Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer

Targeted Methylation of the Epithelial Cell Adhesion Molecule (EpCAM) Promoter to Silence Its Expression in Ovarian Cancer Cells

(2014) Suneetha Nunna et al.   PLoS One

Directed Evolution of Improved Zinc Finger Methyltransferases

(2014) Brian Chaikind et al.   PLoS One

SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma

(2013) P. M. Bareiss et al.   CANCER RESEARCH

The Epigenetic Modifier Ubiquitin-specific Protease 22 (USP22) Regulates Embryonic Stem Cell Differentiation via Transcriptional Repression of Sex-determining Region Y-box 2 (SOX2)

(2013) Robyn T. Sussman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics and Memory of Heterochromatin in Living Cells

(2012) Nathaniel A. Hathaway et al.   CELL

Cancer epigenomics: beyond genomics

(2012) Juan Sandoval et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epigenetic reprogramming of cancer cells via targeted DNA methylation

(2012) Ashley G. Rivenbark et al.   Epigenetics

Targeting Serous Epithelial Ovarian Cancer with Designer Zinc Finger Transcription Factors

(2012) Haydee Lara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Methylation and Gene Silencing of VEGF-A in Human Cells by Using a Designed Dnmt3a–Dnmt3L Single-Chain Fusion Protein with Increased DNA Methylation Activity

(2012) Abu Nasar Siddique et al.   JOURNAL OF MOLECULAR BIOLOGY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

DNA methylation profiling in the clinic: applications and challenges

(2012) Holger Heyn et al.   NATURE REVIEWS GENETICS

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

(2012) M. L. de Groote et al.   NUCLEIC ACIDS RESEARCH

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer

(2012) Sabine Stolzenburg et al.   NUCLEIC ACIDS RESEARCH

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer

(2011) R Xiang et al.   BRITISH JOURNAL OF CANCER

Silencing chromatin: comparing modes and mechanisms

(2011) Christian Beisel et al.   NATURE REVIEWS GENETICS

Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas

(2011) Marta M. Alonso et al.   PLoS One

TAL Effectors: Customizable Proteins for DNA Targeting

(2011) A. J. Bogdanove et al.   SCIENCE

What an epigenome remembers

(2010) Ulrike C. Lange et al.   BIOESSAYS

SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

(2009) Adam J Bass et al.   NATURE GENETICS

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

The Molecular Mechanism Governing the Oncogenic Potential of SOX2 in Breast Cancer

(2008) Yupeng Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic modifications ofSOX2 enhancers, SRR1 and SRR2, correlate with in vitro neural differentiation

(2008) Marianna Sikorska et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells

(2008) J. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA