Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3

A Network of High-Mobility Group Box Transcription Factors Programs Innate Interleukin-17 Production

(2013) Nidhi Malhotra et al.   IMMUNITY

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation

(2012) Makoto Kuwahara et al.   NATURE IMMUNOLOGY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

Integrative genomics viewer

(2011) James T Robinson et al.   NATURE BIOTECHNOLOGY

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells

(2011) Sascha Rutz et al.   NATURE IMMUNOLOGY

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis

(2010) Lydia Durant et al.   IMMUNITY

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

(2010) Kazuo Okamoto et al.   NATURE

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

(2010) Kamran Ghoreschi et al.   NATURE

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

(2010) Vanja Lazarevic et al.   NATURE IMMUNOLOGY

A Transcription Factor Map as Revealed by a Genome-Wide Gene Expression Analysis of Whole-Blood mRNA Transcriptome in Multiple Sclerosis

(2010) Carlos Riveros et al.   PLoS One

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

The SoxD transcription factors – Sox5, Sox6, and Sox13 – are key cell fate modulators

(2009) Véronique Lefebvre   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

All purpose Sox: The many roles of Sox proteins in gene expression

(2009) Michael Wegner   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-β inhibits c-Maf-induced IL-21 production in CD4+ T cells

(2009) Yukiko Hiramatsu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Structural Basis of Alternative DNA Recognition by Maf Transcription Factors

(2009) H. Kurokawa et al.   MOLECULAR AND CELLULAR BIOLOGY

ChIP-seq accurately predicts tissue-specific activity of enhancers

(2009) Axel Visel et al.   NATURE

The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo

(2009) Mandy J McGeachy et al.   NATURE IMMUNOLOGY

Generation of mice harboring aSox5conditional null allele

(2008) Peter Dy et al.   GENESIS

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Development and characterization of IL-21–producing CD4+T cells

(2008) Akira Suto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY