Tumor-suppressor NFκB2 p100 interacts with ERK2 and stabilizes PTEN mRNA via inhibition of miR-494

The Chinese Herb Isolate Yuanhuacine (YHL-14) Induces G2/M Arrest in Human Cancer Cells by Up-regulating p21 Protein Expression through an p53 Protein-independent Cascade

(2014) Ruowen Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of p27 upregulates MnSOD in a STAT3-dependent manner, disrupts intracellular redox activity and enhances cell migration

(2014) D. Zhang et al.   JOURNAL OF CELL SCIENCE

Quantitative Dissection and Modeling of the NF-κB p100-p105 Module Reveals Interdependent Precursor Proteolysis

(2014) Zekiye Buket Yılmaz et al.   Cell Reports

Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency

(2013) Karin Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Involvement of Intercellular Adhesion Molecule-1 Up-Regulation in Bradykinin Promotes Cell Motility in Human Prostate Cancers

(2013) Hsin-Shan Yu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NF-κB1 p50 promotes p53 protein translation through miR-190 downregulation of PHLPP1

(2013) Y Yu et al.   ONCOGENE

Structural and Functional Characterization of the Recombinant Death Domain from Death-Associated Protein Kinase

(2013) Evangelos Dioletis et al.   PLoS One

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK

(2013) Peter D. Mace et al.   Nature Communications

Epithelial-to-Mesenchymal Transition Induced by TGF- 1 Is Mediated by Blimp-1-Dependent Repression of BMP-5

(2012) M. Romagnoli et al.   CANCER RESEARCH

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

PTEN at a glance

(2012) Y. Shi et al.   JOURNAL OF CELL SCIENCE

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma

(2012) Luca Busino et al.   NATURE CELL BIOLOGY

Endogenous viruses: insights into viral evolution and impact on host biology

(2012) Cédric Feschotte et al.   NATURE REVIEWS GENETICS

MiR-494 is regulated by ERK1/2 and modulates TRAIL-induced apoptosis in non-small-cell lung cancer through BIM down-regulation

(2012) G. Romano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway

(2012) Azadeh Arabi et al.   Nature Communications

SCFFbw7 Modulates the NFκB Signaling Pathway by Targeting NFκB2 for Ubiquitination and Destruction

(2012) Hidefumi Fukushima et al.   Cell Reports

MicroRNA-494 Downregulates KIT and Inhibits Gastrointestinal Stromal Tumor Cell Proliferation

(2011) W. K. Kim et al.   CLINICAL CANCER RESEARCH

AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

(2010) Eitan Shaulian   CELLULAR SIGNALLING

MicroRNA-494 Targeting Both Proapoptotic and Antiapoptotic Proteins Protects Against Ischemia/Reperfusion-Induced Cardiac Injury

(2010) Xiaohong Wang et al.   CIRCULATION

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

Subtle variations in Pten dose determine cancer susceptibility

(2010) Andrea Alimonti et al.   NATURE GENETICS

Targeting the RAF–MEK–ERK pathway in cancer therapy

(2009) Clara Montagut et al.   CANCER LETTERS

Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide

(2009) Linhua Liu et al.   LIFE SCIENCES

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Stabilization of RelB Requires Multidomain Interactions with p100/p52

(2008) Amanda J. Fusco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Production of NF-κB2 p52 Is Not Tumorigenic but Predisposes Mice to Inflammatory Autoimmune Disease by Repressing Bim Expression

(2008) Zhe Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY