Article
Endocrinology & Metabolism
Saartje Straetemans, Raoul Rooman, Jean De Schepper
Summary: In GHD children, the growth response after 2 prepubertal years of GH treatment did not significantly improve the prediction of poor AH outcome compared to first-year growth response parameters, suggesting that re-evaluation of diagnosis or adjustment of GH dosage should not be postponed if poor response is observed after the first year.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Emanuele Varaldo, Fabio Bioletto, Daniela Cuboni, Nunzia Prencipe, Chiara Bona, Marco Barale, Ezio Ghigo, Silvia Grottoli, Alessandro Maria Berton, Valentina Gasco
Summary: This study aimed to investigate the potential use of intranasal glucagon as a stimulus test for the evaluation of pituitary function. The results showed that intranasal glucagon administration is not effective for pituitary secretion and can lead to hypokalemia as a complication.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Gajanthan Muthuvel, Andrew Dauber, Eirene Alexandrou, Leah Tyzinski, Melissa Andrew, Vivian Hwa, Philippe Backeljauw
Summary: This study aimed to evaluate the efficacy and safety of recombinant human growth hormone (rhGH) therapy for linear growth in children with ACAN deficiency. The results showed that rhGH treatment improved linear growth in these patients and no adverse events related to rhGH were observed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Paul Saenger, Reiko Horikawa
Summary: This study evaluated the efficacy, safety, and tolerability of once-weekly somapacitan treatment for GH deficiency in children over a three-year period. The results showed sustained efficacy in height-related outcomes with similar safety and tolerability to daily GH treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Jun Mori, Volker Boettcher, Ho-Seong Kim, Rikke Beck Bang, Michel Polak, Reiko Horikawa
Summary: This study evaluated the efficacy and tolerability of somapacitan in children with growth hormone deficiency (GHD) for 2 years and after switching from daily growth hormone treatment. The results showed that somapacitan was effective and well-tolerated during the 2-year period, and patients and caregivers preferred once-weekly somapacitan treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lars Savendahl, Tadej Battelino, Michael Hojby Rasmussen, Meryl Brod, Sebastian Rohrich, Paul Saenger, Reiko Horikawa
Summary: This study aimed to assess the efficacy and safety of somapacitan in treating growth hormone deficiency (GHD) in children, as well as the burden of treatment. The results showed that weekly injections of somapacitan could reduce the burden for patients and their parents/guardians compared to daily GH injections.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Nektarios Barabutis
Summary: This article discusses the association between endothelial barrier dysfunction and sepsis and lung injury, as well as the role of unfolded protein response in the protective effects of heat shock protein 90 inhibitors and growth hormone releasing hormone antagonists on the vascular barrier.
Article
Endocrinology & Metabolism
Bradley S. Miller, Joanne C. Blair, Michael Hojby Rasmussen, Aristides Maniatis, Rasmus Juul Kildemoes, Jun Mori, Michel Polak, Rikke Beck Bang, Volker Boettcher, Stefano Stagi, Reiko Horikawa
Summary: Similar efficacy and safety were demonstrated for Somapacitan compared to daily GH over 52 weeks of treatment in children with GH deficiency.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Aristides K. Maniatis, Samuel J. Casella, Ulhas M. Nadgir, Paul L. Hofman, Paul Saenger, Elena D. Chertock, Elena M. Aghajanova, Maria Korpal-Szczyrska, Elpis Vlachopapadopoulou, Oleg Malievskiy, Tetyana Chaychenko, Marco Cappa, Wenjie Song, Meng Mao, Per Holse Mygind, Alden R. Smith, Steven Chessler, Allison S. Komirenko, Michael Beckert, Aimee D. Shu, Paul S. Thornton
Summary: This trial aims to assess the long-term safety and efficacy of lonapegsomatropin in children with growth hormone deficiency. The results show that lonapegsomatropin treatment can continue to improve height without causing excessive advancement of bone age. Patients using the TransCon hGH Auto-Injector reported fewer local tolerability reactions.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Veterinary Sciences
Fengyang Wu, Lijie Gao, Fei Li, Jia Cui, Xinyu Yang, Yanhua Liu, Saijuan Chen, Baojiang Chen
Summary: This experiment aimed to investigate the effects of zearalenone on ovarian development in prepubertal gilts. The results showed that zearalenone promoted the development of ovaries and follicles through the growth hormone axis, and exerted reproductive toxicity by increasing the expression levels of growth hormone receptor and related proteins.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Cheri Deal, Joel Steelman, Elpis Vlachopapadopoulou, Renata Stawerska, Lawrence A. Silverman, Moshe Phillip, Ho-Seong Kim, Cheol Woo Ko, Oleg Malievskiy, Jose F. Cara, Carl L. Roland, Carrie Turich Taylor, Srinivas Rao Valluri, Michael P. Wajnrajch, Aleksandra Pastrak, Bradley S. Miller
Summary: This study compared the efficacy and safety of once-weekly somatrogon with once-daily somatropin in prepubertal children with growth hormone deficiency. The results showed that once-weekly somatrogon was noninferior to once-daily somatropin in terms of height velocity and change in height standard deviation score. Both treatments were well tolerated.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Mirela-Diana Ilie, Antoine Tabarin, Alexandre Vasiljevic, Jean-Francois Bonneville, Lucile Moreau-Grange, Franck Schillo, Brigitte Delemer, Anne Barlier, Dominique Figarella-Branger, Segolene Bisot-Locard, Alexandre Santos, Philippe Chanson, Gerald Raverot
Summary: This study aimed to explore the factors related to SRLs in the treatment of acromegaly and confirmed that SST2A and adenoma granularity are good predictors of response to octreotide. In addition, the optimization of MRI sequences is important for using T2WSI as a predictor of treatment response.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Chiara Mameli, Massimiliano Orso, Valeria Calcaterra, Malgorzata Gabriela Wasniewska, Tommaso Aversa, Simona Granato, Pietro Bruschini, Liliana Guadagni, Daniela d'Angela, Federico Spandonaro, Barbara Polistena, Gianvincenzo Zuccotti
Summary: This study evaluated the effectiveness, safety, adherence, quality of life, and cost-effectiveness of long-acting growth hormone (LAGH) compared to daily growth hormone (GH) in the treatment of growth hormone deficiency (GHD) in children. The results showed that all LAGH formulations were similar to daily GH in terms of efficacy, safety, adherence, and quality of life. However, more high-quality studies are needed to confirm these findings, and further research on adherence, quality of life, and cost-effectiveness is also necessary.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Jakub Kasprzyk, Marcin Wlodarczyk, Aleksandra Sobolewska-Wlodarczyk, Katarzyna Wieczorek-Szukala, Renata Stawerska, Maciej Hilczer, Andrzej Lewinski
Summary: The study analyzed the effects of different types of Turner syndrome (TS) karyotype abnormalities on the response to recombinant human growth hormone (rhGH) therapy in 57 prepubertal patients with TS. It found that patients with X-monosomy or isochromosome had a poorer response to rhGH therapy in the second and third year, while better outcomes were achieved in patients with marker chromosome and X-mosaicism. The results suggest that the type of TS karyotype may impact the effectiveness of rhGH therapy in TS patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ling Hou, Ke Huang, Chunxiu Gong, Feihong Luo, Haiyan Wei, Liyang Liang, Hongwei Du, Jianping Zhang, Yan Zhong, Ruimin Chen, Xinran Chen, Jiayan Pan, Xianjiang Jin, Ting Zeng, Wei Liao, Deyun Liu, Dan Lan, Shunye Zhu, Zhiya Dong, Huamei Ma, Yu Yang, Feng Xiong, Ping Lu, Shengquan Cheng, Xuefan Gu, Runming Jin, Yu Liu, Jinzhun Wu, Xu Xu, Linqi Chen, Qin Dong, Hui Pan, Zhe Su, Lijun Liu, Xiaoming Luo, Shining Ni, Zhihong Chen, Yuhua Hu, Chunlin Wang, Jing Liu, Li Liu, Biao Lu, Xinli Wang, Yunfeng Wang, Fan Yang, Manyan Zhang, Lizhi Cao, GeLi Liu, Hui Yao, Yaqin Zhan, Mingjuan Dai, Guimei Li, Li Li, Yanjie Liu, Kan Wang, Yanfeng Xiao, Xingxing Zhang, Junhua Dong, Zaiyan Gu, Lirong Ying, Feng Huang, Yanling Liu, Zheng Liu, Jin Ye, Dongmei Zhao, Xu Hu, Zhihong Jiang, Kan Ye, Hong Zhu, Shaoke Chen, Xiaobo Chen, Naijun Wan, Zhuangjian Xu, Qingjin Yin, Hongxiao Zhang, Xiaodong Huang, Jianying Yin, Huifeng Zhang, Pin Li, Ping Yin, Junfen Fu, XiaoPing Luo
Summary: This study examined the effectiveness and safety of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric growth hormone deficiency (GHD). The results showed that PEG-rhGH had favorable outcomes and was safe for treating children with GHD. The high-dose subgroup had better treatment outcomes compared to the low-dose subgroup, and a weekly dose of 0.2 mg/kg might have additional benefits.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Ecology
Marjolein Bruijning, Erlend I. F. Fossen, Eelke Jongejans, Helene Vanvelk, Joost A. M. Raeymaekers, Lynn Govaert, Kristien Brans, Sigurd Einum, Luc De Meester
Summary: This study shows that interactions between temperature and parasitism shape competition among Daphnia populations, with Belgian clones performing better under infection than Norwegian clones. Infected populations perform better at higher temperatures due to increased host capability to reduce parasite loads. Temperature strongly affects individual vital rates, while parasitism consistently reduces fitness through negative effects on all vital rates, highlighting the importance of considering biotic interactions in predicting the competitive ability of populations under global warming.
FUNCTIONAL ECOLOGY
(2022)
Article
Fisheries
B. M. Perriman, P. Bentzen, B. F. Wringe, S. Duffy, S. S. Islam, I. A. Fleming, M. F. Solberg, I. R. Bradbury
Summary: The escape of Atlantic salmon from aquaculture poses a significant threat to wild salmon populations. The phenotypic impacts of hybridization remain unresolved. This study evaluated the phenotypic consequences of hybridization using geometric morphometrics, suggesting that the observed differences between wild and farm-wild hybrid individuals in laboratory conditions may not be noticeable in the wild.
AQUACULTURE ENVIRONMENT INTERACTIONS
(2022)
Article
Physiology
Ningping Gong, Jakob Lundin, Daniel Morgenroth, Mark A. Sheridan, Erik Sandblom, Bjorn Trandur Bjornsson
Summary: This study found that increased Lep in rainbow trout during fasting has important effects on the GH-IGF-I system and metabolism. The increase in Lep suppressed the expression of IGF-I, indicating its involvement in acquired GH resistance. Additionally, the increase in Lep also suppressed the expression of key enzymes involved in lipid utilization and gluconeogenesis.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shahinur S. Islam, Xi Xue, Albert Caballero-Solares, Ian R. Bradbury, Matthew L. Rise, Ian A. Fleming
Summary: This study examines the genetic differences between farmed and wild Atlantic salmon, as well as the consequences of hybridization between escaped farmed fish and wild populations. The findings suggest that the escaped farmed fish, especially those of European origin, have a greater impact on gene transcription and potential effects on wild populations compared to locally derived farmed strains. This research provides insights into the genetic interactions and disruptive effects of introgression in salmon populations.
Article
Ecology
Semona Issa, Safa Chaabani, Alexandros G. Asimakopoulos, Veerle L. B. Jaspers, Sigurd Einum
Summary: Dopamine plays an important role in regulating responses to food abundance, but the costs of high dopamine levels are poorly understood. This study investigates the effects of maternal dopamine levels on offspring fitness in the water flea Daphnia magna. The results show that although dopamine-exposed mothers produced smaller offspring, these offspring had a superior starvation resistance compared to controls.
ECOLOGY AND EVOLUTION
(2022)
Article
Evolutionary Biology
Ian R. Bradbury, Sarah Jean Lehnert, Tony Kess, Mallory Van Wyngaarden, Steven Duffy, Amber M. Messmer, Brendan Wringe, Silje Karoliussen, J. Brian Dempson, Ian A. Fleming, Monica Favnebe Solberg, Kevin A. Glover, Paul Bentzen
Summary: Gene flow between wild and domestic populations has been demonstrated in various species. This study found evidence of European gene introgression into North American aquaculture salmon, despite the absence of approval for the use of European salmon in Canada. The results suggest that individuals with European ancestry have been used and escaped into the wild, potentially impacting wild salmon populations.
EVOLUTIONARY APPLICATIONS
(2022)
Article
Biodiversity Conservation
Tim Burton, Irja Ida Ratikainen, Sigurd Einum
Summary: This article examines the rate at which reversible phenotypic plasticity (RPP) occurs and its potential impact on how organisms overcome environmental challenges. The study suggests that current theoretical models do not consider the evolutionary potential of RPP rates. If the rate of plasticity itself can evolve, it may alter the organism's perception of environmental predictability and influence the slope of the evolved reaction norm. The optimization of phenotypic plasticity rates, their evolutionary dynamics in different environments, and the costs associated with them warrant further exploration in future research.
GLOBAL CHANGE BIOLOGY
(2022)
Article
Ecology
Varsha Rani, Tim Burton, Matthew Walsh, Sigurd Einum
Summary: Predator-induced mortality can lead to the evolution of metabolic rate, both directly and indirectly. This study found that the metabolic rate of Daphnia pulicaria decreased after the invasive event of the predator Bythotrephes. The potential roles of direct and indirect selection in driving this change were discussed.
ECOLOGY AND EVOLUTION
(2022)
Article
Fisheries
Samantha E. Crowley, Ian R. Bradbury, Amber M. Messmer, Steven J. Duffy, Christopher C. Parrish, Shahinur S. Islam, Ian A. Fleming
Summary: Based on the lipid and fatty acid analysis of different cross types of Atlantic salmon, this study found differences in storage and foraging ability among them. Farm fish showed the greatest differentiation at recapture and may have a feeding disadvantage.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
Article
Ecology
Sigurd Einum, Emil R. Ullern, Matthew Walsh, Tim Burton
Summary: Invasive predatory species can cause evolutionary responses in prey phenotypes, leading to changes in prey population dynamics. This study examined the impact of an invader, Bythotrephes longimanus, on the population dynamics of zooplankton Daphnia pulicaria in Lake Kegonsa, Wisconsin. The findings suggest that post-invasion Daphnia had higher population growth rates and carrying capacities compared to pre-invasion Daphnia under controlled laboratory conditions. However, caution should be exercised when extrapolating these results to wild populations due to the complexities of ecological interactions.
ECOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Peng Yin, Bjorn Thrandur Bjornsson, Per Gunnar Fjelldal, Takaya Saito, Sofie Charlotte Remo, Rolf Brudvik Edvardsen, Tom Hansen, Sandeep Sharma, Rolf Erik Olsen, Kristin Hamre
Summary: Accumulating evidence suggests a close relationship between oxidative stress and growth rate in fish, but the underlying mechanisms are not clear. This study investigated the combined effect of dietary antioxidants and growth hormone (GH) on the redox status of liver and muscle in Atlantic salmon. The results show that GH implantation decreases vitamin C and E levels, increases oxidative stress in the liver, and affects the expression of genes and pathways related to antioxidant enzymes and redox balance. Dietary antioxidants do lower oxidative stress but have no effect on the growth rate.
Article
Ecology
Sigurd Einum, Tim Burton
Summary: An individual's fitness cost associated with environmental change depends on the rate of adaptive phenotypic plasticity. However, understanding of plasticity rates in an ecological and evolutionary context remains limited. A quantitative synthesis of existing plasticity rate data reveals considerable variation in plasticity rates among species, with different rates observed among higher taxa.
Article
Ecology
Sigurd Einum, Vitalija Bartuseviciute, Erlend I. F. Fossen, Christophe Pelabon
Summary: Populations originating from colder environments often exhibit higher somatic growth rates, suggesting adaptation to seasonality or temperature. The relationship between somatic growth rate and population growth rate, as well as the mortality rate in the wild, play important roles in determining the type of adaptation.
JOURNAL OF EVOLUTIONARY BIOLOGY
(2023)
Article
Fisheries
Morten Falkegard, Robert J. Lennox, Eva B. Thorstad, Sigurd Einum, Peder Fiske, Oyvind A. Garmo, Ase H. Garseth, Helge Skoglund, Monica F. Solberg, Kjell R. Utne, Knut W. Vollset, Leif Asbjorn Vollestad, Vidar Wennevik, Torbjorn Forseth
Summary: Managers and stakeholders are concerned about the impact of predation on the status of Atlantic salmon. A review of literature suggests that predation alone may not be the main driver of decline in salmon populations. While predation may hinder recovery, there is a lack of strong evidence to support the effectiveness of predator control in restoring threatened salmon populations.
CANADIAN JOURNAL OF FISHERIES AND AQUATIC SCIENCES
(2023)
Meeting Abstract
Zoology
S. D. McCormick, D. J. Hall, B. T. Bjornsson
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2023)