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Oncology
Fatima Junaid, Goran Tomic, Richard Kemp, Doug J. Winton
Summary: Using human colon cancer DLD-1 cells, the study engineered a cell line with inducible Snail expression and found that partial EMT induced by Snail overexpression in DLD-1 cells leads to chemoresistance, increased tumor growth, and decreased apoptosis, highlighting the importance of bioavailable Snail in determining the phenotypic outcome.
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Cell Biology
Yang Li, Yao Xing, Xu Wang, Bingtao Hu, Xin Zhao, Hongyan Zhang, Fuyi Han, Nanxi Geng, Fei Wang, Yanshu Li, Jiabin Li, Feng Jin, Feng Li
Summary: This study revealed the important role of PAK5 in breast cancer, with PAK5 deficiency inhibiting breast tumor formation. Phosphorylation of DDX5 is a substrate of PAK5, promoting breast cancer cell proliferation and metastasis. PAK5 facilitates the phosphorylation-dependent sumoylation of DDX5, enhancing microRNA biogenesis.
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Barbora Kvokackova, Jan Remsik, Mohit Kumar Jolly, Karel Soucek
Summary: Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) play critical roles in the development of TNBC, shaping aggressive and heterogeneous biological features, but may also contribute to the progression of metastatic disease.
Article
Cell Biology
Qing Song, Zhifen Han, Xinnan Wu, Yan Wang, Lihong Zhou, Liu Yang, Ningning Liu, Hua Sui, Jianfeng Cai, Qing Ji, Qi Li
Summary: In colorectal cancer (CRC), beta-arrestin1 promotes migration and metastasis of CRC cells by regulating the EMT process through the Wnt/β-catenin signaling pathways. This provides a novel therapeutic target for CRC metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Eva Hadadi, Herve Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Summary: The study demonstrates that BMAL1 plays a crucial role in maintaining the balance between epithelial and mesenchymal properties of CRC cell lines, influencing their capacities for adhesion, migration, invasion, and chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Shelan Rasool, Qais Al Ismaeel, Srdar H. Arif
Summary: This study investigated the expression pattern of matricellular proteins SPARC and CYR61 in colorectal cancer and found their association with cancer progression. High expression of CYR61 was associated with migration, invasion, proliferation, and apoptosis of colorectal cancer cells. This discovery provides new insights for the treatment of colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Nutrition & Dietetics
Homa Hajimehdipoor, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi
Summary: This study investigated the effects of rutin on the proliferation, metastasis, and angiogenesis of breast cancer cells. Rutin was found to stimulate the proliferation and migration of MDA-MB-231 and MCF-7 cells. It also modulated the expression of genes involved in cell adhesion and angiogenesis.
Article
Multidisciplinary Sciences
Zhennan Li, Cheng Lu, Fengliang Wang, Haowei Guo, Zhipeng Wang, Hong Yin, Jian Li
Summary: Insufficient microwave ablation (MWA) can induce autophagy and epithelial-mesenchymal transition (EMT) in breast cancer cells, leading to tumor metastasis. Heat treatment promotes the growth and metastasis of breast cancer cells through the TGF-02/Smad2-mediated EMT pathway. Inhibition of autophagy may be a suitable strategy to overcome the progression and metastasis of residual breast cancer cells following insufficient MWA.
Article
Cell Biology
Zhongwei Li, Diandian Wang, Xintian Chen, Wenwen Wang, Pengfei Wang, Pingfu Hou, Minle Li, Sufang Chu, Shuxi Qiao, Junnian Zheng, Jin Bai
Summary: This study uncovers the critical role of PRMT1-mediated methylation of EZH2 at the R342 site in promoting breast cancer cell proliferation, accelerating cell cycle progression, repressing P16 and P21 transcription, and enhancing EZH2 binding with SUZ12 and PRC2 assembly. Additionally, it highlights the potential of meR342-EZH2 as a novel therapeutic target for breast cancer treatment, indicating a negative correlation with pT311-EZH2 expression.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Jing Quan, Namei Li, Yue Tan, Huiwen Liu, Weihua Liao, Ya Cao, Xiangjian Luo
Summary: This study elucidated the metabolic alteration in TGF-beta 1-induced EMT and metastasis of NPC cells, and found that PGC1 alpha-mediated FAO promotes EMT and metastasis of NPC cells. This study is of great significance for understanding the mechanistic connection between energy metabolic reprogramming and the aggressive phenotype of NPC.
