Review
Biochemistry & Molecular Biology
Eliza Mari Kwesi-Maliepaard, Heinz Jacobs, Fred van Leeuwen
Summary: T-AIM cells are a subset of memory T cells that develop memory features independently of antigen exposure. They exhibit characteristics similar to conventional memory cells, including antigen-specific responses and responsiveness to innate stimuli. T-AIM cells are suggested to provide additional levels of protection against infections and cancer.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Amani Odeh, Hossam Eddini, Lujain Shawasha, Anastasia Chaban, Aaron Avivi, Imad Shams, Irena Manov
Summary: Subterranean blind mole rat, Spalax, has developed strategies to withstand cancer by maintaining genome stability and suppressing the inflammatory response. Conditioned medium from senescent Spalax fibroblasts can induce senescence in cancer cells without inducing an inflammatory response, thereby suppressing malignant behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Catherine T. Le, Logan V. Vick, Craig Collins, Cordelia Dunai, Michael K. Sheng, Lam T. Khuat, Isabel Barao, Sean J. Judge, Ethan G. Aguilar, Brendan Curti, Maneesh Dave, Dan L. Longo, Bruce R. Blazar, Robert J. Canter, Arta M. Monjazeb, William J. Murphy
Summary: Memory T cells can be activated through bystander activation with cytokine signaling, but this response is inhibited by the PD-1 pathway. PD-1 blockade reverses this inhibition, but leads to activation-induced cell death and eventual loss of T cells.
Article
Cell Biology
Carolina R. Melo-Silva, Marisa I. Roman, Cory J. Knudson, Lingjuan Tang, Ren-Huan Xu, Michel Tassetto, Patrick Dolan, Raul Andino, Luis J. Sigal
Summary: The study reveals that infected and bystander inflammatory monocytes (iMOs) and B cells differentially control gene transcription important for immune cell function and cell identity. Bystander cells upregulate metabolism and interferon-stimulated genes, while infected cells downregulate cell-type-specific genes and upregulate genes typical of non-immune cells.
Article
Biochemistry & Molecular Biology
Huafeng Zhang, Jincheng Liu, Zhuoshun Yang, Liping Zeng, Keke Wei, Liyan Zhu, Liang Tang, Dianheng Wang, Yabo Zhou, Jiadi Lv, Nannan Zhou, Ke Tang, Jingwei Ma, Bo Huang
Summary: Glycolysis plays a crucial role in the recall response of CD8(+) memory T cells. This study reveals that intracellular glycogen serves as the major carbon source for the early recall response, and TCR signaling regulates this process through the phosphorylation of PYGB. This discovery highlights the specific dependence of memory T cell activation on glycogen and its potential therapeutic implications.
Article
Gastroenterology & Hepatology
Yongyin Li, Chunhua Wen, Shuqin Gu, Weibin Wang, Ling Guo, Chris Kafai Li, Xuan Yi, Yang Zhou, Zheyu Dong, Xin Fu, Shihong Zhong, Yuhao Wang, Kuiyuan Huang, Junhua Yin, Chunxiu Zhong, Xieer Liang, Rong Fan, Haitao Chen, Deke Jiang, Xiaoyong Zhang, Jian Sun, Libo Tang, Jie Peng, Jinlin Hou
Summary: This study aimed to investigate the relationship between HBV-specific T-cell responses and clinical outcomes in CHB patients after NA discontinuation. Enhanced HBV-specific CD4(+)T-cell responses were observed in patients with long-term viral control and HBsAg loss. CD4(+)T cells specific to distinct HBV antigens may have divergent antiviral potential.
Article
Biochemistry & Molecular Biology
Philip A. Mudd, Anastasia A. Minervina, Mikhail Pogorelyy, Jackson S. Turner, Wooseob Kim, Elizaveta Kalaidina, Jan Petersen, Aaron J. Schmitz, Tingting Lei, Alem Haile, Allison M. Kirk, Robert C. Mettelman, Jeremy Chase Crawford, Thi H. O. Nguyen, Louise C. Rowntree, Elisa Rosati, Katherine A. Richards, Andrea J. Sant, Michael K. Klebert, Teresa Suessen, William D. Middleton, Joshua Wolf, Sharlene A. Teefey, Jane A. O'Halloran, Rachel M. Presti, Katherine Kedzierska, Jamie Rossjohn, Paul G. Thomas, Ali H. Ellebedy
Summary: SARS-CoV-2 mRNA vaccines induce potent immune responses, including antibodies and CD4(+) T cell responses. Research has found that vaccine-induced follicular helper CD4(+) T cell responses play a key role in establishing long-term immunity.
