Article
Immunology
Yunchao Cao, Tianshun Kou, Liaotian Peng, Hetron Mweemba Munang'andu, Bo Peng
Summary: Aquatic food is an important source of micronutrients for human beings, and aquaculture plays an increasingly important role in providing this food source. However, bacterial infection poses a severe threat to aquaculture and strategies for managing these infections without antibiotics are lacking. This study investigates the metabolic changes of crucian carp infected with Aeromonas hydrophila and identifies fructose as a crucial biomarker. Supplementation of fructose increases fish survival rate by enhancing the expression of lysozyme and complement 3, leading to reduced bacterial load. These findings demonstrate a metabolism-based approach to manage bacterial infection by modulating the immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Mave Harshitha, Ashwath Nayak, Somanath Disha, Uchangi Satyaprasad Akshath, Saurabh Dubey, Hetron Mweemba Munang'andu, Anirban Chakraborty, Indrani Karunasagar, Biswajit Maiti
Summary: The application of nanotechnology in aquaculture for developing efficient vaccines has shown great potential. Nanovaccination, through encapsulating fish pathogen antigens and achieving sustained release, enhances immune responses and protective efficacy of vaccines. However, thorough evaluation of the potential toxicity of nanoparticles is necessary before widespread application.
Article
Fisheries
Chen Feng, Xiaofeng Liu, Yiyang Tang, Mengzhe Feng, Zejun Zhou, Shaojun Liu
Summary: In this study, the expression and function of a ladderlectin homologue (WR-ladderlectin) from hybrid crucian carp were examined. The results showed that WR-ladderlectin is a pattern recognition receptor that protects the intestinal mucosal barrier against bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad Valibeknejad, Seyed Majid Abdoli, Reza Alizadeh, Silvia M. Mihaila, Amir Raoof
Summary: Pharmaceuticals and nutrients need to cross various barriers to enter and be eliminated from the body. The gastrointestinal mucosa acts as a critical barrier, facilitating nutrient transport and impeding the transit of toxins and bacteria. This study investigates the penetration of particles and drugs through the mucus layer, finding that internal fluid flow has a significant impact on particle transport, necessitating the consideration of convection mechanism for mass transfer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Chao Liu, Wei Liu, Yanhong Liu, Hongxia Duan, Liqing Chen, Xintong Zhang, Mingji Jin, Minhu Cui, Xiuquan Quan, Libin Pan, Jiachun Hu, Zhonggao Gao, Yan Wang, Wei Huang
Summary: A high-density PEGylation-based glycocholic acid-decorated micelle (PTX@GNPs) was constructed to overcome the obstacles in the gastrointestinal environment. This micelle possesses mucus trapping escape ability and excellent intestine epithelium targeting, enhancing the oral bioavailability of paclitaxel (PTX) and exhibiting similar antitumor efficacy compared to intravenous injection. Furthermore, it can increase in vivo retention time of PTX and remodel the immune microenvironment, enhancing oral chemotherapy efficacy.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Environmental Sciences
Ayan Srivastava, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
Summary: This study elucidated the effect of aloin on mucosal immune response and disease resistance in Labeo rohita infected with Aeromonas hydrophila. The treatment of aloin significantly restored the activity of certain immune parameters and reduced the cumulative mortality in bacteria-infected fish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Mareike Neumann, Alex Steimle, Erica T. Grant, Mathis Wolter, Amy Parrish, Stephanie Willieme, Dirk Brenner, Eric C. Martens, Mahesh S. Desai
Summary: The study reveals that the change in dietary habits in Western societies, particularly reduced fiber intake, is linked to alterations in gut microbial ecology, which can lead to disruption of the intestinal barrier and increased susceptibility to enteric pathogens.
Article
Cell Biology
Gaoliang Yuan, Weihua Zhao, Yanwei Zhang, Zhao Jia, Kangyong Chen, Junya Wang, Hao Feng, Jun Zou
Summary: IL-21 is induced in grass carp leukocytes and tissues in response to bacterial infection. It promotes the expression of antibacterial genes and inhibits the NF-kappa B signaling pathway. IL-21 is expressed in CD3γ/δT cells and accumulates in the intestine, indicating its important role in regulating intestinal inflammation induced by bacterial infection in grass carp.
