Article
Cell & Tissue Engineering
Zenghua Lin, Maile K. Hollinger, Zhijie Wu, Wanling Sun, Kaylind Batey, Jisoo Kim, Jichun Chen, Xingmin Feng, Neal S. Young
Summary: It was found that sirolimus enhanced the regeneration of hematopoietic stem and progenitor cells in mice exposed to sublethal total body irradiation and other regenerative stressors. The effects were associated with increased expression of hematopoietic genes, reduced DNA damage and clearance of cellular reactive oxygen species. Sirolimus also showed potential clinical applications for the treatment and prevention of hematopoietic injury.
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell & Tissue Engineering
Manoj Kumar K. Azhagiri, Prathibha Babu, Vigneshwaran Venkatesan, Saravanabhavan Thangavel
Summary: The field of gene therapy has been transformed by next-generation genome engineering tools like CRISPR-Cas9, with HSPCs being the ideal target cells for gene manipulation. While lentiviral gene augmentation and NHEJ-based gene editing have shown substantial clinical progress, HDR-mediated gene editing for HSPCs has not yet advanced to clinical testing, indicating unique challenges in exploiting the HDR pathway for gene therapy in this context.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Devki D. Sukhtankar, Juan Jose Fung, Mi-na Kim, Thomas Cayton, Valerie Chiou, Nina G. Caculitan, Piotr Zalicki, Sujeong Kim, Yoonjung Jo, SoHui Kim, Jae Min Lee, Junhee Choi, SeongGyeong Mun, Ashley Chin, Yongdae Jang, Ji Yeong Lee, Gowoon Kim, Eun Hee Kim, Won-Ki Huh, Jae-Yeon Jeong, Dong-Seung Seen, Pina M. Cardarelli
Summary: Autologous Stem Cell Transplant (ASCT) is a common method for treating hematological malignancies. The combination of G-CSF and GPC-100 shows potential for sufficient and rapid collection of stem cells.
Article
Multidisciplinary Sciences
Runfeng Miao, Harim Chun, Xing Feng, Ana Cordeiro Gomes, Jungmin Choi, Joao P. Pereira
Summary: This study reveals that a complex homeostatic balance between hematopoietic stem cells (HSCs) and hematopoietic progenitor cells is maintained through competition for a limited amount of cell signaling molecule. When early hematopoietic progenitors fail to interact with specific cells, HSC numbers increase.
NATURE COMMUNICATIONS
(2022)
Article
Developmental Biology
Shizheng Zhao, Ao Zhang, Hao Zhu, Zilong Wen
Summary: The study reports the identification and characterization of a new member of the ETS transcription factors, Spi2, in ray-finned fish. It shows that Spi2 is crucial for hematopoietic stem and progenitor cell development and myeloid lineage differentiation. A reporter line is created to track these cells from early development to adulthood.
Article
Cell Biology
Juan Gao, Shuaibing Hou, Shengnan Yuan, Yuxia Wang, Yanan Gao, Xiaolu Sun, Weili Wang, Yajing Chu, Yuan Zhou, Xiaoming Feng, Hongbo R. Luo, Tao Cheng, Jun Shi, Weiping Yuan, Xiaomin Wang
Summary: Research shows that Rheb1-deficiency in neutrophils can remodel the bone marrow environment and induce HSC expansion, possibly by impairing their ability to secrete IL-6, affecting the production of SCF by MSCs, and promoting HSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Marco De Zuani, Jan Fric
Summary: Recent evidence shows that innate immune cells, in addition to B and T cells, can retain immunological memory of their encounters and provide long-term resistance against infections. Hematopoietic stem cells play a crucial role in trained immunity and are influenced by specific cytokines and Toll-like receptor ligands in terms of their memory phenotype and molecular mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Irene Mariam Roy, P. V. Anu, Samantha Zaunz, Srinu Reddi, Aravind M. Giri, Rithika Saroj Sankar, Sarah Schouteden, Joerg Huelsken, Catherine M. Verfaillie, Satish Khurana
Summary: Interaction with microenvironmental factors is crucial for the regulation of hematopoietic stem cell function. In this study, it was found that integrin signaling regulates the expression of SDF-1 alpha through transcriptional regulation. Inhibition of SRC gene or pharmacological inhibition resulted in increased expression of the chemokine SDF-1 alpha. Systemic inhibition of SRC led to increased SDF-1 alpha levels in BM plasma, which improved the homing efficiency of transplanted HSCs and enhanced hematopoietic function.
Article
Cell & Tissue Engineering
Kenji Kitajima, Minako Shingai, Hikaru Ando, Mako Hamasaki, Takahiko Hara
Summary: Researchers developed a novel method for hematopoietic differentiation of human-induced pluripotent stem cells to address the issue of low production of CD38(+) hematopoietic progenitor cells. They found that the lack of FLT3 expression was responsible for this problem and solved it by adding interferon-gamma.
