Evaluation of targeted therapies in advanced breast cancer: the need for large-scale molecular screening and transformative clinical trial designs

Capturing intra-tumor genetic heterogeneity by de novo mutation profiling of circulating cell-free tumor DNA: a proof-of-principle

(2014) L. De Mattos-Arruda et al.   ANNALS OF ONCOLOGY

Plasma circulating tumor DNA as an alternative to metastatic biopsies for mutational analysis in breast cancer

(2014) F. Rothé et al.   ANNALS OF ONCOLOGY

Prospective evaluation of the conversion rate in the receptor status between primary breast cancer and metastasis: results from the GEICAM 2009-03 ConvertHER study

(2014) Eduardo Martínez de Dueñas et al.   BREAST CANCER RESEARCH AND TREATMENT

The AURORA initiative for metastatic breast cancer

(2014) D Zardavas et al.   BRITISH JOURNAL OF CANCER

Mutant p53 in Cancer: New Functions and Therapeutic Opportunities

(2014) Patricia A.J. Muller et al.   CANCER CELL

HER2 aberrations in cancer: Implications for therapy

(2014) Min Yan et al.   CANCER TREATMENT REVIEWS

Anticancer drug development

(2014) Felipe Ades et al.   CURRENT OPINION IN ONCOLOGY

Luminal B Breast Cancer: Molecular Characterization, Clinical Management, and Future Perspectives

(2014) Felipe Ades et al.   JOURNAL OF CLINICAL ONCOLOGY

Comparative genomic hybridisation array and DNA sequencing to direct treatment of metastatic breast cancer: a multicentre, prospective trial (SAFIR01/UNICANCER)

(2014) Fabrice André et al.   LANCET ONCOLOGY

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution

(2014) Peter Eirew et al.   NATURE

Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial

(2013) Olöf Bjarnadottir et al.   BREAST CANCER RESEARCH AND TREATMENT

I-SPY 2 may change how clinical trials are conducted

(2013) Carrie Printz   CANCER

Personalized therapy for breast cancer: a dream or a reality?

(2013) Dimitrios Zardavas et al.   Future Oncology

Single-patient (n-of-1) trials: a pragmatic clinical decision methodology for patient-centered comparative effectiveness research

(2013) Naihua Duan et al.   JOURNAL OF CLINICAL EPIDEMIOLOGY

Designing Transformative Clinical Trials in the Cancer Genome Era

(2013) Stefan Sleijfer et al.   JOURNAL OF CLINICAL ONCOLOGY

Emerging targeted agents in metastatic breast cancer

(2013) Dimitrios Zardavas et al.   Nature Reviews Clinical Oncology

Circulating tumour cells and cell-free DNA as tools for managing breast cancer

(2013) Leticia De Mattos-Arruda et al.   Nature Reviews Clinical Oncology

Discordances in Estrogen Receptor Status, Progesterone Receptor Status, and HER2 Status Between Primary Breast Cancer and Metastasis

(2013) E. Curtit et al.   ONCOLOGIST

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Clinically Used Breast Cancer Markers Such As Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2 Are Unstable Throughout Tumor Progression

(2012) Linda Sofie Lindström et al.   JOURNAL OF CLINICAL ONCOLOGY

Pathologic Complete Response Predicts Recurrence-Free Survival More Effectively by Cancer Subset: Results From the I-SPY 1 TRIAL—CALGB 150007/150012, ACRIN 6657

(2012) Laura J. Esserman et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequence analysis of mutations and translocations across breast cancer subtypes

(2012) Shantanu Banerji et al.   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Molecular prescreening to select patient population in early clinical trials

(2012) Jordi Rodón et al.   Nature Reviews Clinical Oncology

Molecular Alterations Between the Primary Breast Cancer and the Subsequent Locoregional/Metastatic Tumor

(2012) R. Macfarlane et al.   ONCOLOGIST

EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib

(2012) Ryan B. Corcoran et al.   Cancer Discovery

Should liver metastases of breast cancer be biopsied to improve treatment choice?

(2011) G. Curigliano et al.   ANNALS OF ONCOLOGY

Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial

(2011) Sirwan Hadad et al.   BREAST CANCER RESEARCH AND TREATMENT

PI3K Pathway Mutations and PTEN Levels in Primary and Metastatic Breast Cancer

(2011) A. M. Gonzalez-Angulo et al.   MOLECULAR CANCER THERAPEUTICS

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

HER2 status in a population-derived breast cancer cohort: discordances during tumor progression

(2010) Ulla Wilking et al.   BREAST CANCER RESEARCH AND TREATMENT

PIK3CA Mutations May Be Discordant between Primary and Corresponding Metastatic Disease in Breast Cancer

(2010) J. Dupont Jensen et al.   CLINICAL CANCER RESEARCH

Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers

(2010) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists

(2010) Sunil Badve et al.   MODERN PATHOLOGY

Genome remodelling in a basal-like breast cancer metastasis and xenograft

(2010) Li Ding et al.   NATURE

Triple-Negative Breast Cancer

(2010) William D. Foulkes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Does confirmatory tumor biopsy alter the management of breast cancer patients with distant metastases?

(2009) C. Simmons et al.   ANNALS OF ONCOLOGY

A Comparison of Phase II Study Strategies

(2009) S. Hunsberger et al.   CLINICAL CANCER RESEARCH

N-of-1 double-blind, randomized controlled trial of tramadol to treat chronic cough

(2009) Priscila Gebrim Louly et al.   CLINICAL THERAPEUTICS

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

(2009) Sohrab P. Shah et al.   NATURE