Article
Developmental Biology
Eric Paulissen, Benjamin L. Martin
Summary: The development of the vertebrate embryonic midline vasculature is closely related to the development of skeletal muscle. During development, angioblasts migrate from bilateral positions along the ventral edge of the somites to the midline and differentiate into the dorsal aorta and the cardinal vein. The absence of skeletal myogenesis leads to the migration of angioblasts to the midline but only the formation of the cardinal vein, not the dorsal aorta. This is due to the failure to activate the expression of vascular endothelial growth factor ligand vegfaa in the somites, which is required for the specification of the adjacent angioblasts into the dorsal aorta. Myod and Myf5 cooperate with Hedgehog signaling to activate and maintain vegfaa expression in the medial somites, which is necessary for angiogenic sprouting from the dorsal aorta.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Genetics & Heredity
Lin-Lin Shi, Ke-Cheng Zhu, Huan-Ling Wang
Summary: This study characterized the sequences and expression patterns of Myod and Myf5 in Megalobrama amblycephala. The results showed that these genes were predominantly expressed in skeletal muscle, with highest expression in white muscle. Additionally, the effects of LPS on muscle-related gene expression and satellite cell proliferation and differentiation were evaluated.
Article
Dentistry, Oral Surgery & Medicine
Shen Shiying, Wang Weihong, Tang Xiuqiong, Qian Yemei
Summary: This study investigated the relationship between congenital coronoid process hyperplasia (CPH) and TGFB3 gene mutation, and found that compound heterozygous mutations in the TGFB3 gene or homozygous mutations in the 3'UTR may be correlated with CPH.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2023)
Article
Cell & Tissue Engineering
Wan-Jing Chen, I-Hsuan Lin, Chien-Wei Lee, Kiyoshi Yoshioka, Yusuke Ono, Yu-Ting Yan, Yun Yen, Yi-Fan Chen
Summary: The balance and fate of skeletal muscle stem cells (MuSCs) is tightly regulated by their intrinsic and extrinsic properties. Ribonucleotide reductase M2B (Rrm2b) plays a critical role in modulating MuSC fate by modifying the microenvironment in muscle fibers. Lack of Rrm2b leads to muscle weakness and impaired muscle fiber repair.
NPJ REGENERATIVE MEDICINE
(2022)
Review
Cell Biology
Yong-ho Choe, Jacob Sorensen, Daniel J. Garry, Mary G. Garry
Summary: Organ transplantation is the only curative therapy for many endstage diseases, but the limited supply of donor organs calls for new strategies. Recent advancements in gene editing and stem cell technologies have enabled the pursuit of interspecies chimeric organs with promising early results. However, there are still hurdles to be addressed in order to successfully transplant these organs to patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hirofumi Uchiyama, Daisuke Muramatsu, Hideaki Higashi, Hiroshi Kida, Atsushi Iwai
Summary: Chondroitin sulfate oligosaccharides (Oligo-CS) derived from skate have higher bioactivity compared to high molecular weight CS. Oligo-CS significantly inhibits osteoclast differentiation and promotes cell viability in C2C12 cells, while high molecular weight CS does not have these effects.
Article
Biochemistry & Molecular Biology
Lili Wang, Zheng Chen, Yu Feng, Rongrong Wang, Xiaohui Bai, Weihua Liu, Dawei Wang
Summary: The study revealed that 4-octyl itaconate (OI) inhibits muscle differentiation by affecting MyoD-regulated activity through the inhibition of AKT1 phosphorylation during differentiation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biology
Zhenzhen Xiong, Mengni Wang, Shanshan You, Xiaoyan Chen, Jiangguo Lin, Jianhua Wu, Xiaozhong Shi
Summary: In this study, we identified the mechanism regulating the dynamic expression of Tceal7 during skeletal muscle regeneration, and demonstrated the interaction between the triple complex of Mef2c, Creb1, and Myod and the Mef2#3-CRE#3-E#4 motifs in the Tceal7 promoter, which drives Tceal7 expression.
Article
Biochemistry & Molecular Biology
Shufang Cai, Bin Hu, Qi Zhu, Tianqi Duo, Xiaoyu Wang, Xian Tong, Xiaorong Luo, Renqiang Yuan, Yaosheng Chen, Jing Wang, Chenglong Luo, Baosong Xing, Delin Mo
Summary: Delving into porcine embryonic myogenesis is crucial for understanding the complex regulation of breed-specific differences in growth performance and meat production. This study reveals that pigs with less meat production exhibit earlier embryonic myogenesis, and the Notch signaling pathway plays a crucial role in regulating myogenic progenitor maintenance and differentiation. Inhibition of Notch signaling promotes myogenic differentiation and accelerates the process of myogenic progenitors differentiating into myoblasts. These findings provide valuable insights into the underlying mechanisms of breed-specific differences in meat production.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Oncology
Ines Lahmann, Yao Zhang, Katharina Baum, Jana Wolf, Carmen Birchmeier
Summary: The balance between proliferation and differentiation of muscle stem cells is tightly controlled by Notch signaling, with oscillatory expression of HES1 playing a crucial role in maintaining the 'undecided' state where cells can either differentiate or self-renew. This oscillatory network, dependent on DLL1 inputs, ensures the appropriate balance between self-renewal and differentiation in muscle progenitor cells.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oceanography
Jiao Shuang, Tan Xungang, You Feng, Pang Qiuxiang
Summary: This study investigated the roles of different isoforms of Pax3a and Pax3b in myogenesis. The results showed that different isoforms have different subcellular localizations and transcriptional activities, and they regulate the expression of different target genes during embryonic myogenesis. These findings contribute to a better understanding of the functions of Pax3a and Pax3b in muscle development.
JOURNAL OF OCEAN UNIVERSITY OF CHINA
(2022)
Article
Cell & Tissue Engineering
Luca Dalle Carbonare, Gianluigi Dorelli, Veronica Li Vigni, Arianna Minoia, Jessica Bertacco, Samuele Cheri, Michela Deiana, Giulio Innamorati, Mattia Cominacini, Cantor Tarperi, Federico Schena, Monica Mottes, Maria Teresa Valenti
Summary: MicroRNAs play an important role in myogenesis and muscle activity, and can be modulated by physical exercise. A study examined the expression of microRNAs in response to physical performance, and found gender-specific expression patterns before exercise. The levels of certain microRNAs changed after a half marathon in both males and females, and these changes were reflected in the blood. In addition, the serum of marathon runners had a positive effect on myogenesis in cell cultures. These findings suggest that microRNAs could be potential targets for therapies involving myogenic stem cells in diseases.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Sport Sciences
Michaela Wehrstein, Axel Schoeffel, Nadine Weiberg, Thomas Gwechenberger, Theresa Betz, Mareike Rittweg, Mario Parstorfer, Maximilian Pilz, Birgit Friedmann-Bette
Summary: The study aimed to assess if one bout of concentric/eccentric exercise with damaging eccentric overload provides a sufficient stimulus to induce satellite cell (SC) activation, proliferation, and differentiation. The results showed that eccentric overload during leg extension exercise induced significant SC activation and increases in SC content, but there were no signs of increased SC differentiation or formation of new myofibers.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Biochemistry & Molecular Biology
Jing Zhang, Bolin Cai, Manting Ma, Shaofen Kong, Zhen Zhou, Xiquan Zhang, Qinghua Nie
Summary: This study identified a new lncRNA called SMARCD3-OT1, which strongly regulates myogenesis by improving the expression of SMARCD3X4. Cell experiments showed that SMARCD3-OT1 and SMARCD3X4 promoted myoblast proliferation through the CDKN1A pathway and improved differentiation of differentiated myoblasts through the MYOD pathway. Furthermore, they facilitated the slow-twitch fiber to transform into the fast-twitch fiber.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Zhao Zhao He, Tiantian Zhao, Naren Qimuge, Tingting Tian, Wenyong Yan, Xudong Yi, Jianjun Jin, Rui Cai, Taiyong Yu, Gongshe Yang, Weijun Pang
Summary: COPS3 AS lncRNA is identified as a key regulator in myogenesis, functioning through its interaction with miR-762 to promote myogenic differentiation and Fast-MyHC expression.
CELLULAR SIGNALLING
(2022)
