Article
Infectious Diseases
Sarah Amele, Anastasia Karachalia Sandri, Alison Rodger, Linos Vandekerckhove, Thomas Benfield, Ana Milinkovic, Claudine Duvivier, Hans-Jurgen Stellbrink, Helen Sambatakou, Nikoloz Chkhartishvili, Luis Caldeira, Monserrat Laguno, Pere Domingo, Gilles Wandeler, Martin Gisinger, Elena Kuzovatova, Gordana Dragovic, Brygida Knysz, Raimonda Matulionyte, Jurgen Kurt Rockstroh, Jens Dilling Lundgren, Amanda Mocroft, Lars Peters
Summary: Among HIV/HCV-coinfected individuals in Europe, 7.3% were reinfected with HCV within 24 months of achieving SVR, with evidence suggesting that this is decreasing over time and with use of newer HCV regimens. Harm reduction to reduce reinfection and surveillance to detect early reinfection with an offer of treatment are essential to eliminate HCV.
Article
Immunology
Erich S. Tusch, Lene Ryom, Olga Fursa, Lars Peters, Lars Ostergaard, Eric Florence, Simon Edwards, Christian Hoffmann, Helen Sambatakou, Peter Reiss, Eduardo Shahar, Dag Henrik Reikvam, Brigitte Schmied, Dzmitry Paduta, Alexei Yakovlev, Janos Szlavik, Jovan Ranin, Kai Zilmer, Vilma Uzdaviniene, Annegret Pelchen-Matthews, Amanda Mocroft, Joanne Reekie
Summary: This study aimed to investigate the incidence and risk factors of mortality among people with HIV due to suicide, substance use, and violence/accident. The results showed that a recent AIDS diagnosis and HIV infection acquired through injection drug use were associated with an increased risk of death due to substance use and violent/accidental deaths.
Article
Multidisciplinary Sciences
Louise Thorlacius-Ussing, Patrick Terrence Brooks, Henrik Nielsen, Bitten Aagaard Jensen, Lothar Wiese, Susanne Gjorup Saekmose, Stine Johnsen, Mikkel Gybel-Brask, Isik S. Johansen, Mie Topholm Bruun, Nina Breinholdt Staerke, Lars Ostergaard, Christian Erikstrup, Sisse Rye Ostrowski, Keld Mikkelsen Homburg, Jorgen Georgsen, Susan Mikkelsen, Hakon Sandholdt, Caecilie Leding, Nichlas Hovmand, Clara Lundetoft Clausen, Michaela Tinggaard, Karen Brorup Heje Pedersen, Katrine Kjaer Iversen, Sandra Tingsgard, Simone Bastrup Israelsen, Thomas Benfield
Summary: Passive immunotherapy with convalescent plasma does not affect clinical progression, survival, or length of hospitalization in patients with COVID-19 pneumonia.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Jane Agergaard, Benjamin Yamin Ali Khan, Thomas Engell-Sorensen, Berit Schiottz-Christensen, Lars ostergaard, Eva K. Hejbol, Henrik D. Schroder, Henning Andersen, Jakob Udby Blicher, Thomas Holm Pedersen, Thomas Harbo, Hatice Tankisi, M. U. L. T. I. C. O. V. Consortium MULTICOV Consortium
Summary: This study examined 84 patients with long COVID using qEMG and sfEMG, and performed muscle biopsies in a subset of patients. The results showed that the mean MUP duration was decreased in >= 1 muscles in 52% of the patients, and the mean jitter was increased in 17% of the patients in the tibialis anterior and 25% in the extensor digitorum communis. Muscle biopsies revealed damage of terminal nerves and motor endplate with abundant basal lamina material. These findings suggest a muscle pathophysiology behind fatigue in long COVID.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Immunology
Maarten van Wijhe, Kamille Fogh, Steen Ethelberg, Kasper Karmark Iversen, Henrik Nielsen, Lars Ostergaard, Berit Andersen, Henning Bundgaard, Charlotte S. Jorgensen, Bibi F. Ss Scharff, Svend Ellermann-Eriksen, Isik S. Johansen, Anders Fomsgaard, Tyra Grove Krause, Lothar Wiese, Thea K. Fischer, Kare Molbak, Thomas Benfield, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Anders Koch, Christian Erikstrup, Anne-Marie Vangsted, Anna Irene Vedel Sorensen, Henrik Ullum, Robert Leo Skov, Lone Simonsen, Susanne Dam Nielsen
