Article
Fisheries
Feng Hu, Yingying Li, Qing Wang, Bin Zhu, Siyu Wu, Yingying Wang, Weiwei Zeng, Jiyuan Yin, Chun Liu, Sven M. Bergmann, Cunbin Shi
Summary: The study demonstrates that the DNA vaccine system based on SWCNTs can effectively combat KHV, with high concentration SWCNTs-p149 inducing stronger and longer-lasting immune responses compared to p149 alone. The vaccine also provided a high level of protection against KHV in juvenile koi fish. This research offers a new approach for controlling KHV in koi fish populations.
Article
Fisheries
Sven Michael Bergmann, Juliane Dabels, Sandro Klafack, Yeonwha Jin, Pei-Yu Lee, Arndt Christian Hofmann, Yingying Wang, Qing Wang, Yingying Li, Weiwei Zeng, Angela Lusiastuti, Shucheng Zheng, Yijuan Jin, Jolanta Kielpinska, Sean Monaghan
Summary: The study found that experimentally infected rainbow trout could transmit KHV to naive carp at different temperatures, and rainbow trout developed humoral response against KHV at both temperatures. The antibodies produced by rainbow trout in response to KHV differed from those observed in carp.
JOURNAL OF FISH DISEASES
(2021)
Article
Fisheries
Allahbagash Badhusha, Abdul Nafeez Ahmed, Selvam Suryakodi, Mohamed Jaffer Abdul Wazith, Sivaraj Mithra, Kumarasamy Kanimozhi, Seepoo Abdul Majeed, Gani Taju, Azeez Sait Sahul Hameed
Summary: This study reports the occurrence of Cyprinid herpesvirus 3 (CyHV-3) in koi carp for the first time in India. PCR assay and sequence analysis confirmed the presence of CyHV-3 in infected fish samples. CyHV-3 was found to replicate in cell lines of koi carp and catla, and tissue tropism analysis revealed its presence in vital organs with prominent band in gill and gut tissue.
JOURNAL OF FISH DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Zhuoyu Wang, Nan Zheng, Jie Liang, Qiuju Wang, Xiujie Zu, Hao Wang, Haiyan Yuan, Ruixue Zhang, Shanshan Guo, Yanhui Liu, Jingxiang Zhou
Summary: The study found that emodin can effectively suppress the replication of CyHV-3, increase the survival rate of koi, and protect against the adverse effects induced by CyHV-3 by enhancing antioxidant function and reducing oxidative stress and inflammation cytokines expression.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Fisheries
Wenping Ren, Xiaoyi Pan, Caijiao Dai, Tiancheng Shu, Lijuan Li, Junfa Yuan
Summary: The study found that CyHV-2 infection triggered secondary bacterial infections, with mortality depending on pathogen burden. Evaluation of the integrity of the intestinal mucosal barrier and transcriptome analysis showed disruption of gut homeostasis after CyHV-2 infection in crucian carp.
Article
Agriculture, Dairy & Animal Science
Isaiah E. Tolo, Przemyslaw G. Bajer, Tiffany M. Wolf, Sunil K. Mor, Nicholas B. D. Phelps
Summary: This article investigates the transmission mechanisms and factors influencing the spread of Cyprinid herpesvirus 3 (CyHV-3) in fish populations. The study shows that direct contact is the primary transmission route for CyHV-3, and transmission mainly occurs during the incubation period of the disease. Furthermore, potential virulence-transmission tradeoffs and disease avoidance behaviors relevant to CyHV-3 transmission were identified.
Article
Fisheries
Chang Wei, Chaonan Xu, Yuyu Sun, Jinzhou Li, Motohiko Sano, Qiang Li
Summary: This study found that CyHV-2 can establish persistent or latent infection in asymptomatic farmed gibel carp, and different viral mRNA expression patterns were observed in different individuals. This indicates that apparently healthy gibel carp can also be a source of infection.
