a bench-stable diazo reagent has been developed to obtain a series of novel 3H-pyrazoles bearing difluoromethyl phosphonate unit in moderate-to-excellent yields. This method provides an efficient and easy route to synthesize valuable compounds.
JOURNAL OF FLUORINE CHEMISTRY
(2024)