期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 210, 期 1, 页码 5-13出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20121466
关键词
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资金
- Program for New Century Excellent Talents in University [NCET-08-0928]
- KC Wong Magna Fund in Ningbo University
Leukocyte cell-derived chemotaxin 2 (LECT2) is a multifunctional cytokine and reduced plasma levels were found in patients with sepsis. However, precise functions and mechanisms of LECT2 remain unclear. The aim of the present study was to determine the role of LECT2 in modulating immune responses using mouse sepsis models. We found that LECT2 treatment improved outcome in mice with bacterial sepsis. Macrophages (M Phi), but not polymorphonuclear neutrophils, mediated the beneficial effect of LECT2 on bacterial sepsis. LECT2 treatment could alter gene expression and enhance phagocytosis and bacterial killing of M Phi in vitro. CD209a was identified to specifically interact with LECT2 and mediate LECT2-induced M. activation. CD209a-expressing M Phi was further confirmed to mediate the effect of LECT2 on sepsis in vivo. Our data demonstrate that LECT2 improves protective immunity in bacterial sepsis, possibly as a result of enhanced M. functions via the CD209a receptor. The modulation of M Phi functions by LECT2 may serve as a novel potential treatment for sepsis.
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