Article
Chemistry, Multidisciplinary
Zhi-Hao Wang, Wanting Huang, Shuhao Zhang, Mengyu Chu, Na Yin, Chaoran Zhu, Zhenzhong Zhang, Jinjin Shi, Junjie Liu
Summary: Self-thermophoretic nanoparticles (CTPB) have been developed to enhance intestinal mucus penetration and reduce pathogenic bacteria interception, resulting in improved drug delivery efficiency for colorectal cancer therapy.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Engineering, Biomedical
Sony Priyanka Bandi, Shubhmita Bhatnagar, Venkata Vamsi Krishna Venuganti
Summary: Mucus is a viscoelastic gel that traps pathogens and foreign particles, while also being essential for drug carriers to access underlying epithelial tissues. Various strategies have been developed to achieve mucoadhesion and mucus penetration in drug delivery systems. Advances in materials chemistry have led to the expansion of materials available for mucosal drug delivery applications.
ACTA BIOMATERIALIA
(2021)
Article
Environmental Sciences
Shantkriti Srinivasan, Senthil Kumar Sadasivam
Summary: Both non-adapted and adapted bacteria can efficiently biodegrade azo dyes under optimized physicochemical conditions, suggesting their potential use in effluent treatment.
ENVIRONMENTAL RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Andressa Vieira de Moraes, Marco Shizuo Owatari, Eduardo da Silva, Marina de Oliveira Pereira, Marina Piola, Claudio Ramos, Daniel Rosa Farias, Delano Dias Schleder, Gabriel Fernandez Alves Jesus, Adolfo Jatoba
Summary: This study evaluated the use of two microencapsulated probiotic additives in extruded diets for juvenile Nile tilapia, and found that the addition of probiotics improved the zootechnical and health aspects of the fish. The fish fed with probiotic diets showed greater survival, improvements in feed conversion, as well as in the specific growth rate. Histological and histomorphometric analysis revealed that the probiotic treatments had a positive effect on the intestinal health of the fish. Metagenomic evaluation also showed significant differences in the intestinal microbiomes between the treatments. In the challenge against the pathogen A. hydrophila, the probiotic treatments exhibited lower cumulative mortality compared to the control group.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Morteza Yousefi, Seyyed Morteza Hoseini, Afaf N. Abdel Rahman, Yury Anatolyevich Vatnikov, Evgeny Vladimirovich Kulikov, Elena Valentinovna Kharlitskaya, Sergey Borisovich Seleznev
Summary: This study examines the effects of dietary limonene treatment on growth performance, immune response, and disease resistance in common carp. The results indicate that adding 200 mg/kg limonene to the diet improves feed efficiency, boosts innate immunity, and increases resistance against Aeromonas hydrophila.
Article
Fisheries
Ning-Xia Xiong, Sheng-Wei Luo, Lan -Fen Fan, Zhuang-Wen Mao, Kai-Kun Luo, Shao-Jun Liu, Chang Wu, Fang-Zhou Hu, Shi Wang, Ming Wen, Qing-Feng Liu
Summary: The study revealed that challenge with Aeromonas hydrophila could lead to erythrocyte hemolysis, increased free hemoglobin levels, and decreased antioxidant capacity and enzyme levels in red crucian carp and triploid hybrid fish. Elevated expression of various proteins and metabolic products were observed in infected fish, highlighting the differential metabolic responses to bacterial infection.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Aldo Aparecido Proietti-Junior, Luciana Sampaio Lima, Emily Moraes Roges, Yan Correa Rodrigues, Karla Valeria Batista Lima, Dalia Prazeres Rodrigues, Marcos Tavares-Dias
Summary: This study reported an outbreak of disease in pirarucu caused by Aeromonas, conducted experimental co-infection research, and characterized resistance profile, virulence factors, and phenotypic and molecular differentiation. The findings support the existence of synergism between A. hydrophila and A. jandaei in pirarucu, with implications for occurrences of this co-infection and determinants of virulence.
