Review
Biochemistry & Molecular Biology
Natthaphat Siri-Angkul, Behzad Dadfar, Riya Jaleel, Jazna Naushad, Jaseela Parambathazhath, Angelia Doye, Lai-Hua Xie, Judith Gwathmey
Summary: Heart failure remains a major issue globally, with efforts by clinicians and scientists to find effective treatments and cures not yet yielding major breakthroughs. The heart is not simply a pump, and treating heart failure requires consideration of its pathophysiological complexity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Benjamin Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, Maria E. Andres, Patrick Yu-Wai-Man, Gyoergy Hajnoczky, Veronica Eisner
Summary: Autosomal Dominant Optic Atrophy (ADOA), caused by OPA1 mutations, affects Ca2+ homeostasis by modulating ER-mitochondria coupling, potentially contributing to the progression of ADOA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Physiology
Simona Boncompagni, Claudia Pecorai, Antonio Michelucci, Laura Pietrangelo, Feliciano Protasi
Summary: The study shows that exercise can prevent the improper accumulation of STIM1 and ORAI1 in TAs during aging, maintaining the ability of aged muscles to refill intracellular Ca2+ stores via SOCE. Aging causes STIM1 and ORAI1 to accumulate in TAs, while long-term exercise can significantly reduce the formation of TAs. Aged muscles exhibit faster decay of contractile force and exercise can restore their capability to use external Ca2+ through the promotion of maintenance of CEUs.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shanna Hamilton, Radmila Terentyeva, Richard T. Clements, Andriy E. Belevych, Dmitry Terentyev
Summary: This article reviews the major cause of sudden cardiac death due to ventricular tachyarrhythmias and the enhanced propensity to malignant cardiac arrhythmias associated with heart failure, diabetic cardiomyopathy, old age related cardiac dysfunction and inherited disorders. Defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as key contributing factors to pathophysiology and arrhythmogenesis in these conditions. The article also discusses the bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these organelles increase arrhythmic risk in cardiac disease.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Physiology
J. Matthew Kittelberger, Clara Franzini-Armstrong, Simona Boncompagni
Summary: By studying the muscles of mice and fish, it has been found that calcium entry units (CEUs) in exercised muscles are correlated with muscle fatigue and high levels of muscle activity. This phenomenon is believed to be widely present across vertebrates, providing insights into the mechanisms of muscle activity and adaptation to different environments.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ying Wang, Meimi Zhao, Bing Xu, Sherif M. F. Bahriz, Chaoqun Zhu, Aleksandra Jovanovic, Haibo Ni, Ariel Jacobi, Nina Kaludercic, Fabio Di Lisa, Johannes W. Hell, Jean C. Shih, Nazareno Paolocci, Yang K. Xiang
Summary: In this study, the authors investigate the integrative control of intracellular catecholamine for subcellular beta(1)AR signaling and cardiac function. They identify the role of organic cation transporter 3 (OCT3) and monoamine oxidase A (MAO-A) in regulating beta(1)AR-PKA signaling and cardiac function. The results show that MAO-A deletion or inhibition enhances beta(1)AR-PKA activity and improves cardiac contractile response, while OCT3 deletion or inhibition prevents the effects induced by MAO-A. These findings provide insights into the regulation of cardiac function and suggest a drug contraindication between corticosterone and MAO inhibitors.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Review
Cell Biology
Felipe Salazar-Ramirez, Roberto Ramos-Mondragon, Gerardo Garcia-Rivas
Summary: Ca2+plays a crucial role in mitochondrial function, and the communication between mitochondria and SR is essential for cellular energy production and signaling. The balance between mitochondria and SR maintains normal cellular function, and any imbalance can lead to abnormal excitability of cardiac cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Weihong He, Charlotte S. McCarroll, Katrin Nather, Kristopher Ford, Kenneth Mangion, Alexandra Riddell, Dylan O'Toole, Ali Zaeri, David Corcoran, David Carrick, Mathew M. Y. Lee, Margaret McEntegart, Andrew Davie, Richard Good, Mitchell M. Lindsay, Hany Eteiba, Paul Rocchiccioli, Stuart Watkins, Stuart Hood, Aadil Shaukat, Lisa McArthur, Elspeth B. Elliott, John McClure, Catherine Hawksby, Tamara Martin, Mark C. Petrie, Keith G. Oldroyd, Godfrey L. Smith, Keith M. Channon, Colin Berry, Stuart A. Nicklin, Christopher M. Loughrey
Summary: The study identified that direct cardiac release of cathepsin-L in STEMI patients post-PPCI leads to elevated serum levels, and higher levels in the first 24 hours post-reperfusion are associated with reduced cardiac function and increased infarct size. Preclinical studies showed that inhibiting cathepsin-L release post-reperfusion injury can reduce infarct size and improve cardiac function by limiting abnormal calcium handling and apoptosis.
CARDIOVASCULAR RESEARCH
(2022)
Review
Toxicology
Joshua A. Keefe, Oliver M. Moore, Kevin S. Ho, Xander H. T. Wehrens
Summary: This review provides a comprehensive overview of the roles of Ca2+-handling proteins in healthy cardiac function and the mechanisms by which mutations in these proteins contribute to inherited arrhythmias. The major Ca2+ channels and Ca2+-sensitive regulatory proteins involved in cardiac excitation-contraction coupling are discussed, with special emphasis on the function of the RyR2 macromolecular complex. Inherited arrhythmia disorders caused by mutations in Ca2+-handling proteins are also discussed.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Cell Biology
Daniela Rossi, Stefania Lorenzini, Enrico Pierantozzi, Filip Van Petegem, David Osamwonuyi Amadsun, Vincenzo Sorrentino
Summary: Junctin is a transmembrane protein that plays a role in striated muscles by interacting with calsequestrin and the ryanodine receptor. Our study found that junctin and calsequestrin co-localize in the endoplasmic reticulum and triads, and identified specific regions of junctin that can bind calsequestrin and the RyR. Deletion of these regions affects junctin's localization at the junctional SR.
JOURNAL OF CELL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Bengt Svensson, Florentin R. Nitu, Robyn T. Rebbeck, Lindsey M. Mcgurran, Tetsuro Oda, David D. Thomas, Donald M. Bers, Razvan L. Cornea
Summary: Current studies have shown that Ca2+ leakage from cardiomyocyte sarcoplasmic reticulum through hyperactive resting cardiac ryanodine receptor channels (RyR2) has a pro-arrhythmic effect. An exogenous peptide (DPc10) binding promotes leaky RyR2 in cardiomyocytes and reports on the endogenous state. Conversely, binding of calmodulin (CaM) inhibits RyR2 leak and low CaM affinity is indicative of leaky RyR2. These findings have led to the development of a FRET biosensor for drug discovery targeting RyR2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessia Di Fonso, Laura Pietrangelo, Laura D'Onofrio, Antonio Michelucci, Simona Boncompagni, Feliciano Protasi
Summary: The study examined alterations in mitochondria and CRUs in the hearts of adult and aged mice, revealing improper organization and disposition in aged cardiomyocytes. These changes may lead to inefficient supply of Ca2+ ions and ATP, potentially contributing to cardiac dysfunction in aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jaime Balderas-Villalobos, J. M. L. Medina-Contreras, Christopher Lynch, Rajiv Kabadi, Rafael J. Ramirez, Alex Y. Tan, Karoly Kaszala, Montserrat Samso, Jose F. Huizar, Jose M. Eltit
Summary: Premature ventricular contractions (PVCs) are common ventricular arrhythmias that can enhance contractility acutely but lead to cardiomyopathy over time. Altered Ca2+ reuptake, as observed in PVC-CM, may contribute to contractile dysfunction. Study findings suggest delayed Ca2+ reuptake, reduced SERCA2 activity, and altered expression and phosphorylation of SERCA2 and PLB in PVC-CM. These alterations moderately contribute to functional adaptations in PVC-CM.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew J. Wleklinski, Dmytro O. Kryshtal, Kyungsoo Kim, Shan S. Parikh, Daniel J. Blackwell, Isabelle Marty, V. Ramesh Iyer, Bjorn C. Knollmann
Summary: CASQ2-K180R causes CPVT2 through impairing dynamic buffering of Ca within the SR, which is different from other CASQ2-related forms of CPVT2.
CIRCULATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Angela J. Kampfer, Edward M. Balog
Summary: SAM was found to have complex voltage dependent effects on heart RyR2 through the adenine nucleotide binding site. ATP and SAM interacted at a common binding site, with ATP interfering with the effects of SAM at both positive and negative potentials. *)__*
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Minna Hassinen, Jaakko Haverinen, Matti Vornanen
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2015)
Article
Physiology
Denis V. Abramochkin, Matti Vornanen
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2015)
Article
Physiology
Minna Hassinen, Jaakko Haverinen, Matt E. Hardy, Holly A. Shiels, Matti Vornanen
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2015)
Article
Physiology
M. Vornanen, J. Haverinen
Article
Physiology
Thomas Eliot Haworth, Jaakko Haverinen, Holly A. Shiels, Matti Vornanen
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Denis V. Abramochkin, Matti Vornanen
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Y. Itokazu, R. Kakela, J. Piironen, X. L. Guan, P. Kiiskinen, M. Vornanen
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Denis V. Abramochkin, Eugenia I. Alekseeva, Matti Vornanen
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Jaakko Haverinen, Matti Vornanen
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Hanna Korajoki, Matti Vornanen
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Physiology
Hanna Korajoki, Matti Vornanen
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2013)
Article
Physiology
Minna Hassinen, Denis V. Abramochkin, Matti Vornanen
JOURNAL OF COMPARATIVE PHYSIOLOGY B-BIOCHEMICAL SYSTEMS AND ENVIRONMENTAL PHYSIOLOGY
(2014)
Article
Biology
Matti Vornanen, Jaakko Haverinen, Stuart Egginton
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Biology
Denis V. Abramochkin, Svetlana V. Tapilina, Matti Vornanen
JOURNAL OF EXPERIMENTAL BIOLOGY
(2014)
Article
Physiology
Jaakko Haverinen, Stuart Egginton, Matti Vornanen
PHYSIOLOGICAL AND BIOCHEMICAL ZOOLOGY
(2014)