Review
Pharmacology & Pharmacy
Youheng Wang, Rusheng Zhao, Chengyan Wu, Xuefei Liang, Lei He, Libo Wang, Xuehui Wang
Summary: Myocardial remodeling refers to structural and functional disorders of the heart caused by molecular biological changes in the cardiac myocytes. Sirt1 plays a role in regulating myocardial remodeling through processes such as oxidative stress, apoptosis, autophagy, and inflammation. Understanding the involvement of Sirt1 in myocardial remodeling and heart failure can contribute to the prevention and treatment of heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Review
Cell Biology
Alexander Nolze, Sebastian Matern, Claudia Grossmann
Summary: Calcineurin, a serine/threonine phosphatase, plays important roles in immune modulation, cardiac hypertrophy, and vascular function. It regulates various aspects of vascular smooth muscle cells, including proliferation, migration, differentiation, and function. Understanding the mechanisms of Calcineurin signaling provides insights into vascular development and pathogenesis.
Article
Pathology
Qiaoling Hu, Yimin Guo, Huan Fan, Xiaobin Wu, Honglei Chen, Chao Zeng
Summary: This study investigates the pathological structure of the vascular wall in Dieulafoy's disease and finds that the thickness of the vascular wall is uneven, there is an increase in collagen and elastic fibers, and the structure of the internal elastic plate is disrupted.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Physiology
Shiliang Chen, Hanbing Zhang, Qianwen Hou, Yu Zhang, Aike Qiao
Summary: Hemodynamics-induced low wall shear stress (WSS) is a critical factor in vascular remodeling. However, the coupling effects of WSS and cellular kinetics have not been well modeled. This study established a multiscale model to investigate the interaction between macroscale WSS loading and microscale cell evolution in vascular remodeling. The results showed that regions of low WSS were associated with significant wall thickening, while normal WSS regions did not exhibit evident changes in wall thickness. When the damage index approached zero, the amount and distribution of smooth muscle cells and extracellular matrix reached a stable state, indicating vascular homeostasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Hematology
Prisca K. Lin, George E. Davis
Summary: Large and medium-sized vessels react differently from capillaries to stimuli inducing vascular disease, undergoing extracellular matrix (ECM) remodeling. While arteries persist and undergo modifications in response to injurious stimuli, capillaries may undergo regression responses.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xiaopei Cui, Guopin Pan, Ye Chen, Xiaosun Guo, Tengfei Liu, Jing Zhang, Xiaofan Yang, Mei Cheng, Haiqing Gao, Fan Jiang
Summary: Pathological vascular remodeling plays a critical role in various vascular diseases, and activation of p53 may help counteract vascular remodeling and reduce inflammation. Currently, targeting the p53 pathway through pharmacological interventions could be a novel strategy to prevent the development of vascular remodeling.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Priscilla Kyi, Kathryn Hendee, Tendai Hunyenyiwa, Kienna Matus, Tadanori Mammoto, Akiko Mammoto
Summary: Cellular senescence plays a crucial role in pulmonary hypertension by modulating TWIST1-PDGFB signaling and controlling vascular remodeling.
FRONTIERS IN MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Mengyi Lao, Xiaozhen Zhang, Tao Ma, Jian Xu, Hanshen Yang, Yi Duan, Honggang Ying, Xiaoyu Zhang, Chengxiang Guo, Junyu Qiu, Xueli Bai, Tingbo Liang
Summary: The study revealed an important role of regulator of calcineurin 1.4 (RCAN1.4) in regulating the progression of PDAC (pancreatic ductal adenocarcinoma), suppressing tumor cell migration, proliferation, and angiogenesis. Additionally, interferon alpha inducible protein 27 (IFI27) and VEGFA play crucial roles in RCAN1.4-mediated PDAC migration, invasion, and angiogenesis.
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Carmen Gutierrez-Munoz, Luis Miguel Blanco-Colio
Summary: Pathological vascular wall remodeling refers to the changes in structure and function of the vessel wall in response to injury, potentially leading to cardiovascular disease. Communication between endothelial cells and vascular smooth muscle cells is crucial for vasculature development and vessel homeostasis, with aberrant communication associated with various disease states including vascular wall remodeling. Different mechanisms such as paracrine regulations and direct contact play a role in this interplay.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Qi Chen, Si Min Lai, Shaohai Xu, Yingrou Tan, Keith Leong, Dehua Liu, Jia Chi Tan, Roshan Ratnakar Naik, Anna M. Barron, Sunil S. Adav, Jinmiao Chen, Shu Zhen Chong, Lai Guan Ng, Christiane Ruedl
Summary: Tissue-resident macrophages in white adipose tissue (WAT) dynamically adapt to metabolic changes and play a protective role against pathological remodeling during obesity. They control vascular integrity, adipocyte function, lipid metabolism, extracellular matrix accumulation, and fibrosis in WAT. The protective role of ATMs in obesity-driven WAT dysfunction challenges the traditional assumption of them as foes.
Article
Plant Sciences
Xinyu Guo, Jipeng Luo, Ran Zhang, Hairong Gao, Liangcai Peng, Yongchao Liang, Tingqiang Li
Summary: In this study, the effects of CuO nanoparticles (CuO NPs) on root growth of lettuce were investigated. The results showed that low concentration of CuO NPs promoted root elongation, while high concentration of CuO NPs inhibited root extension. CuO NPs also caused changes in the composition and structure of the root cell wall.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Cardiac & Cardiovascular Systems
Sachiko Yoshikawa, Manabu Nagao, Ryuji Toh, Masakazu Shinohara, Takuya Iino, Yasuhiro Irino, Makoto Nishimori, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata
Summary: This study demonstrates that increased GLS1 expression and subsequent activation of glutaminolysis are associated with exacerbation of cardiac hypertrophy and fibrosis. Inhibition of GLS1 antagonized adverse cardiac remodeling in vitro and in vivo, partly due to reduction of glutamine-derived metabolites necessary for cellular growth and proliferation. Increased glutamine utilization in cardiac cells may be related to the pathogenesis and development of HF.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Oncology
Manale Karam, Annette Ives, Christian Auclair
Summary: This paper proposes a novel approach for inducing tumor vascular normalization and reducing hypoxia in cancer patients through the pharmacological modulation of plasma S1P levels. The approach is based on clinical observations and pre-clinical data, supported by a review of the biological role of S1P in vascular functionality regulation. The results suggest that tumor vasculature normalization could be an effective strategy to enhance therapy efficacy in solid tumors.
Article
Cardiac & Cardiovascular Systems
Yijun Yang, Justin Kurian, Giana Schena, Jaslyn Johnson, Hajime Kubo, Joshua G. Travers, Chunya Kang, Anna Maria Lucchese, Deborah M. Eaton, Maoting Lv, Na Li, Lorianna G. Leynes, Daohai Yu, Fengzhen Yang, Timothy A. McKinsey, Raj Kishore, Mohsin Khan, Sadia Mohsin, Steven R. Houser
Summary: The study suggests that metabolic syndrome in obese pregnant women may lead to pathological cardiac remodeling, increasing the risk of chronic heart disorders.
Article
Cardiac & Cardiovascular Systems
Maria Gonzalez-Amor, Ana B. Garcia-Redondo, Inmaculada Jorge, Guillermo Zalba, Martina Becares, Maria J. Ruiz-Rodriguez, Cristina Rodriguez, Hugo Bermeo, Raquel Rodrigues-Diez, Francisco J. Rios, Augusto C. Montezano, Jose Martinez-Gonzalez, Jesus Vazquez, Juan Miguel Redondo, Rhian M. Touyz, Susana Guerra, Mercedes Salaices, Ana M. Briones
Summary: The study revealed that ISG15 plays a crucial role in vascular damage associated with hypertension by inducing oxidative stress and inflammation. The expression of ISG15 was positively correlated with high systolic and diastolic blood pressure as well as carotid intima-media thickness, while ISG15 knockout mice showed protection against hypertension and vascular damage.
CARDIOVASCULAR RESEARCH
(2022)
Review
Genetics & Heredity
Juan Luque, Ingrid Mendes, Beatriz Gomez, Beatriz Morte, Miguel Lopez de Heredia, Enrique Herreras, Virginia Corrochano, Juan Bueren, Pia Gallano, Rafael Artuch, Cristina Fillat, Luis A. Perez-Jurado, Lluis Montoliu, Angel Carracedo, Jose M. Millan, Susan M. Webb, Francesc Palau, Pablo Lapunzina
Summary: CIBERER, a thematic area of CIBER, focuses on rare disease research. It aims to facilitate collaboration between biomedical and clinical research groups and provide new tools for the diagnosis and therapy of low-prevalence diseases.
Article
Cardiac & Cardiovascular Systems
Eusebio Garcia-Izquierdo, Susana Mingo-Santos, Consuelo Olivo-Rodriguez, Vanessa Monivas-Palomero, Mercedes Rivas-Lasarte, Carlos E. Martin-Lopez, Silvia Rosado-Garcia, Antonio J. Sanchez-Lopez, Juan Miguel Redondo, Fernando Rodriguez-Pascual, Javier Segovia-Cubero, Alberto Forteza-Gil
Summary: This study found an association between increased collagen cross-linking and reduced left atrial strain in patients with Marfan syndrome. These results suggest that excessive collagen cross-linking may play a role in the development of myocardial impairment in these patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Urology & Nephrology
Diego Martin-Sanchez, Juan Guerrero-Mauvecin, Miguel Fontecha-Barriuso, Nerea Mendez-Barbero, Maria Laura Saiz, Ana M. Lopez-Diaz, Maria D. Sanchez-Nino, Susana Carrasco, Pablo Cannata-Ortiz, Marta Ruiz-Ortega, Alberto Ortiz, Ana B. Sanz
Summary: RIPK3 plays a key role in kidney inflammation by mediating NF-κB activation independently of tubular cell death. Targeting bone marrow-derived RIPK3 may help limit kidney inflammation effectively.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Multidisciplinary Sciences
Raquel Roldan-Montero, Juan M. Perez-Saez, Isabel Cerro-Pardo, Jorge Oller, Diego Martinez-Lopez, Estefania Nunez, Sebastian M. Maller, Carmen Gutierrez-Munoz, Nerea Mendez-Barbero, Joan C. Escola-Gil, Jean-Baptiste Michel, Maria Mittelbrunn, Jesus Vazquez, Luis M. Blanco-Colio, Gabriel A. Rabinovich, Jose L. Martin-Ventura
Summary: Galectin-1 (Gal-1) plays a significant role as a therapeutic target for atherosclerosis and abdominal aortic aneurysm (AAA). Lack of Gal-1 leads to severe atherosclerosis and VSMC phenotypic switch, while treatment with recombinant Gal-1 prevents these effects and alleviates the conditions of atherosclerosis and AAA.
Article
Allergy
Emilio Nunez-Borque, Diana Betancor, Carlos Pastor-Vargas, Sergio Fernandez-Bravo, Ariadna Martin-Blazquez, Natalia Casado-Navarro, David Lopez-Dominguez, Alicia Gomez-Lopez, Pablo Rodriguez del Rio, Paloma Tramon, Juan Maria Beitia, Carmen Moreno-Aguilar, David Gonzalez-de-Olano, Maria Jose Goikoetxea, Maria Dolores Ibanez-Sandin, Jose Julio Laguna, Javier Cuesta-Herranz, Vanesa Esteban
Summary: This study evaluates the extravasation underlying human anaphylaxis based on the severity of the reaction using measurements of serum albumin (HSA) and protein concentration. The findings propose new diagnostic and potential therapeutic approaches for this pathological event.