AQUACULTURE RESEARCH
(2021)
Article
Fisheries
M. Adamek, J. Hellmann, V. Jung-Schroers, F. Teitge, D. Steinhagen
JOURNAL OF FISH DISEASES
(2018)
Article
Fisheries
Mikolaj Adamek, Felix Teitge, Verena Jung-Schroers, Max Heling, David Gela, Veronika Piackova, Martin Kocour, Dieter Steinhagen
JOURNAL OF FISH DISEASES
(2018)
Article
Fisheries
Julia Bauer, Felix Teitge, Lisa Neffe, Mikolaj Adamek, Arne Jung, Christina Peppler, Dieter Steinhagen, Verena Jung-Schroers
JOURNAL OF FISH DISEASES
(2018)
Article
Fisheries
Verena Jung-Schroers, Mikolaj Adamek, Angela Boley, Anna Korshun, Dieter Steinhagen
JOURNAL OF FISH DISEASES
(2019)
Article
Fisheries
Verena Jung-Schroers, Arne Jung, Martin Ryll, Julia Bauer, Felix Teitge, Dieter Steinhagen
JOURNAL OF FISH DISEASES
(2019)
Article
Fisheries
Snjezana Zrncic, Drazen Oraic, Ivana Giovanna Zupicic, Zeljko Pavlinec, Dragan Brnic, Zaklin Acinger Rogic, Ivica Sucec, Dieter Steinhagen, Mikolaj Adamek
JOURNAL OF FISH DISEASES
(2020)
Article
Veterinary Sciences
Verena Jung-Schroers, Uta Hildebrandt, Karina Retter, Karl-Heinz Esser, John Hellmann, Dirk Willem Kleingeld, Karl Rohn, Dieter Steinhagen
BMC VETERINARY RESEARCH
(2020)
Article
Fisheries
Felix Teitge, Christina Peppler, Dieter Steinhagen, Verena Jung-Schroers
JOURNAL OF FISH DISEASES
(2020)
Article
Microbiology
L'ubomir Pojezdal, Mikolaj Adamek, Eva Syrova, Dieter Steinhagen, Hana Minarova, Ivana Papezikova, Veronika Seidlova, Stanislava Reschova, Miroslava Palikova
Article
Fisheries
Felix Teitge, Christina Peppler, Dieter Steinhagen, Verena Jung-Schroers
JOURNAL OF FISH DISEASES
(2020)
Article
Fisheries
Julia Bauer, Felix Teitge, Lisa Neffe, Mikolaj Adamek, Arne Jung, Christina Peppler, Dieter Steinhagen, Verena Jung-Schroers
Summary: In land-based recirculating aquaculture systems, low water salinities can impact the disease resistance of shrimp and alter the microbial composition, posing a higher risk of disease outbreaks and potentially affecting food safety. Maintaining high water salinities is recommended for producing healthy shrimp as safe food for human consumption.
JOURNAL OF FISH DISEASES
(2021)
Article
Fisheries
Martin Felten, Mikolaj Adamek, Marina Gebert, Sebastian Rakers, Dieter Steinhagen
Summary: Cell characteristics and immune responses have an influence on the susceptibility of carp cell lines to viral infection. Cells with lower levels of type I interferon responses may be more susceptible to replication of certain viruses.
JOURNAL OF FISH DISEASES
(2022)
Article
Microbiology
Stephanie Gross, Anja Mueller, Diana Seinige, Manuela Oliveira, Dieter Steinhagen, Ursula Siebert, Corinna Kehrenberg
Summary: This study investigates the occurrence of antimicrobial-resistant Escherichia coli in free-living great cormorants in Germany. The results show that resistant E. coli were isolated from a significant proportion of the samples, and a substantial number of the resistant isolates exhibited multidrug resistance. Most of the isolates belonged to the phylogenetic group B1, and a portion of them were identified as avian pathogenic E. coli with multidrug resistance. These findings provide valuable information on the dissemination of antimicrobial-resistant bacteria in wild birds and potential public health concerns.
Article
Infectious Diseases
Stephanie Gross, Anja Mueller, Diana Seinige, Peter Wohlsein, Manuela Oliveira, Dieter Steinhagen, Corinna Kehrenberg, Ursula Siebert
Summary: Antimicrobial resistance is a global health threat with wildlife acting as a reservoir and vector for resistant bacteria and genes. This study found resistant strains of Escherichia coli in marine mammals of the North and Baltic Seas, highlighting their role as sentinels for antimicrobial-resistant bacteria. The distribution of resistant bacteria in these sea areas provides important information from a One Health perspective.
Review
Immunology
Japhette E. E. Kembou-Ringert, Dieter Steinhagen, John Readman, Janet M. M. Daly, Mikolaj Adamek
Summary: Tilapia tilapinevirus (TiLV) is a newly emerged virus that causes a novel disease and reduces tilapia populations worldwide. It has been reported in 17 countries, causing high mortalities. Currently, there are no therapeutics or vaccines specifically designed for TiLV control. Vaccination has shown potential in inducing protective immunity in tilapia. Various vaccine strategies are being explored, but a comprehensive overview of their efficacy is lacking. This review discusses recent advances in TiLV vaccine development, highlighting the need for further research and the incorporation of different approaches to enhance vaccine effectiveness.