Article
Biochemistry & Molecular Biology
Maria Elisa Giuliani, Alessandro Nardi, Marta Di Carlo, Maura Benedetti, Francesco Regoli
Summary: The study found that although metallothioneins and mRNA of antioxidant genes in the gills increased after Cd exposure, these effects were softened in warming and acidification scenarios. Limited effects were observed in the liver due to higher baseline antioxidant protection. Combined stressors resulted in increased genotoxic damage.
Article
Biochemistry & Molecular Biology
Jonas Knittel, Nadja Itani, Rolf Schreckenberg, Jacqueline Heger, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlueter
Summary: Serotonin effects on cardiac hypertrophy, senescence, and failure depend on specific receptors or serotonin uptake and degradation by MAOs. MAO-dependent effects are non-specific. MAOA expression increases in maladaptive hypertrophic stages. MAO-A inhibition suppresses serotonin-dependent damage. Serotonin induces mitochondria-dependent oxidative stress.
Article
Chemistry, Multidisciplinary
Fanghui Liang, Jian Jiang, Xinyue Yang, Guoyang Zhang, Jiaying Zhou, Jiahao Han, Yujie Geng, Zhuo Wang
Summary: Neuroinflammation leads to oxidative stress in the brain and is linked to various neurological disorders. A fluorescent probe, SiR-FH, was developed for detecting HClO. This probe demonstrated high selectivity, rapid response, and sensitivity, successfully detecting endogenous and exogenous HClO in living cells. Real-time monitoring of HClO flux in the brains of mice with LPS-induced neuroinflammation was achieved using SiR-FH, providing a practical tool for studying oxidative stress related to neuroinflammation.
CHEMICAL COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Dino A. Giussani
Summary: The article explores the impact of chronic fetal hypoxia during pregnancy on the development of cardiovascular disease in offspring and potential therapeutic approaches, with a focus on molecular-level research and potential targets for clinical intervention.
Article
Cardiac & Cardiovascular Systems
Huijing Yu, Fang Zhang, Pengyi Yan, Shasha Zhang, Yingmei Lou, Zilong Geng, Zixuan Li, Yan Zhang, Yuejuan Xu, Yanan Lu, Chen Chen, Daowen Wang, Wei Zhu, Xinyang Hu, Jian'an Wang, Tao Zhuang, Yuzhen Zhang, Gengze Wu, Junling Liu, Chunyu Zeng, William T. Pu, Kun Sun, Bing Zhang
Summary: LARP7 plays a crucial role in mitochondrial biogenesis, energy production, and cardiac function by modulating SIRT1 homeostasis and activity. Reduction of LARP7 in diseased hearts contributes to heart failure pathogenesis, while restoring LARP7 in the injured heart confers myocardial protection, identifying the ATM-LARP7-SIRT1 pathway as a potential therapeutic target in heart failure.
Review
Cell Biology
Matthew Batty, Martin R. Bennett, Emma Yu
Summary: Atherosclerosis is a leading cause of cardiovascular diseases globally, and excessive generation of reactive oxygen species (ROS) due to oxidative stress is a major risk factor for its development and progression. While ROS are important for maintaining vascular health, they can also activate pro-atherogenic processes. Enzymatic sources of vascular ROS include NADPH oxidases, xanthine oxidase, etc., and antioxidant systems play a role in balancing ROS production. Changes in ROS sources and antioxidants have been observed in human atherosclerosis, and animal models have provided mechanistic insight. However, clinical trials have not yet demonstrated atheroprotective effects of antioxidant molecules.
