Article
Biochemistry & Molecular Biology
Evelyn Kelemen, Eva Adam, Stella Marta Sagi, Aniko Goblos, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Marta Szell, Judit Danis
Summary: Psoriasis is a chronic inflammatory skin disease influenced by both genetic and environmental factors. Increased levels of free nucleic acids in psoriatic skin are associated with IL-23 expression. The study reveals that free nucleic acids regulate IL-23 mRNA expression in epithelial keratinocytes through TLR3 receptor and specific signaling pathways, contributing to the development of an inflammatory milieu favorable for psoriatic symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria G. Tsokos, Iannis E. Adamopoulos
Summary: Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation and IL-27 also inhibits IL-23-induced inflammation associated with myeloid cell infiltration in the joints and spleen. The IL-27 anti-inflammatory response is associated with reduced levels of myeloid cells in the spleen and bone marrow.
CLINICAL IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gavin W. Sewell, Arthur Kaser
Summary: The cytokine interleukin-23 (IL-23), mainly produced by macrophages and dendritic cells in response to microbial stimulation, plays a critical role in chronic intestinal inflammation. IL-23 has been found to be associated with disease protection through genetic variations, and therapeutic targeting of the shared p40 subunit of IL-12/IL-23 has shown success in treating inflammatory bowel disease (IBD). Recent phase 2 studies have shown promise in targeting the specific p19 subunit of IL-23. However, the exact pathways downstream of IL-23 in mucosal inflammation in the gut are still debated.
JOURNAL OF CROHNS & COLITIS
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Laura A. Lucaciu, Maria Ilies, Stefan C. Vesa, Radu Seicean, Shahida Din, Cristina Adela Iuga, Andrada Seicean
Summary: Interleukin (IL)-23 and fecal calprotectin levels were significantly elevated in severe inflammatory bowel disease (IBD), while IL-17 and C-reactive protein were associated with disease severity. IL-23 may serve as a promising novel biomarker for severe Crohn's disease, guiding clinical decision-making on biologic therapy. Identifying the main IL pathway involved in IBD severity could provide valuable insights for personalized treatment approaches.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yukio Takamori, Takehiro Ando, Masashi Sato, Santhana Vedi, Daisuke Fuji, Takumi Yokoyama, Keita Tsukamoto, Mizuki Yamamoto, Takashi Kawakami
Summary: The RNA aptamer selected against IL-23 through SELEX can bind to IL-23 and inhibit interaction between IL-23 and IL-23R, showing potential for the treatment of inflammatory autoimmune diseases.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Immunology
Ikram Mezghiche, Hanane Yahia-Cherbal, Lars Rogge, Elisabetta Bianchi
Summary: This review focuses on the expression and regulation of IL-23R in immune cells, aiming to explore its importance in the pathogenesis of several chronic inflammatory diseases.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Takahiro Yamazaki, Sayuri Yamada, Konomi Ohshio, Miho Sugamata, Yuji Morita
Summary: Lactobacillus paracasei KW3110 has anti-inflammatory effects and prevents inflammatory stress-induced mitochondrial damage by promoting IL-10 production in mouse macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Maria C. Rezcallah, Trisha Al-mazi, Alaina J. Ammit
Summary: TTP is an important mRNA binding protein that regulates gene expression through phosphorylation, with key S sites being recognized as crucial. In addition to these key sites, other sites on TTP also play an important role in regulating cellular signaling and functions. Understanding phosphorylation sites and regulatory mechanisms of TTP is crucial for studying treatments for inflammatory diseases.
CELLULAR SIGNALLING
(2021)
Review
Gastroenterology & Hepatology
Tommaso Lorenzo Parigi, Marietta Iacucci, Subrata Ghosh
Summary: IL-23 plays a key role in the pathogenesis of CD and UC, the combined blockade of IL-23 and 2 with ustekinumab has been proven effective in treating IBD, selective inhibition of IL-23 may be beneficial for IBD.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Biochemistry & Molecular Biology
Alberto Carreno, Jens Lykke-Andersen
Summary: This study investigates the regulation of mRNA decay activator TTP by the p38 MAPK-MK2 pathway. The results show that the UP CIM recruits the CCR4-NOT deadenylase complex and activates mRNA degradation cooperatively with the conserved tryptophan residues of UP. Interestingly, the UP CIM remains unphosphorylated and can still promote association with the CCR4-NOT complex and mRNA decay upon activation of the p38-MAPK-activated kinase MK2.
MOLECULAR AND CELLULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ai Yaku, Tadakatsu Inagaki, Ryotaro Asano, Makoto Okazawa, Hiroyoshi Mori, Ayuko Sato, Fabian Hia, Takeshi Masaki, Yusuke Manabe, Tomohiko Ishibashi, Alexis Vandenbon, Yoshinari Nakatsuka, Kotaro Akaki, Masanori Yoshinaga, Takuya Uehata, Takashi Mino, Satoshi Morita, Hatsue Ishibashi-Ueda, Akio Morinobu, Tohru Tsujimura, Takeshi Ogo, Yoshikazu Nakaoka, Osamu Takeuchi
Summary: The study found that Regnase-1 maintains lung immune homeostasis by regulating IL-6 and platelet-derived growth factor in alveolar macrophages, suppressing the development of PAH. Mice lacking Regnase-1 showed severe PAH, mirroring the pathology of patients. IL-6 and PDGF are potential targets of Regnase-1 in regulating PAH in alveolar macrophages.
Article
Biochemistry & Molecular Biology
Mohammed El-Gedamy, Zakaria El-khayat, Hassan Abol-Enein, Afaf El-said, Eslam El-Nahrery
Summary: The genetic variant rs1884444 G/T of IL-23R is significantly associated with a reduced risk of bladder urothelial carcinoma (BUC), with the T allele potentially serving as a reliable genetic marker for good prognosis. The G/T variation may regulate BUC risk through modulation of the IL-23/IL-17 pathway.
Article
Medicine, Research & Experimental
Qiong Luo, Xin Ye Ji, Liang Zhang, Xin Huang, Xiao Qin Wang, Bo Zhang
Summary: The main active compound of Radix Arnebiae, Shikonin (SK), has been found to have anti-inflammatory and antioxidative effects in heat stroke models. It delays core temperature rise, prolongs survival time, and improves organ injury and coagulation function. The expression of IL-17A is reduced by SK, contributing to liver and lung protection.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Celine Mathey, Caroline Keyzer, Didier Blocklet, Gaetan Van Simaeys, Nicola Trotta, Simon Lacroix, Bernard Corvilain, Serge Goldman, Rodrigo Moreno-Reyes
Summary: This study found that F-18-FCH PET/CT performs better than C-11-MET PET/CT in detecting and localizing abnormal parathyroid tissue in patients with pHPT when Tc-99m-MIBI SPECT results are negative or inconclusive.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Pathology
Chandra S. Bathula, Jian Chen, Rahul Kumar, Perry J. Blackshear, Yogesh Saini, Sonika Patial
Summary: The study reveals that inactivation of ZFP36L1 can protect the liver from alcohol-induced hepatic steatosis, injury, and inflammation, possibly by stabilizing Fgf21 mRNA. Modulation of ZFP36L1 may be beneficial in the prevention and treatment of alcoholic liver disease.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Genetics & Heredity
Leonard Scharfen, Dagmar Zigackova, Kirsten A. Reimer, Martha R. Stark, Viktor A. Slat, Nancy J. Francoeur, Melissa L. Wells, Lecong Zhou, Perry J. Blackshear, Karla M. Neugebauer, Stephen D. Rader
Summary: By studying a highly diverged red alga, researchers discovered the presence of alternative polyadenylation (APA) in this non-model organism, suggesting its potential importance in regulating gene expression.
FRONTIERS IN GENETICS
(2022)
Article
Biophysics
Stephanie N. Hicks, Ronald A. Venters, Perry J. Blackshear
Summary: Members of the TTP family of RNA binding proteins play a crucial role in maintaining RNA homeostasis in eukaryotes. In this study, we focused on the recognition and binding of the TZF domain to target RNA using the spikemoss Selaginella moellendorffii as our research model. We reported the nearly complete resonance assignments of the spikemoss TZF domain, including the RNA-TZF domain complex, which is a valuable resource for further investigations into RNA recognition and TTP-mediated mRNA decay.
BIOMOLECULAR NMR ASSIGNMENTS
(2022)
Article
Oncology
Corentin Martens, Antonin Rovai, Daniele Bonatto, Thierry Metens, Olivier Debeir, Christine Decaestecker, Serge Goldman, Gaetan Van Simaeys
Summary: This research proposed a deep learning-based approach to address problems in glioma growth models. By training deep neural networks, it is possible to reconstruct the cell-density distribution of the tumor and accurately evaluate model parameters. This approach has significant potential application value for glioma characterization and therapy planning.
Article
Medicine, Research & Experimental
Elisa Brauns, Abdulkader Azouz, David Grimaldi, Hanxi Xiao, Severine Thomas, Muriel Nguyen, Veronique Olislagers, Ines Vu Duc, Carmen Orte Cano, Veronique Del Marmol, Pieter Pannus, Frederick Libert, Sven Saussez, Nicolas Dauby, Jishnu Das, Arnaud Marchant, Stanislas Goriely
Summary: Severe COVID-19 disease can lead to dysregulation of the myeloid compartment during acute infection. In this study, impaired cytokine production by monocytes was observed in patients with severe COVID-19 during the acute phase, but was restored in convalescent patients. However, recovered patients showed increased responsiveness to TLR1/2 ligation, suggesting different functional properties of these cells at different stages of the disease.