Article
Fisheries
Isaiah E. Tolo, Przemyslaw G. Bajer, Sunil K. Mor, Nicholas B. D. Phelps
Summary: Cyprinid herpesvirus-3 (CyHV-3) is a significant pathogen that affects common carp populations worldwide. A study conducted in Minnesota revealed low prevalence of CyHV-3 in native fish species but infection rates ranging from 10% to 50% in carp populations across five lakes. Further investigations in Lake Elysian showed no positive detections of CyHV-3 in fish tissues, although the virus was detected in carp tissues, suggesting a potential latency site in the brain. The study also found that young carp, particularly males, were most impacted by CyHV-3-associated mortality and acute infections.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Fengjun Liu, Shaoping Weng, Jianguo He, Chuanfu Dong
Summary: This study revealed the involvement of CypA protein in CyHV-3 replication, as it interacts with the viral envelope protein VP32. Inhibition of CypA reduces viral proliferation, while overexpression enhances it.
Article
Immunology
Mikolaj Adamek, Marek Matras, Alexander Rebl, Magdalena Stachnik, Alberto Falco, Julia Bauer, Anne-Carina Miebach, Felix Teitge, Verena Jung-Schroers, Muhammad Abdullah, Torben Krebs, Lars Schroeder, Walter Fuchs, Michal Reichert, Dieter Steinhagen
Summary: Vaccination is the best way to protect fish from viral diseases. Live attenuated virus vaccines have shown to be most effective. This study demonstrates that vaccination with a live attenuated virus can enhance fish immune responses and protect against severe disease caused by a specific pathogen.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Z. H. Fan, Y. Xu, W. Luo, X. C. He, T. T. Zheng, J. J. Zhang, X. Y. Xu, Q. W. Qin, X. Z. Lee
Summary: In this study, ccCD63 was cloned from common carp and found to be expressed in various tissues with higher levels in spleen and brain. After KHV infection, the expression levels of ccCD63 varied in different tissues, with knockdown of ccCD63 promoting KHV infection. ccCD63 may be involved in antiviral response through the RIG-I signaling pathway.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Fisheries
Yihua Zheng, Yi Zhou, Lupin Zhao, Jiaxun Li, Liqun Lu, Yousheng Jiang
Summary: CyHV-3 is the main pathogen causing koi herpesvirus disease. A lateral flow immuno-chromatographic assay (LFIA) using specific monoclonal antibodies has been developed for on-site detection of CyHV-3. The LFIA strip showed a low detection limit and high specificity, making it an effective device for early detection of CyHV-3 in the future.
JOURNAL OF FISH DISEASES
(2023)
Article
Fisheries
Yaojia Zhou, Ping Ouyang, Yu Tao, Lizi Yin, Kaiyu Wang, Yi Geng, Weiming Lai, Defang Chen, Hongrui Guo, Jing Fang, Zhengli Chen, Li Tang, Xiaoli Huang
Summary: This study revealed the regulatory role of CyHV-3 vTNFRs in host immune response and cell apoptosis, indicating that vTNFRs participate in virus invasion by up-regulating the expression levels of certain immune-related factors and inducing cell apoptosis.
AQUACULTURE REPORTS
(2021)
Article
Fisheries
Zhuoran Han, Jingfeng Sun, Boyun Jiang, Xiucai Hu, Aijun Lv, Limei Chen, Yongjun Guo
Summary: This study found that both Aeromonas veronii and Vibrio cholerae were involved in the disease outbreaks of koi carp, resulting in mass mortality at a breeding farm in Tianjin. Experimental results showed that A. veronii was more virulent than V. cholerae in causing the disease in koi carp.
Article
Immunology
Alicia D. O'Toole, Fawzi M. Mohamed, Jian Zhang, Corrie C. Brown
Summary: This study provides detailed insights into the early tissue distribution and innate immune response to rabbit hemorrhagic disease virus 2 (RHDV2), revealing the progression of the virus from the gastrointestinal tract to the liver and the subsequent increase in inflammatory cytokines in the liver and spleen.
MICROBIAL PATHOGENESIS
(2022)
Review
Microbiology
Maria Chiara Cascarano, Orestis Stavrakidis-Zachou, Ivona Mladineo, Kim D. Thompson, Nikos Papandroulakis, Pantelis Katharios
Summary: Climate change will have a significant impact on global aquaculture, especially in the Mediterranean Sea. Rising temperatures will affect fish farming and potentially lead to an increase in disease outbreaks, resulting in severe economic losses for aquaculture systems.
