Article
Medicine, General & Internal
Adithya Chedere, Kishore Hari, Saurav Kumar, Annapoorni Rangarajan, Mohit Kumar Jolly
Summary: The double-negative feedback loop between AMPK and Akt in breast cancer cells plays a crucial role in regulating cell adaptation to stress conditions. This feedback loop results in two distinct cell states that can co-exist and switch between each other under specific parameters. Experimental validation and clinical data analysis support the prediction that this feedback loop can generate multi-stability and drive phenotypic switching and heterogeneity in cancer cell populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Uttom Kumar, Anastasia Ardasheva, Zimam Mahmud, R. Charles Coombes, Ernesto Yague
Summary: This passage discusses the different subtypes of breast cancer in terms of their genetic expression profiles and the role of FOXA1 in regulating drug sensitivity and resistance. By modulating FOXA1 expression levels, studies have shown that FOXA1 plays a significant role in tumor aggressiveness.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Silvia Mara Baez Rodriguez, Georgiana-Adeline Staicu, Ani-Simona Sevastre, Carina Baloi, Vasile Ciubotaru, Anica Dricu, Ligia Gabriela Tataranu
Summary: Glioblastoma stem cells (GSCs) are self-renewing cells that can initiate tumors and are linked to tumor heterogeneity. Standard treatments fail to eradicate GSCs, leading to disease recurrence. Understanding the biology and survival mechanisms of GSCs is crucial for targeting them effectively.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Karina Biserova, Arvids Jakovlevs, Romans Uljanovs, Ilze Strumfa
Summary: Cancer stem cells, particularly in glioblastoma, play a crucial role in tumor resistance to treatment and recurrence. The regulatory mechanisms of glioma stem cells include tumor microenvironment, niche concept, metabolism, immunity, genetics, and epigenetics, which serve as potential targets for future treatments.Understanding the molecular markers and treatment resistance of GSCs in glioblastoma may lead to more effective therapeutic strategies in the future.
Review
Oncology
Malak Amer, Lidan Shi, Haguy Wolfenson
Summary: Cells can sense the mechanical properties of their extracellular matrix through adhesion sites, converting this information into biochemical signals that affect cell behavior. Cancer cells respond differently to different stiffness substrates compared to normal cells, potentially leading to cancer progression.
Article
Oncology
Joana Vieira de Castro, Celine S. Goncalves, Eduarda P. Martins, Irene Miranda-Lorenzo, Mariana T. Cerqueira, Adhemar Longatto-Filho, Afonso A. Pinto, Rui L. Reis, Nuno Sousa, Christopher Heeschen, Bruno M. Costa
Summary: Identifying and isolating glioblastoma stem cells (GSCs) is crucial for understanding tumor biology and developing targeted therapies. A novel subpopulation of autofluorescent cells in GBM has been discovered with all the functional characteristics of GSCs, providing a simple and reliable biomarker for targeting these highly malignant tumors. This discovery has significant implications for both biological and clinical research in glioblastoma.
Article
Medicine, Research & Experimental
Mehdi Bouhaddou, Rex H. Lee, Hua Li, Neil E. Bhola, Rachel A. O'Keefe, Mohammad Naser, Tian Ran Zhu, Kelechi Nwachuku, Umamaheswar Duvvuri, Adam B. Olshen, Ritu Roy, Aaron Hechmer, Jennifer Bolen, Stephen B. Keysar, Antonio Jimeno, Gordon B. Mills, Scott Vandenberg, Danielle L. Swaney, Daniel E. Johnson, Nevan J. Krogan, Jennifer R. Grandis
Summary: Unbiased hierarchical clustering analysis identified predictive biomarkers for response to cetuximab therapy in patients with head and neck squamous cell carcinoma, while a minimalist biomarker signature consisting of 8 proteins was validated for accurate prediction of cetuximab response.
Article
Biochemistry & Molecular Biology
Laverne D. Robilliard, Jane Yu, Akshata Anchan, Graeme Finlay, Catherine E. Angel, E. Scott Graham
Summary: Glioblastoma is a challenging cancer due to its resistance to therapy and suppressive effects on the immune system. This study investigated the different phenotypes of glioblastoma cells and their secretion patterns of cytokines. The results showed heterogeneity in secretion patterns between serum-derived and glioblastoma stem-like cells, with the serum-derived cells being the primary producers of cytokines associated with immune cell recruitment. These findings highlight the importance of targeting these cells in glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Juyeun Lee, Katie Troike, R'ay Fodor, Justin D. Lathia
Summary: Biological sex impacts organismal development and disease trajectory. In glioblastoma (GBM), there is a male bias in incidence and outcome, and key genetic and epigenetic differences, as well as differences in immune response, have been revealed. Understanding the contribution of sex hormones vs sex chromosomes to CSC function is important for exploring new treatment strategies.
