Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential

(2011) S. Shin et al.   GENES & DEVELOPMENT

Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice

(2011) C. Dorrell et al.   GENES & DEVELOPMENT

Local Mesenchymal Stem/Progenitor Cells Are a Preferential Target for Initiation of Adult Soft Tissue Sarcomas Associated with p53 and Rb Deficiency

(2010) Jinhyang Choi et al.   AMERICAN JOURNAL OF PATHOLOGY

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

(2010) Agustin Chicas et al.   CANCER CELL

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

Combined Functional Genome Survey of Therapeutic Targets for Hepatocellular Carcinoma

(2010) R. Satow et al.   CLINICAL CANCER RESEARCH

Hepatic Progenitor Cells: An Update

(2010) Tania Roskams et al.   Clinics in Liver Disease

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

(2010) J. J. Hofmann et al.   DEVELOPMENT

The changing pattern of epidemiology in hepatocellular carcinoma

(2010) Helena Nordenstedt et al.   DIGESTIVE AND LIVER DISEASE

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

(2010) S. Benhamouche et al.   GENES & DEVELOPMENT

Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

(2010) T. van Harn et al.   GENES & DEVELOPMENT

Rb deletion in mouse mammary progenitors induces luminal-B or basal-like/EMT tumor subtypes depending on p53 status

(2010) Zhe Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

(2010) Uta Kossatz et al.   JOURNAL OF CLINICAL INVESTIGATION

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

(2010) Ichiro Onoyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of RB Transcription In Vivo by RB Family Members

(2010) D. L. Burkhart et al.   MOLECULAR AND CELLULAR BIOLOGY

Rb regulates fate choice and lineage commitment in vivo

(2010) Eliezer Calo et al.   NATURE

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

(2010) S Whittaker et al.   ONCOGENE

Identification of Epidermal Pdx1 Expression Discloses Different Roles of Notch1 and Notch2 in Murine KrasG12D-Induced Skin Carcinogenesis In Vivo

(2010) Pawel K. Mazur et al.   PLoS One

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitogen-activated protein kinases in hepatocellular carcinoma development

(2010) Lihua Min et al.   SEMINARS IN CANCER BIOLOGY

The isolation and in vitro expansion of hepatic Sca-1 progenitor cells

(2009) Elizabeth Clayton et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Hepatitis B virus X protein overcomes stress-induced premature senescence by repressing p16INK4a expression via DNA methylation

(2009) Ye-Jin Kim et al.   CANCER LETTERS

Notch signaling controls liver development by regulating biliary differentiation

(2009) Y. Zong et al.   DEVELOPMENT

Stem Cells and Liver Regeneration

(2009) Andrew W. Duncan et al.   GASTROENTEROLOGY

The epidemiology of hepatocellular cancer: from the perspectives of public health problem to tumor biology

(2009) Stephen Caldwell et al.   JOURNAL OF GASTROENTEROLOGY

The retinoblastoma gene Rb and its family member p130 suppress lung adenocarcinoma induced by oncogenic K-Ras

(2009) V M Ho et al.   ONCOGENE

RB has a critical role in mediating the in vivo checkpoint response, mitigating secondary DNA damage and suppressing liver tumorigenesis initiated by aflatoxin B1

(2009) C A Reed et al.   ONCOGENE

Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family

(2008) Patrick Viatour et al.   Cell Stem Cell

Liver stem cells and hepatocellular carcinoma

(2008) Lopa Mishra et al.   HEPATOLOGY

The stem cell niche of human livers: Symmetry between development and regeneration

(2008) Lili Zhang et al.   HEPATOLOGY

Liver-specific inactivation ofNotch2, but notNotch1, compromises intrahepatic bile duct development in mice

(2008) Fabian Geisler et al.   HEPATOLOGY

Surface markers for the murine oval cell response

(2008) Craig Dorrell et al.   HEPATOLOGY

Hepatitis B Virus X Protein via the p38MAPK Pathway Induces E2F1 Release and ATR Kinase Activation Mediating p53 Apoptosis

(2008) Wen-Horng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling networks in hepatic oval cell activation

(2008) Laura Erker et al.   Stem Cell Research

Insights from mouse models into human retinoblastoma

(2008) David MacPherson   Cell Division

Stem cells, cell transplantation and liver repopulation

(2007) Michael Oertel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE