Article
Pharmacology & Pharmacy
Ling Liu, Jinglei Xu, Ziyu Zhai, Mengyao Cao, Zile Huang, Yihao Xing, Jingjing Chen
Summary: The study found that JS-K could induce cell G2/M arrest through PTEN-mediated inhibition of the PI3K/Akt pathway, leading to apoptosis of hepatocellular carcinoma cells and inhibition of tumor growth. However, the effects of G2/M cell arrest and inhibition induced by JS-K could be reversed by bpv(pic) and Carboxy-PTIO.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guangya Xu, Xueling Yan, Zhongjia Hu, Lulu Zheng, Ke Ding, Yamei Zhang, Yi Qing, Tao Liu, Lijia Cheng, Zheng Shi
Summary: Glucocappasalin (GCP) from Descurainia sophia seeds shows potential antitumor activity in HeLa cervical carcinoma cells. GCP induces cell cycle G2/M-phase arrest, apoptosis, and autophagy by acting on the PI3K/AKT/mTOR signaling pathways, making it a promising agent for cervical cancer eradication.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jia Liu, Liangyan Deng, Lingyu Wang, Die Qian, Chengxun He, Qiang Ren, Qing Zhang, Yunhui Chen
Summary: The study suggests that Licochalcone A (LCA) has great therapeutic potential for esophageal cancer (EC) by regulating the p53 signaling pathway to induce cell cycle arrest and apoptosis. In vitro experiments showed that LCA inhibited EC cell proliferation, migration, and invasion, and promoted apoptosis. In vivo experiments demonstrated that LCA administration inhibited tumor growth without causing significant toxicities.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Huan Liu, Wenchao Zhang, Lijie Jin, Shasha Liu, Liying Liang, Yanfei Wei
Summary: This study investigates the anticancer mechanism of Plumbagin (PLB) and its potential connections with oxidative stress, genotoxicity, and cell cycle arrest. The results indicate that PLB significantly inhibits HCC cell viability and colony formation, induces G2/M cell cycle arrest, oxidative stress, and DNA damage. These effects can be attenuated by NAC pretreatment. PLB triggers a DNA damage response by activating ATM, Chk1, Chk2, and p53. Furthermore, the key modulator of the G2/M transition factor, cdc25C, is downregulated in an ROS-dependent manner. Inhibition of the ATM-p53 pathway can reduce the occurrence of G2/M cell cycle arrest. Therefore, ROS-mediated oxidative stress plays a crucial role in PLB-induced G2/M cell cycle arrest mediated by the ATM-p53 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sai-Fung Chung, Suet-Ying Tam, Chi-Fai Kim, Hiu-Chi Chong, Leo Man-Yuen Lee, Yun-Chung Leung
Summary: Gastric cancer is a common malignant tumor with high mortality, and BCA-M-PEG20 shows potential as an effective drug against gastric cancer by inhibiting cell growth and inducing apoptosis.
INVESTIGATIONAL NEW DRUGS
(2022)
Article
Oncology
Yuhang Bao, Xiuxian Wu, Xinghua Jin, Akihiro Kanematsu, Michio Nojima, Yoshiyuki Kakehi, Shingo Yamamoto
Summary: Apigenin has inhibitory effects on renal cell carcinoma (RCC), suppressing cell growth and inducing cell cycle arrest. It shows potential as a novel therapeutic strategy for RCC treatment due to its anticancer activity and ability to modulate the cell cycle.
Article
Cell Biology
Tzu-Chien Lin, Ping-Jung Chung, Chen-An Shen, Thi My Hang Nguyenb, Yi-Syuan Lin, Shih-Chieh Lin, Shih-Chuan Hsiao, Wen-Tai Chiu
Summary: Intracellular calcium regulates the function of FOXM1, a transcription factor involved in cancer development. Depletion of calcium causes FOXM1 to aggregate on the nuclear envelope, and it is affected by the activity of exportin 1. Reduced calcium leads to increased SUMOylation of FOXM1, which is responsible for its sequestration.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Zhanqi Dong, Xinling Zhang, Miao Xiao, KeJie Li, Jie Wang, Peng Chen, Zhigang Hu, Cheng Lu, Minhui Pan
Summary: Bombyx mori nucleopolyhedrovirus (BmNPV) arrests the cell cycle in the G2/M phase to promote virus replication, with viral protein LEF-11 inhibiting host cell proliferation by targeting cell cycle checkpoint proteins and interacting with BmIMPI to regulate cell proliferation.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Tai-Hsin Tsai, Cheng-Yu Tsai, Sin-Hua Moi, Chieh-Hsin Wu, Kuan-Ting Lee, Yi-Chiang Hsu, Yu-Feng Su
Summary: CDDO-dhTFEA has anticancer effects on glioblastoma cells by reducing cell proliferation and regulating cell cycle proteins. It induces G2/M cell cycle arrest and inhibits proliferation in U87MG and GBM8401 cells.