Article
Health Care Sciences & Services
Turkey Refaee, Benjamin Bondue, Gaetan Van Simaeys, Guangyao Wu, Chenggong Yan, Henry Woodruff, Serge Goldman, Philippe Lambin
Summary: The study investigates whether a CT-based radiomics approach can accurately identify patients with idiopathic pulmonary fibrosis (IPF) and interstitial lung diseases (ILD) associated with IPF. The results show that radiomic features can discriminate different types of ILD via HRCT, reducing the need for unnecessary lung biopsies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Isabel Vogel, Valerie Acolty, Tibor Keler, Stanislas Goriely, Oberdan Leo, Muriel Moser
Summary: CD27/CD70 costimulation enhances T-cell function and suppresses IL-17 production, suggesting its potential as a therapeutic target for diseases characterized by excessive IL-17 production.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Simon Lecoutre, Fatiha Merabtene, Elie-Julien El Hachem, Camille Gamblin, Christine Rouault, Nataliya Sokolovska, Hedi Soula, Wi S. Lai, Perry J. Blackshear, Karine Clement, Isabelle Dugail
Summary: The study reveals the potential of beta-hydroxybutyrate to limit adipose tissue matrix deposition, which is significant in the context of obesity-related tissue dysfunction.
MOLECULAR METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Brittany L. Snyder, Perry J. Blackshear
Summary: This article discusses how abnormal regulation of pro-inflammatory cytokine and chemokine mediators can contribute to the excess inflammation characteristic of many autoimmune diseases. The authors introduce the function of the TTP family and provide evidence that increasing TTP activity can promote the decay of inflammatory transcripts. The study suggests that utilizing TTP for the development of anti-inflammatory treatments holds potential in humans.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Kyu Hwan Kwack, Lixia Zhang, Elliot D. Kramer, Ramkumar Thiyagarajan, Natalie A. Lamb, Yukitomo Arao, Jonathan E. Bard, Kenneth L. Seldeen, Bruce R. Troen, Perry J. Blackshear, Scott I. Abrams, Keith L. Kirkwood
Summary: The study revealed that aging leads to increased myelopoiesis, resulting in higher prevalence of myeloid leukemias and myeloid-derived suppressor cells (MDSCs). Furthermore, the research identified the crucial role of tristetraprolin (TTP) in regulating age-related myelopoiesis by expanding specific myeloid progenitors and M-MDSCs, and recruiting them to sites of injury, inflammation, or other pathologic perturbations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Melissa E. Cook, Tara R. Bradstreet, Ashlee M. Webber, Jongshin Kim, Andrea Santeford, Kevin M. Harris, Maegan K. Murphy, Jennifer Tran, Nada M. Abdalla, Elizabeth A. Schwarzkopf, Suellen C. Greco, Carmen M. Halabi, Rajendra S. Apte, Perry J. Blackshear, Brian T. Edelson
Summary: RNA binding proteins of the ZFP36 family play a crucial role in regulating T cell quiescence, with specific functions of ZFP36L1 and ZFP36L2 in antigen-specific T cell clonal expansion.
SCIENCE IMMUNOLOGY
(2022)
Article
Biology
Brittany L. Snyder, Rui Huang, Adam B. Burkholder, Danielle R. Donahue, Beth W. Mahler, Carl D. Bortner, Wi S. Lai, Perry J. Blackshear
Summary: This study reveals the importance of the tristetraprolin (TTP) family of RNA-binding proteins in controlling inflammation. All three family members play critical roles in myeloid cell function and prevent inflammation. These findings contribute to a better understanding of the regulation of inflammation.
LIFE SCIENCE ALLIANCE
(2023)
Article
Medicine, Research & Experimental
Hidemichi Kouzu, Yuki Tatekoshi, Hsiang-Chun Chang, Jason S. Shapiro, Warren A. McGee, Adam De Jesus, Issam Ben-Sahra, Zoltan Arany, Jonathan Leor, Chunlei Chen, Perry J. Blackshear, Hossein Ardehali
Summary: Pregnancy is associated with significant physiological changes in the heart, and disruptions in these changes can lead to peripartum cardiomyopathy. A novel pathway for the regulation of mTORC1 through mRNA stabilization was discovered, which plays a role in inhibiting cardiomyocyte hypertrophy during pregnancy and is critical for normal cardiac growth.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Irina Vierasu, Nicola Trotta, Simone Albisinni, Celine Mathey, Gil Leurquin-Sterk, Simon Lacroix, Gaetan Van Simaeys, Thierry Quackels, Thierry Roumeguere, Serge Goldman
Summary: This study aimed to explore the performance of F-18-JK-PSMA-7 imaging on a digital PET/CT system with an adapted protocol, and considered the influence of previous therapy on PET/CT performance in prostate cancer patients. The study found that with adjusted administered dose and acquisition time on the digital system, valuable information can be provided for patients with biochemical recurrence.
EUROPEAN JOURNAL OF HYBRID IMAGING
(2022)
