Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

The Many Substrates of Presenilin/γ-Secretase

(2018) Annakaisa Haapasalo et al.   JOURNAL OF ALZHEIMERS DISEASE

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

(2012) Jinfang Zhu et al.   IMMUNITY

Preclinical Analysis of the  -Secretase Inhibitor PF-03084014 in Combination with Glucocorticoids in T-cell Acute Lymphoblastic Leukemia

(2012) J. B. Samon et al.   MOLECULAR CANCER THERAPEUTICS

Novel Protein Transduction Domain Mimics as Nonviral Delivery Vectors for siRNA Targeting NOTCH1 in Primary Human T cells

(2012) A. Özgül Tezgel et al.   MOLECULAR THERAPY

Redundant Notch1 and Notch2 Signaling Is Necessary for IFNγ Secretion by T Helper 1 Cells During Infection with Leishmania major

(2012) Floriane Auderset et al.   PLoS Pathogens

Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions

(2011) D. Yao et al.   BLOOD

The polymorphisms of T cell–specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia

(2011) Meili Ge et al.   HUMAN IMMUNOLOGY

Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells

(2011) Barbara Varnum-Finney et al.   JOURNAL OF CLINICAL INVESTIGATION

Clinical management of aplastic anemia

(2011) Amy E DeZern et al.   Expert Review of Hematology

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

Activation of Notch signal pathway is associated with a poorer prognosis in acute myeloid leukemia

(2010) Xin Xu et al.   MEDICAL ONCOLOGY

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Aberrant expression of Notch signaling molecules in patients with immune thrombocytopenic purpura

(2009) Daoxin Ma et al.   ANNALS OF HEMATOLOGY

The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone-marrow failure

(2009) Y. Tang et al.   BLOOD

Hedgehog Signaling Is Dispensable for Adult Hematopoietic Stem Cell Function

(2009) Jie Gao et al.   Cell Stem Cell

Myelodysplasia and Acute Leukemia as Late Complications of Marrow Failure: Future Prospects for Leukemia Prevention

(2009) Grover C. Bagby et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Non-canonical Wnt signaling pathways in hematopoiesis

(2009) Kathleen Kokolus et al.   IMMUNOLOGIC RESEARCH

Integration of Distinct Intracellular Signaling Pathways at Distal Regulatory Elements Directs T-bet Expression in Human CD4+ T Cells

(2009) K. Placek et al.   JOURNAL OF IMMUNOLOGY

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

(2009) R. G. Jenner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling and diseases: An evolutionary journey from a simple beginning to complex outcomes

(2008) Claudio Talora et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases

(2008) I. Joshi et al.   BLOOD

Canonical Notch Signaling Is Dispensable for the Maintenance of Adult Hematopoietic Stem Cells

(2008) Ivan Maillard et al.   Cell Stem Cell

Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In Vivo

(2008) Heather E. Fleming et al.   Cell Stem Cell

Aplastic anemia

(2008) Neal S Young et al.   CURRENT OPINION IN HEMATOLOGY

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

Targeting Notch signaling in autoimmune and lymphoproliferative disease

(2007) D. T. Teachey et al.   BLOOD