Article
Immunology
Wei Luo, Laura Conter, Rebecca A. Elsner, Shuchi Smita, Florian Weisel, Derrick Callahan, Shuxian Wu, Maria Chikina, Mark Shlomchik
Summary: IL-21R plus CD40 signals have different effects on germinal center B cells compared with BCR plus CD40 signals, leading to the differentiation of a subset of cells into plasma cells, representing a second positive selection pathway.
SCIENCE IMMUNOLOGY
(2023)
Review
Immunology
Hoyoung Lee, Seongju Jeong, Eui-Cheol Shin
Summary: Bystander activation refers to the activation of pre-existing memory CD8(+) T cells by cytokines without cognate antigens, which can have protective or detrimental effects on the host depending on the infection model or disease. Research has elucidated the mechanisms and immunopathological roles of bystander activation in various microbial infections. T cell receptor-independent triggering of T cells, known as bystander activation, plays an important role in homeostatic antimicrobial responses and immunopathology.
Article
Immunology
Alexander A. Lehmann, Greg A. Kirchenbaum, Ting Zhang, Pedro A. Reche, Paul V. Lehmann
Summary: SARS-CoV-2 infection may not induce a durable antibody response in all infected individuals, leading researchers to focus on specific T cell memory against the virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Curtis J. Pritzl, Mark A. Daniels, Emma Teixeiro
Summary: CD8 positive, tissue resident memory T cells are a specialized subset of T cells that provide critical protection against tumors and pathogen re-infection. The development and maintenance of these cells involve a myriad of signals, including tissue-derived signals and antigenic/pro-inflammatory cytokines. Recent research suggests additional roles for antigenic and pro-inflammatory signals in the establishment of resident memory T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jesus Herrera-Imbroda, Maria Flores-Lopez, Paloma Ruiz-Sastre, Carlos Gomez-Sanchez-Lafuente, Antonio Bordallo-Aragon, Fernando Rodriguez de Fonseca, Fermin Mayoral-Cleries
Summary: Psychosis and substance use disorders have been associated with pro-inflammatory changes in the central nervous system, and multiple studies have found a link between these disorders. Inflammatory mediators such as cytokines, chemokines, endocannabinoids, eicosanoids, lysophospholipids, and bacterial products are involved in both psychosis and substance use disorders. The abnormal neurodevelopment caused by neuroinflammation may be a common origin for these disorders, and the transcriptional factors NF kappa B and PPAR gamma may play a role in this process.
Article
Immunology
Chien-Hung Chen, Cheng-Yuan Peng, Yuan-Hung Kuo, Tsung-Hui Hu, Chao-Hung Hung, Jing-Houng Wang, Sheng-Nan Lu
Summary: Tenofovir disoproxil fumarate (TDF) therapy, HBeAg loss without seroconversion during treatment, and higher end-of-treatment hepatitis B core-related antigen were significant predictors of HBV relapse in HBeAg-positive patients who discontinued ETV or TDF.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Thomas Hagglof, Melissa Cipolla, Maximilian Loewe, Spencer T. Chen, Luka Mesin, Harald Hartweger, Mohamed A. ElTanbouly, Alice Cho, Anna Gazumyan, Victor Ramos, Leonidas Stamatatos, Thiago Y. Oliveira, Michel C. Nussenzweig, Charlotte Viant
Summary: Antibody responses increase in both affinity and diversity over time, with affinity maturation occurring in germinal centers through somatic mutation and selection. The process of diversification while undergoing affinity maturation is not well understood.
Article
Medicine, Research & Experimental
Joshua Slysz, Arjun Sinha, Matthew Deberge, Shalini Singh, Harris Avgousti, Inhyeok Lee, Kristofor Glinton, Reina Nagasaka, Prarthana Dalal, Shaina Alexandria, Ching Man Wai, Ricardo Tellez, Mariavittoria Vescovo, Ashwin Sunderraj, Xinkun Wang, Matthew Schipma, Ryan Sisk, Rishab Gulati, Jenifer Vallejo, Ryosuke Saigusa, Donald M. Lloyd-Jones, Jon Lomasney, Samuel Weinberg, Karen Ho, Klaus Ley, Chiara Giannarelli, Edward B. Thorp, Matthew J. Feinstein
Summary: This study compared the phenotypes and transcriptional polarization of leukocytes in human femoral and carotid atherosclerotic plaques using single-cell RNA sequencing, flow cytometry, and immunohistochemistry. The results showed that noninflammatory foam cell-like macrophages and LYVE1-overexpressing macrophages were more prevalent in femoral plaques, while inflammatory foam cell-like macrophages and monocytes were more prevalent in carotid plaques. In addition, B cells were more prevalent with an anti-inflammatory profile in femoral plaques, whereas cytotoxic CD8+ T cells were more prevalent in carotid plaques.