Article
Oncology
Guobin Jiang, Hongyan Fang, Xi Shang, Xiaopin Chen, Feilin Cao
Summary: The study revealed upregulation of CHFR in breast cancer and its association with tumor metastasis. High expression levels of CHFR were correlated with poorer overall survival rates in patients.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemical Research Methods
Yingying Ma, Songbiao Zhu, Meiqi Yi, Wenhao Zhang, Yuanyuan Xue, Xiaohui Liu, Haiteng Deng
Summary: Protein S-glutathionylation is an important post-translational modification that regulates cellular processes. This study investigated the changes in glutathionylome during epithelial-mesenchymal transition (EMT) and found that the glutathionylation level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) increased, inhibiting its enzymatic activity and promoting EMT.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Cell Biology
Xu Liu, Yao-Jie Pan, Meng-Jie Kang, Xin Jiang, Zhong-Ying Guo, Dong-Sheng Pei
Summary: In this study, it was found that P21-activated kinase 5 (PAK5) is overexpressed in renal cell carcinoma (RCC) and promotes metastasis by enhancing epithelial-mesenchymal transition. PAK5 binds to Slug and phosphorylates it, leading to the activation of N-cadherin. Therefore, phosphorylated Slug-S87 could serve as a therapeutic target for progressive RCC.
CELLULAR SIGNALLING
(2023)
Review
Genetics & Heredity
Rakesh Kumar, Rahul Sanawar, Xiaodong Li, Feng Li
Article
Chemistry, Medicinal
Chenzhou Hao, Fan Zhao, Hongyan Song, Jing Guo, Xiaodong Li, Xiaolin Jiang, Ran Huan, Shuai Song, Qiaoling Zhang, Ruifeng Wang, Kai Wang, Yu Pang, Tongchao Liu, Tianqi Lu, Wanxu Huang, Jian Wang, Bin Lin, Zhonggui He, Haitao Li, Feng Li, Dongmei Zhao, Maosheng Cheng
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Cell Biology
Xiumei Zhang, Xia Zhang, Yang Li, Yangguang Shao, Jianying Xiao, Ge Zhu, Feng Li
CELL DEATH & DISEASE
(2017)
Article
Medicine, Research & Experimental
Funan Liu, Zhenguo Cheng, Xiaodong Li, Yanshu Li, Hongyan Zhang, Jiabin Li, Furong Liu, Huimian Xu, Feng Li
MOLECULAR THERAPY-NUCLEIC ACIDS
(2017)
Article
Biochemistry & Molecular Biology
Yuxin Tong, Yan Li, Hui Gu, Chunyu Wang, Funan Liu, Yangguang Shao, Feng Li
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Oncology
Hongdan Li, Feng Li
BRITISH JOURNAL OF CANCER
(2018)
Article
Biochemistry & Molecular Biology
Yanshu Li, Hongyan Zhang, Yue Zhao, Chunyu Wang, Zhenguo Cheng, Lina Tang, Yunling Gao, Furong Liu, Jiabin Li, Yan Li, Yang Li, Nanxi Geng, Xue Rui, Yuee Teng, Yunpeng Liu, Liu Cao, Rakesh Kumar, Feng Jin, Feng Li
Article
Oncology
Jiao Liu, Yangguang Shao, Yuxin He, Ke Ning, Xi Cui, Furong Liu, Zhenning Wang, Feng Li
Article
Biochemistry & Molecular Biology
Fei Wang, Yunling Gao, Lina Tang, Ke Ning, Nanxi Geng, Hongyan Zhang, Yanshu Li, Yang Li, Furong Liu, Feng Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Oncology
Nanxi Geng, Yang Li, Wenyu Zhang, Fei Wang, Xu Wang, Zining Jin, Yao Xing, Danni Li, Hongyan Zhang, Yanshu Li, Xiaodong Li, Maosheng Cheng, Feng Jin, Feng Li
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Ke Ning, Yangguang Shao, Yuxin He, Fei Wang, Xi Cui, Furong Liu, Danni Li, Feng Li
Article
Cell Biology
Yang Li, Yao Xing, Xu Wang, Bingtao Hu, Xin Zhao, Hongyan Zhang, Fuyi Han, Nanxi Geng, Fei Wang, Yanshu Li, Jiabin Li, Feng Jin, Feng Li
Summary: This study revealed the important role of PAK5 in breast cancer, with PAK5 deficiency inhibiting breast tumor formation. Phosphorylation of DDX5 is a substrate of PAK5, promoting breast cancer cell proliferation and metastasis. PAK5 facilitates the phosphorylation-dependent sumoylation of DDX5, enhancing microRNA biogenesis.
Article
Biochemistry & Molecular Biology
Yao Xing, Yang Li, Bingtao Hu, Fuyi Han, Xin Zhao, Hongyan Zhang, Yanshu Li, Danni Li, Jiabin Li, Feng Jin, Feng Li
Summary: The study revealed that PAK5 inhibits apoptosis in breast cancer cells by preventing the nuclear translocation of AIF. PAK5 phosphorylates AIF to inhibit its complex formation with importin β3, leading to decreased nuclear translocation. The expression of PAK5 and AIF in breast cancer is positively correlated with poor patient prognosis, while PAK5 expression is negatively correlated with AIF nuclear translocation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lina Tang, Yunling Gao, Yongqi Song, Yang Li, Yanshu Li, Hongyan Zhang, Danni Li, Jiabin Li, Caigang Liu, Feng Li
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
Article
Oncology
Hong-Yan Zhang, Jian Zhang, Chen-Zhou Hao, Ying Zhou, Jian Wang, Mao-Sheng Cheng, Dong-Mei Zhao, Feng Li
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2017)