Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung

Protein Kinase D1: A New Component in TLR9 Signaling

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GPCR activation of Ras and PI3Kγ in neutrophils depends on PLCβ2/β3 and the RasGEF RasGRP4

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p38  and p38  kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation

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Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling

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Rolling on E- or P-selectin induces the extended but not high-affinity conformation of LFA-1 in neutrophils

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Myeloid PTEN Promotes Inflammation but Impairs Bactericidal Activities during Murine Pneumococcal Pneumonia

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Direct positive regulation of PTEN by the p85 subunit of phosphatidylinositol 3-kinase

(2010) R. B. Chagpar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia

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ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

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Protein Kinase D Regulates Cell Migration by Direct Phosphorylation of the Cofilin Phosphatase Slingshot 1 Like

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Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

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Myeloid-Specific Deletion of Tumor Suppressor PTEN Augments Neutrophil Transendothelial Migration during Inflammation

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Large-scale Proteomics Analysis of the Human Kinome

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p85 Associates with Unphosphorylated PTEN and the PTEN-Associated Complex

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Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot

(2009) Tim Eiseler et al.   NATURE CELL BIOLOGY

Animal models of acute lung injury

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Moving towards a Better Understanding of Chemotaxis

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PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

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PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

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Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils

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Understanding PTEN regulation: PIP2, polarity and protein stability

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Requirement of protein kinase D1 for pathological cardiac remodeling

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