Article
Food Science & Technology
Ana Lemus-Conejo, Mayte Medrano, Sergio Lopez, Maria C. Millan-Linares, Maria A. Rosillo, Jose A. Perez-Simon, Francisco J. G. Muriana, Rocio Abia
Summary: This study reveals that altering the types of fatty acids in the diet can influence the generation and trafficking of immune cells in obesity, with diets rich in MUFAs playing a beneficial role in combating dysfunctional immune systems induced by obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Hematology
Huan Cai, Makoto Kondo, Lakshmi Sandhow, Pingnan Xiao, Anne-Sofie Johansson, Takako Sasaki, Joanna Zawacka-Pankau, Karl Tryggvason, Johanna Ungerstedt, Julian Walfridsson, Marja Ekblom, Hong Qian
Summary: This study demonstrates the critical role of Lama4 in impeding AML progression and chemoresistance. Lama4 deletion results in impaired hematopoiesis regeneration and accelerated AML progression and relapse.
Review
Biochemistry & Molecular Biology
Nattaya Damkham, Surapol Issaragrisil, Chanchao Lorthongpanich
Summary: This review provides an update on the regulation of YAP and TAZ, transcriptional coactivators in the Hippo signaling pathway, in stem cell behaviors and differentiation. It highlights their roles in mechanosensing and mechanotransduction, as well as the importance of understanding how cells perceive and respond to their microenvironment for improving the efficiency and efficacy of stem cell products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Dongwei Guan, Yonghao Yang, Mao Pang, Xinlei Liu, Yang Li, Pengju Huang, Haitao Shang, Hong Wei, Zhijia Ye
Summary: A study found that Indole-3-carboxaldehyde (I3A), a metabolite derived from gut microbiota, can extend the lifespan of mice exposed to high-dose ionizing radiation. Currently, there are limited therapeutic options for the most common and fatal complication of nuclear accidents and radiotherapy, which is persistent myelosuppression. However, it is still unknown whether and how I3A protects against radiation-induced hematopoietic toxicity.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Jessica Doernen, Thomas Dittmar
Summary: Regenerative medicine focuses on investigating therapeutic agents to promote regeneration after injury or in diseases, with MSCs and EVs being of interest for their roles in tissue regeneration. Clinical studies on MSCs have shown conflicting efficacies, and cell fusion may also play a role in regeneration alongside immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Zachary J. DeBruine, Jiyuan Ke, Kaleeckal G. Harikumar, Xin Gu, Peter Borowsky, Bart O. Williams, Wenqing Xu, Laurence J. Miller, H. Eric Xu, Karsten Melcher
GENES & DEVELOPMENT
(2017)
Article
Biochemistry & Molecular Biology
Jianshuang Li, Di Lu, Huadie Liu, Bart O. Williams, Paul A. Overbeek, Brendan Lee, Ling Zheng, Tao Yang
HUMAN MOLECULAR GENETICS
(2017)
Article
Endocrinology & Metabolism
Alexis Bergsma, Sourik S. Ganguly, Daniel Dick, Bart O. Williams, Cindy K. Miranti
Editorial Material
Biochemistry & Molecular Biology
Megan N. Michalski, Bart O. Williams
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Endocrinology & Metabolism
Di Lu, Jianshuang Li, Huadie Liu, Gabrielle E. Foxa, Kevin Weaver, Jie Li, Bart O. Williams, Tao Yang
JOURNAL OF BONE AND MINERAL RESEARCH
(2018)
Article
Multidisciplinary Sciences
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T. H. Yeh, Bart O. Williams, Tao Yang, Ling Zheng
NATURE COMMUNICATIONS
(2018)
Correction
Multidisciplinary Sciences
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T. H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang
NATURE COMMUNICATIONS
(2018)
Article
Multidisciplinary Sciences
Huadie Liu, Jianshuang Li, Di Lu, Jie Li, Minmin Liu, Yuanzheng He, Bart O. Williams, Jiada Li, Tao Yang
SCIENTIFIC REPORTS
(2018)
Editorial Material
Biochemistry & Molecular Biology
Christopher K. Mirabelli, Roel Nusse, David A. Tuveson, Bart O. Williams
Article
Endocrinology & Metabolism
Kevin A. Maupin, Daniel Dick, Johan Lee, Bart O. Williams
CALCIFIED TISSUE INTERNATIONAL
(2020)
Article
Endocrinology & Metabolism
Alexis Bergsma, Sourik S. Ganguly, Mollie E. Wiegand, Daniel Dick, Bart O. Williams, Cindy K. Miranti
Article
Cell & Tissue Engineering
Babita Madan, Mitchell J. McDonald, Gabrielle E. Foxa, Cassandra R. Diegel, Bart O. Williams, David M. Virshup
Article
Cell & Tissue Engineering
Kevin A. Maupin, Kevin Weaver, Alexis Bergsma, Cheryl Christie, Zhendong A. Zhong, Tao Yang, Bart O. Williams
Article
Endocrinology & Metabolism
Bart O. Williams
Article
Endocrinology & Metabolism
Casey J. Droscha, Cassandra R. Diegel, Nicole J. Ethen, Travis A. Burgers, Mitchell J. McDonald, Kevin A. Maupin, Agni S. Naidu, PengFei Wang, Bin T. Teh, Bart O. Williams