Article
Toxicology
Bethany A. Parker, Evelyn Valentini, Stephen E. Graham, James M. Starr
Summary: This study used in vitro assays to determine the bioaccessibility of 14 PFAS in 33 sets of soils and dusts. The results showed that PFAS had higher bioaccessibility in soils compared to dusts, and the addition of a sink increased the bioaccessibility in the test system. The study suggests that the bioaccessibility of PFAS in soils and dusts can be predicted using a limited set of physical chemical characteristics and could inform risk assessment models.
TOXICOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Efstratios Kelepertzis, Vladislav Chrastny, Fotini Botsou, Evangelia Sigala, Zacharenia Kypritidou, Michael Komarek, Konstantinos Skordas, Ariadne Argyraki
Summary: This study conducted a multidisciplinary analysis on soil, road dust, and house dust samples from a heavy industrial area in Greece, revealing the widespread presence of anthropogenic Fe-containing particles in all sampling media, which are associated with the bioaccessibility of most analyzed elements. By combining magnetic measurements, SEM/EDS analyses, bioaccessibility measurements, and isotopic analyses, it was found that industrial Pb and Pb related to the past usage of leaded petrol are the primary sources of solubilized Pb in simulated gastric and lung extractions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Xiaoyu Liu, Edgar Folk
Summary: The study investigated the emission, sorption, and migration of organophosphorus flame retardants (OPFRs) from different sources to settled dust. It was found that dust with lower organic content and smaller size tended to absorb more OPFRs, but different types of dust did not significantly affect OPFRs emission into chamber air from the same source. The partitioning between dust-air favored less volatile OPFRs, while emission from sources favored volatile chemicals.
Article
Environmental Sciences
Leila Arfaeinia, Taybeh Tabatabaie, Mohammad Miri, Hossein Arfaeinia
Summary: This study investigated the levels of PAHs in indoor dust samples collected from various building microenvironments in Bushehr city. The results showed that smoking cafes had the highest levels of contaminants, while laboratories had the lowest. Additionally, the study found significant associations between PAHs concentration and ventilation rate, as well as smoking indoors.
ENVIRONMENTAL RESEARCH
(2022)
Review
Public, Environmental & Occupational Health
Alastair Kierulf, Cameron Ollson, Caroline Whitehead, Diane Beauchemin, Iris Koch
Summary: When soils are contaminated, conducting a human health risk assessment is helpful for evaluating the potential risks to human health. Validated bioaccessibility methods can accurately assess the relative absorption of contaminants during soil ingestion. However, when validated methods are not available, risk assessors face the challenge of conducting their own literature search, creating their own validation study, or using default assumptions. This study provides a literature search and meta-analysis of the analysis of various elements from different bioaccessibility methodologies in the past 28 years, aiming to inform further method validation and future risk assessments.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Agriculture, Dairy & Animal Science
Amrit Pal, Alexandra P. Jackson, Andrea Urrutia, Kenneth S. Macklin, Stuart B. Price, Richard Jeff Buhr, Dianna Bourassa
Summary: This study evaluated the bacteria levels in settled dust during the growout of broilers and found that the levels can fluctuate and Salmonella may be present in the dust.
Article
Environmental Sciences
Oddny Ragnarsdottir, Mohamed Abou-Elwafa Abdallah, Stuart Harrad
Summary: PFAS are known contaminants of indoor dust, but their dermal penetration potential is not well understood. This study assessed the bio-accessibility of 17 PFAS from indoor dust to synthetic human sweat sebum mixtures and found that commonly applied cosmetics significantly impacted the dermal bioaccessibility of PFAS.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Oddny Ragnarsdottir, Mohamed Abou-Elwafa Abdallah, Stuart Harrad
Summary: This study assessed the bioaccessibility of PFAS from indoor dust to synthetic human sweat sebum mixtures (SSSM) using in vitro tests. The composition of the SSSM significantly affected the bioaccessibility of all target compounds. Common cosmetics were found to impact the dermal bioaccessibility of PFAS. The findings highlight the potential substantial contribution of dermal exposure to human body burdens of PFAS and the need for further consideration of this pathway in risk assessment studies.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Xiaoqing Wang, Gianluca Brunetti, Wenjie Tian, Gary Owens, Yang Qu, Chaoxi Jin, Enzo Lombi
Summary: This study evaluated potential practical techniques for chemical immobilization of molybdenum (Mo) contaminated agricultural soils using up to six different amendments from four materials. The results showed that biosolids, water treatment residues, and magnetite were effective in reducing molybdenum extractability and uptake by plants in lightly and moderately contaminated soils.
ENVIRONMENTAL POLLUTION
(2021)
Article
Construction & Building Technology
Donghyun Kim, Ji Young Park, Dong Hyun Lee, Jae-Eun Lim, Hyo-Bang Moon, Sungkyoon Kim, Kiyoung Lee
Summary: This study investigated settled house dust (SHD) samples collected from 106 houses in Seoul and Gyeonggi Province, Korea, and found various chemical and biological contaminants in the dust, with the highest concentrations detected for organophosphate flame retardants, phthalates, alternative plasticizers, and trace metals. The study also identified significant associations between the concentrations of contaminants in the dust and factors such as the type and number of electronic appliances and combustion activities, while ventilation, vacuum cleaning, and wet cleaning or dry mopping were found to significantly reduce the levels of contaminants in the dust.
Article
Environmental Sciences
Elisa Sonego, Giulia Simonetti, Patrizia Di Filippo, Carmela Riccardi, Francesca Buiarelli, Alice Fresta, Matteo Olivastri, Donatella Pomata
Summary: An analytical method was modified and optimized for the detection of flame retardants and applied to the simultaneous determination of organophosphate esters (OPEs) and polyfluoralkyl substances (PFASs) in dust samples from different workplaces and houses. The study found that the OPE pollution was more severe in workplaces, while PFAS content in house dust was over ten times higher than in workplaces.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Engineering, Environmental
Marija Zupancic, Mojca Sustersic, Spela Bavec, Mateja Gosar
Summary: This study evaluated the oral and inhalation bioaccessibility of PTE in household dust in a small town, revealing low bioaccessibility for mercury and varying bioaccessibility for different elements in the stomach and intestine. Daily ingestion and inhalation doses of PTE from household dust were found to be below recommended limits by the European Food Safety Authority.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2021)
Review
Geosciences, Multidisciplinary
Claudio Zucca, Nick Middleton, Utchang Kang, Hanspeter Liniger
Summary: Sand and Dust Storms (SDS) are a natural phenomenon with significant impacts on ecosystems and human society. Their hotspots are mainly located in drylands, but they have global implications beyond national and regional boundaries. Sustainable land and water management measures are urgently needed to reduce the impacts of SDS.
Article
Environmental Sciences
Helle Vibeke Andersen, Marie Frederiksen
Summary: The study investigated human exposure pathways to PCB in a high-rise estate in Denmark by conducting an experiment on the sorption of PCB from air to settled house dust. Different origin house dust samples were exposed to elevated air concentrations of PCB in a vacant apartment, and most samples reached equilibrium for PCB congeners after 40 days. The measured partition coefficients were in agreement with literature values, and comparisons with predicted estimates showed good correlation with some overestimation. Additionally, dust-air ratios from field investigations confirmed the results from the exposure experiment, indicating near steady state conditions for PCB congeners in the dust.
Article
Soil Science
Eyal Ben Dor, Nicolas Francos, Yaron Ogen, Amos Banin
Summary: Soil aggregation status can be assessed directly or indirectly using spectral analysis and a data-mining approach. This study provides insight into predicting aggregate size fractions and their relation to cementing agents. This approach may pave the way for remote monitoring of soil aggregation status.
Article
Hematology
Tiffany Pascreau, Maria E. de la Morena-Barrio, Dominique Lasne, Mercedes Serrano, Elsa Bianchini, Manoelle Kossorotoff, Nathalie Boddaert, Arnaud Bruneel, Nathalie Seta, Vicente Vicente, Pascale de Lonlay, Javier Corral, Delphine Borgel
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2019)
Article
Pharmacology & Pharmacy
Dominique Vodovar, Sebastien Beaune, Jerome Langrand, Eric Vicaut, Laurence Labat, Bruno Megarbane
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Virology
Athena Labeau, Etienne Simon-Loriere, Mohamed-Lamine Hafirassou, Lucie Bonnet-Madin, Sarah Tessier, Alessia Zamborlini, Thierry Dupre, Nathalie Seta, Olivier Schwartz, Marie-Laure Chaix, Constance Delaugerre, Ali Amara, Laurent Meertens
JOURNAL OF VIROLOGY
(2020)
Article
Biochemistry & Molecular Biology
Victor Echeverry-Alzate, Jerome Jeanblanc, Pierre Sauton, Vanessa Bloch, Laurence Labat, Marion Soichot, Florence Vorspan, Mickael Naassila
Summary: Research suggests that R(+)-Baclofen is more effective than RS(+/-)-Baclofen in reducing ethanol intake and seeking, while S(-)-Baclofen and RS(+/-)-Baclofen may lead to an increase in alcohol intake in certain individuals.
