Focal adhesion kinase-promoted tumor glucose metabolism is associated with a shift of mitochondrial respiration to glycolysis

A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells

(2014) Jianliang Zhang et al.   CELL CYCLE

FOXM1 Promotes the Warburg Effect and Pancreatic Cancer Progression via Transactivation of LDHA Expression

(2014) J. Cui et al.   CLINICAL CANCER RESEARCH

Monocarboxylate Transporter 4 Facilitates Cell Proliferation and Migration and Is Associated with Poor Prognosis in Oral Squamous Cell Carcinoma Patients

(2014) Jiang Zhu et al.   PLoS One

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Metabolism addiction in pancreatic cancer

(2014) R Blum et al.   Cell Death & Disease

Inhibiting the Interaction of cMET and IGF-1R with FAK Effectively Reduces Growth of Pancreatic Cancer Cells in vitro and in vivo

(2013) Deniz A. Ucar et al.   Anti-Cancer Agents in Medicinal Chemistry

Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression

(2013) Antonio F. Santidrian et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo imaging of glucose uptake and metabolism in tumors

(2013) Simon Walker-Samuel et al.   NATURE MEDICINE

The role of FAK in tumor metabolism and therapy

(2013) Jianliang Zhang et al.   PHARMACOLOGY & THERAPEUTICS

RHOA-FAK Is a Required Signaling Axis for the Maintenance of KRAS-Driven Lung Adenocarcinomas

(2013) Georgia Konstantinidou et al.   Cancer Discovery

Clinical Importance and Potential Use of Small Molecule Inhibitors of Focal Adhesion Kinase

(2012) Alexander Schultze et al.   Anti-Cancer Agents in Medicinal Chemistry

Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas

(2012) K. R. Keshari et al.   CANCER RESEARCH

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

(2012) Kristy K. Ward et al.   CLINICAL & EXPERIMENTAL METASTASIS

BTG2 suppresses cancer cell migration through inhibition of Src-FAK signaling by downregulation of reactive oxygen species generation in mitochondria

(2012) Seo-Kyung Lim et al.   CLINICAL & EXPERIMENTAL METASTASIS

α-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations

(2012) Àngels Díaz-Ramos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

(2011) Alan Serrels et al.   INTERNATIONAL JOURNAL OF CANCER

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

A role for focal adhesion kinase in cardiac mitochondrial biogenesis induced by mechanical stress

(2010) Thais F. Tornatore et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Caveolin-1 and integrin β1 regulate embryonic stem cell proliferation via p38 MAPK and FAK in high glucose

(2010) Sang Hun Lee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circulating Autoantibodies to Phosphorylated α-Enolase are a Hallmark of Pancreatic Cancer

(2010) Barbara Tomaino et al.   JOURNAL OF PROTEOME RESEARCH

The FERM domain: organizing the structure and function of FAK

(2010) Margaret C. Frame et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting of the protein interaction site between FAK and IGF-1R

(2009) Donghang Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Focal adhesion kinase (FAK) activates and stabilizes IGF-1 receptor

(2009) Sandra Andersson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial cell–laminin interaction: modulation of LDH expression involves α6β4 integrin–FAK–p38MAPK pathway

(2008) P. R. Sudhakaran et al.   GLYCOCONJUGATE JOURNAL

Antixenograft tumor activity of a humanized anti-insulin-like growth factor-I receptor monoclonal antibody is associated with decreased AKT activation and glucose uptake

(2008) Y. Shang et al.   MOLECULAR CANCER THERAPEUTICS

Pyruvate kinase M2 is a phosphotyrosine-binding protein

(2008) Heather R. Christofk et al.   NATURE

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE