Article
Oncology
Samuel Peter Heilbroner, Reed Few, Judith Mueller, Jitesh Chalwa, Francois Charest, Somasekhar Suryadevara, Christine Kratt, Andres Gomez-Caminero, Brian Dreyfus, Tomas G. Neilan
Summary: The study used a machine learning model to predict cardiac events risk factors in patients receiving immune checkpoint inhibitors therapy, including increased age, corticosteroids, laboratory abnormalities, cardiac history, extremes of weight, decreased lymphocyte percentage, and increased neutrophil percentage.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Mario Mandala, Paul Lorigan, Matilde De Luca, Andrea Bianchetti, Barbara Merelli, Anna Cecilia Bettini, Lucia Bonomi, Sharon Nahm, Maria Grazia Vitale, Giorgia Negrini, Andrea Di Croce, Paolo Antonio Ascierto, Eliana Rulli, Carlo Alberto Tondini
Summary: In ambulatory cancer patients with asymptomatic or pauci-symptomatic SARS-CoV-2 infection, the safety of targeted therapies, chemotherapy, or immune checkpoint inhibitors therapy remains uncertain. A prospective study conducted in Bergamo, Italy found that SARS-CoV-2 positive patients had a significantly higher mortality rate and more frequent serious adverse events compared to SARS-CoV-2 negative patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Urology & Nephrology
Kathleen W. Zhang, Melissa A. Reimers, Adam Christopher Calaway, Michael G. Fradley, Lee Ponsky, Jorge A. Garcia, Jennifer Cullen, Brian C. Baumann, Daniel Addison, Courtney M. Campbell, Arjun K. Ghosh, Daniel J. Lenihan, Nihar R. Desai, Neal Weintraub, Avirup Guha
Summary: In men treated for prostate cancer, arterial vascular events were the most commonly reported cardiovascular adverse events. GnRH antagonists were associated with fewer cardiovascular adverse events compared to GnRH agonists.
JOURNAL OF UROLOGY
(2021)
Article
Oncology
Yuka Yokoyama, Michiko Kubo-kaneda, Kimi Sunada, Yasuhiro Teishikata, Asa Kitamura, Kota Okamoto, Kuniaki Toriyabe, Masafumi Nii, Kenta Yoshida, Eiji Kondo, Tomoaki Ikeda
Summary: This study evaluated the adverse events of bevacizumab combined with chemotherapy for treating ovarian cancer, which has been poorly documented in Japan. The results showed that hypertension and proteinuria were the most common adverse events, and gastrointestinal perforation occurred more frequently in patients with a history of radiation therapy.
ANTICANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Andreas Carlsson, Anna-Lotta Irewall, Anna Graipe, Anders Ulvenstam, Thomas Mooe, Joachim oegren
Summary: This prospective cohort study explores the long-term outcomes after ischemic stroke (IS) and transient ischemic attack (TIA) and identifies factors associated with new events. The study finds that IS patients have a higher risk of major adverse cardiovascular events (MACE) and cardiovascular death compared to TIA patients. Factors such as age, kidney failure, prior IS, prior acute myocardial infarction (AMI), congestive heart failure, and impaired functional status are associated with an increased risk of MACE.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
James D. Theuerle, Ali H. Al-Fiadh, Fakir M. Amirul Islam, Sheila K. Patel, Louise M. Burrell, Tien Yin Wong, Omar Farouque
Summary: Assessing retinal microvascular endothelial dysfunction can predict long-term cardiovascular events. Retinal arteriolar dysfunction is an independent predictor of MACE in patients with CAD. Dynamic retinal vessel analysis may enhance risk stratification for cardiovascular events.
