期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 211, 期 6, 页码 1019-1025出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20131768
关键词
-
资金
- Medical Research Council Discipline Hopping Grant
- EU [LSHB-CT-2004-512074]
- European Research Council grant
- University of Ghent MRP-GROUP-ID grant
- MRC [G0802620] Funding Source: UKRI
- Medical Research Council [G0802620] Funding Source: researchfish
There is currently no paradigm in immunology that enables an accurate prediction of how the immune system will respond to any given agent. Here we show that the immunological responses induced by members of a broad class of inorganic crystalline materials are controlled purely by their physicochemical properties in a highly predictable manner. We show that structurally and chemically homogeneous layered double hydroxides (LDHs) can elicit diverse human dendritic cell responses in vitro. Using a systems vaccinology approach, we find that every measured response can be modeled using a subset of just three physical and chemical properties for all compounds tested. This correlation can be reduced to a simple linear equation that enables the immunological responses stimulated by newly synthesized LDHs to be predicted in advance from these three parameters alone. We also show that mouse antigen-specific antibody responses in vivo and human macrophage responses in vitro are controlled by the same properties, suggesting they may control diverse responses at both individual component and global levels of immunity. This study demonstrates that immunity can be determined purely by chemistry and opens the possibility of rational manipulation of immunity for therapeutic purposes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据