Review
Medicine, Research & Experimental
Chi Zhang, Hao Li, Jie Li, Jiajin Hu, Keda Yang, Lin Tao
Summary: Osteoporosis is a major concern and high-risk populations need regular bone mineral density testing and appropriate preventive treatment. Oxidative stress, including the direct effect of reactive oxygen species and the reduction of antioxidant enzyme activity, plays a significant role in the development of osteoporosis. Understanding the impact of oxidative stress on osteoporosis can greatly optimize therapeutic schedules.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Geriatrics & Gerontology
Sirawit Sriwichaiin, Nattayaporn Apaijai, Arintaya Phrommintikul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Nisakron Thongmung, Usanee Mahantassanapong, Prin Vathesatogkit, Chagriya Kitiyakara, Piyamitr Sritara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Mitochondrial dysfunction is potentially associated with aging, although there is limited evidence regarding the relationship between mitochondrial function and aging. In this study, mitochondrial function was found to decline with age, with several parameters related to mitochondrial respiration significantly lower in older adults. However, mitochondrial ATP production and mitochondrial coupling efficiency were slightly increased in older adults. Additionally, mitochondrial mass and oxidative stress were significantly reduced in older individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Environmental Sciences
Sarah Easson, Radha Dutt Singh, Liam Connors, Taylor Scheidl, Larissa Baker, Anshul Jadli, Hai-Lei Zhu, Jennifer Thompson
Summary: This study found that the commonly used BPA substitute BPS can disturb redox balance and increase the production of reactive oxygen species (ROS), leading to impaired endothelial function.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Seongchun Min, Ji Yeon Kim, Hyo Min Cho, Sujin Park, Ji Min Hwang, Hyejin You, Young Chan Chae, Won-Jae Lee, Woong Sun, Dongmin Kang, Sanghyuk Lee, Sang Won Kang
Summary: This study reveals a novel signaling pathway in which mitochondria communicate with the cytosol via the release of heat shock protein 60, leading to the activation of survival genes in the nucleus.
Article
Biochemistry & Molecular Biology
Shenghao Zhang, Xun Wu, Jin Wang, Yingwu Shi, Qing Hu, Wenxing Cui, Hao Bai, Jinpeng Zhou, Yong Du, Liying Han, Dayun Feng, Shunnan Ge, Yan Qu
Summary: The APN/AdipoR1 signaling pathway plays a protective role in oxidative damage after TBI by restoring SIRT3-mediated mitochondrial homeostasis and antioxidant system.
Article
Biochemistry & Molecular Biology
Sylwia M. Kacprzak, Olivier Van Aken
Summary: Mitochondria play vital roles in plant metabolism and stress responses. Quality control systems, including mitophagy, are important for maintaining a healthy mitochondrial pool. The 'Friendly Mitochondria' protein (FMT) has been identified as a crucial player in mitophagy during dark-induced senescence in Arabidopsis.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Medicine, Research & Experimental
Yaqian Qu, Ruonan Zhai, Dandan Wang, Zheng Wang, Guangjie Hou, Chenchen Wu, Meian Tang, Xiongbin Xiao, Jie Jiao, Yue Ba, Fang Zhou, Jian Qiu, Wu Yao
Summary: In this study, the upregulation of proteins involved in mitochondrial folate metabolism during myofibroblast differentiation and the negative regulation of myofibroblast differentiation by the proteins MTHFD2 and SLC25A32 were revealed. Furthermore, reduced plasma folate concentration in patients and mice with silicosis was observed. Folate supplementation elevated the expression of MTHFD2 and SLC25A32, alleviated oxidative stress, and effectively suppressed myofibroblast differentiation and silica-induced pulmonary fibrosis in mice.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Tarun Pant, Nnamdi Uche, Matea Juric, Zeljko J. Bosnjak
Summary: Metabolic imbalances and persistent hyperglycemia in diabetes mellitus drive the production of reactive oxygen species (ROS), leading to vascular complications. Recent studies show that changes in long non-coding RNA (lncRNA) regulate mitochondrial function in oxidative stress. Mitochondria-targeted antioxidants (MTAs) have emerged as a promising therapeutic option for managing oxidative stress-induced diseases. This review discusses the potential of lncRNA as a diagnostic biomarker and regulator of oxidative stress in diabetes-associated vascular complications, as well as the use of MTAs in animal models and clinical trials.
Review
Food Science & Technology
Jing Yang, Huayi Suo, Jiajia Song
Summary: MitoQ reduces mitochondrial oxidative stress and promotes autophagy and mitochondrial biogenesis to alleviate MetS symptoms such as obesity, insulin resistance, hypertension, and cardiovascular disease. Its regulatory effect on mitochondrial homeostasis is mediated through AMPK and its downstream signaling pathways.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)