Summary: This study assessed the burden of long COVID among nonhospitalized adults with PCR-confirmed SARS-CoV-2 infection. The results showed that 25 out of 100 cases reported at least one long-COVID symptom. Infected individuals had worse general health, higher odds of various symptoms, particularly loss of taste and smell, and significantly reduced physical and mental health. Female sex and severity of infection were identified as major risk factors for long COVID.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Microbiology
Kamille Fogh, Alexandra R. R. Eriksen, Tine Graakjaer Larsen, Rasmus B. Hasselbalch, Henning Bundgaard, Bibi F. S. S. Scharff, Susanne D. Nielsen, Charlotte S. Jorgensen, Christian Erikstrup, Lars ostergaard, Svend Ellermann-Eriksen, Berit Andersen, Henrik Nielsen, Isik S. Johansen, Lothar Wiese, Lotte Hindhede, Susan Mikkelsen, Susanne G. Saekmose, Bitten Aagaard, Dorte K. Holm, Lene Harritshoj, Lone Simonsen, Thea K. Fischer, Fredrik Folke, Freddy Lippert, Sisse R. Ostrowski, Thomas Benfield, Kare Molbak, Steen Ethelberg, Anders Koch, Anne-Marie Vangsted, Tyra Grove Krause, Anders Fomsgaard, Henrik Ullum, Robert Skov, Kasper Iversen
Summary: This study investigated the immunity against COVID-19, risk factors, and behavior among employees in day care facilities and preschools (DCS) in Denmark. The study found that DCS staff had a higher risk of exposure within their own household than at their workplace. The study also found that most employees expressed fear of contracting COVID-19 and there was limited use of personal protective equipment at work.
MICROBIOLOGY SPECTRUM
(2023)
Article
Medicine, Research & Experimental
Maria Lange Pedersen, Dennis Vestergaard Pedersen, Mikael Becher Lykkegaard Winkler, Heidi Gytz Olesen, Ole Schmeltz Sogaard, Lars Ostergaard, Nick Stub Laursen, Anna Halling Folkmar Rahimic, Martin Tolstrup
Summary: The complement system, an important part of the innate immune response, can be utilized to eliminate HIV-1-infected cells. Researchers developed a new therapeutic approach, a bispecific complement engager (BiCE), which can direct complement activity to the surface of HIV-1-infected cells. This BiCE has shown the ability to increase complement deposition and mediate complement-dependent cytotoxicity (CDC) of HIV-1-infected cells.
EMBO MOLECULAR MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Anne Tvilum, Mikkel Johansen, Laerke N. Glud, Diana M. Ivarsen, Amanda B. Khamas, Sheiliza Carmali, Snehit Satish Mhatre, Ane B. Sogaard, Emma Faddy, Lisanne de Vor, Suzan H. M. Rooijakkers, Lars Ostergaard, Nis P. Jorgensen, Rikke L. Meyer, Alexander N. Zelikin
Summary: In this study, antibody-drug conjugates (ADCs) containing mitomycin C, an anti-neoplastic drug with antimicrobial properties, were engineered to target bacteria in biofilms. The ADCs released the drug without entering the bacterial cells, likely through interaction with thiols on the bacterial cell surface. The targeted ADCs showed superior antimicrobial effects compared to non-specific counterparts in vitro, in biofilms, and in an in vivo osteomyelitis model. These findings have significant translational potential for the development of ADCs as a treatment for bacterial biofilm infections.
