Article
Pharmacology & Pharmacy
Xin Meng, Kai Yin, Yue Zhang, Dongxu Wang, Hongmin Lu, Lulu Hou, Hongjing Zhao, Mingwei Xing
Summary: This study found that exposure to microplastics can cause mitochondrial damage, altered antioxidant enzyme activity, inflammation, and necroptosis in the kidneys of chickens. The extent of damage varies with the concentration of microplastics.
Article
Biochemistry & Molecular Biology
Yongjun Hu, Hongwei Pan, Jianqiang Peng, Jin He, Mingxiang Tang, Sulan Yan, Jingjing Rong, Junshan Li, Zhaofen Zheng, Haijun Wang, Yanfu Liu, Xin Zhong
Summary: The study showed that RES attenuates cell necroptosis induced by myocardial hypoxia/reoxygenation injury by inhibiting the TNF-α/RIP1/RIP3/MLKL signaling pathway, leading to increased cell viability and decreased necroptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Immunology
Jianxin Qiu, Xiaohang Zheng, Guoping Cai, Jiajing Ye, Ting Jiang, Lihua Chen, Ze Li, Yuhang Gong, Zhenghua Hong, Haixiao Chen
Summary: This study provides evidence supporting the potential role of AZD8330 in the management of osteoarthritis by attenuating inflammation and regulating the NF-kappa B/P65 signaling pathway to alleviate chondrocyte degradation. The findings from animal experiments and in vitro cell experiments support this conclusion.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhenzhen Yan, Jingwei Dai, Jiayue Wang, Qianxi Feng, Yaguang Wang, Tongye Han, Chen Wu
Summary: In this study, ubiquitination was identified as a post-translational modification on Tollip, and RNF167 was found to be the potential E3 ligase for Tollip. Tollip's ubiquitination plays a crucial role in TNF-a signaling.
Article
Environmental Sciences
Huanhuan Wang, Yao Chen, Xudan Liu, Ruo Zhang, Xiaotong Wang, Qianhui Zhang, Yuting Wei, Fang Fang, Ye Yuan, Qianqian Zhou, Yinqiao Dong, Sainan Shi, Xiaojing Jiang, Xin Li
Summary: This study investigated the mechanisms of microglia activation and TNF-alpha production induced by arsenic in the nervous system. It was found that microglia-derived TNF-alpha induced necroptosis in neuronal cells, suggesting its role in arsenic-related neurotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Pharmacology & Pharmacy
Xia Zhao, Shengchen Wang, Xiaojing Li, Honggui Liu, Shiwen Xu
Summary: Cadmium exposure induced necrotic cell death and ion homeostasis imbalance in swine myocardium. Furthermore, Cd exposure increased LXA4 content, inhibited FPR2 expression, activated TGF-beta pathway, suppressed Nrf2 pathway, and activated NF-kappa B pathway. Cd exposure also increased the expressions of necroptosis-related genes.
Article
Biochemistry & Molecular Biology
Minho Won, Kyeong Ah Park, Sup Kim, Eunjin Ju, Youngbok Ko, Heonjong Yoo, Hyunju Ro, Jaeseob Lee, Junseo Oh, Eun Gyo Lee, Sang Yean Kim, Suk Woo Nam, Han-Ming Shen, Min-Kyung Yeo, Jin Man Kim, Gang Min Hur
Summary: The study shows that ANKRD13a is a novel component in TNF signaling, influencing the threshold of cell death signals and reducing the risk of cell death. Lack of ANKRD13a promotes the formation of complex-II, shifting cell response from survival to death without affecting NF-κB activation.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Immunology
Darshika J. Udawatte, Diane M. M. Lang, Jeffrey R. Currier, Carey L. Medin, Alan L. Rothman
Summary: Dengue virus, a prevalent arthropod-borne virus, targets the human protein RIPK1 to evade the innate immune response. This interaction inhibits the activation of NF-kappa B, a key player in inflammation and cell death. The NS3 protein of DENV is responsible for this suppression, independent of its protease activity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Orthopedics
Xiaoyu Fan, Xin Xu, Xinjie Wu, Runzhi Xia, Fuqiang Gao, Qingyu Zhang, Wei Sun
Summary: In this study, a TNF-alpha-induced ONFH model in human BMECs was established in vitro, and the AptTNF-alpha was shown to protect BMECs from necroptosis by inhibiting the RIP1/RIP3/MLKL signaling pathway.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2022)
Article
Plant Sciences
Yixi Yang, Yujin Zhang, Xun Chen, Zhou Su, Yu Deng, Qi Zhao
Summary: This study explored the bioactivity of Khasianine and showed that it possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Feoktistova, Roman Makarov, Amir S. Yazdi, Diana Panayotova-Dimitrova
Summary: TNF-induced cell death is regulated by RIPK1 and TRADD, with RIPK1 playing a critical role in apoptosis and necroptosis in the absence of IAPs, while TRADD functions as a negative regulator of NIK stabilization and ripoptosome formation. Additionally, MAPK signaling activation does not require RIPK1 and TRADD, and partial repression of NF-kappa B activation in these cells does not sensitize them to TNF due to the lack of NIK stabilization. RIPK1 is essential for preventing TRADD ubiquitination and degradation during TNF signaling, highlighting the intricate balance between cell death and survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Zhijie Li, Heming Wang, Junjin Zhu, Ning Nan, Yi Lin, Xuran Zhuang, Ling Li, Yamin Zhang, Pengyu Huang
Summary: The TWEAK/Tnfrsf12a axis activates RIPK1 in hepatocytes, leading to RIPK1-dependent apoptosis and liver injury in acute liver failure (ALF). Inhibition of either the TWEAK/Tnfrsf12a axis or RIPK1-dependent apoptosis attenuates liver injury, providing a new potential therapeutic target for the treatment of ALF.
CELL DEATH DISCOVERY
(2022)
Article
Cell Biology
James M. Murphy, Kyuho Jeong, Donna L. Cioffi, Pamela Moore Campbell, Hanjoong Jo, Eun-Young Erin Ahn, Ssang-Taek Steve Lim
Summary: The study reveals that focal adhesion kinase (FAK) plays a crucial role in regulating sustained NF-kappa B activation in endothelial cells (ECs) stimulated by tumor necrosis factor-alpha (TNF-alpha). Inhibition of FAK disrupts the formation of TNF-alpha receptor complex-I (TNFRC-I) and diminishes recruitment of downstream proteins, leading to reduced NF-kappa B activity. Targeting FAK may hold promise for treating chronic inflammatory diseases.
Article
Microbiology
Jianxiong Guo, Xiaomin Zhao, Zhihao Liu, Dan Liu, Xiaoyi Tang, Kaili Wang, Mengli Wang, Yong Huang, Dewen Tong
Summary: The study revealed that TGEV-ORF3b counteracted the effects of NF-κ B pathway and TNF-α by regulating miR-885-3p and Bcl-10.
VETERINARY MICROBIOLOGY
(2021)
Article
Food Science & Technology
Kanittha Chantarasakha, Thiti Asawapanumas, Rinrada Suntivich, Atikorn Panya, Natthaporn Phonsatta, Parameth Thiennimitr, Kobkul Laoteng, Surapun Tepaamorndech
Summary: This study demonstrated the anti-inflammatory potential and mechanism of Hatakabb herbal extract, with pyrogallol identified as a novel mediator inhibiting LPS-induced inflammation.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Oncology
Stephan Macher-Goeppinger, Martina Keith, Volker Endris, Roland Penzel, Katrin E. Tagscherer, Sascha Pahernik, Markus Hohenfellner, Humphrey Gardner, Carsten Gruellich, Peter Schirmacher, Wilfried Roth
Article
Gastroenterology & Hepatology
Hendrik Blaeker, Elizabeth Alwers, Alexander Arnold, Esther Herpel, Katrin E. Tagscherer, Wilfried Roth, Lina Jansen, Viola Walter, Matthias Kloor, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2019)
Article
Oncology
Elizabeth Alwers, Hendrik Blaeker, Viola Walter, Lina Jansen, Matthias Kloor, Alexander Arnold, Julia Sieber-Frank, Esther Herpel, Katrin E. Tagscherer, Wilfried Roth, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
Article
Oncology
