期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 210, 期 10, 页码 1911-1918出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20130876
关键词
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资金
- National Institutes of Health [R01 A145846, R01 A151378, R37 AI054636]
- Swiss National Fund [SNF 310030_132713]
- Swiss National Science Foundation (SNF) [310030_132713] Funding Source: Swiss National Science Foundation (SNF)
Antigen receptor editing-a process of secondary rearrangements of antigen receptor genes in autoreactive lymphocytes-is a well-established tolerance mechanism in B cells, whereas its role in T cells remains controversial. Here, we investigated this issue using a novel Tcra knock-in locus, which ensured appropriate timing of TCR alpha expression and allowed secondary rearrangements. Under these conditions the only response to self-antigen that could be unambiguously identified was negative selection of CD4/CD8 double positive thymocytes. No evidence could be obtained for antigen-induced TCR editing, whereas replacement of the transgenic TCR alpha chain by ongoing gene rearrangement occurred in some cells irrespective of the presence or absence of self-antigen.
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