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Medicine, Research & Experimental
Hongcheng Luo, Tingzhuang Yi, Deyou Huang, Xiaoping Chen, Xu Li, Qianquan Wan, Haineng Huang, Huadong Huang, Hongyu Wei, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Chuanliu Lan, Wencheng Chen, Dan Zhou, Qisheng Luo
Summary: The study revealed that circ_PTN promotes DDP resistance in GBM cells through activating the PI3K/AKT pathway, with in vivo experiments demonstrating that circ_PTN silencing inhibits DDP resistance in GBM tumors.
MOLECULAR THERAPY NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Ya-Li Zhang, Liang Liu, Yu-Wen Su, Cory J. Xian
Summary: The study shows that miR-542-3p is downregulated during bone loss and marrow adiposity induced by MTX treatment in childhood malignancies. Through target prediction and luciferase assays, it was confirmed that miR-542-3p targets sFRP-1 and Smurf2 to regulate osteogenesis and adipogenesis balance. Additionally, further analyses revealed that miR-542-3p influences Wnt/beta-catenin and TGF-beta signaling pathways in osteoblastic cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Endocrinology & Metabolism
Fernanda Alvarado-Flores, Tomoko Kaneko-Tarui, William Beyer, Jacqueline Katz, Tianjiao Chu, Patrick Catalano, Yoel Sadovsky, Marie-France Hivert, Perrie O'Tierney-Ginn
Summary: Maternal insulin resistance during late pregnancy is associated with the expression of placental miRNA-3940-3p, suggesting a potential regulatory role of this miRNA in modulating maternal insulin resistance.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Ancuta Jurj, Oana Zanoaga, Lajos Raduly, Vlad Morhan, Zsofia Papi, Cristina Ciocan, Laura-Ancuta Pop, Ioana Berindan-Neagoe, Cornelia Braicu
Summary: The lack of estrogen or progesterone receptors and absence of HER2 amplification/overexpression limit treatment options for triple-negative breast cancer (TNBC). MicroRNAs (miRNAs), particularly miR-29b-3p, have been of interest for TNBC and correlated with overall survival rates. This study explored the potential therapeutic effects of miR-29b-3p inhibition in TNBC cell lines, observing decreased cell proliferation, activation of apoptosis and autophagy, and altered miRNA expression patterns. Target analysis revealed ECM receptor interaction and TP53 signaling as the main predicted targets, with additional validation showing upregulation of MCL1 and TGFB1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Anna Zubrzycka, Monika Migdalska-Sek, Slawomir Jedrzejczyk, Ewa Brzezianska-Lasota
Summary: The altered expression of genes and miRNAs in endometrial cells of women with endometriosis may disrupt the intracellular signaling pathways associated with EMT. This study explored the expression profile of miR-542-3p and EMT markers in endometriosis patients and healthy women, revealing the potential role of miR-542-3p as a negative regulator of BMP7-SMAD4-CDH1 signaling in EMT and endometriosis pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Federica Rascio, Federica Spadaccino, Maria Teresa Rocchetti, Giuseppe Castellano, Giovanni Stallone, Giuseppe Stefano Netti, Elena Ranieri
Summary: The PI3K/Akt pathway plays a crucial role in drug resistance in cancer by impacting tumor cell growth and metastasis through different signaling pathways. Its multi-level deregulation contributes to resistance in various cancer types. Understanding the pathway is essential in developing potential inhibition strategies for overcoming drug resistance.
Article
Immunology
Jin-Seok Byun, Ho Yeop Lee, Jingwen Tian, Ji Sun Moon, Jaejin Choi, Sang-Hee Lee, Yong-Gun Kim, Hyon-Seung Yi
Summary: Periodontitis is caused by an imbalance of the local immune microenvironment due to oral microbial dysbiosis, which is exacerbated by insulin resistance and obesity. Increased levels of exosomal miR-25-3p in the saliva of obese patients with type 2 diabetes are found to be associated with periodontitis. The study also reveals that CD69 mRNA is a target of miR-25-3p and regulates the activation of gamma delta T cells and inflammatory response. Inhibition of miR-25-3p prevents local inflammation and reduces ligature-induced periodontal bone loss in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Qing-Hua Xiong, Lei Zhao, Guan-Qun Wan, Yun-Gang Hu, Xiao-Lin Li
Summary: This study demonstrated that miRNA-542-3p-Exo derived from BMSCs have regenerative effects on skin wounds. The interaction between BMSCs-Exo and HSFs/HMECs enhances their proliferation, migration, and angiogenesis, playing a critical role in wound repair.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Review
Biochemistry & Molecular Biology
Yordan Sbirkov, Bozhidar Vergov, Nikolay Mehterov, Victoria Sarafian
Summary: MicroRNAs play a significant role in the treatment outcome of lymphoid malignancies and are closely related to drug response. This article summarizes the impact of microRNAs on chemotherapy resistance in adult and pediatric acute lymphoblastic leukemia as well as chronic lymphocytic leukemia and discusses the potential of using microRNAs as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Pooja Gulhane, Shailza Singh
Summary: Sphingolipid metabolism plays a crucial role in the progression and metastasis of NSCLC. Our study reveals the impact of sphingolipid metabolism on the PI3K/AKT pathway, providing potential targets for precision medicine in NSCLC.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Ying Yang, Zhifang Yang, Ruili Zhang, Chunli Jia, Rui Mao, Shaya Mahati, Yuefen Zhang, Ge Wu, Yan Na Sun, Xiao Yan Jia, Ainiwaer Aimudula, Hua Zhang, Yongxing Bao
Summary: This study revealed that miR-27a-3p expression was down-regulated in HCC tissues and associated with metastasis, Child-Pugh grade, and race. Overexpression of miR-27a-3p inhibited cell growth, promoted apoptosis, and increased sensitivity to cisplatin in HCC, potentially through regulating the PI3K/Akt signaling pathway.
BIOSCIENCE REPORTS
(2021)
Review
Oncology
Aysooda Hosseinzadeh, Parnaz Merikhian, Nazanin Naseri, Mohammad Reza Eisavand, Leila Farahmand
Summary: This article discusses the resistance mechanisms to trastuzumab in breast cancer and proposes MUC1 as a potential target to overcome this resistance. It has been found that silencing the MUC1-C proto-oncogene can increase the sensitivity of HER2(+) cells to trastuzumab.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Xiangjie Huang, Xinping Zhu, Yun Yu, Wangyu Zhu, Libo Jin, Xiaodong Zhang, Shaotang Li, Peng Zou, Congying Xie, Ri Cui
Summary: Colorectal cancer is the third most common cancer globally with a poor 5-year survival rate. MicroRNAs play a crucial role in the progression and metastasis of CRC by regulating target genes. This review provides updated information on tumor suppressive and oncogenic miRNAs, circulatory miRNAs, and the causes of dysregulated miRNAs in CRC, as well as their important functions in drug resistance.
Review
Pharmacology & Pharmacy
Hang Yan, Shengjie Tang, Shoujun Tang, Jun Zhang, Haiyang Guo, Chao Qin, Haiyang Hu, Chuan Zhong, Li Yang, Yunhe Zhu, Haining Zhou
Summary: Non-small cell lung cancer (NSCLC) is a common malignant tumor with suboptimal clinical success due to late diagnosis, limited treatment options, high recurrence rates, and drug resistance. MicroRNAs (miRNAs), small non-coding RNAs, have emerged as important players in NSCLC initiation, progression, and drug resistance. This review provides an overview of miRNA dysregulation and resistance in NSCLC and discusses their potential applications in different anti-cancer treatments.
FRONTIERS IN PHARMACOLOGY
(2022)