Melissa Marie Radspieler, Mario Schindeldecker, Philipp Stenzel, Sebastian Foersch, Katrin E. Tagscherer, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Wilfried Roth, Stephan Macher-Goeppinger
Article
Oncology
Min Jia, Yan Zhang, Lina Jansen, Viola Walter, Dominic Edelmann, Melanie Guendert, Katrin E. Tagscherer, Wilfried Roth, Melanie Bewerunge-Hudler, Esther Herpel, Matthias Kloor, Alexis Ulrich, Barbara Burwinkel, Hendrik Blaeker, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
CLINICAL EPIGENETICS
(2019)
Article
Oncology
Steve Z. Martin, Daniel C. Wagner, Nina Hoerner, David Horst, Hauke Lang, Katrin E. Tagscherer, Wilfried Roth
Article
Oncology
Elizabeth Alwers, Lina Jansen, Hendrik Blaeker, Matthias Kloor, Katrin E. Tagscherer, Wilfried Roth, Daniel Boakye, Esther Herpel, Carsten Gruellich, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
MOLECULAR ONCOLOGY
(2020)
Article
Oncology
Philipp J. Stenzel, Mario Schindeldecker, Katrin E. Tagscherer, Sebastian Foersch, Esther Herpel, Markus Hohenfellner, Gencay Hatiboglu, Juergen Alt, Christian Thomas, Axel Haferkamp, Wilfried Roth, Stephan Macher-Goeppinger
TRANSLATIONAL ONCOLOGY
(2020)
Article
Gastroenterology & Hepatology
Elizabeth Alwers, Lina Jansen, Jakob Kather, Efrat Amitay, Hendrik Blaeker, Matthias Kloor, Katrin E. Tagscherer, Wilfried Roth, Esther Herpel, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
Summary: This study found no significant associations between patient and molecular characteristics with tumor response and pCR in rectal cancer patients. However, patients who responded to neoadjuvant treatment had significantly better cancer-specific and overall survival compared to non-responders. Future studies should consider incorporating molecular biomarkers from biopsy samples before neoadjuvant treatment.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Oncology
Anita Thomas, Sascha Reetz, Philipp Stenzel, Katrin Tagscherer, Wilfried Roth, Mario Schindeldecker, Martin Michaelis, Florian Rothweiler, Jindrich Cinatl, Jaroslav Cinatl Jr, Robert Dotzauer, Olesya Vakhrusheva, Maarten Albersen, Stephan Macher-Goeppinger, Axel Haferkamp, Eva Juengel, Andreas Neisius, Igor Tsaur
Summary: Penile cancer is a rare but aggressive malignancy, which can be successfully cured by surgery in localized diseases but lacks effective options for metastatic diseases. The study evaluated the value of selected members of the PI3K/mTOR/AKT pathway as tumor markers or therapeutic targets for penile cancer, finding that AKT and pmTOR expression were associated with tumor grade and prognosis, with capivasertib showing significant therapeutic effects in PeCa cell lines.
Meeting Abstract
Urology & Nephrology
Anita Thomas, Sascha Reetz, Katrin Tagscherer, Axel Haferkamp, Philipp Stenzel, Stephan Macher-Goeppinger, Silvia Regina Rogatto, Maarten Albersen, Joren Vanthoor, Eva Juengel, Igor Tsaur
JOURNAL OF UROLOGY
(2020)
Meeting Abstract
Medicine, Research & Experimental
Franziska Gach, Aurelie Fernandez, Katrin Tagscherer, Sabrina Schecher, Esther Huettermann, Achim Heintz, Wilfried Roth, Sebastian Foersch
LABORATORY INVESTIGATION
(2020)
Meeting Abstract
Pathology
Franziska Gach, Aurelie Fernandez, Katrin Tagscherer, Sabrina Schecher, Esther Huettermann, Achim Heintz, Wilfried Roth, Sebastian Foersch
Meeting Abstract
Oncology
A. Elizabeth, L. Jansen, B. Hendrik, M. Kloor, K. Tagscherer, W. Roth, D. Boakye, E. Herpel, C. Gruellich, J. Chang-Claude, H. Brenner, M. Hoffmeister
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
M. Jia, Y. Zhang, L. Jansen, V. Walter, D. Edelmann, M. Maierthaler, K. Tagscherer, W. Roth, M. Bewerunge-Hudler, E. Herpel, M. Kloor, A. Ulrich, B. Burwinkel, H. Blaeker, J. Chang-Claude, H. Brenner, M. Hoffmeister
ANNALS OF ONCOLOGY
(2017)