Review
Oncology
Yasaman Iranmanesh, Biao Jiang, Okoye C. Favour, Zhangqi Dou, Jiawei Wu, Jinfan Li, Chongran Sun
Summary: Glioblastoma (GBM) is a deadly primary brain malignancy with limited response to existing therapies, mainly due to glioblastoma stem cells (GSCs) which play a crucial role in therapy resistance. Mitochondria have been identified as important regulators in maintaining GSCs and potential targets for novel therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai Zhao, Agnes Schaefer, Zhuo Zhang, Katharina Elsaesser, Carsten Culmsee, Li Zhong, Axel Pagenstecher, Christopher Nimsky, Joerg W. Bartsch
Summary: Carbonic anhydrase CA2 is highly expressed in recurrent glioblastoma and temozolomide-resistant glioblastoma stem-like cells (GSCs), promoting cell invasion. The CA2 inhibitor brinzolamide is more effective than the pan-CA inhibitor acetazolamide in sensitizing GSCs to TMZ-induced cell death. The combined treatment of TMZ and brinzolamide induces autophagy in GBM cell lines and GSCs, suggesting a potential treatment strategy for tackling GBM chemoresistance and recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Tingyu Shi, Jun Zhu, Xiang Zhang, Xinggang Mao
Summary: Glioblastoma multiforme (GBM) is a highly malignant brain tumor characterized by a small population of glioblastoma stem-like cells (GSCs) that possess self-renewal, proliferative, invasive, and tumorigenic capabilities, leading to radio- and chemoresistance. Hypoxia inducible factors (HIFs) play a crucial role in the maintenance and progression of GSCs. This review summarizes the roles of hypoxia-associated GSCs in GBM development, including hypoxia-induced signatures, genes, pathways, and metabolic alterations. The concept of the hypoxic peri-arteriolar niche of GSCs is discussed. Autophagy and potential causes of therapeutic resistance in GBM are explored, along with chemotherapeutic agents to enhance the effectiveness of chemo-, radio-, or immunotherapy. Hyperbaric oxygen therapy (HBOT) is proposed as an adjuvant therapy to reverse the hypoxic microenvironment in GBM. Overall, understanding the intricate interactions between hypoxia and GSCs can lead to the development of novel therapeutic strategies to improve GBM patient survival.
Article
Oncology
Hiroko Ishii, Yuki Mimura, Maram H. Zahra, Shota Katayama, Ghmkin Hassan, Said M. Afify, Masaharu Seno
Summary: In this study, stem-like cells were isolated and characterized from the human glioblastoma cell line U-251MG, resulting in the establishment of the U-251MGSC1 cell line with high expression of stem cell markers and enhanced tumorigenicity and sphere-forming ability. The U-251MGSC1 cells exhibited properties of cancer stem cells and could serve as a valuable tool for developing therapeutic agents against CSCs and studying the mechanism of tumor development in brain gliomas.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Sai Balaji Andugulapati, Ananthalakshmy Sundararaman, Mohini Lahiry, Annapoorni Rangarajan
Summary: AMPK plays a crucial role in the maintenance of breast cancer stem cells and chemoresistance. AMPK regulates the expression of stemness genes and promotes their function through the upregulation of TWIST. AMPK activity increases after chemotherapy, accompanied by an increase in stemness markers. Targeting AMPK may reduce the stem cell pool and improve the efficacy of chemotherapy.
DISEASE MODELS & MECHANISMS
(2022)
Review
Biology
Francesco Pasqualetti, Mario Miniati, Alessandra Gonnelli, Giovanni Gadducci, Noemi Giannini, Laura Palagini, Maricia Mancino, Taiusha Fuentes, Fabiola Paiar
Summary: Glioblastoma is highly resistant to radiotherapy. Cancer stem cells play an important role in the growth and resistance of GB. The radiosensitivity of stem cells and biomarkers of stemness are crucial in this field.
Review
Cell Biology
Chang-Nim Im
CELL STRESS & CHAPERONES
(2016)
Article
Biochemistry & Molecular Biology
Chang-Nim Im
Article
Oncology
Chang-Nim Im, Hye HyeonYun, Byunghoo Song, Dong-Ye Youn, Mei Nu Cui, Hong Sug Kim, Gyeong Sin Park, Jeong-Hwa Lee
Article
Biochemistry & Molecular Biology
Chang-Nim Im, Hye Hyeon Yun, Jeong-Hwa Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biotechnology & Applied Microbiology
Chang-Nim Im
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Chemistry, Multidisciplinary
Chang-Nim Im, Nam-Young Kang, Hyung-Ho Ha, Xuezhi Bi, Jae Jung Lee, Sung-Jin Park, Sang Yeon Lee, Marc Vendrell, Yun Kyung Kim, Jun-Seok Lee, Jun Li, Young-Hoon Ahn, Bo Feng, Huck-Hui Ng, Seong-Wook Yun, Young-Tae Chang
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2010)
Article
Biochemistry & Molecular Biology
Chang-Nim Im, Jeong-Sun Seo
Article
Pharmacology & Pharmacy
Hyung Jae Yoo, Chang-Nim Im, Dong-Ye Youn, Hye Hyeon Yun, Jeong-Hwa Lee
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Woo Sirl Lee, Chang-Nim Im, Qi Ying Teng, Young-Tae Chang, Dong-Chan Kim, Kyong-Tae Kim, Sung-Kee Chung
MOLECULAR BIOSYSTEMS
(2009)
Article
Biochemistry & Molecular Biology
Hye Yun Kim, Yong-Sam Kim, Hye Hyeon Yun, Chang-Nim Im, Jeong-Heon Ko, Jeong-Hwa Lee
EXPERIMENTAL AND MOLECULAR MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Chang-Nim Im, Jae-Seon Lee, Ying Zheng, Jeong-Sun Seo
JOURNAL OF CELLULAR BIOCHEMISTRY
(2007)
Article
Biochemistry & Molecular Biology
Ying Zheng, Chang-Nim Im, Jeong-Sun Seo
EXPERIMENTAL AND MOLECULAR MEDICINE
(2006)
Article
Biochemistry & Molecular Biology
WY Park, CI Hwang, CN Im, MJ Kang, JH Woo, JH Kim, YS Kim, JH Kim, H Kim, KA Kim, HJ Yu, SJ Lee, YS Lee, JS Seo