Cross talk between Wnt/β-catenin andIrf8in leukemia progression and drug resistance

Wnt/β-catenin pathway regulates ABCB1 transcription in chronic myeloid leukemia

(2012) Stephany Corrêa et al.   BMC CANCER

Impact of mutant β-catenin on ABCB1 expression and therapy response in colon cancer cells

(2012) U Stein et al.   BRITISH JOURNAL OF CANCER

Selective elimination of leukemia stem cells: Hitting a moving target

(2012) Leslie A. Crews et al.   CANCER LETTERS

Genetic and Pharmacologic Inhibition of β-Catenin Targets Imatinib-Resistant Leukemia Stem Cells in CML

(2012) Florian H. Heidel et al.   Cell Stem Cell

Signal transduction pathways regulating hematopoietic stem cell biology: Introduction to a series of Spotlight Reviews

(2012) T C Luis et al.   LEUKEMIA

 -Arrestin2 mediates the initiation and progression of myeloid leukemia

(2012) M. Fereshteh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential niche and Wnt requirements during acute myeloid leukemia progression

(2011) S. W. Lane et al.   BLOOD

Critical Appraisal of the Side Population Assay in Stem Cell and Cancer Stem Cell Research

(2011) Anna Golebiewska et al.   Cell Stem Cell

Canonical Wnt Signaling Regulates Hematopoiesis in a Dosage-Dependent Fashion

(2011) Tiago C. Luis et al.   Cell Stem Cell

Cooperation between both Wnt/ -catenin and PTEN/PI3K/Akt signaling promotes primitive hematopoietic stem cell self-renewal and expansion

(2011) J. M. Perry et al.   GENES & DEVELOPMENT

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

(2011) Christian Hurtz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

(2011) Cihangir Duy et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

Polymorphisms in the multidrug resistance gene MDR1 (ABCB1) predict for molecular resistance in patients with newly diagnosed chronic myeloid leukemia receiving high-dose imatinib

(2010) W. Deenik et al.   BLOOD

β-Catenin Mediates the Establishment and Drug Resistance of MLL Leukemic Stem Cells

(2010) Jenny Yeung et al.   CANCER CELL

Chronic myeloid leukemia: mechanisms of blastic transformation

(2010) Danilo Perrotti et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Irf8 does not co-operate with overexpression of BCL-2 in the induction of leukemias in vivo

(2010) Jessica Koenigsmann et al.   LEUKEMIA & LYMPHOMA

Interferon Consensus Sequence Binding Protein (ICSBP) Decreases  -Catenin Activity in Myeloid Cells by Repressing GAS2 Transcription

(2010) W. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

The combination of gene perturbation assay and ChIP-chip reveals functional direct target genes for IRF8 in THP-1 cells

(2010) Atsutaka Kubosaki et al.   MOLECULAR IMMUNOLOGY

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming

(2010) F Zhao et al.   ONCOGENE

Chronic Myeloid Leukemia Patients Sensitive and Resistant to Imatinib Treatment Show Different Metabolic Responses

(2010) Jiye A et al.   PLoS One

The Wnt/ -Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML

(2010) Y. Wang et al.   SCIENCE

ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines

(2009) V. Nardi et al.   BLOOD

The derivation of diagnostic markers of chronic myeloid leukemia progression from microarray data

(2009) V. G. Oehler et al.   BLOOD

Wnt-Related Molecules and Signaling Pathway Equilibrium in Hematopoiesis

(2009) Sachin Malhotra et al.   Cell Stem Cell

Predictors of Primary Imatinib Resistance in Chronic Myelogenous Leukemia Are Distinct From Those in Secondary Imatinib Resistance

(2009) Wenyong W. Zhang et al.   JOURNAL OF CLINICAL ONCOLOGY

Glycogen synthase kinase 3  missplicing contributes to leukemia stem cell generation

(2009) A. E. Abrahamsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modeling of C/EBPα Mutant Acute Myeloid Leukemia Reveals a Common Expression Signature of Committed Myeloid Leukemia-Initiating Cells

(2008) Peggy Kirstetter et al.   CANCER CELL

β-Catenin is essential for survival of leukemic stem cells insensitive to kinase inhibition in mice with BCR-ABL-induced chronic myeloid leukemia

(2008) Y Hu et al.   LEUKEMIA

Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells

(2008) T Hara et al.   ONCOGENE