Article
Entomology
Qin Xiao, Zhan-Qi Dong, Yan Zhu, Qian Zhang, Xiu Yang, Miao Xiao, Peng Chen, Cheng Lu, Min-Hui Pan
Summary: Our study demonstrated that Bombyx mori nucleopolyhedrovirus (BmNPV) induces G2/M phase arrest in insect cells by downregulating BmCDK1 and BmCyclin B, essential for its replication. The interaction of BmNPV IAP1 with BmCDK1 was confirmed, suggesting a mechanism through which BmNPV impacts cell cycle progression. These findings enhance our understanding of virus-host interaction and provide a potential target gene linking apoptosis and the cell cycle.
Article
Chemistry, Multidisciplinary
Zhiping He, Xingquan Liu, Fenghua Wu, Shaozhen Wu, Gary O'Neal Rankin, Ivan Martinez, Yon Rojanasakul, Yi Charlie Chen
Summary: The study demonstrated that gallic acid (GA) can inhibit ovarian cancer cell proliferation by promoting apoptosis and blocking cell cycle progression, indicating its potential preventive and therapeutic effects in ovarian cancer.
APPLIED SCIENCES-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Shuai Man, Zhuzhu Wu, Rui Sun, Qi Guan, Zengqiang Li, Daiying Zuo, Weige Zhang, Yingliang Wu
Summary: The novel SMART analog W436 showed higher solubility, stability, and antitumor activity against HCC cells compared to SMART. It inhibited cell proliferation in a dose-dependent manner, with superior anticancer effects and mechanisms involving G2/M cell cycle arrest, apoptosis, and suppression of autophagy and epithelial-to-mesenchymal transition. W436 has promising potential for therapeutic treatment of HCC.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Luyang Han, Yuting Wu, Fangming Liu, Hongbing Zhang
Summary: The aberrant activation of the mTOR signaling pathway can lead to tumor growth by stimulating translation initiation and protein synthesis. This study investigated the potential of eFT226, a selective inhibitor of eIF4A-mediated translation, in treating mTOR hyperactive cells caused by the deletion of TSC1/2 or PTEN. Results showed that eFT226 effectively inhibited the proliferation of Tsc2- and Pten-deficient cells by inducing necroptosis and G2/M phase arrest. Additionally, eFT226 blocked the development of TSC2-deficient tumors. Overall, these findings suggest that eFT226, as a translation initiation inhibitor, holds promise in the treatment of hyperactive mTOR-mediated tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Mengjiao Hao, Yijun Guo, Zhikang Zhang, Huihao Zhou, Qiong Gu, Jun Xu
Summary: This study discovers the anti-cancer effect of compound 5o on colorectal cancer cells. It inhibits cell proliferation and induces apoptosis through multiple signaling pathways. The target of compound 5o is identified as GRP94.
BIOORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Soyeon Shin, Kyungeun Kim, Hwa-Ryeon Kim, Kris Ylaya, Sung-Im Do, Stephen M. Hewitt, Hee-Sae Park, Jae-Seok Roe, Joon-Yong Chung, Jaewhan Song
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Hyeon-Gu Kang, Won-Jin Kim, Hyeok-Gu Kang, Kyung-Hee Chun, Seok-Jun Kim
MOLECULAR CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Sang Ah Yi, Dong Hoon Lee, Go Woon Kim, Hyun-Wook Ryu, Jong Woo Park, Jaecheol Lee, Jihoon Han, Jee Hun Park, Hwamok Oh, Jieun Lee, Junjeong Choi, Hyun-Soo Kim, Hyeok Gu Kang, Da-Hyun Kim, Kyung-Hee Chun, Jueng Soo You, Jeung-Whan Han, So Hee Kwon
CELL DEATH AND DIFFERENTIATION
(2020)
Article
Oncology
Hyeon-Gu Kang, Won-Jin Kim, Myung-Giun Noh, Kyung-Hee Chun, Seok-Jun Kim
Article
Biochemistry & Molecular Biology
Hana Lee, Won-Jin Kim, Hyeon-Gu Kang, Jun-Ho Jang, Il Ju Choi, Kyung-Hee Chun, Seok-Jun Kim
Summary: The study found that LAMB1 is upregulated in gastric cancer and contributes to cell growth and motility. The expression level of LAMB1 is closely associated with the prognosis of patients with gastric cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jung-Hwan Baek, Da-Hyun Kim, Jaegyeong Lee, Seok-Jun Kim, Kyung-Hee Chun
Summary: Galectin-1 plays a crucial role in adipogenesis and lipid accumulation by increasing PPAR gamma expression and activation, exacerbating obesity in mice fed a high-fat diet. Knockout of Galectin-1 gene can reduce body weight and adipose tissue mass, lower fasting glucose levels, and downregulate lipogenic genes.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Dong Hoon Lee, Go Woon Kim, Jung Yoo, Sang Wu Lee, Yu Hyun Jeon, So Yeon Kim, Hyeok Gu Kang, Da-Hyun Kim, Kyung-Hee Chun, Junjeong Choi, So Hee Kwon
Summary: The study reveals the crucial role of KDM4C in glioblastoma, showing that its inhibition can effectively suppress tumor proliferation and formation. KDM4C modulates tumor cell growth and apoptosis by demethylating p53 and activating c-Myc in glioblastoma cells.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Seok-Jun Kim, Hyeok-Gu Kang, Kyungeun Kim, Hoyoung Kim, Fredrik Zetterberg, Young Soo Park, Hyun-Soo Cho, Stephen M. Hewitt, Joon-Yong Chung, Ulf J. Nilsson, Hakon Leffler, Kyung-Hee Chun
Summary: The study demonstrates that galectin-3 mediates the crosstalk between the WNT and STAT3 signaling pathways. The specific galectin-3 inhibitor GB1107 shows potential anti-tumor activity against gastric cancer. Further research is needed for its clinical application in gastric cancer therapy.
Article
Dermatology
Min Jung Lee, Gaurav Agrahari, Hae-Young Kim, Eun-Joo An, Kyung-Hee Chun, Hyeokgu Kang, Yeon-Soo Kim, Chul Whan Bang, Lee-Jung Tak, Tae-Yoon Kim
Summary: The study showed that extracellular superoxide dismutase (EC-SOD) can prevent skin aging by promoting collagen production. Overexpression of EC-SOD increased skin thickness and collagen expression, making it a potential target for antiaging therapy in the skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jinho Seo, Young Woo Nam, Seongmi Kim, Doo-Byoung Oh, Jaewhan Song
Summary: Necroptosis is a form of programmed necrosis mediated by cytokines and pattern recognition receptors, leading to extreme inflammatory responses and playing important roles in inflammatory diseases. Understanding the molecular regulatory mechanisms of necroptosis can potentially lead to new therapies for autoimmune and neuroinflammatory conditions. Drugs targeting key mediators of the necroptosis signaling pathway are already in clinical development for the treatment of inflammatory disorders like psoriasis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Yesol Kim, Je Yeong Ko, Soo-Been Lee, Sumin Oh, Jee Won Park, Hyeok-Gu Kang, Da-Hyun Kim, Daeun Chung, Sera Lim, Hyunkyung Kong, Jongmin Kim, Kyung Hyun Yoo, Wonshik Han, Kyung-Hee Chun, Jong Hoon Park
Summary: The study identifies miR-371b-5p as a tumor-suppressive miRNA that regulates the CSDE1/Rac1 axis to inhibit the growth and invasion of TNBC cells. MiR-371b-5p has the potential to be a prognostic biomarker for TNBC.
Article
Biochemistry & Molecular Biology
Min-Seon Hwang, Jung-Hwan Baek, Jun-Kyu Song, In Hye Lee, Kyung-Hee Chun
Summary: Obesity increases the risk of mortality and morbidity due to hypertension, heart disease, and type 2 diabetes. Tschimganidine, a compound from the Umbel-liferae family, has been found to inhibit adipogenesis. In mice experiments, tschimganidine reduced lipid accumulation, improved glucose metabolism, and showed potential as an anti-obesity agent.
Article
Biochemistry & Molecular Biology
Soohyun Lee, Yoonjeong Jeong, Jae-Seok Roe, Hoyoung Huh, Sang Hoon Paik, Jaewhan Song
Summary: Callyspongiolide R form induces caspase-independent cancer cell death by inhibiting mitochondrial complex, leading to autophagy, and shows synergistic effects when combined with other anti-cancer drugs.
Article
Biochemistry & Molecular Biology
Da-Hyun Kim, Hyun-Woo Lee, Hyun-Woo Park, Han-Woong Lee, Kyung-Hee Chun
Review
Biochemistry & Molecular Biology
Seok-Jun Kim, Kyung-Hee Chun