Review
Biology
Ann Huysseune, Robert Cerny, P. Eckhard Witten
Summary: This review discusses competing hypotheses regarding tooth origins, focusing on the evolution of external odontodes into oral teeth, and explores the role of different layers of epithelium in pharyngeal tooth formation.
BIOLOGICAL REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Eva Blondeau-Bidet, Ghizlane Banousse, Thibaut L'Honore, Emilie Farcy, Celine Cosseau, Catherine Lorin-Nebel
Summary: Epigenetic modifications, specifically DNA methylation, play a significant role in generating phenotypic diversity in fish and driving adaptive evolutionary processes. However, the impact of salinity on whole-genome DNA methylation in euryhaline marine species that migrate between salinity-contrasted habitats has not been well-studied. This research investigates the role of salinity-induced DNA methylation in fish, with a focus on the gill as an important organ involved in environmental adaptation.
Article
Multidisciplinary Sciences
Anita Talbot, Laura Gargan, Grainne Moran, Louis Prudent, Ian O'Connor, Luca Mirimin, Jens Carlsson, Eugene MacCarthy
Summary: This study investigated the pre-clinical stage of Amoebic Gill Disease (AGD) using RNA-sequencing technology, identifying a significant number of differentially expressed genes, some of which are related to immune response. The pathogen may evade host immune surveillance by interfering with signal transduction pathways.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Mingzhu Li, Chao Zhao, Yun Zhao, Jingran Li, Jingyuan Wang, Hongxue Luo, Zhijian Tang, Yan Guo, Lihui Wei
Summary: Objective: To investigate the predictive ability of PAX1 methylation (PAX1(m)) for the pathological upgrade of cervical intraepithelial neoplasia (CIN) before cold knife conization (CKC). Results: PAX1(m) was found to be a potential auxiliary marker in predicting the pathological upgrade of CIN.
FRONTIERS IN ONCOLOGY
(2023)
Article
Microbiology
Xuejuan Wang, Zhiying Shao, Minrong Zhu, Bingjie Li, Mingyu You, Xiaoqing Chen
Summary: This study explored the composition and function of the intestinal and pharyngeal microbiota in early neonates and analyzed the impact of limited formula feeding on microbiota colonization. The results indicated that the core microbiota in the intestine and oropharynx were closely correlated, and limited formula feeding did not significantly affect the initial colonization of microbiota.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xuyong Wei, Mengfan Yang, Binhua Pan, Xiaobing Zhang, Hanchao Lin, Wangyao Li, Wenzhi Shu, Kun Wang, Abdul Rehman Khan, Xuanyu Zhang, Beini Cen, Xiao Xu
Summary: This study identified that the overexpression of OS-9 is associated with hepatocellular carcinoma (HCC) recurrence and contributes to the migration and invasion capacities of HCC cells by regulating the HIF-1 and TNF pathways.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Hao Wang, Huan Zhang, Zhaoshan Zhong, Yan Sun, Minxiao Wang, Hao Chen, Li Zhou, Lei Cao, Chao Lian, Chaolun Li
Summary: This study used the cold-seep mussel as a model to investigate host-symbiont interactions, revealing the important roles of the gill's non-symbiotic parts in protecting the symbiosis, bacteriocytes in supplying metabolites and controlling symbiont population, and symbionts in methane oxidation and energy production at tissue, cellular, and molecular levels. The bathymodiolin symbiosis maintains high efficiency and harmony in the chemosynthetic micro niche.
Review
Ecology
Madeleine E. Aase-Remedios, David E. K. Ferrier
Summary: Comparative approaches in studying chordate genomes have revealed the significance of gene duplications, including whole genome duplications, in the evolution of gene families. Duplicated genes are key in developmental biology and play a role in major evolutionary transitions, with mechanisms such as retention, subfunctionalization, neofunctionalization, and specialization. Understanding the impact of gene duplication on chordate evolution, including the retention and loss patterns of duplicated genes, remains a complex topic that requires further exploration with the help of sequencing projects and genomic resources.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Oncology
H. Liang, G. L. Li, J. Liu, M. Fu, H. Huang, K. Zhao, Y. Wei, J. Xiao
Summary: The methylation level of PAX1/ZNF582 gene shows potential as a molecular marker for differentiating the progression of cervical cancer. It has high sensitivity and specificity in diagnosing high-grade cervical lesions and cervical cancer.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
B. M. Shankar, K. Nagamani, I. S. Shivakumara
Summary: The implication of an additional solute concentration field on the stability of natural convection in a vertical porous layer has been investigated. The addition of an extra diffusing component can make the originally stable natural convection become unstable, and there is a change in the mode of instability in some specific parameters.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Arife Zeybek, Necdet Oz, Serdar Kalemci, Kursad Tosun, Tuba Gokdogan Edgunlu, Mehmet Tughan Kiziltug, Leyla Tekin, Mehmet Emin Erdal
Summary: In this study, it was found that DKK-1 expression was suppressed in lung adenocarcinoma tissue, especially in early-stage tumors, while SFRP-5 expression was significantly higher in tumor tissue. This suggests that SFRP-5 may have an oncogenic role in the development of adenocarcinoma.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Fisheries
Anita Talbot, Michelle McCormack, Ankit Dwivedi, Ian O'Connor, Victoria Valdenegro, Eugene MacCarthy
Summary: This study investigated the role of a novel fish feed in mitigating the severity and progression of AGD in Atlantic salmon. The results showed that this fish feed was able to delay the onset of clinical symptoms associated with AGD and have an impact on the maintenance and defense of the mucosal layer in fish.
Article
Cell Biology
Pascal Schmidt, Eva Leman, Ronan Lagadec, Michael Schubert, Sylvie Mazan, Ram Reshef
Summary: This study investigates the role of retinoic acid (RA) in the regulation of chordate and vertebrate pronephros formation through a comparative developmental approach. The results show that the conservation of Pax2 and Lim1 expressions in chordate pronephros homologs is present, but the responsiveness to RA and Hox-dependent regulation is a novelty in gnathostomes.
Article
Biology
Giovanni Annona, Iori Sato, Juan Pascual-Anaya, David Osca, Ingo Braasch, Randal Voss, Jan Stundl, Vladimir Soukup, Allyse Ferrara, Quenton Fontenot, Shigeru Kuratani, John H. Postlethwait, Salvatore D'Aniello
Summary: Nitric oxide (NO) is a crucial signaling molecule in biological systems, playing important roles in cardiovascular, neurological, and immune functions. Understanding the evolution of NO synthases (Nos) genes, which produce NO in vivo, is still a puzzle, especially in fish compared to tetrapods. Recent studies have found the presence of nos3 gene, previously considered lost, in spotted gar, changing our perspective on the origin of nos genes. This study explored nos gene evolution in different vertebrate species and revealed lineage-specific gene duplications and losses, independent losses of nos3 in teleost lineages, and the expression of nos genes in the gills of certain gnathostome species. These findings provide insights into the roles and evolutionary history of nos genes.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jin-Bo Hou, Nigel C. Hughes, Melanie J. Hopkins, Degan Shu
Summary: The study suggests that the trilobite Triarthrus eatoni used countercurrent gaseous exchange in its gills as an efficient respiratory mechanism during the Late Ordovician period. Computational fluid dynamics simulations showed that water velocity decreased in specific regions of the gills, optimizing the oxygen exchange. The findings also indicate that this respiratory strategy was widely adopted by early animals, as seen in the respiratory structures of the Cambrian deuterostome Haikouella.
ROYAL SOCIETY OPEN SCIENCE
(2023)