Article
Fisheries
Sean J. Monaghan, Diana Chee, Alexandra Adams, Sven M. Bergmann, Shin M. Chong, Jing Chen, Kim D. Thompson
Summary: The study found that only 31% of koi from PCR-positive KHV fish groups were seropositive in ELISA testing. Furthermore, over 34% of seropositive but PCR-negative fish had titres of >1/400. These results highlight the concerns related to carp populations that have been screened for KHV using molecular methods alone and emphasize the need for serology to accompany molecular testing in carp for this notifiable virus.
Review
Fisheries
Matthijs Metselaar, Massimo Orioles, Marco Galeotti, Alexandra Adams, Kim D. Thompson
Summary: Red mark syndrome (RMS) is a skin condition affecting rainbow trout aquaculture, first reported in the United States and subsequently spreading to other parts of the world. It causes economic loss to the industry and has been associated with two pathogens, although the exact cause is still unknown.
Article
Biotechnology & Applied Microbiology
Ae Rin Lee, Seong Bin Park, Si Won Kim, Jae Wook Jung, Jin Hong Chun, Jaesung Kim, Young Rim Kim, Jassy Mary S. Lazarte, Ho Bin Jang, Kim D. Thompson, Myunghwan Jung, Min Woo Ha, Tae Sung Jung
Summary: The study demonstrates that membrane vesicles (MVs) from Gram-positive bacteria are capable of transferring beta-lactam antibiotic-resistant substances to antibiotic-sensitive Gram-negative bacteria, resulting in increased resistance to beta-lactam antibiotics.MVs play a role in transferring substances from Gram-positive to Gram-negative bacteria, shown by the release of MVs from RC85-T that were able to protect beta-lactam-susceptible bacteria from beta-lactam antibiotics.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Fisheries
R. Hoare, K. Shahin, K. McLean, A. Adams, K. D. Thompson
JOURNAL OF FISH DISEASES
(2022)
Article
Immunology
Farman Ali, Qilan Cai, Jialing Hu, Lishan Zhang, Rowena Hoare, Sean J. Monaghan, Huanying Pang
Summary: In this study, the predicted structure of AhyI protein was deduced and an inhibitor molecule was identified. The inhibitor molecule showed competitive inhibition of AI-1 biosynthesis. These findings suggest that this molecule could be a potential novel drug candidate for controlling A.hydrophila infections.
MICROBIAL PATHOGENESIS
(2022)
Article
Immunology
Thao Thu Mai, Pattanapon Kayansamruaj, Chayanit Soontara, Pattarawit Kerddee, Dinh-Hung Nguyen, Saengchan Senapin, Janina Z. Costa, Jorge del-Pozo, Kim D. Thompson, Channarong Rodkhum, Ha Thanh Dong
Summary: Immunization of tilapia broodstock with TiLV vaccines can induce antibody response and transfer maternal antibodies to fertilized eggs and larvae, providing protection against TiLV. HKV appears to be more promising than FKV for maternal vaccination.
Article
Fisheries
Ana Herrero, Oswaldo Palenzuela, Hamish Rodger, Chris Matthews, Mar Marcos-Lopez, James E. Bron, Mark P. Dagleish, Kim D. Thompson
Summary: The microsporidian D. lepeophtherii is difficult to detect in tissue sections, and this study developed an ISH protocol specific for D. lepeophtherii, which showed higher sensitivity compared to other methods.
JOURNAL OF FISH DISEASES
(2022)
Article
Microbiology
Seong Bin Park, Yon Kyoung Park, Min Woo Ha, Kim D. Thompson, Tae Sung Jung
Summary: Pathogenic typing, molecular typing, and antimicrobial susceptibility tests were conducted on 75 isolates of E. coli from stool samples of patients suffering from foodborne diseases in Busan, South Korea. The isolates showed high resistance to certain antibiotics but high susceptibility to others, indicating a high level of heterogeneity between the E. coli isolates.