Article
Endocrinology & Metabolism
Walid Haouari, Johanne Dubail, Samra Lounis-Ouaras, Pierre Prada, Rizk Bennani, Charles Roseau, Celine Huber, Alexandra Afenjar, Estelle Colin, Sandrine Vuillaumier-Barrot, Nathalie Seta, Francois Foulquier, Christian Pous, Valerie Cormier-Daire, Arnaud Bruneel
JOURNAL OF INHERITED METABOLIC DISEASE
(2020)
Article
Endocrinology & Metabolism
Muriel Girard, Claire Douillard, Dominique Debray, Florence Lacaille, Manuel Schiff, Sandrine Vuillaumier-Barrot, Thierry Dupre, Monique Fabre, Lena Damaj, Alice Kuster, Stephanie Torre, Karine Mention, Valerie McLin, Dries Dobbelaere, Delphine Borgel, Eric Bauchard, Nathalie Seta, Arnaud Bruneel, Pascale De Lonlay
JOURNAL OF INHERITED METABOLIC DISEASE
(2020)
Article
Genetics & Heredity
Claudia Castiglioni, Francois Feillet, Christine Barnerias, Arnaud Wiedemann, Jordi Muchart, Fanny Cortes, Cristina Hernando-Davalillo, Raquel Montero, Thierry Dupre, Arnaud Bruneel, Nathalie Seta, Sandrine Vuillaumier-Barrot, Mercedes Serrano
Summary: SSR4 is a subunit of the translocon-associated protein complex, with pathogenic variants causing CDG. Patients present with hypotonia, failure to thrive, and dysmorphic traits, emphasizing the importance of genetic testing and diagnosis.
Article
Immunology
Mathieu Fusaro, Aline Vincent, Martin Castelle, Jeremie Rosain, Benjamin Fournier, Maria Veiga-da-Cunha, Takfarinas Kentache, Jill Serre, Catherine Fallet-Bianco, Anne-Lise Delezoide, Laurent Renesme, Fanny Morice Picard, Eulalie Lasseaux, Nathalie Aladjidi, Nathalie Seta, Valerie Cormier-Daire, Emile van Schaftingen, Benedicte Neven, Despina Moshous, Sophie Blesson, Capucine Picard
Summary: PGM3 deficiency is a rare congenital disorder of glycosylation, characterized by symptoms such as eczema, infections, elevated IgE, neurological and skeletal features. In severe cases, patients may have absent T cells and severe skeletal dysplasia.
JOURNAL OF CLINICAL IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Bobby G. Ng, Paulina Sosicka, Francois Fenaille, Annie Harroche, Sandrine Vuillaumier-Barrot, Mindy Porterfield, Zhi-Jie Xia, Shannon Wagner, Michael J. Bamshad, Marie-Christine Vergnes-Boiteux, Sophie Cholet, Stephen Dalton, Anne Dell, Thierry Dupre, Mathieu Fiore, Stuart M. Haslam, Yohann Huguenin, Tadahiro Kumagai, Michael Kulik, Katherine McGoogan, Caroline Michot, Deborah A. Nickerson, Tiffany Pascreau, Delphine Borgel, Kimiyo Raymond, Deepti Warad, Heather Flanagan-Steet, Richard Steet, Michael Tiemeyer, Nathalie Seta, Arnaud Bruneel, Hudson H. Freeze
Summary: The study identified a recurrent mutation in SLC37A4 causing a dominantly inherited congenital disorder of glycosylation characterized by coagulopathy and liver dysfunction with abnormal serum N-glycans. Liver-specific abnormalities in glycosylation were replicated in a CRISPR base-edited hepatoma cell line carrying the mutation. The mutant protein showed relocation to a non-Golgi compartment and altered Golgi morphology and reduced intraluminal pH, potentially explaining the glycosylation alterations.
AMERICAN JOURNAL OF HUMAN GENETICS
(2021)
Article
Environmental Sciences
Emeline Seurat, Anthony Verdin, Fabrice Cazier, Dominique Courcot, Richard Fitoussi, Katell Vie, Isabelle Momas, Valerie Desauziers, Nathalie Seta, Sophie Achard
Summary: The study tested the impact of environmental pollutants on the skin and found that all pollutants affected cellular functionality, with water-based paint VOC having a lesser effect. Different preconditioning conditions influenced the cellular response to pollutants.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Romain Magny, Nicolas Auzeil, Bertrand Lefrere, Bruno Megarbane, Pascal Houze, Laurence Labat
Summary: Identification of xenobiotics and their metabolites in poisoned patients is challenging. This study used a liquid chromatography approach coupled with high-resolution mass spectrometry and molecular network analysis to successfully identify tramadol metabolites in urine and plasma. The use of both positive and negative ion modes allowed for the identification of previously unreported metabolites and clustering of phase II metabolites. The combined use of positive and negative ion modes in molecular network analysis is a suitable and robust tool for identifying a broad range of metabolites in poisoned patients.
Article
Biochemical Research Methods
Pauline Thiebot, Nada Maaziz, Chrystelle Oppon, Laetitia Bertolo, Romain Magny, Lucie Chevillard, Bruno Megarbane, Pascal Houze, Laurence Labat
Summary: A rapid, sensitive and specific LC-HRMS method was developed for the identification and quantification of ricinine in plasma. Micro-solid-phase elution was used to extract ricinine from 100 μL of plasma, eliminating the evaporation step and reducing extraction time. The method was validated according to European Medicines Agency guidelines and showed good linearity, precision, and accuracy. The method allows rapid and reliable identification of ricin-exposed victims in cases of terrorist attacks or poisonings, as demonstrated by the report of three intoxication cases.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Pascal Houze, Ilona Borowski, Eugenie Bito, Romain Magny, Athina Morcos, Sebastian Voicu, Bruno Megarbane, Laurence Labat
Summary: In toxicology, chromatographic methods coupled to HR/MS are commonly used for screenings, with the development of methods for alternative samples such as Volumetric Adsorptive Micro-Sampling. The optimized extraction procedure using Mitra (TM) allowed the confirmation of 87 compounds in spiked whole blood, with identification limits below 12.5 ng center dot mL(-1) for 82.2% of the investigated drugs. The novel screening approach showed a satisfying concordance in the analysis of poisoned patients' samples.
Article
Pharmacology & Pharmacy
Lea Darnaud, Clement Delage, Youssef Daali, Anne-Priscille Trouvin, Serge Perrot, Nihel Khoudour, Nadia Merise, Laurence Labat, Bruno Etain, Frank Bellivier, Celia Lloret-Linares, Vanessa Bloch, Emmanuel Curis, Xavier Decleves
Summary: Drug-metabolizing enzymes and drug transporters play crucial roles in drug pharmacokinetics and response. The cocktail-based phenotyping approach involves administering multiple probe drugs to evaluate the activities of CYP and transporter simultaneously. This study determined the range of phenotyping indices in healthy volunteers and classified patients with therapeutic issues based on CYP and P-gp activities.
Article
Biochemistry & Molecular Biology
Romain Magny, Bruno Megarbane, Pauline Guillaud, Lucie Chevillard, Nicolas Auzeil, Pauline Thiebot, Sebastian Voicu, Isabelle Malissin, Nicolas Deye, Laurence Labat, Pascal Houze
Summary: Metabolomics in clinical toxicology aims to identify and semi-quantify a wide range of endogenous and exogenous metabolites. In this study, a three-step workflow was developed to investigate the metabolic impact of the antidepressant drug venlafaxine in a poisoned patient. Targeted quantitative and untargeted semi-quantitative metabolomic analyses were performed to determine the plasma kinetics of venlafaxine and its metabolites, and correlations between the metabolomic data and endogenous metabolites were explored. This preliminary study is a first step towards the application of toxicometabolomics in clinical toxicology and provides a useful workflow for identifying toxicity biomarkers.
