Article
Chemistry, Multidisciplinary
Ayesha M. Patel, E. Neil G. Marsh
Summary: The study demonstrates that viperin activates a component of the protein ubiquitination machinery, enhancing TRAF6's ubiquitin transfer activity and increasing important polyubiquitinated forms, suggesting a potential role as an agonist of immune signaling pathways.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Biochemistry & Molecular Biology
Shuangze Han, Ruike Wang, Yangnan Zhang, Xiaoying Li, Yu Gan, Feng Gao, Pengfei Rong, Wei Wang, Wei Li
Summary: This review summarizes the regulatory role of ubiquitination in tumor metastasis, particularly focusing on the important roles of E3 ubiquitin ligases and deubiquitinases, and discusses the relationship between ubiquitination components and tumor progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kankan Wang, Kurt M. Reichermeier, Xing Liu
Summary: The study demonstrates that neddylation plays a significant role in activating CRL2, especially under conditions where CRL2-independent degradation of HIF1 alpha is active. In vitro experiments showed that neddylation promotes CRL2(VHL)-dependent substrate ubiquitination.
Article
Plant Sciences
Xiao-Qing Yang, Wei Li, Zhong-Ying Ren, Jun-Jie Zhao, Xin-Yang Li, Xing-Xing Wang, Xiao-Yu Pei, Yan-Gai Liu, Kun-Lun He, Fei Zhang, Xiong-Feng Ma, Dai-Gang Yang
Summary: This study identified GhSINA1 as a negative regulator in cotton fiber development through its interaction with itself and other GhSINA1 proteins, forming homodimers and heterodimers.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Fisheries
Jian Zhang, Xiangyi Sun, Xuepeng Li, Shuning Zhang, Xiudan Xu, Jixing Feng
Summary: Many viruses hijack the host's ubiquitin-proteasome system (UPS) for successful infection. This study identified and characterized a protein called SmE2D2 in turbot, which interacts with the RBIV-C1 virus. The results show that SmE2D2 is an E2 ubiquitin-conjugating enzyme that is used by RBIV-C1 to promote efficient replication.
Review
Immunology
Luiz Pedro Souza-Costa, Josiane Teixeira Andrade-Chaves, Juvana Moreira Andrade, Vivian Vasconcelos Costa, Luis Henrique Franco
Summary: Innate immunity is the body's first line of defense against infections, but uncontrolled or aberrant inflammatory responses can lead to tissue damage and chronic inflammatory diseases. This review focuses on the importance of ubiquitination in regulating innate immune signaling and inflammation, highlighting the role of the protein Smurf1 and its potential as a therapeutic target for infectious and inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Canbin Xie, Fei Long, Liang Li, Xiaorong Li, Min Ma, Zhixing Lu, Runliu Wu, Yi Zhang, Lihua Huang, Jing Chou, Ni Gong, Gui Hu, Changwei Lin
Summary: PTBP3 plays a critical role in colorectal cancer by stabilizing UBE4A to regulate p53 expression, promoting cell proliferation. This finding provides new evidence for PTBP3 as a prognostic biomarker and therapeutic target for colorectal cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Shidong Zhao, Wenwen Ru, Xinyan Chen, Shanhui Liao, Zhongliang Zhu, Jiahai Zhang, Chao Xu
Summary: C-degrons are critical for targeting receptor proteins of Cullin-RING E3 ligase complexes for protein degradation. FEM1 proteins, including FEM1B, recognize specific Arg/C-degrons such as CDK5R1 and SMCR8. The study reveals the binding mechanism between FEM1B and SMCR8, as well as the role of CRL2(FEM1B) in regulating the lifespan of SMCR8.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Man Pan, Yuanyuan Yu, Huasong Ai, Qingyun Zheng, Yuan Xie, Lei Liu, Minglei Zhao
Summary: A series of high-resolution cryo-EM structures of substrate-bound human p97 AAA ATPase revealed critical conformational changes and 'power-stroke'-like motions in the ATPase rings, shedding light on the central role of p97 in cellular protein homeostasis. The cryo-EM structure of p97 complexed with the inhibitor NMS-873 at a resolution of 2.4 angstrom demonstrated the mechanism of allosteric inhibition by blocking substrate translocation.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Pengcheng Wang, Kai Guo, Qian Su, Jinwu Deng, Xianlong Zhang, Lili Tu
Summary: The E2 enzyme GhUBC2L modulates histone monoubiquitination synergistically with E3 ligase GhUbox8 to control organ size in cotton by affecting the expression of genes related to cell cycle and organ development.
Article
Genetics & Heredity
Hongbiao Ran, Chunyan Li, Ming Zhang, Jincheng Zhong, Hui Wang
Summary: Ubiquitination, a post-transcriptional modification, plays a crucial role in protein degradation and is involved in various physiological and pathological processes, including animal adipogenesis. The E3 ligases have been found to regulate adipogenesis, but their role in the recognition and connection between substrate and ubiquitin during ubiquitination has been overlooked. This review summarizes the regulatory and modification targets of E3 ligases in animal adipogenesis, explains the regulatory mechanisms in lipogenic pathways, and analyzes existing positive results, providing valuable research directions for further understanding the regulatory mechanisms of E3 ligases in animal adipogenesis.
Review
Biochemistry & Molecular Biology
Philip Coffino, Yifan Cheng
Summary: Allostery-regulation at distant sites is a crucial concept in biology, and the proteasome provides multiple examples of this regulation. It can span a long distance, influencing the interactions and assembly of proteasome modules, and explain how diverse populations of proteasome assemblies are built and maintained in cells.
Article
Cell Biology
Michelle Harreman Lehner, Jane Walker, Kotryna Temcinaite, Anna Herlihy, Micheal Taschner, Adam C. Berger, Anita H. Corbett, A. Barbara Dirac Svejstrup, Jesper Q. Svejstrup
Summary: The SMY2 gene and its homologs GIGYF1 and GIGYF2 play crucial regulatory roles in the transcription stress response, affecting the function of key factors such as Cdc48/VCP/p97.
Article
Biochemistry & Molecular Biology
Katarzyna Retzer, Jeanette Moulinier-Anzola, Rebecca Lugsteiner, Nataliia Konstantinova, Maximilian Schwihla, Barbara Korbei, Christian Luschnig
Summary: Intracellular sorting and abundance of plasma membrane proteins are crucial for plants to sense and respond to environmental inputs. The reversible covalent modification by ubiquitin plays a key role in inducing adjustments in protein localization and functionality. The RING DOMAIN LIGASE family, including RGLG1, has been implicated in endocytic vacuolar cargo sorting, and this study provides evidence for their role in cargo trafficking between plasma membrane and endosomal compartments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Lidong Wang, Xiaodan Sun, Jingni He, Zhen Liu
Summary: Ubiquitination is a significant posttranslational modification affecting protein stability and function, with the specificity of substrate recognition determined by ubiquitin E3 ligase. The human Deltex (DTX) protein family, functioning as E3 ligases, has five members and plays crucial roles in various physiological and pathological processes, although there is still limited understanding of their structural features and mechanisms of action despite extensive research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Plant Sciences
Chih-Pin Chiang, Won C. Yim, Ying-Hsuan Sun, Miwa Ohnishi, Tetsuro Mimura, John C. Cushman, Hungchen E. Yen
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Plant Sciences
Li-Wei Ho, Ting-Ting Yang, Shyan-Shu Shieh, Gerald E. Edwards, Hungchen E. Yen
FUNCTIONAL PLANT BIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Shu-Jung Lai, Mei-Chin Lai, Ren-Jye Lee, Yu-Hsuan Chen, Hungchen Emilie Yen
PLANT MOLECULAR BIOLOGY
(2014)
Article
Plant Sciences
Chang-Hua Li, Chih-Pin Chiang, Jun-Yi Yang, Chia-Jou Ma, Yu-Chan Chen, Hungchen Emilie Yen
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Nu-Chuan Huang, Chang-Hua Li, Jun-Yi Lee, Hungchen Emilie Yen
Article
Biochemical Research Methods
Chih-Wei Liu, Tao-Shan Chang, Yu-Kai Hsu, Arthur Z. Wang, Hung-Chen Yen, Yung-Pei Wu, Chang-Sheng Wang, Chien-Chen Lai
Article
Biochemical Research Methods
Chih-Wei Liu, Yu-Kai Hsu, Yu-Hsiang Cheng, Hung-Chen Yen, Yung-Pei Wu, Chang-Sheng Wang, Chien-Chen Lai
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
(2012)
Article
Plant Sciences
Hau-Hsuan Hwang, Chih-Hao Wang, Hsiao-Huei Chen, Jia-Fang Ho, Shin-Fei Chi, Fan-Chen Huang, Hungchen Emilie Yen
Article
Plant Sciences
Hau-Hsuan Hwang, Chih-Hao Wang, Hsiao-Wei Huang, Chih-Pin Chiang, Shin-Fei Chi, Fan-Chen Huang, Hungchen E. Yen
PLANT CELL REPORTS
(2019)
Article
Pharmacology & Pharmacy
Tsing-Fen Ho, Chieh-Ju Ma, Chien-Hsing Lu, Yo-Ting Tsai, Yu-Hong Wei, Jo-Shu Chang, Jun-Kai La, Pin-Ju Cheuh, Chi-Tai Yeh, Pin-Chi Tang, Jinghua Tsai Chang, Jiunn-Liang Ko, Fu-Shing Liu, Hungchen E. Yen, Chia-Che Chang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2007)
Article
Plant Sciences
Y Jou, CP Chiang, GY Jauh, HE Yen
Article
Biochemistry & Molecular Biology
Y Jou, PH Chou, MC He, YH Hung, HCE Yen
PLANT MOLECULAR BIOLOGY
(2004)
Article
Biochemistry & Molecular Biology
Yingtzy Jou, Chih-Pin Chiang, Hungchen Emilie Yen
PLANT SIGNALING & BEHAVIOR
(2013)
Article
Plant Sciences
Yingtzy Jou, Ya-Ling Wang, Hungchen Emilie Yen
FUNCTIONAL PLANT BIOLOGY
(2007)