Article
Biochemistry & Molecular Biology
Ciara N. Murphy, Susan P. Walker, Teresa M. MacDonald, Emerson Keenan, Natalie J. Hannan, Mary E. Wlodek, Jenny Myers, Jessica F. Briffa, Tania Romano, Alexandra Roddy Mitchell, Carole-Anne Whigham, Ping Cannon, Tuong-Vi Nguyen, Manju Kandel, Natasha Pritchard, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: SPINT2 is identified as a potential biomarker for placental dysfunction, associated with preterm preeclampsia and intrauterine growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Rugina Neuman, Langeza Saleh, Koen Verdonk, Anton H. van den Meiracker, Henk Russcher, Herold J. Metselaar, Willy Visser, A. H. Jan Danser
Summary: The study indicates that PlGF production is significantly upregulated in AFLP patients, mainly originating from the placenta. Compared to other disease groups, AFLP patients have significantly elevated levels of PlGF, which rapidly decline postpartum.
Article
Pediatrics
Huan Li, Juanjuan Chen, Yuanhui Hu, Xin Cai, Pingan Zhang
Summary: The study found that serum C1q levels were significantly elevated in children with sepsis, correlated with disease severity, positively correlated with PCT levels, and negatively correlated with PCIS score. Children infected with different pathogens also showed significantly higher serum C1q levels.
FRONTIERS IN PEDIATRICS
(2021)
Review
Immunology
Mi Zhou, Dana T. Graves
Summary: Periodontitis is caused by an immune response to bacterial dysbiosis, leading to bone resorption and limited bone repair processes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Natasha de Alwis, Sally Beard, Natalie K. Binder, Natasha Pritchard, Tu'uhevaha J. Kaitu'u-Lino, Susan P. Walker, Owen Stock, Katie Groom, Scott Petersen, Amanda Henry, Joanne M. Said, Sean Seeho, Stefan C. Kane, Stephen Tong, Lisa Hui, Natalie J. Hannan
Summary: Elevated levels of OLAH in the placenta may be associated with placental dysfunction in pregnancies complicated by preterm preeclampsia and fetal growth restriction. Further research is required to understand the role of OLAH in the placenta, and whether these changes are a maternal adaptation or consequence of disease.
Article
Biochemistry & Molecular Biology
Masaru Matsuoka, Junko Yamaguchi, Kosaku Kinoshita
Summary: This study aimed to investigate the relationship between blood levels of uric acid (UA), xanthine dehydrogenase (XDH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) in sepsis patients. The results showed that UA and XDH levels were correlated with the severity of sepsis and poor outcomes. Elevated XDH levels were associated with reduced survival rates. The findings suggest that increased oxidative stress in sepsis can be counteracted by elevated UA levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Esther Dos Santos, Marta Hita Hernandez, Valerie Serazin, Francois Vialard, Marie-Noelle Dieudonne
Summary: Maternal obesity is associated with increased morbidity and mortality rates in mothers and children, and the placenta plays a crucial role in mediating the effects of the maternal environment on fetal development. This review focuses on the impact of maternal obesity (without gestational diabetes) on various aspects of placental function, including endocrine function, morphology, nutrient exchanges and metabolism, inflammatory/immune status, oxidative stress, and transcriptome. Understanding the sex-specific placental responses to maternal obesity is important for improving pregnancy outcomes and maternal and child health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Anjali Jadhav, Amrita Khaire, Shridevi Gundu, Nisha Wadhwani, Nomita Chandhiok, Sanjay Gupte, Sadhana Joshi
Summary: This study found that levels of nerve growth factor (NGF) in the placenta were lower in women with gestational diabetes mellitus (GDM) compared to those without GDM. However, placental brain-derived growth factor (BDNF) levels were similar between the two groups. The gender of the baby influenced the BDNF levels in the placenta, while maternal BMI and mode of delivery influenced NGF levels.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
(2021)
Article
Ophthalmology
Kenichi Nakamura, Sachi Kojima, Miyuki Inoue-Mochita, Hidenobu Tanihara, Toshihiro Inoue
Summary: We investigated the levels of VEGF, sVEGFR1, and sVEGFR2 in the aqueous humor of glaucoma patients and found correlations among them. sVEGFR1 levels were significantly higher in neovascular glaucoma patients, while sVEGFR2 levels were significantly higher in all glaucoma patients compared to controls. The levels of sVEGFR1 and sVEGFR2 were positively correlated in glaucoma patients, and VEGF levels were negatively correlated with both sVEGFR1 and sVEGFR2 in primary open angle glaucoma patients.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Medicine, General & Internal
Matt G. Sorrells, Yurim Seo, Melia Magnen, Bliss Broussard, Roya Sheybani, Ajay M. Shah, Hollis R. O'Neal, Henry T. K. Tse Jr, Mark R. Looney, Dino Di Carlo
Summary: This study examined the correlation between the measurements performed using the IntelliSep test and biological markers and processes associated with sepsis. The results showed a linear correlation between the IntelliSep Index (ISI) scores and the quantities of neutrophil DNA and citrullinated histone DNA, indicating that the IntelliSep test may indicate changes consistent with sepsis.
Article
Obstetrics & Gynecology
Swati Agrawal, W. Tony Parks, Helen Dehui Zeng, Anjana Ravichandran, Eran Ashwal, Rory C. Windrim, Sebastian R. Hobson, Nir Melamed, John C. Kingdom
Summary: Serial placental growth factor measurements and uterine artery Doppler waveform assessments can reveal the patterns of specific placental pathology development and their relationships with the timing of disease onset and pregnancy outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Environmental Sciences
Sivakoti Ramana, Awadhesh Kumar Tripathi, Kollah Bharati, Amar Bahadur Singh, Ajay Kumar, Asha Sahu, Poonam Singh Rajput, Pradip Dey, Jayanta Kumar Saha, Ashok K. Patra
Summary: The study found that cotton plants have a certain tolerance to lead, but are not suitable as hyperaccumulators of lead. They mainly use an exclusion mechanism to cope with lead stress, and have very low bioconcentration and translocation efficiency for lead.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Samuel Parry, Benjamin A. Carper, William A. Grobman, Ronald J. Wapner, Judith H. Chung, David M. Haas, Brian Mercer, Robert M. Silver, Hyagriv N. Simhan, George R. Saade, Uma M. Reddy, Corette B. Parker
Summary: The study aimed to investigate placental physiology and identify novel biomarkers related to adverse pregnancy outcomes. The findings indicate that certain analytes in maternal serum during early pregnancy are associated with adverse pregnancy outcomes, but the test characteristics of these analytes do not support their use as clinical biomarkers for predicting adverse pregnancy outcomes, either alone or in combination with maternal clinical characteristics.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Anesthesiology
Matthew B. A. Harmon, Nanon F. L. Heijnen, Sanne de Bruin, Niek H. Sperna Weiland, Joost C. M. Meijers, Anita M. De Boer, Marcus J. Schultz, Janneke Horn, Nicole P. Juffermans
Summary: In this study of healthy volunteers during LPS-induced endotoxaemia, induced normothermia was found to decrease markers of endothelial activation and DIC, potentially reducing coagulopathy in hyperinflammatory states.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Medical Laboratory Technology
Sarah E. Donoghue, Oliver Heath, James Pitt, Kai Mun Hong, Maria Fuller, Joel Smith
Summary: By retrospectively reviewing clinical records of a group of patients with Streptococcus pneumoniae sepsis, we found that the infection could lead to elevated levels of urine free sialic acid (UFSA). This research expands our knowledge of UFSA as a biomarker in human disease and suggests that infections with organisms possessing neuraminidase activity should be considered in patients with unexplained increases in UFSA.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Lisa M. Becker, Shiau-Haln Chen, Julie Rodor, Laura P. M. H. de Rooij, Andrew H. Baker, Peter Carmeliet
Summary: Endothelial cells play a crucial role in the human body but their heterogeneity poses challenges in therapy. Recent studies have revealed the diverse functions of endothelial cells and their roles in diseases, and proposed strategies to deal with this heterogeneity.
CARDIOVASCULAR RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Jie Li, Yan Zhou, Guy Eelen, Qing-tong Zhou, Wen-bo Feng, Viktorija Labroska, Fen-fen Ma, Hui-ping Lu, Mieke Dewerchin, Peter Carmeliet, Ming-wei Wang, De-hua Yang
Summary: The growth of solid tumors relies on tumor vascularization and endothelial cells. Targeting the glycolytic activity of endothelial cells can normalize tumor vessels, reduce metastasis, and improve chemotherapy outcomes.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Laura P. M. H. de Rooij, Lisa M. Becker, Laure Anne Teuwen, Bram Boeckx, Sander Jansen, Simon Feys, Stijn Verleden, Laurens Liesenborghs, Anna K. Stalder, Sasha Libbrecht, Tina Van Buyten, Gino Philips, Abhishek Subramanian, Sebastien J. Dumas, Elda Meta, Mila Borri, Liliana Sokol, Amelie Dendooven, Anh Co K. Truong, Jan Gunst, Pierre Van Mol, Jasmin D. Haslbauer, Katerina Rohlenova, Thomas Menter, Robbert Boudewijns, Vincent Geldhof, Stefan Vinckier, Jacob Amersfoort, Wim Wuyts, Dirk Van Raemdonck, Werner Jacobs, Laurens J. Ceulemans, Birgit Weynand, Bernard Thienpont, Martin Lammens, Mark Kuehnel, Guy Eelen, Mieke Dewerchin, Luc Schoonjans, Danny Jonigk, Jo van Dorpe, Alexandar Tzankov, Els Wauters, Massimiliano Mazzone, Johan Neyts, Joost Wauters, Diether Lambrechts, Peter Carmeliet
Summary: This study provides new insights into the abundance, expression patterns, and interactomes of endothelial cell (EC) subtypes in COVID-19 and idiopathic pulmonary fibrosis (IPF). The findings suggest the importance of ECs in the pathophysiology of both conditions and may contribute to future investigations into the progression and treatment of COVID-19 and IPF.
CARDIOVASCULAR RESEARCH
(2023)
Article
Critical Care Medicine
Eilise M. Ryan, Pranvera Sadiku, Patricia Coelho, Emily R. Watts, Ailiang Zhang, Andrew J. M. Howden, Manuel A. Sanchez-Garcia, Martin Bewley, Joby Cole, Brian J. McHugh, Wesley Vermaelen, Bart Ghesquiere, Peter Carmeliet, Giovanny Rodriguez Blanco, Alex Von Kriegsheim, Yolanda Sanchez, William Rumsey, James F. Callahan, George Cooper, Nicholas Parkinson, Kenneth Baillie, Doreen A. Cantrell, John McCafferty, Gourab Choudhury, Dave Singh, David H. Dockrell, Moira K. B. Whyte, Sarah R. Walmsley
Summary: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and impaired macrophage function. This study found that COPD alveolar macrophages (AMs) and peripheral monocyte-derived macrophages (MDMs) exhibit metabolic deficiencies and impairments in redox balance. Activation of the NRF2 pathway can rescue these defects and improve macrophage function in COPD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Mengyao Tang, Anders Berg, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Sahir Kalim
Summary: The impact of glycated hemoglobin (HbA(1c)) on renal outcomes in patients with diabetes and chronic kidney disease (CKD) is modified by carbamylation and anemia.
Review
Peripheral Vascular Disease
Takahiko Nakagawa, Ana Andres-Hernando, Tomoki G. Kosugi, Laura Sanchez-Lozada, Peter Stenvinkel, Karolina Kublickiene, S. Ananth Karumanchi, Duk-Hee Kang, Hideto Kojima, Bernardo R. Rodriguez-Iturbe, Dean A. Tolan, Miguel J. Lanaspa, Richard Johnson
Summary: Preeclampsia is a hypertensive disorder of pregnancy caused by abnormal placentation. Fructose, which plays a critical role in fetal growth, is produced in the placenta during early pregnancy to assist fetal survival in a hypoxic environment. Impaired placentation leads to excessive fructose production, which drives various pathological features of preeclampsia. In addition, dietary fructose intake has been identified as an independent risk factor for preeclampsia.
HYPERTENSION RESEARCH
(2023)
Article
Urology & Nephrology
Sahir Kalim, Sophia Zhao, Mengyao Tang, Eugene P. Rhee, Andrew S. Allegretti, Sagar Nigwekar, S. Ananth Karumanchi, James P. Lash, Anders H. Berg
Summary: Protein carbamylation, driven by elevated blood urea levels, is associated with adverse outcomes in ESKD. However, its relationship to clinical outcomes in earlier stages of CKD is not well understood.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren A. Biwer, Qing Lu, Jaime Ibarrola, Alec Stepanian, Joshua J. Man, Brigett V. Carvajal, Nicholas D. Camarda, Zsuzsanna Zsengeller, Geraldine Skurnik, Ellen W. Seely, S. Ananth Karumanchi, Iris Z. Jaffe
Summary: Preeclampsia is associated with hypertension and end organ damage, and women exposed to preeclampsia have an increased risk of hypertension after pregnancy. This study found that exposure to sFlt1 during pregnancy leads to enhanced responsiveness of smooth muscle cell mineralocorticoid receptors (SMC-MR) to hypertensive stimuli, contributing to postpartum hypertension. These findings suggest that targeting SMC-MR could be a potential intervention to mitigate cardiovascular risk in women after preeclampsia.
CIRCULATION RESEARCH
(2023)
Review
Neurosciences
Thomas Waelchli, Jeroen Bisschop, Peter Carmeliet, Gelareh Zadeh, Philippe P. Monnier, Katrien De Bock, Ivan Radovanovic
Summary: This review examines the mechanisms of angiogenesis in brain development, brain vascular malformations, and brain tumors. The CNS critically relies on the formation and proper function of its vasculature during different stages, and angiogenesis plays a key role in vascular-dependent brain diseases. However, the exact molecular pathways and mechanisms underlying angiogenesis in the CNS are not fully understood.
NATURE REVIEWS NEUROSCIENCE
(2023)
Correction
Neurosciences
Carmen Ruiz de Almodovar, Pierre J. Fabre, Ellen Knevels, Cathy Coulon, Inmaculada Segura, Patrick C. G. Haddick, Liesbeth Aerts, Nicolas Delattin, Geraldine Strasser, Won-Jong Oh, Christian Lange, Stefan Vinckier, Jody Haigh, Coralie Fouquet, Chengua Gu, Kari Alitalo, Valerie Castellani, Marc Tessier-Lavigne, Alain Chedotal, Frederic Charron, Peter Carmeliet
Article
Biochemistry & Molecular Biology
Chunsik Lee, Rongyuan Chen, Guangli Sun, Xialin Liu, Xianchai Lin, Chang He, Liying Xing, Lixian Liu, Lasse D. Jensen, Anil Kumar, Harald F. Langer, Xiangrong Ren, Jianing Zhang, Lijuan Huang, Xiangke Yin, JongKyong Kim, Juanhua Zhu, Guanqun Huang, Jiani Li, Weiwei Lu, Wei Chen, Juanxi Liu, Jiaxin Hu, Qihang Sun, Weisi Lu, Lekun Fang, Shasha Wang, Haiqing Kuang, Yihan Zhang, Geng Tian, Jia Mi, Bi-Ang Kang, Masashi Narazaki, Aaron Prodeus, Luc Schoonjans, David M. Ornitz, Jean Gariepy, Guy Eelen, Mieke Dewerchin, Yunlong Yang, Jing-Song Ou, Antonio Mora, Jin Yao, Chen Zhao, Yizhi Liu, Peter Carmeliet, Yihai Cao, Xuri Li
Summary: Although the angiogenic effect of VEGF-B is not well understood, inhibitors of VEGF-B are being used in the treatment of neovascular diseases. In this study, we reveal a previously unrecognized function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway. We found that VEGF-B binds to FGFR1, induces FGFR1/VEGFR1 complex formation, suppresses FGF2-induced Erk activation, and inhibits FGF2-driven angiogenesis and tumor growth.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Obstetrics & Gynecology
Eynav Accortt, James Mirocha, Dongsheng Zhang, Sarah J. Kilpatrick, Towia Libermann, S. Ananth Karumanchi
Summary: This study aimed to determine if a panel of novel third-trimester plasma protein biomarkers in pregnant women can be used to identify those who have a high predisposed risk for perinatal mood and anxiety disorders. The results showed that participants with perinatal mood and anxiety disorders had a unique and distinct plasma protein signature that regulated a variety of neuronal signaling and proinflammatory pathways. Further validation studies with larger sample sizes are needed to determine the potential use of these molecules for early detection of perinatal mood and anxiety disorders when combined with traditional risk factors.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Review
Oncology
Qun Zeng, Mira Mousa, Aisha Shigna Nadukkandy, Lies Franssens, Halima Alnaqbi, Fatima Yousif Alshamsi, Habiba Al Safar, Peter Carmeliet
Summary: In this review, the authors summarize recent single-cell omics studies that have revealed the heterogeneity of human tumor endothelial cells and go on to demonstrate that these cells have phenotypes beyond simply being angiogenic. This finding has potential implications for improving the success rate of current anti-angiogenic therapies.
NATURE REVIEWS CANCER
(2023)
Article
Multidisciplinary Sciences
Anh-Co K. Truong, Lisa M. Becker, Nora Dekoning, Ann Bouche, Koen Veys, Baharak Hosseinkhani, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
Summary: This paper provides a step-by-step description of the corneal thermal cauterization assay in mice and discusses ethical considerations and aspects related to animal welfare guidelines. The assay is a simple, low-cost, reproducible, insightful, and labor-saving method to evaluate the role of inflammation in angiogenesis and lymphangiogenesis.
Meeting Abstract
Cardiac & Cardiovascular Systems
R. Tillie, J. De Bruijn, R. Dobie, J. Perales-Paton, K. Van Kuijk, M. Gijbels, L. Temmerman, Y. Ghosheh, G. Goossens, P. Carmeliet, K. Ley, N. Henderson, J. Saez-Rodriguez, K. Wouters, J. Sluimer