Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

Tumor Cells Require Thymidylate Kinase to Prevent dUTP Incorporation during DNA Repair

(2012) Chun-Mei Hu et al.   CANCER CELL

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

New and improved methods for measuring lymphocyte proliferation in vitro and in vivo using CFSE-like fluorescent dyes

(2012) Benjamin J.C. Quah et al.   JOURNAL OF IMMUNOLOGICAL METHODS

A Deficiency in Nucleoside Salvage Impairs Murine Lymphocyte Development, Homeostasis, and Survival

(2012) O. Choi et al.   JOURNAL OF IMMUNOLOGY

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells

(2012) G. Pontarin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

(2012) Jean-Michel Fustin et al.   Cell Reports

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization

(2011) James Wesley Fairman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Review Comparing Deoxyribonucleoside Triphosphate (dNTP) Concentrations in the Mitochondrial and Cytoplasmic Compartments of Normal and Transformed Cells

(2011) Vishal V. Gandhi et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Hydroxyurea induces de novo copy number variants in human cells

(2011) M. F. Arlt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limited dCTP Availability Accounts for Mitochondrial DNA Depletion in Mitochondrial Neurogastrointestinal Encephalomyopathy (MNGIE)

(2011) Emiliano González-Vioque et al.   PLoS Genetics

Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cells

(2010) Hiroyuki Niida et al.   CANCER SCIENCE

Regulation and Functional Contribution of Thymidine Kinase 1 in Repair of DNA Damage

(2010) Yen-Ling Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome

(2010) Xiaoshan Zhou et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

Chk1 Haploinsufficiency Results in Anemia and Defective Erythropoiesis

(2010) Nathan C. Boles et al.   PLoS One

Requirement for deoxycytidine kinase in T and B lymphocyte development

(2010) G. Toy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice

(2008) X. Zhou et al.   HUMAN MOLECULAR GENETICS

Structural Basis for Substrate Promiscuity of dCK

(2008) Elisabetta Sabini et al.   JOURNAL OF MOLECULAR BIOLOGY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular Mechanisms of Mitochondrial DNA Depletion Diseases Caused by Deficiencies in Enzymes in Purine and Pyrimidine Metabolism

(2008) Staffan Eriksson et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

An Oncogene-Induced DNA Damage Model for Cancer Development

(2008) T. D. Halazonetis et al.   SCIENCE