Article
Microbiology
Ana Herrero, Hamish Rodger, Adam D. Hayward, Chris Cousens, James E. Bron, Mark P. Dagleish, Kim D. Thompson
Summary: Complex gill disorder (CGD) is an important condition in Atlantic salmon aquaculture, but the roles of the putative aetiological agents in the pathogenesis are uncertain. This study shows that the loads of certain pathogens are significantly associated with the severity of CGD, and water temperature and management factors also have an impact on gill lesions.
Review
Fisheries
Bei Wang, Kim D. Thompson, Eakapol Wangkahart, Jidapa Yamkasem, Melba G. Bondad-Reantaso, Puntanat Tattiyapong, Jianchang Jian, Win Surachetpong
Summary: In recent years, emerging and re-emerging diseases have had a significant economic impact on the tilapia industry. Without effective management and appropriate biosecurity measures, infectious diseases will continue to challenge the sustainability of global tilapia aquaculture. Enhancing immune response and improving husbandry management can help reduce the impact of diseases.
REVIEWS IN AQUACULTURE
(2023)
Article
Fisheries
Anurak Bunnoy, Kim D. Thompson, Patcharapong Thangsunan, Putita Chokmangmeepisarn, Teerapong Yata, Nopadon Pirarat, Sirikorn Kitiyodom, Pattanapong Thangsunan, Pimwarang Sukkarun, Pochara Prukbenjakul, Naphat Panthukumphol, Manami Morishita, Prapansak Srisapoome, Channarong Rodkhum
Summary: A new bivalent mucoadhesive nanovaccine was developed for immersion vaccination of tilapia against francisellosis and columnaris disease. It has the potential to improve innate and adaptive immunity in vaccinated fish, increasing survival rates.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Immunology
Kim D. Thompson, Channarong Rodkhum, Anurak Bunnoy, Patcharapong Thangsunan, Sirikorn Kitiyodom, Pimwarang Sukkarun, Jakarwan Yostawornkul, Teerapong Yata, Nopadon Pirarat
Summary: Tilapia is extensively farmed and provides an important source of food and income for low-income families. However, disease outbreaks caused by bacteria and viruses have increased with the intensification of farming systems. Nanoparticle-based vaccines offer potential solutions to improve vaccine acceptance and uptake among tilapia farmers.
Article
Fisheries
Mariana Vaz, Damiana Pires, Pedro Pires, Marco Simoes, Ana Pombo, Paulo Santos, Beatriz do Carmo, Ricardo Passos, Janina Z. Costa, Kim D. Thompson, Teresa Baptista
Summary: The early host-pathogen interaction between European seabass and Betanodavirus was examined by infecting juvenile fish with RGNNV. The study found that the host's immune system was activated shortly after infection, and significant changes in hematological, antioxidant, and immunological responses were observed. Furthermore, the peak expression of certain immune markers coincided with disease symptoms and high levels of fish mortality.
Review
Food Science & Technology
Stacia Stetkiewicz, Rachel A. Norman, Edward Hugh Allison, Neil L. Andrew, Gulshan Ara, Gill Banner-Stevens, Ben Belton, Malcolm Beveridge, Jessica R. Bogard, Simon R. Bush, Pete Coffee, Margaret Crumlish, Peter Edwards, Mahmoud Eltholth, Lynne Falconer, Joao G. Ferreira, Angus Garrett, Iain Gatward, Faruk U. Islam, Alexander M. Kaminski, Marian Kjellevold, Froukje Kruijssen, William Leschen, Abdullah-Al Mamun, Bruce McAdam, Richard Newton, Birgitte Krogh-Poulsen, Alexandra Pounds, Belinda Richardson, Nanna Roos, Elin Roeoes, Andrea Schapper, Tori Spence-McConnell, Sharon K. Suri, Shakuntala Haraksingh Thilsted, Kim D. Thompson, Michael F. Tlusty, Max Fredrik Troell, Raffaele Vignola, James A. Young, Wenbo Zhang, David C. Little
Summary: This review assesses the representation of seafood in recent food security literature and finds that seafood is under-researched compared to terrestrial production systems. The study also reveals a lack of research on the interaction between terrestrial and aquatic systems. Therefore, there is a need for more attention to be given to the role of seafood in global food security and for its integration into interdisciplinary research.
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2022)