Review
Allergy
Nieves Fernandez-Gallego, Raquel Castillo-Gonzalez, Nerea Mendez-Barbero, Celia Lopez-Sanz, David Obeso, Alma Villasenor, Maria M. Escribese, Beatriz Lopez-Melgar, Jorge Salamanca, Amparo Benedicto-Buendia, Luis Jesus Jimenez-Borreguero, Borja Ibanez, Joaquin Sastre, Maria Teresa Belver, Francisco Vega, Carlos Blanco, Domingo Barber, Francisco Sanchez-Madrid, Hortensia de la Fuente, Pilar Martin, Vanesa Esteban, Rodrigo Jimenez-Saiz
Summary: Allergic diseases and atherosclerosis are two different types of immune disorders, and they have a complex clinical association and mutual influence.
Editorial Material
Allergy
D. Betancor, A. Gomez-Lopez, E. Nunez-Borque, S. Fernandez-Bravo, B. Barroso, V Esteban, C. Pastor-Vargas, J. Cuesta-Herranz
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Isabel Pijuan, Elisa Balducci, Cristina Soto-Sanchez, Eduardo Fernandez, Maria Jose Barallobre, Maria L. Arbones
Summary: Mutation in the DYRK1A gene can affect the development of glial cells and the morphological features of the brain's white matter tract, potentially leading to abnormal neuronal circuit development and impaired brain function.
SCIENTIFIC REPORTS
(2022)
Article
Allergy
Jaime Tome-Amat, Zulema Gonzalez-Klein, Diego Pazos-Castro, Jose Luis Resuela-Gonzalez, Gonzalo Vilchez-Pinto, Helena Berreiros-Hortala, Lucia Palacio-Garcia, Sergio Fernandez-Bravo, Vanesa Esteban, Araceli Diaz-Perales, Maria Garrido-Arandia
Editorial Material
Cardiac & Cardiovascular Systems
Alvaro Montes Muniz, Beatriz Lopez Melgar, Gian Luca De Toffol, Luis Jesus Jimenez Borreguero, Fernando Alfonso
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Immunology
Emilio Nunez-Borque, Sergio Fernandez-Bravo, Pablo Rodriguez Del Rio, Lucia Palacio-Garcia, Angela Di Giannatale, Virginia Di Paolo, Angela Galardi, Marta Colletti, Luisa Pascucci, Jaime Tome-Amat, Javier Cuesta-Herranz, Maria Dolores Ibanez-Sandin, Jose Julio Laguna, Alberto Benito-Martin, Vanesa Esteban
Summary: This study investigates the involvement of miRNAs in anaphylactic reactions and their potential as biomarkers. The researchers found differential expression profiles of circulating miRNAs in patients with anaphylaxis, particularly miR-375-3p. Functional and molecular experiments demonstrated that miR-375-3p plays a negative role in the stability of the endothelial barrier. These findings provide insights into the molecular mechanisms underlying anaphylactic reactions and suggest the potential of miR-375-3p as a biomarker.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Food Science & Technology
Santiago Rodriguez, Aina Garcia-Garcia, Eduardo Garcia-Calvo, Vanesa Esteban, Carlos Pastor-Vargas, Araceli Diaz-Perales, Teresa Garcia, Rosario Martin
Summary: This study describes the use of phage display technology to generate a recombinant antibody for specific detection of hen's ovomucoid, addressing the need for reliable egg allergen detection methods. The developed phage enzyme-linked immunosorbent assay (ELISA) demonstrated good sensitivity and accuracy, and showed consistent results with a commercial egg detection assay in the analysis of various food products. In silico modeling of the antigen-antibody complex provided insights into the interaction mechanism.
Meeting Abstract
Medicine, Research & Experimental
Andrea de la Fuente-Alonso, Marta Toral, Miguel R. Campanero, Juan M. Redondo
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)