Article
Endocrinology & Metabolism
Luchen Yang, Zhenghuan Liu, Zhufeng Peng, Pan Song, Jing Zhou, Linchun Wang, Junhao Chen, Qiang Dong
Summary: This study found a potential association between DEHP exposure and BPH based on NHANES data, with a biphasic effect of DEHP concentration.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Reproductive Biology
Brittany Trnka, Maya Polan, Victoria A. Zigmont
Summary: This study used NHANES data and multiple logistic regression analysis to examine the association between DEHP exposure and female infertility, finding a significant correlation in the second and third quartiles, suggesting the need for further population-based cohort studies to confirm these findings.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Shivani Popli Goyal, Tripti Agarwal, Vijendra Mishra, Ankur Kumar, Chakkaravarthi Saravanan
Summary: This study identified two strains of Lactobacillus (Lactobacillus rhamnosus GG and Lactobacillus plantarum MTCC 25,433) that can rapidly adsorb over 85% of DEHP. The adsorption of DEHP was affected by cell wall polysaccharides, proteins, lipids, and peptidoglycan. These findings suggest that these Lactobacillus strains could be potential strategies for detoxification of DEHP-contaminated foods.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Chemistry, Multidisciplinary
Kuo-Cheng Lan, Te- Weng, Wei-Che Chiang, Chen-Yuan Chiu, Ding-Cheng Chan, Rong-Sen Yang, Shing-Hwa Liu
Summary: DEHP and its metabolite MEHP have been found to inhibit myogenesis in vitro, suggesting their potential role as environmental risk factors affecting muscle differentiation.
APPLIED SCIENCES-BASEL
(2022)
Article
Environmental Sciences
Randall Jenkins, Katia Farnbach, Sandra Iragorri
Summary: The incidence of hypertension in very low birthweight infants decreased significantly in a neonatal intensive care unit when IV fluid containing DEHP was replaced with a DEHP-free formulation, and increased again when DEHP-containing IVF was reintroduced. The study suggests that exposure to DEHP from IV fluid may play a major role in neonatal hypertension.
Article
Toxicology
V. Plichta, W. Voelkel, L. Fembacher, M. Woeckner, D. Nowak, H. Fromme
Summary: Phthalates and other plasticizers are found in high amounts in the indoor environment, making house dust a potential exposure source. This study investigated the oral bioavailability of phthalates and DINCH (R) in humans through ingestion of house dust. The results showed that high molecular weight phthalates, DINP, and DINCH (R) reached their maximum concentration in urine 2-19 hours after ingestion. It was also found that a daily intake of 50 mg of dust could significantly contribute to the overall plasticizer exposure, especially in toddlers.
TOXICOLOGY LETTERS
(2022)
Article
Environmental Sciences
Ling Yang, Jiao Zou, Zhenle Zang, Liuyongwei Wang, Zhulin Du, Dandan Zhang, Yun Cai, Minghui Li, Qiyou Li, Junwei Gao, Haiwei Xu, Xiaotang Fan
Summary: Using a human cerebral organoid model, researchers found that DEHP exposure inhibited cell proliferation and increased apoptosis, impairing the morphogenesis of the human cerebral cortex. DEHP exposure disrupted neurogenesis and neural progenitor migration, possibly due to dysplasia of radial glia cells. RNA sequencing analysis showed that DEHP-induced disorder in cell-extracellular matrix interactions might play a crucial role in the neurodevelopment of human cerebral organoids.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
XueXia Liu, YaNan Liu, Zi Teng, YuSheng Zhang, ZeLin Wang, Peng Zhu, MeiNa Xie, FuJun Liu
Summary: This study found that DEHP exposure reduces testis weight, serum testosterone levels, and sperm quality and function in male mice. DEHP exposure leads to decreased sperm count, motility, acrosome reaction rate, sperm-egg binding capacity, and blastocyte formation. DEHP also affects antioxidant indicators, protein expressions, cell proliferation, and apoptosis pathways in the testis.
Article
Environmental Sciences
Xiaohan Yin, Rabia Zeb, Hui Wei, Ling Cai
Summary: DEHP, a plasticizer, is widely present in the global environment and has adverse effects such as endocrine disruption; acute exposure to DEHP in marine medaka led to impaired immunity, metabolism, and endocrine system; ferroptosis occurred in response to DEHP exposure in medaka, inducing cell death.
Article
Engineering, Environmental
Xia Li, Jianpeng Li, Sijia Hao, Ailing Han, Yayu Yang, Guozhen Fang, Jifeng Liu, Shuo Wang
Summary: A enzyme mimic material inspired by serine proteases was developed to degrade DEHP, which was then immobilized onto RC membranes for continuous recycling degradation. This biocatalytic membrane showed effective DEHP degradation and good stability, offering a promising biomaterial for water decontamination and liquid food depollution.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Environmental Sciences
Nuran Cikcikoglu Yildirim, Tuba Parlak Ak, Omer Samasas
Summary: This study revealed the toxic characteristics of DEHP in Gammarus pulex by examining biochemical and histopathological changes. Changes in SOD, CAT, and GST activities were identified as potential sensitive biomarkers for environmental risk assessment, and increased immunoreactivity in G. pulex due to DEHP exposure was observed.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biology
Yukiko Tando, Hitoshi Hiura, Asuka Takehara, Yumi Ito-Matsuoka, Takahiro Arima, Yasuhisa Matsui
Summary: Maternal exposure to DEHP induces DNA hypermethylation of spermatogenesis-related gene promoters in fetal testicular germ cells in F1 mice, leading to downregulation of gene expression in spermatogonia and subsequent defects in spermatogenesis.
Article
Oncology
Chang-Yi Tsai, Te-Ping Fang, Shuoh-Wen Chen, Hsiao-Wen Chen, Eric Chang-Yi Lin, Ting-An Lin, Der-Cherng Tarng, Yuan- Chang
Summary: This study found that DEHP affects hematopoietic stem and progenitor cells and erythroid differentiation by upregulating Klotho expression. Removing DEHP restores hematopoietic stem cell activity.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Environmental Sciences
Yao Li, Yun Zhao, Yu Lu, Xianxian Lu, Yingdan Hu, Qiulin Li, Menglei Shuai, Rui Li
Summary: Autism spectrum disorders (ASD), also known as childhood autism, are common neurological developmental disorders. This study found that perinatal exposure to DEHP can induce ASD-like behavioral changes in rat offspring, possibly through the activation of the mTOR signaling pathway and inhibition of autophagy in the brain.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Hyojung Yoon, Tae Hwan Kim, Byoung-cheun Lee, Byeongwoo Lee, Pilje Kim, Beom Soo Shin, Jinhee Choi
Summary: This study compared the estimated daily intake of DEHP in six subpopulations in Korea using two exposure assessment approaches. The results showed that the exposure doses of DEHP exceeded the reference dose set by the US EPA in toddlers and young children. In addition to food, indoor dust was also an important source of DEHP exposure.
Article
Environmental Sciences
Lesa L. Aylward, Sean M. Hays, Angelika Zidek
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2017)
Article
Environmental Sciences
Yiqin Chen, Andreas Sjodin, Michael S. McLachlan, Karin English, Lesa L. Aylward, Leisa-Maree L. Toms, Julie Varghese, Peter D. Sly, Jochen F. Mueller
ENVIRONMENT INTERNATIONAL
(2017)
Article
Public, Environmental & Occupational Health
A. L. Heffernan, T. K. Cunningham, D. S. Drage, L. L. Aylward, K. Thompson, S. Vijayasarathy, J. F. Mueller, S. L. Atkin, T. Sathyapalan
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2018)
Article
Medicine, Legal
Sean M. Hays, Devika Poddalgoda, Kristin Macey, Lesa Aylward, Andy Nong
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Medicine, Legal
Lesa L. Aylward, Kim Irwin, Annie St-Amand, Andy Nong, Sean M. Hays
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2018)
Article
Environmental Sciences
Leisa-Maree L. Toms, Andreas Sjodin, Peter Hobson, Fiona A. Harden, Lesa L. Aylward, Jochen F. Mueller
ENVIRONMENT INTERNATIONAL
(2018)
Article
Environmental Sciences
Peter Fantke, Lesa Aylward, Jane Bare, Weihsueh A. Chiu, Robin Dodson, Robert Dwyer, Alexi Ernstoff, Brett Howard, Matti Jantunen, Olivier Jolliet, Richard Judson, Nienke Kirchhubel, Dingsheng Li, Aubrey Miller, Greg Paoli, Paul Price, Lorenz Rhomberg, Beverly Shen, Hyeong-Moo Shin, Justin Teeguarden, Daniel Vallero, John Wambaugh, Barbara A. Wetmore, Rosemary Zaleski, Thomas E. McKone
ENVIRONMENTAL HEALTH PERSPECTIVES
(2018)
Article
Environmental Sciences
Lesa Aylward, Giulia Vilone, Christina Cowan-Ellsberry, Jon A. Arnot, John N. Westgate, Cian O'Mahony, Sean M. Hays
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2020)
Article
Medicine, General & Internal
David I. McBride, James J. Collins, Thomas John Bender, Kenneth M. Bodner, Lesa L. Aylward
Article
Public, Environmental & Occupational Health
L. M. L. Toms, J. Braunig, S. Vijayasarathy, S. Phillips, P. Hobson, L. L. Aylward, M. D. Kirk, J. F. Mueller
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2019)
Article
Environmental Sciences
Yan Li, Xianyu Wang, Leisa-Maree L. Toms, Chang He, Peter Hobson, Peter D. Sly, Lesa L. Aylward, Jochen F. Mueller
ENVIRONMENTAL RESEARCH
(2019)
Article
Public, Environmental & Occupational Health
Sarah Faure, Nolwenn Noisel, Kate Werry, Subramanian Karthikeyan, Lesa L. Aylward, Annie St-Amand
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2020)
Article
Environmental Sciences
Daniel S. Drage, Amy L. Heffernan, Thomas K. Cunningham, Lesa L. Aylward, Jochen F. Mueller, Thozhukat Sathyapalan, Stephen L. Atkin
ENVIRONMENTAL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Harshal Deshmukh, Lesa L. Aylward, Martin Rose, Alwyn Fernandes, Peter Sedman, Natalie J. Thatcher, Stephen L. Atkin, Thozhukat Sathyapalan
CLINICAL ENDOCRINOLOGY
(2020)
Article
Environmental Sciences
Marc-Andre Verner, Hassan Salame, Conrad Housand, Linda S. Birnbaum, Maryse F. Bouchard, Jonathan Chevrier, Lesa L. Aylward, Daniel Q. Naiman, Judy S. LaKind
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)