Article
Immunology
Chrysothemis C. Brown, Daria Esterhazy, Aurelien Sarde, Mariya London, Venu Pullabhatla, Ines Osma-Garcia, Raya al-Bader, Carla Ortiz, Raul Elgueta, Matthew Arno, Emanuele de Rinaldis, Daniel Mucida, Graham M. Lord, Randolph J. Noelle
Article
Immunology
Eirini Pantazi, Ellen Marks, Emilie Stolarczyk, Nils Lycke, Randolph J. Noelle, Raul Elgueta
JOURNAL OF IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
R. Alhabbab, P. Blair, R. Elgueta, E. Stolarczyk, E. Marks, P. D. Becker, K. Ratnasothy, L. Smyth, N. Safinia, E. Sharif-Paghaleh, S. O'Connell, R. J. Noelle, G. M. Lord, J. K. Howard, J. Spencer, R. I. Lechler, G. Lombardi
SCIENTIFIC REPORTS
(2015)
Article
Immunology
Raul Elgueta, Dan Tse, Sophie J. Deharvengt, Marcus R. Luciano, Catherine Carriere, Randolph J. Noelle, Radu V. Stan
JOURNAL OF IMMUNOLOGY
(2016)
Review
Transplantation
Victor C. de Vries, Karina Pino-Lagos, Raul Elgueta, Randolph J. Noelle
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2009)
Article
Cell Biology
Radu V. Stan, Dan Tse, Sophie J. Deharvengt, Nicole C. Smits, Yan Xu, Marcus R. Luciano, Caitlin L. McGarry, Maarten Buitendijk, Krishnamurthy V. Nemani, Raul Elgueta, Takashi Kobayashi, Samantha L. Shipman, Karen L. Moodie, Charles P. Daghlian, Patricia A. Ernst, Hong-Kee Lee, Arief A. Suriawinata, Alan R. Schned, Daniel S. Longnecker, Steven N. Fiering, Randolph J. Noelle, Barjor Gimi, Nicholas W. Shworak, Catherine Carriere
DEVELOPMENTAL CELL
(2012)
Article
Immunology
Aurelie Moreau, Paul A. Blair, Jian-Guo Chai, Kulachelvy Ratnasothy, Emilie Stolarczyk, Rowa Alhabbab, Chloe L. Rackham, Peter M. Jones, Lesley Smyth, Raul Elgueta, Jane K. Howard, Robert I. Lechler, Giovanna Lombardi
EUROPEAN JOURNAL OF IMMUNOLOGY
(2015)
Review
Immunology
Raul Elgueta, Micah J. Benson, Victor C. de Vries, Anna Wasiuk, Yanxia Guo, Randolph J. Noelle
IMMUNOLOGICAL REVIEWS
(2009)
Review
Immunology
Raul Elgueta, Victor C. de Vries, Randolph J. Noelle
IMMUNOLOGICAL REVIEWS
(2010)
Article
Medicine, Research & Experimental
Juan R. Cubillos-Ruiz, Xavier Engle, Uciane K. Scarlett, Diana Martinez, Amorette Barber, Raul Elgueta, Li Wang, Yolanda Nesbeth, Yvon Durant, Andrew T. Gewirtz, Charles L. Sentman, Ross Kedl, Jose R. Conejo-Garcia
JOURNAL OF CLINICAL INVESTIGATION
(2009)
Article
Immunology
Raul Elgueta, Jaime A. Tobar, Kenji F. Shoji, Jaime De Calisto, Alexis M. Kalergis, Maria R. Bono, Mario Rosemblatt, Juan C. Saez
JOURNAL OF IMMUNOLOGY
(2009)
Article
Immunology
Raul Elgueta, Ellen Marks, Elizabeth Nowak, Shinelle Menezes, Micah Benson, Vanitha S. Raman, Carla Ortiz, Samuel O'Connell, Henry Hess, Graham M. Lord, Randolph Noelle
JOURNAL OF IMMUNOLOGY
(2015)
Article
Immunology
V. C. de Vries, R. Elgueta, D. M. Lee, R. J. Noelle
TRANSPLANTATION PROCEEDINGS
(2010)
Article
Multidisciplinary Sciences
Estefania Nova-Lamperti, Giorgia Fanelli, Pablo D. Becker, Prabhjoat Chana, Raul Elgueta, Philippa C. Dodd, Graham M. Lord, Giovanna Lombardi, Maria P. Hernandez-Fuentes
SCIENTIFIC REPORTS
(2016)