CARDIOVASCULAR RESEARCH
(2021)
Article
Oncology
Wen Gao, Lingxiang Wu, Shidai Jin, Jun Li, Xinyin Liu, Jiali Xu, Wei Zhang, Qixing Gong, Chunxiao Sun, Wei Wang, Zidun Wang, Yang W. Shao, Jiani C. Yin, Lu Shen, Liang Chen, Qianghu Wang, Renhua Guo
Summary: Through genomic analysis, a pathogenic variant in SLC22A5 gene was identified in a thymoma case with ICI-induced MG, which is associated with fatty acid oxidation through L-carnitine level regulation. Rechallenge with ICI and pretreatment with L-carnitine led to long-lasting relief of MG symptoms.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Critical Care Medicine
Evdoxia Kyriazopoulou, Lydia Liaskou-Antoniou, George Adamis, Antonia Panagaki, Nikolaos Melachroinopoulos, Elina Drakou, Konstantinos Marousis, Georgios Chrysos, Andronikos Spyrou, Nikolaos Alexiou, Styliani Symbardi, Zoi Alexiou, Styliani Lagou, Virginia Kolonia, Theologia Gkavogianni, Miltiades Kyprianou, Ioannis Anagnostopoulos, Garyfallia Poulakou, Malvina Lada, Anna Makina, Efrosyni Roulia, Marina Koupetori, Vasileios Apostolopoulos, Dimitra Petrou, Thomas Nitsotolis, Anastasia Antoniadou, Evangelos J. Giamarellos-Bourboulis
Summary: PCT-guided antimicrobial discontinuation in sepsis patients effectively reduces the rate of infection-associated adverse events, 28-day mortality, and hospitalization costs.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Eleanor F. Gerhard, Lu Wang, Ramesh Singh, Stephan Schueler, Leonard D. Genovese, Andrew Woods, Daniel Tang, Nicola Robinson Smith, Mitchell A. Psotka, Sian Tovey, Shashank S. Desai, Djordje G. Jakovljevic, Guy A. MacGowan, Palak Shah
Summary: In patients who underwent LVAD decommissioning for myocardial recovery, long-term survival free from recurrent heart failure and preservation of ventricular size and function up to 3 years were achieved. However, preventing recurrent infections remains an important therapeutic goal for this management strategy.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Oncology
Maryam B. Lustberg, Nicole M. Kuderer, Aakash Desai, Cristiane Bergerot, Gary H. Lyman
Summary: Despite the lack of systematic efforts, this review provides a comprehensive analysis of the most common long-term and late adverse events associated with chemotherapy and other anticancer treatments. It discusses the underlying mechanisms, management strategies, and clinical practice guidelines for these adverse events. Additionally, it highlights the need for effective management of treatment-related events in oncology.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Oncology
Bilal A. Siddiqui, Jinesh S. Gheeya, Rohit Goswamy, Tharakeswara K. Bathala, Devaki Shilpa Surasi, Jianjun Gao, Amishi Shah, Matthew T. Campbell, Pavlos Msaouel, Sangeeta Goswami, Jennifer Wang, Amado J. Zurita, Eric Jonasch, Paul G. Corn, Ana M. Aparicio, Arlene O. Siefker-Radtke, Padmanee Sharma, Sumit K. Subudhi, Nizar Tannir
Summary: This study evaluated the safety and efficacy of ICT rechallenge after moderate-to-severe irAEs in patients with RCC, UC, and prostate cancer. Results showed deep and durable responses in a subset of patients, with acceptable safety and no fatal events. Strategies to enable ICT resumption after moderate-to-severe irAEs, such as targeted immunosuppression, warrant further study.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Pharmacology & Pharmacy
Frank M. C. Besag, Michael J. Vasey
Summary: Although the frequency of adverse events associated with long-term melatonin use is low and few clinically significant adverse events have been reported, the scarcity of data from double-blind randomized placebo-controlled trials should caution against complacency. More rigorous evaluation of the safety profile should be based on analysis of data from large well-established research databases.
EXPERT OPINION ON DRUG SAFETY
(2022)
Article
Obstetrics & Gynecology
Mei-Yi Wu, Ping-Jen Hu, Chung-Shun Wong, Tzu-Ting Chen, Jui-Yuan Hsueh, Yuh-Feng Lin, Yu-Kang Tu
Summary: A population-based cohort study conducted in Taiwan National Health Insurance Research Database found an association between hypertensive disorders of pregnancy and adverse events after pregnancy, such as chronic kidney disease and major adverse cardiovascular events. Women with hypertensive disorders of pregnancy are at a higher risk of developing chronic kidney disease and major adverse cardiovascular events compared to those without hypertensive disorders of pregnancy. Further research is needed to better understand and address these associations for improved public health interventions.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Multidisciplinary Sciences
Yung-Tsu Cho, Yi-Tsz Lin, Che-Wen Yang, Chia-Yu Chu
Summary: A study conducted in Taiwan found that cutaneous immune-related adverse events are common in cancer patients receiving immunotherapies, with skin rash and pruritus being most frequently identified. Patients receiving different drugs may have varying incidence rates, and concurrent usage of molecular targeted therapy is associated with higher rates.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Johanna E. J. Jacobs, Wouter L'Hoyes, Lieselotte Lauwens, Yu-Ling Yu, Marius Brusselmans, Caroline Weltens, Jens-Uwe Voigt, Hans Wildiers, Patrick Neven, Joerg Herrmann, Lutgarde Thijs, Jan A. Staessen, Stefan Janssens, Lucas N. L. Van Aelst
Summary: This study compared the rates of cardiovascular events in the first decade following curative radiotherapy for breast cancer. It found that heart failure and atrial fibrillation/flutter were common during this period. These results highlight the need for early dedicated cardio-oncological follow-up after radiotherapy.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)