Article
Environmental Sciences
Drew R. Van Orden
Summary: Two analytical studies have derived a discriminant function to differentiate asbestiform amphibole minerals, particularly fibers longer than 10 μm, emphasizing the importance of accurately identifying materials containing these minerals.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Matthew S. Sanchez, Monica McGrath-Koerner, Brittani D. McNamee
Summary: Elongate mineral particles, such as asbestos, have been frequently found in talc and other mineral powders. Recent concerns about talc containing asbestos have arisen due to litigation and reports from international laboratories and government bodies. This study highlights the importance of understanding mineralogy and its application through microscopy, using conflicting analyses from two independent laboratories as examples. The study discusses the need for accurate measurement and characterization of mineral-based samples using various techniques, as well as the misidentification of different mineral types. These findings emphasize the necessity for stricter analytical requirements in monitoring mineral particles in powders.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Maxime Misseri
Summary: This article proposes a model of natural asbestiform minerals growing in four stages. The study focuses on calcium amphiboles cross-fibers, which develop from altered calcium amphiboles. The observations were made on rocks from France using PLM and TEM. The stages include the development of metasomatic veins, the formation of subgrains, fracturing, and nucleation and growth. The morphology and width of the asbestos minerals are influenced by microcracks and dissolution by hydrothermal fluid.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Lucy Darnton
Summary: This study aimed to update the previous meta-analysis of mortality studies on asbestos-exposed worker populations by incorporating new data from increased follow-up and studies of worker populations exposed predominantly to single fibre types. Results showed significant differences in the risks of mesothelioma and lung cancer among different types of asbestos fibers.
ENVIRONMENTAL RESEARCH
(2023)
Article
Toxicology
Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Summary: This research presents the development of a prototype nose-only exposure system for studying the inhalation toxicity of natural mineral fibers. The system was able to generate stable and controllable fiber aerosol, as confirmed by characterization tests using Libby Amphibole 2007. Transmission electron microscopy analysis demonstrated the consistency of the aerosol fibers with the bulk material. The results indicate that the prototype system is suitable for studying the inhalation toxicity of natural mineral fibers.
INHALATION TOXICOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Kathleen Mahoney, Tim Driscoll, Julia Collins, Justine Ross
Summary: Exposure to asbestos fibres leads to asbestos-related diseases (ARDs) such as asbestosis and mesothelioma. Australia has experienced high levels of asbestos use and is still facing ongoing concerns about potential exposure sources from past use. Without targeted actions, Australians will continue to be exposed to legacy asbestos and develop ARDs. It is important to understand and prevent ongoing exposures to effectively manage risks and develop sustainable policies and practices for preventing future diseases.
Article
Environmental Sciences
E. J. Chatfield
Summary: Respirable fractions of crushed amphibole samples were sorted and measured to address three questions: 1. Can amphiboles be classified according to the level of inhalation hazard? 2. Can prismatic amphibole be differentiated from amphibole asbestos based on particle size distributions? 3. How do different exposure indices compare when applied to these amphibole samples? The data showed that the concentration of respirable elongate mineral particles (EMPs) and their dimensions contribute to the inhalation hazard, and certain parameters can be used to discriminate prismatic amphibole from asbestiform amphibole. Additionally, exposures in terms of different metrics showed variations between asbestos and non-asbestiform amphiboles.
ENVIRONMENTAL RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Albert Miller, Charles B. Black, Gregory Loewen, Curtis W. Noonan, Tracy McNew, Alan C. Whitehouse, Arthur L. Frank
Summary: Occupational and environmental exposure to Libby amphibole (LA) can lead to asbestos-related pleuropulmonary disease (ARPPD), with asbestos as the leading cause of mortality. Of the 203 deaths observed in this study, 55% were attributed to asbestos-related causes, including asbestos-related malignancy, parenchymal asbestosis, and respiratory failure.
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
David M. Bernstein, Balazs Toth, Rick A. Rogers, Peter Kunzendorf, James Phillips, Dirk Schaudien
Summary: The study found that brake dust exposure caused significant differences in lung pathological responses and tumorigenicity compared to chrysotile asbestos and other amphiboles. While chrysotile showed short-term effects in the rat respiratory tract, crocidolite and amosite resulted in persistent inflammation and lung tumor response.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Toxicology
Anbo Wang, Amit Gupta, Michael D. Grimm, David T. Pressburger, Barney R. Sparrow, Jamie S. Richey, John R. Shaw, Karen E. Elsass, Georgia K. Roberts, Pei-Li Yao, Matthew D. Stout, Benjamin J. Ellis, Robyn L. Ray
Summary: This study developed a large-scale exposure system for conducting nose-only inhalation toxicity studies of Libby amphibole (LA) 2007. The system was able to deliver stable LA 2007 aerosol to individual carousels at different concentrations. The results showed that the exposure atmospheres were chemically and physically similar across carousels.
INHALATION TOXICOLOGY
(2023)
Article
Health Care Sciences & Services
Antonietta Porzio, Alessandro Feola, Giuseppe Parisi, Angelo Lauro, Carlo Pietro Campobasso
Summary: This study reviewed 35 claims of occupational colorectal cancer among asbestos-exposed workers and identified some interesting characteristics, providing clues for the assessment of the causal relationship between asbestos exposure and colorectal cancer.
Article
Biochemistry & Molecular Biology
Reagan Badger, Kyewon Park, Ralph A. Pietrofesa, Melpo Christofidou-Solomidou, Kinta M. Serve
Summary: The study found that LGM2605 can alleviate late inflammation post-exposure to LA, inhibiting immune cell influx, oxidative stress, and immunoglobulin changes, indicating its potential efficacy in prolonged treatment of LA-related diseases and other inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Hyun-Sung Jung, Jinyoung Jang, Yangseok Cho, Jong-Chun Lee, Hyunwook Kim
Summary: The study investigated the type, concentration, size, morphology, and composition of asbestos fibers in the ambient air of various regions in South Korea, revealing the highest asbestos concentrations in residential areas and baseball fields.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Article
Environmental Sciences
Yuwan Deng, Dexin Gan, Na Tang, Zhengwu Cai, Xinyi Li, Simin Chen, Xiaoma Li
Summary: This study investigated outdoor thermal benchmarks and activities in summer subtropical residential areas. The results revealed that temperature and adjustments in time and space played a significant role in residents' thermal comfort. It provides valuable insights into the outdoor thermal comfort and activities of people living in subtropical regions.
Article
Pharmacology & Pharmacy
Alessandro F. Gualtieri, Alessandro Zoboli, Monica Filaferro, Monia Benassi, Sonia Scarfi, Serena Mirata, Rossella Avallone, Giovanni Vitale, Mark Bailey, Martin Harper, Dario Di Giuseppe
Summary: The study investigated the toxicity effects of fibrous glaucophane on lung cells, revealing that it may lead to a decrease in cell viability, an increase in extracellular lactate dehydrogenase release, and induction of oxidative stress. Although fibrous glaucophane exhibits lower toxic effects compared to crocidolite, exposure to this fiber could still potentially cause lung diseases in exposed unprotected workers and the population.
Article
Environmental Sciences
Danielle J. Carlin, Theodore C. Larson, Jean C. Pfau, Stephen H. Gavett, Arti Shukla, Aubrey Miller, Ronald Hines
ENVIRONMENTAL HEALTH PERSPECTIVES
(2015)
Article
Toxicology
Micah Kingston, Jean C. Pfau, John Gilmer, Richard Brey
JOURNAL OF IMMUNOTOXICOLOGY
(2016)
Article
Public, Environmental & Occupational Health
Jaime Szeinuk, Curtis W. Noonan, Claudia I. Henschke, Jean Pfau, Brad Black, Albert Miller, David F. Yankelevitz, Mingzhu Liang, Ying Liu, Rowena Yip, Laura Linker, Tracy McNew, Raja M. Flores
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE
(2017)
Article
Physiology
John Gilmer, Kinta Serve, Chad Davis, Marti Anthony, Robert Hanson, Tanner Harding, Jean C. Pfau
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2016)
Article
Toxicology
John Gilmer, Tanner Harding, Linda Woods, Brad Black, Raja Flores, Jean Pfau
INHALATION TOXICOLOGY
(2017)
Article
Neurosciences
Gaurav Kaushik, Yu Xia, Jean C. Pfau, Michael A. Thomas
NEUROSCIENCE LETTERS
(2017)
Article
Pharmacology & Pharmacy
Jean C. Pfau, Brenda Buck, Rodney V. Metcalf, Zoie Kaupish, Caleb Stair, Maria Rodriguez, Deborah E. Keil
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2017)
Article
Public, Environmental & Occupational Health
Albert Miller, Jaime Szeinuk, Curtis W. Noonan, Claudia I. Henschke, Jean Pfau, Brad Black, David F. Yankelevitz, Mingzhu Liang, Ying Liu, Rowena Yip, Tracy McNew, Laura Linker, Raja Flores
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2018)
Article
Environmental Sciences
Roger Diegel, Brad Black, Jean C. Pfau, Tracy McNew, Curtis Noonan, Raja Flores
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2018)
Article
Environmental Sciences
Jean C. Pfau, Christopher Barbour, Brad Black, Kinta M. Serve, Marvin J. Fritzler
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2018)
Article
Pharmacology & Pharmacy
Melpo Christofidou-Solomidou, Ralph A. Pietrofesa, Kyewon Park, Steven M. Albelda, Kinta M. Serve, Deborah E. Keil, Jean C. Pfau
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Environmental Sciences
Renee N. Carey, Jean C. Pfau, Marvin J. Fritzler, Jenette Creaney, Nicholas de Klerk, Arthur (Bill) Musk, Peter Franklin, Nita Sodhi-Berry, Fraser Brims, Alison Reid
Summary: The study examined the hypothesis that autoantibodies are more common in individuals exposed to asbestos with lung cancer or mesothelioma. Contrary to expectations, individuals without malignancies were more likely to have specific autoantibodies, but autoantibodies to histone and Ro-60 were associated with lung cancer. Further research is needed to identify potential target antigens for these antibodies.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2021)
Article
Toxicology
Jean C. Pfau, Tracy McNew, Kerensa Hanley, Lindsay Swan, Brad Black
INHALATION TOXICOLOGY
(2019)
Article
Physiology
Robert Hanson, Caryn Evilia, John Gilmer, Linda Woods, Brad Black, Raja Flores, Jean C. Pfau
PHYSIOLOGICAL REPORTS
(2016)