Article
Immunology
Wendy P. Bannister, Dorthe Raben, Palle Valentiner-Branth, Martin Tolstrup, Lykke Larsen, Britta Tarp, Mette Brouw Iversen, Ole Schmeltz Sogaard, Sisse Rye Ostrowski, Nina Breinholt Staerke, Marie Louise Jakobsen, Susan Olaf Lindvig, Maria Ruwald Juhl, Isik Somuncu Johansen, Ahmed B. Mustafa, Lars Ostergaard, Fredrikke Dam Larsen, Lene Surland Knudsen, Vibeke Klastrup, Lothar Wiese, Thomas Benfield, Kristine Toft Petersen, Kasper K. Iversen, Henrik Nielsen, Joanne Reekie, Jens Lundgren
Summary: Concerns about side effects may contribute to vaccine hesitancy, but knowing that SARS-CoV-2 vaccines can lead to a stronger immune response may encourage more individuals to get vaccinated. Severe adverse reactions were associated with a stronger antibody response after the second vaccine dose, but not after the first. Regardless of side effects, most people experienced an effective immune response following vaccination.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Virology
Kristoffer Skaalum Hansen, Sofie Eg Jorgensen, Morten Kelder Skouboe, Jane Agergaard, Berit Schiottz-Christensen, Line Khalidan Vibholm, Martin Tolstrup, Lars Ostergaard, Steffen Leth, Trine H. Mogensen
Summary: Long COVID is an emerging global health concern, and its underlying mechanism and pathophysiology are still unclear. This study found that autoantibodies against type 1 interferons in patients with Long COVID do not contribute to the symptoms.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jesper D. Gunst, Jesper F. Hojen, Marie H. Pahus, Miriam Rosas-Umbert, Birgitte Stiksrud, James H. Mcmahon, Paul W. Denton, Henrik Nielsen, Isik S. Johansen, Thomas Benfield, Steffen Leth, Jan Gerstoft, Lars Ostergaard, Mariane H. Schleimann, Rikke Olesen, Henrik Stovring, Line Vibholm, Nina Weis, Anne M. Dyrhol-Riise, Karen B. H. Pedersen, Jillian S. Y. Lau, Dennis C. Copertino, Noemi Linden, Tan T. Huynh, Victor Ramos, R. Brad Jones, Sharon R. Lewin, Martin Tolstrup, Thomas A. Rasmussen, Michel C. Nussenzweig, Marina Caskey, Dag Henrik Reikvam, Ole S. Sogaard
Summary: In people with HIV-1 undergoing antiretroviral treatment interruption, combining lefitolimod with broadly neutralizing antibodies (bNAbs) did not delay viral rebound beyond that achieved with bNAbs alone, raising the question of how to optimize combination immunotherapy to control HIV-1.
Article
Multidisciplinary Sciences
Stine Sofie Frank Lende, Nanna Mller Barnkob, Randi Westh Hansen, Harsh Bansia, Mike Vestergaard, Frederik Holm Rothemejer, Anne Worsaae, Deijona Brown, Maria Lange Pedersen, Anna Halling Folkmar Rahimic, Anna Karina Juhl, Torben Gjetting, Lars Ostergaard, Amedee Des Georges, Laurent-Michel Vuillard, Mariane Hgsbjerg Schleimann, Klaus Koefoed, Martin Tolstrup
Summary: By analyzing samples from convalescent individuals, researchers have identified a cluster of activated B cells enriched for SARS-CoV-2 neutralizing antibodies. These antibodies, which bind to the receptor binding motif of the virus, show prophylactic efficacy in vivo.
Article
Multidisciplinary Sciences
Mikkel Illemann Johansen, Soren Jensen Rahbek, Soren Jensen-Fangel, Gabriel Antonio S. Minero, Louise Kruse Jensen, Ole Halfdan Larsen, Lise Tornvig Erikstrup, Anders Marthinsen Seefeldt, Lars J. Ostergaard, Rikke Louise J. Meyer, Nis Pedersen J. Jorgensen
Summary: We developed a rat model of prosthetic vascular graft infection and evaluated whether tPA could enhance antibiotic therapy. The combination of vancomycin and rifampicin was more effective than vancomycin monotherapy, while the addition of tPA did not significantly reduce bacterial load or increase cure rate.
Article
Medicine, General & Internal
Christina V. Konrad, Emma F. Iversen, Jesper D. Gunst, Ida Monrad, Andreas Holleufer, Rune Hartmann, Lars J. Ostergaard, Ole S. Sogaard, Mariane H. Schleimann, Martin Tolstrup
Summary: In this study, we have developed an immunotherapy technology that utilizes vaccination-induced CTLs to be redirected and kill antigen-expressing target cells through RoVER. This technology is highly specific and eliminates the need for adoptive transfer of CTLs.
Article
Multidisciplinary Sciences
Eva A. M. Baerends, Astrid K. Hvidt, Joanne Reekie, Ole S. Sogaard, Nina B. Staerke, Dorthe Raben, Henrik Nielsen, Kristine T. Petersen, Maria R. Juhl, Isik S. Johansen, Susan O. Lindvig, Lone W. Madsen, Lothar Wiese, Lene S. Knudsen, Mette B. Iversen, Thomas Benfield, Kasper K. Iversen, Sidsel D. Andersen, Anna K. Juhl, Lisa L. Dietz, Signe R. Andreasen, Thea K. Fischer, Christian Erikstrup, Palle Valentiner-Branth, Jens Lundgren, Lars Ostergaard, Martin Tolstrup
Summary: SARS-CoV-2 Omicron is rapidly spreading globally, even in regions with high vaccination coverage. A study found that high levels of vaccine-induced antibodies provide partial protection against Omicron breakthrough infections. This is important knowledge to further understand the threshold for protection against new variants and to determine the necessity and timing of booster vaccination.
